{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:21:15Z","timestamp":1773786075612,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Glycemic variability (GV) and hypoglycemia during nighttime are presumed to be associated with fatal bradycardia. The aim of this prospective study was to evaluate blood glucose dynamics during sleep in patients with obstructive sleep apnea syndrome (OSA) and normal glucose tolerance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with OSA\u00a0and no diabetes who underwent type 1 overnight polysomnography from December 2018 to May 2020 participated in this study. GV was evaluated in all participants for 14 days using a flash glucose monitoring device. Correlations were examined between GV indexes and indexes related to sleep breathing disorders, the effects of treatment with continuous positive airway pressure (CPAP) on these GV indexes, and the characteristics of glucose dynamics in different OSA subtypes classified by sleep stage.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among\u00a042 patients with OSA and no diabetes, the standard deviation of GV during sleep correlated significantly with sleep time spent with oxygen saturation &lt;90% (<jats:italic>r<\/jats:italic>=0.591, <jats:italic>p<\/jats:italic>=0.008). High blood glucose index during sleep correlated significantly with stage N1% (<jats:italic>r<\/jats:italic>=0.491, <jats:italic>p<\/jats:italic>=0.032) and negatively with stage N2% (<jats:italic>r<\/jats:italic>=\u22120.479, <jats:italic>p<\/jats:italic>=0.038). High blood glucose index correlated significantly with sleep time spent with oxygen saturation &lt;90% (<jats:italic>r<\/jats:italic>=0.640, <jats:italic>p<\/jats:italic>=0.003). The rapid eye movement\u2013related OSA group had a higher incidence of hypoglycemia. One-week with\u00a0CPAP treatment significantly improved GV during sleep, standard deviation of GV (from 12.1 to 9.0 mg\/dL, <jats:italic>p<\/jats:italic>&lt;0.001), and high blood glucose index (from 0.7 to 0.4, <jats:italic>p<\/jats:italic>=0.006).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To evaluate GV during sleep in patients with OSA may be useful for clinical risk management. CPAP treatment for 1 week may have an improving GV and high blood glucose index.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration<\/jats:title>\n                <jats:p>UMIN000038489 2019\/11\/04, UMIN 000025433 2016\/12\/27<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11325-021-02442-9","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T20:02:33Z","timestamp":1628712153000},"page":"771-781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blood glucose dynamics during sleep in patients with obstructive sleep apnea and normal glucose tolerance: effects of CPAP therapy"],"prefix":"10.1007","volume":"26","author":[{"given":"Kimimasa","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Torimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"4","key":"2442_CR1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/sleep\/32.4.447","volume":"32","author":"ES Arnardottir","year":"2009","unstructured":"Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI (2009) Molecular signatures of obstructive sleep apnea in adults: a review and perspective. 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Our manuscript is not under consideration for publication in any other journal. If accepted, the authors agree that the paper will not be published elsewhere in the same or a similar form, in English or in any other language, without written consent of the copyright holder.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}