{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:01:08Z","timestamp":1783065668400,"version":"3.54.6"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s11325-021-02452-7","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T09:02:31Z","timestamp":1631264551000},"page":"1277-1280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Children with Congenital Central Hypoventilation Syndrome Do Not Wake up to Ventilator Alarms"],"prefix":"10.1007","volume":"26","author":[{"given":"Shreya","family":"Mathur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Laifman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Keens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L. Davidson","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-0130","authenticated-orcid":false,"given":"Iris A.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"2452_CR1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1164\/rccm.200807-1069ST","volume":"181","author":"DE Weese-Mayer","year":"2010","unstructured":"Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Keens TG, Loghmanee DA, Trang H (2010) An official ATS clinical policy statement: congenital central hypoventilation syndrome: genetic basis, diagnosis, and management. Am J Respir Crit Care Med 181:626\u2013644","journal-title":"Am J Respir Crit Care Med"},{"key":"2452_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13023-019-1279-y","volume":"15","author":"H Trang","year":"2020","unstructured":"Trang H, Samuels M, Ceccherini I et al (2020) Guidelines for diagnosis and management of congenital central hypoventilation syndrome. Orphanet J Rare Dis 15:1\u201321","journal-title":"Orphanet J Rare Dis"},{"key":"2452_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/17476348.2018.1445970","volume":"12","author":"MA Maloney","year":"2018","unstructured":"Maloney MA, Kun SS, Keens TG, Perez IA (2018) Congenital central hypoventilation syndrome: diagnosis and management. Expert Rev Respir Med 12:283\u2013292","journal-title":"Expert Rev Respir Med"},{"key":"2452_CR4","doi-asserted-by":"publisher","unstructured":"Vanderlaan M, Holbrook CR, Wang M, Tuell A, Gozal D (2004) Epidemiologic survey of 196 patients with congenital central hypoventilation syndrome. Pediatr Pulmonol. https:\/\/doi.org\/10.1002\/ppul.10438","DOI":"10.1002\/ppul.10438"},{"key":"2452_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1159\/000381401","volume":"89","author":"B Diep","year":"2015","unstructured":"Diep B, Wang A, Kun S, McComb JG, Shaul DB, Shin CE, Keens TG, Perez IA (2015) Diaphragm pacing without tracheostomy in congenital central hypoventilation syndrome patients. Respiration 89:534\u2013538","journal-title":"Respiration"},{"key":"2452_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.sleh.2016.11.006","volume":"3","author":"M Ohayon","year":"2017","unstructured":"Ohayon M, Wickwire EM, Hirshkowitz M et al (2017) National Sleep Foundation\u2019s sleep quality recommendations: first report. Sleep Heal 3:6\u201319","journal-title":"Sleep Heal"},{"key":"2452_CR7","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1542\/peds.88.1.132","volume":"88","author":"CL Marcus","year":"1991","unstructured":"Marcus CL, Bautista DB, Amihyia A, Ward SL, Keens TG (1991) Hypercapneic arousal responses in children with congenital central hypoventilation syndrome. Pediatrics 88:993\u2013998","journal-title":"Pediatrics"},{"key":"2452_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13023-017-0569-5","volume":"12","author":"V Attali","year":"2017","unstructured":"Attali V, Straus C, Pottier M, Buzare MA, Mor\u00e9lot-Panzini C, Arnulf I, Similowski T (2017) Normal sleep on mechanical ventilation in adult patients with congenital central alveolar hypoventilation (Ondine\u2019s curse syndrome). Orphanet J Rare Dis 12:1\u20135","journal-title":"Orphanet J Rare Dis"},{"key":"2452_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0299-z","author":"H Trang","year":"2015","unstructured":"Trang H, Masri Zada T, Heraut F (2015) Abnormal auditory pathways in PHOX2B mutation positive congenital central hypoventilation syndrome. BMC Neurol. https:\/\/doi.org\/10.1186\/s12883-015-0299-z","journal-title":"BMC Neurol"},{"key":"2452_CR10","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/archneur.1986.00520070054018","volume":"43","author":"R Beckerman","year":"1986","unstructured":"Beckerman R, Meltzer J, Sola A, Dunn D, Wegmann M (1986) Brain-Stem Auditory Response in Ondine\u2019s Syndrome. Arch Neurol 43:698\u2013701","journal-title":"Arch Neurol"},{"issue":"Supplement_1","key":"2452_CR11","doi-asserted-by":"publisher","first-page":"A333","DOI":"10.1093\/sleep\/zsaa056.870","volume":"43","author":"SK Mathur","year":"2020","unstructured":"Mathur SK, Kun S, Keens TG, Perez IA (2020) Patients with Congenital central hypoventilation syndrome do not wake up to ventilator alarms. Sleep 43(Supplement_1):A333. https:\/\/doi.org\/10.1093\/sleep\/zsaa056.870","journal-title":"Sleep"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02452-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-021-02452-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-021-02452-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T15:59:41Z","timestamp":1661529581000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-021-02452-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,10]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2452"],"URL":"https:\/\/doi.org\/10.1007\/s11325-021-02452-7","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,10]]},"assertion":[{"value":"5 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The questionnaire and methodology for this study was approved by the Institutional Review Board of the Children\u2019s Hospital Los Angeles (IRB#:\u00a0CHLA-19\u201300249). Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A. Patients were notified in the consent form that they will not be identified in publications of the research results.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}