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Patients were evaluated with portable apnea monitoring, echocardiography, and cardiopulmonary exercise testing at baseline and 3\u00a0months later.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of a total of 18 patients, 9 (50%) had OA, 7 (39%) had CA, and 2 (11%) had normal breathing. SV therapy was related to a reduction in NT-pro BNP and an improvement in LV function after 3\u00a0months. Portable apnea monitoring revealed a significant decrease of the respiratory event index (REI) after treatment with SV (20\u2009\u00b1\u200923 events\/h to 7\u2009\u00b1\u20097 events\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). When subgrouping according to type of apneas, REI, and time spent below 90% saturation (T90) decreased in patients with CA and OA (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In this prospective study, SV treatment for 3\u00a0months in patients with CA and OA is associated with a significant decrease in REI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11325-022-02623-0","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T11:37:41Z","timestamp":1651232261000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of sacubitril-valsartan on central and obstructive apneas in heart failure patients with reduced ejection fraction"],"prefix":"10.1007","volume":"27","author":[{"given":"Youmeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Fernandes","family":"Branco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Salanitro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Penzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sch\u00f6bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"2623_CR1","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/ejhf.1858","volume":"22","author":"A Groenewegen","year":"2020","unstructured":"Groenewegen A, Rutten FH, Mosterd A, Hoes AW (2020) Epidemiology of heart failure. 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