{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:47:42Z","timestamp":1792518462643,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Hypoglossal nerve stimulation (HNS) has been shown to treat obstructive sleep apnea (OSA) effectively. The aim of this study was to compare HNS with positive airway pressure (PAP) treatment regarding outcome parameters: (1) sleepiness, (2) apnea\u2013hypopnea index (AHI), and (3) effectiveness.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Propensity score matching with nearest neighbor algorithm was used to compare outcomes of HNS and PAP therapy in a real-world setting. Data were collected at baseline and 12\u00a0months after initiating OSA treatment including demographics, Epworth Sleepiness Scale (ESS), AHI, and objective adherence data. To account for overall treatment efficacy, the mean disease alleviation (MDA) was calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 227 patients who received treatment consecutively, 126 could be matched 1:1 with regard to age, body mass index, and AHI. After matching, no statistically significant differences between the groups were found. A clinically important symptom improvement was seen at 12\u00a0months in both cohorts, though there was a greater difference in ESS improvement in patients treated with HNS (8.0\u2009\u00b1\u20095.1\u00a0points vs. 3.9\u2009\u00b1\u20096.8\u00a0points; <jats:italic>p<\/jats:italic>\u2009=\u20090.042). In both groups, mean posttreatment AHI was significantly reduced (HNS: 8.1\u2009\u00b1\u20096.3\/h; PAP: 6.6\u2009\u00b1\u20098.0\/h; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Adherence after 12\u00a0months among patients treated with HNS was higher than in those receiving PAP therapy (5.0\u2009\u00b1\u20092.6\u00a0h\/night; 4.0\u2009\u00b1\u20092.1\u00a0h\/night) but not with statistical significance. Overall effectiveness calculated with the MDA was 59% in patients treated with HNS compared to 51% receiving PAP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients treated with HNS therapy had significantly greater improvements in daytime sleepiness compared to PAP therapy, while the mean reduction of AHI and overall effectiveness were comparable for both treatments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrial.gov Identifier: NCT03756805.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11325-022-02663-6","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T07:05:53Z","timestamp":1656745553000},"page":"693-701","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Hypoglossal nerve stimulation versus positive airway pressure therapy for\u00a0obstructive sleep apnea"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-2891","authenticated-orcid":false,"given":"Clemens","family":"Heiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Patrick J.","family":"Strollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Giaie-Miniet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier M.","family":"Vanderveken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Hofauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"issue":"8","key":"2663_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","volume":"7","author":"AV Benjafield","year":"2019","unstructured":"Benjafield AV et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. 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Claire Giai-Miniet has nothing to disclose. Benedikt Hofauer reports personal fees and other from Inspire Medical Systems, outside the submitted work. Patrick Strollo reports grants, personal fees, and other from Inspire Medical Systems; grants, personal fees, and other from ResMed; personal fees and other from Itamar Medical; grants, personal fees, and other from Jazz Pharmaceuticals; grants from Philips Respironics; and grants from NHLBI, outside the submitted work. Olivier Vanderveken reports grants and personal fees from Senior Clinical Fellowship Grant (Fundamenteel Klinisch Mandaat 1833517\u00a0N) from Research Foundation Flanders Vlaanderen (FWO); grants and personal fees from Inspire Medical Systems; grants from Philips Respironics; grants from Nyxoah; and grants from Somnomedics, outside the submitted work. Armin Steffen reports grants, personal fees and non-financial support from Inspire Medical, personal fees from Panak\u00e8s Partners SGR SpA, outside the submitted work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}