{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:25Z","timestamp":1740126865874,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Municipal Science and Technology Committee","award":["D171100008217005"],"award-info":[{"award-number":["D171100008217005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s11325-022-02772-2","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T04:13:19Z","timestamp":1672027999000},"page":"1945-1952","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between nocturnal intermittent hypoxemia and mild cognitive impairment in the older adult and the role of BDNF Val66Met polymorphism: a hospital-based cross-sectional study"],"prefix":"10.1007","volume":"27","author":[{"given":"L. H.","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. X.","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-2054","authenticated-orcid":false,"given":"J. T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"10","key":"2772_CR1","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/jamaneurol.2017.2180","volume":"74","author":"Y Leng","year":"2017","unstructured":"Leng Y, McEvoy CT, Allen IE, Yaffe K (2017) Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis. JAMA Neurol 74(10):1237\u20131245. https:\/\/doi.org\/10.1001\/jamaneurol.2017.2180","journal-title":"JAMA Neurol"},{"issue":"6","key":"2772_CR2","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1001\/jama.2011.1115","volume":"306","author":"K Yaffe","year":"2011","unstructured":"Yaffe K, Laffan AM, Harrison SL et al (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306(6):613\u2013619. https:\/\/doi.org\/10.1001\/jama.2011.1115","journal-title":"JAMA"},{"issue":"8","key":"2772_CR3","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1177\/0193945920907308","volume":"42","author":"T Liu","year":"2020","unstructured":"Liu T, Li H, Colton JP, Ge S, Li C (2020) The BDNF Val66Met polymorphism, regular exercise, and cognition: a systematic review. West J Nurs Res 42(8):660\u2013673. https:\/\/doi.org\/10.1177\/0193945920907308","journal-title":"West J Nurs Res"},{"issue":"2","key":"2772_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.55782\/ane-2005-1558","volume":"65","author":"A Brzecka","year":"2005","unstructured":"Brzecka A (2005) Brain preconditioning and obstructive sleep apnea syndrome. Acta Neurobiol Exp (Wars) 65(2):213\u2013220","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"2772_CR5","doi-asserted-by":"publisher","unstructured":"Quialheiro A, Bobinski F, Haefliger JG, et al (2021) A comprehensive program of cognitive stimulation with digital inclusion, physical activity and social interaction can modify BDNF levels and improve cognition in adults over 50: a randomized controlled pilot study. Aging Ment Health :1\u20139. https:\/\/doi.org\/10.1080\/13607863.2021.1966742","DOI":"10.1080\/13607863.2021.1966742"},{"issue":"1","key":"2772_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3233\/JAD-180971","volume":"68","author":"H Xia","year":"2019","unstructured":"Xia H, Wang M, Li JQ et al (2019) The influence of BDNF Val66Met polymorphism on cognition, cerebrospinal fluid, and neuroimaging markers in non-demented elderly. J Alzheimers Dis 68(1):405\u2013414. https:\/\/doi.org\/10.3233\/JAD-180971","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2772_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41398-019-0601-8","volume":"9","author":"A Ferrer","year":"2019","unstructured":"Ferrer A, Labad J, Salvat-Pujol N et al (2019) BDNF genetic variants and methylation: effects on cognition in major depressive disorder. Transl Psychiatry 9(1):265. https:\/\/doi.org\/10.1038\/s41398-019-0601-8","journal-title":"Transl Psychiatry"},{"issue":"3","key":"2772_CR8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1001\/jamaneurol.2021.5181","volume":"79","author":"YY Lim","year":"2022","unstructured":"Lim YY, Maruff P, Barthelemy NR et al (2022) Association of BDNF Val66Met with Tau hyperphosphorylation and cognition in dominantly inherited Alzheimer disease. JAMA Neurol 79(3):261\u2013270. https:\/\/doi.org\/10.1001\/jamaneurol.2021.5181","journal-title":"JAMA Neurol"},{"issue":"9","key":"2772_CR9","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1007\/s10072-017-3048-9","volume":"38","author":"QG Ren","year":"2017","unstructured":"Ren QG, Chang JH, Lu WJ, Gong WG, Zhou H (2017) Low plasma BDNF is not a biomarker for cognitive dysfunction in elderly T2DM patients. Neurol Sci 38(9):1691\u20131696. https:\/\/doi.org\/10.1007\/s10072-017-3048-9","journal-title":"Neurol Sci"},{"issue":"1","key":"2772_CR10","doi-asserted-by":"publisher","first-page":"e0227834","DOI":"10.1371\/journal.pone.0227834","volume":"15","author":"KR Flores","year":"2020","unstructured":"Flores KR, Viccaro F, Aquilini M et al (2020) Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients. PLoS One 15(1):e0227834. https:\/\/doi.org\/10.1371\/journal.pone.0227834","journal-title":"PLoS One"},{"key":"2772_CR11","doi-asserted-by":"publisher","first-page":"110930","DOI":"10.1016\/j.ijporl.2021.110930","volume":"151","author":"S Thavagnanam","year":"2021","unstructured":"Thavagnanam S, H\u2019Ng SY, Nathan AM et al (2021) WRISTOX2 is a reliable tool to diagnose obstructive sleep apnoea syndrome. Int J Pediatr Otorhinolaryngol 151:110930. https:\/\/doi.org\/10.1016\/j.ijporl.2021.110930","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"14","key":"2772_CR12","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1001\/jama.283.14.1829","volume":"283","author":"FJ Nieto","year":"2000","unstructured":"Nieto FJ, Young TB, Lind BK et al (2000) Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study Sleep Heart Health Study. JAMA 283(14):1829\u20131836. https:\/\/doi.org\/10.1001\/jama.283.14.1829","journal-title":"JAMA"},{"issue":"10","key":"2772_CR13","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1111\/j.1532-5415.2012.04183.x","volume":"60","author":"H Frohnhofen","year":"2012","unstructured":"Frohnhofen H, Roffe C (2012) Intermittent nocturnal hypoxemia in individuals with dementia: prevalence and relationship with functional status. J Am Geriatr Soc 60(10):1997\u20131999. https:\/\/doi.org\/10.1111\/j.1532-5415.2012.04183.x","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"2772_CR14","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-141278","volume":"43","author":"JP Tan","year":"2015","unstructured":"Tan JP, Li N, Gao J et al (2015) Optimal cutoff scores for dementia and mild cognitive impairment of the Montreal Cognitive Assessment among elderly and oldest-old Chinese population. J Alzheimers Dis 43(4):1403\u20131412. https:\/\/doi.org\/10.3233\/JAD-141278","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"2772_CR15","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.12740\/PP\/45368","volume":"50","author":"N Ciesielska","year":"2016","unstructured":"Ciesielska N, Sokolowski R, Mazur E, Podhorecka M, Polak-Szabela A, Kedziora-Kornatowska K (2016) Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis. Psychiatr Pol 50(5):1039\u20131052. https:\/\/doi.org\/10.12740\/PP\/45368","journal-title":"Meta-analysis. Psychiatr Pol"},{"issue":"3","key":"2772_CR16","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","volume":"256","author":"B Winblad","year":"2004","unstructured":"Winblad B, Palmer K, Kivipelto M et al (2004) Mild cognitive impairment\u2013beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256(3):240\u2013246. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01380.x","journal-title":"J Intern Med"},{"issue":"10","key":"2772_CR17","doi-asserted-by":"publisher","first-page":"e11203","DOI":"10.7759\/cureus.11203","volume":"12","author":"W Akberzie","year":"2020","unstructured":"Akberzie W, Hesselbacher S, Aiyer I, Surani S, Surani ZS (2020) The prevalence of anxiety and depression symptoms in obstructive sleep apnea. Cureus 12(10):e11203. https:\/\/doi.org\/10.7759\/cureus.11203","journal-title":"Cureus"},{"issue":"1","key":"2772_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12931-016-0448-y","volume":"17","author":"OI Emilsson","year":"2016","unstructured":"Emilsson OI, Benediktsdottir B, Olafsson I et al (2016) Erratum to: respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux. Respir Res 17(1):130. https:\/\/doi.org\/10.1186\/s12931-016-0448-y","journal-title":"Respir Res"},{"key":"2772_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.sleep.2019.12.019","volume":"69","author":"SA Lee","year":"2020","unstructured":"Lee SA, Kim HJ, Lee Y (2020) Subjective nocturnal symptoms have different associations with depressive symptoms and anxiety than with daytime sleepiness in patients with obstructive sleep apnea. Sleep Med 69:58\u201364. https:\/\/doi.org\/10.1016\/j.sleep.2019.12.019","journal-title":"Sleep Med"},{"key":"2772_CR20","doi-asserted-by":"publisher","first-page":"112504","DOI":"10.1016\/j.psychres.2019.112504","volume":"280","author":"KM Park","year":"2019","unstructured":"Park KM, Kim SY, Sung D et al (2019) The relationship between risk of obstructive sleep apnea and other sleep problems, depression, and anxiety in adolescents from a community sample. Psychiatry Res 280:112504. https:\/\/doi.org\/10.1016\/j.psychres.2019.112504","journal-title":"Psychiatry Res"},{"issue":"1","key":"2772_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/1573402112666160114094222","volume":"12","author":"RS Santos","year":"2016","unstructured":"Santos RS, Motwani SS, Elias RM (2016) Chronic kidney disease and sleeping disordered breathing (SDB). Curr Hypertens Rev 12(1):43\u201347. https:\/\/doi.org\/10.2174\/1573402112666160114094222","journal-title":"Curr Hypertens Rev"},{"issue":"1","key":"2772_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2174\/1573402112666160114093307","volume":"12","author":"H Sawatari","year":"2016","unstructured":"Sawatari H, Chishaki A, Ando SI (2016) The epidemiology of sleep disordered breathing and hypertension in various populations. Curr Hypertens Rev 12(1):12\u201317. https:\/\/doi.org\/10.2174\/1573402112666160114093307","journal-title":"Curr Hypertens Rev"},{"issue":"4","key":"2772_CR23","doi-asserted-by":"publisher","first-page":"516","DOI":"10.4103\/njcp.njcp_500_18","volume":"22","author":"O Yazici","year":"2019","unstructured":"Yazici O, Hatipoglu ON (2019) Evaluation of quality of life, anxiety, and depression in the spouses of patients with obstructive sleep apnea syndrome. Niger J Clin Pract 22(4):516\u2013520. https:\/\/doi.org\/10.4103\/njcp.njcp_500_18","journal-title":"Niger J Clin Pract"},{"issue":"21","key":"2772_CR24","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1212\/WNL.0b013e318238ee89","volume":"77","author":"CB Peltz","year":"2011","unstructured":"Peltz CB, Corrada MM, Berlau DJ, Kawas CH (2011) Incidence of dementia in oldest-old with amnestic MCI and other cognitive impairments. Neurol 77(21):1906\u20131912. https:\/\/doi.org\/10.1212\/WNL.0b013e318238ee89","journal-title":"Neurol"},{"issue":"PT C","key":"2772_CR25","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuropharm.2013.04.024","volume":"76","author":"P Bekinschtein","year":"2014","unstructured":"Bekinschtein P, Cammarota M, Medina JH (2014) BDNF and memory processing. Neuropharmacol 76(PT C):677\u2013683. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.04.024","journal-title":"Neuropharmacol"},{"issue":"5","key":"2772_CR26","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1177\/1073858418810142","volume":"25","author":"M Notaras","year":"2019","unstructured":"Notaras M, van den Buuse M (2019) Brain-derived neurotrophic factor (BDNF): novel insights into regulation and genetic variation. Neurosci 25(5):434\u2013454. https:\/\/doi.org\/10.1177\/1073858418810142","journal-title":"Neurosci"},{"issue":"7","key":"2772_CR27","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.4088\/jcp.v69n0710","volume":"69","author":"H Yu","year":"2008","unstructured":"Yu H, Zhang Z, Shi Y et al (2008) Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry 69(7):1104\u20131111. https:\/\/doi.org\/10.4088\/jcp.v69n0710","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"2772_CR28","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/s41380-019-0404-6","volume":"26","author":"N Franzmeier","year":"2021","unstructured":"Franzmeier N, Ren J, Damm A et al (2021) The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer\u2019s disease. Mol Psychiatry 26(2):614\u2013628. https:\/\/doi.org\/10.1038\/s41380-019-0404-6","journal-title":"Mol Psychiatry"},{"key":"2772_CR29","doi-asserted-by":"publisher","first-page":"8148","DOI":"10.1038\/srep08148","volume":"5","author":"SL Chen","year":"2015","unstructured":"Chen SL, Lee SY, Chang YH et al (2015) The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients. Sci Rep 5:8148. https:\/\/doi.org\/10.1038\/srep08148","journal-title":"Sci Rep"},{"key":"2772_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jad.2015.07.023","volume":"186","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zhang H, Li Y et al (2015) BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder. J Affect Disord 186:7\u201312. https:\/\/doi.org\/10.1016\/j.jad.2015.07.023","journal-title":"J Affect Disord"},{"issue":"18","key":"2772_CR31","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1001\/jama.2019.4783","volume":"321","author":"MTV Chan","year":"2019","unstructured":"Chan MTV, Wang CY, Seet E et al (2019) Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major noncardiac surgery. JAMA 321(18):1788\u20131798. https:\/\/doi.org\/10.1001\/jama.2019.4783","journal-title":"JAMA"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-022-02772-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-022-02772-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-022-02772-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:03:48Z","timestamp":1728605028000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-022-02772-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["2772"],"URL":"https:\/\/doi.org\/10.1007\/s11325-022-02772-2","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"type":"print","value":"1520-9512"},{"type":"electronic","value":"1522-1709"}],"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"27 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethical committee of the Peking University People\u2019s Hospital, and all participants provided written informed consent. The study followed the guidelines of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}