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The purpose of this prospective cohort study was to observe if OSA treatment provides a reduction in temporo-mandibular disorder (TMD) pain and headache attributed to TMD in patients with obstructive sleep apnea (OSA) after 18\u00a0months of OSA treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A prospective cohort study was conducted on consecutive patients suffering from OSA. Patients underwent polysomnography and TMD examination according to the DC\/TMD protocol at baseline and after 18\u00a0months. Intensity of TMD pain and headache attributed to TMD were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 40 patients (31 men, mean age 51.3 \u00b1 10.3 years), 33\u00a0underwent OSA treatment. At the follow-up examination after 18\u00a0months, significant improvements in the intensity of pain-related TMD and headache attributed to TMD were observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Seven patients did not start treatment for OSA or discontinued treatment. These patients did not show any significant difference in intensity of TMD-pain or headache attributed to TMD after 18\u00a0months (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Significant reductions in intensity of\u00a0pain-related TMD and headache attributed to TMD were observed in patients with OSA after 18\u00a0months of OSA treatment onset, while no difference was observed in subjects not undergoing or discontinuing OSA treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The protocol was registered on ClinicalTrials.gov database with number NCT04948541.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11325-023-02883-4","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T16:03:27Z","timestamp":1690301007000},"page":"203-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Obstructive sleep apnea treatment improves temporomandibular disorder pain"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-1403","authenticated-orcid":false,"given":"Anna","family":"Alessandri-Bonetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Mangino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghizlane","family":"Aarab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Gallenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"issue":"3","key":"2883_CR1","doi-asserted-by":"crossref","first-page":"100908","DOI":"10.1016\/j.dhjo.2020.100908","volume":"13","author":"D Amtmann","year":"2020","unstructured":"Amtmann D, Bamer AM, Askew R, Jensen MP (2020) Cross-lagged longitudinal analysis of pain intensity and sleep disturbance. 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