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Longer term, repeated episodes of hypercapnia and hypoxemia during sleep are associated with inflammatory and atherosclerosis-related factors. The aim of this study was to explore the effect of continuous positive airway pressure (CPAP) therapy on cerebral vasoreactivity and early atherosclerosis in patients with severe OSAHS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Forty-one patients with severe OSAHS were enrolled. The mean follow-up time was 39.8\u2009\u00b1\u20099.1 months. Cardiovascular risk factors were assessed, and laboratory tests, carotid artery intima-media thickness (CIMT) measurement and cerebrovascular reserve capacity (CRC) measurement were performed. After the baseline examination, 28 patients received CPAP therapy (treated group), which was not available for 13 patients (untreated group). Parameters were compared before and after treatment, between treated and untreated patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Cardiovascular risk factors, baseline polysomnographic parameters, laboratory values, CIMT and CRC of the two groups were similar at baseline. At the follow-up, CRC did not differ between the two groups, but CIMT was significantly lower in the treated group than in the untreated group (0.73\u2009\u00b1\u20090.11\u00a0mm vs. 0.84\u2009\u00b1\u20090.21\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.027). The CIMT of both groups increased significantly during the follow-up period (from 0.65\u2009\u00b1\u20090.11\u00a0mm to 0.73\u2009\u00b1\u20090.11\u00a0mm in the treated group, and from 0.69\u2009\u00b1\u20090.11\u00a0mm to 0.84\u2009\u00b1\u20090.21\u00a0mm in the untreated group), but the increase in the treated group was smaller than in the untreated group (0.09\u2009\u00b1\u20090.09\u00a0mm vs. 0.15\u2009\u00b1\u20090.15\u00a0mm).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In patients with severe OSAHS, CPAP treatment significantly reduced the progression of CIMT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11325-024-03189-9","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T11:17:56Z","timestamp":1736335076000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of continuous positive airway pressure therapy on early atherosclerosis in patients with severe obstructive sleep apnea-hypopnea syndrome"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2488-8225","authenticated-orcid":false,"given":"D\u00f3ra","family":"Sulina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-1288","authenticated-orcid":false,"given":"Szilvia","family":"Pusk\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2982-349X","authenticated-orcid":false,"given":"M\u00e1ria T\u00fcnde","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-5948","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Ol\u00e1h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-8080","authenticated-orcid":false,"given":"Norbert","family":"Koz\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"3189_CR1","doi-asserted-by":"publisher","unstructured":"Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. 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Approval was granted by the Regional Institutioanl Research Ethics Committee of the University of Debrecen (DEOEC RKEB\/IKEB 3096\u2009\u2212\u20092010.), and informed consent was signed by all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"71"}}