{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:10:21Z","timestamp":1743221421265,"version":"3.40.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>In heart failure (HF) and chronic obstructive pulmonary disease (COPD) populations, sleep-disordered breathing (SDB) is associated with impaired health outcomes. We evaluated whether in patients with HF, concomitant HF and COPD or COPD, the number of hospitalizations would be reduced in the year after testing for SDB with and without treatment initiation compared to the year before.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed a multicentre retrospective study of 390 consecutive sleep-clinic patients who had a primary diagnosis of chronic HF, HF and COPD or COPD and a secondary diagnosis of SDB. The date of SDB-testing was defined as the index date. Data on healthcare utilization was extracted for the 12-month period prior to and after this date.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The initiation of adaptive servoventilation (ASV) and non-invasive ventilation (NIV) treatment resulted in a statistically significant reduction in the number of hospitalisations. While continuous positive airway pressure (CPAP) treatment also demonstrated a reduction in hospitalisations, the observed effect did not reach the level of statistical significance. After accounting for demographics and comorbidities in multivariable regression analyses, only NIV was significantly associated with a reduction in hospitalizations, while CPAP or ASV were not. NIV appears to be underutilized in COPD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our data indicate, that patients with HF or COPD and concomitant SDB may benefit from the initiation of appropriate PAP-therapy. Whether treating SDB in HF- and COPD-patients influences healthcare utilization merits further investigation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11325-024-03242-7","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T11:29:37Z","timestamp":1736940577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time course of hospitalizations in patients with heart failure and chronic obstructive pulmonary disease around sleep-disordered-breathing diagnosis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-6716","authenticated-orcid":false,"given":"Maria","family":"Tafelmeier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Penzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schoebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Randerath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Treml","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Pepin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Arzt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"issue":"21","key":"3242_CR1","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","volume":"64","author":"RJ Mentz","year":"2014","unstructured":"Mentz RJ, Kelly JP, von Lueder TG et al (2014) Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J Am Coll Cardiol 64(21):2281\u20132293. https:\/\/doi.org\/10.1016\/j.jacc.2014.08.036","journal-title":"J Am Coll Cardiol"},{"key":"3242_CR2","doi-asserted-by":"publisher","unstructured":"McNicholas WT, Hansson D, Schiza S, Grote L (2019) Sleep in chronic respiratory disease: COPD and hypoventilation disorders. Eur Respir Rev 28(153). https:\/\/doi.org\/10.1183\/16000617.0064-2019","DOI":"10.1183\/16000617.0064-2019"},{"issue":"2","key":"3242_CR3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jchf.2015.09.014","volume":"4","author":"M Arzt","year":"2016","unstructured":"Arzt M, Woehrle H, Oldenburg O et al (2016) Prevalence and predictors of sleep-disordered breathing in patients with stable chronic heart failure: the SchlaHF Registry. JACC Heart Fail 4(2):116\u2013125. https:\/\/doi.org\/10.1016\/j.jchf.2015.09.014","journal-title":"JACC Heart Fail"},{"key":"3242_CR4","doi-asserted-by":"publisher","unstructured":"Adler DBS, Benmerad M, Joyeux-Faure M, Jullian-Desayes I, Soccal PM, Janssens JP, Sap\u00e8ne M, Grillet Y, Stach B, Tamisier R, P\u00e9pin JL (2020) Clinical presentation and comorbidities of obstructive sleep apnea-COPD overlap syndrome. PLoS ONE 15 (7):e0235331. https:\/\/doi.org\/10.1371\/journal.pone.0235331","DOI":"10.1371\/journal.pone.0235331"},{"key":"3242_CR5","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.2147\/COPD.S222803","volume":"14","author":"M Dreher","year":"2019","unstructured":"Dreher M, Neuzeret PC, Windisch W et al (2019) Prevalence of chronic hypercapnia in severe chronic obstructive Pulmonary Disease: Data from the HOmeVent Registry. Int J Chron Obstruct Pulmon Dis 14:2377\u20132384. https:\/\/doi.org\/10.2147\/COPD.S222803","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4","key":"3242_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1164\/rccm.201003-0406OC","volume":"183","author":"S Javaheri","year":"2011","unstructured":"Javaheri S, Caref EB, Chen E, Tong KB, Abraham WT (2011) Sleep apnea testing and outcomes in a large cohort of Medicare beneficiaries with newly diagnosed heart failure. Am J Respir Crit Care Med 183(4):539\u2013546. https:\/\/doi.org\/10.1164\/rccm.201003-0406OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"3242_CR7","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1093\/eurjhf\/hfs085","volume":"14","author":"T Damy","year":"2012","unstructured":"Damy T, Margarit L, Noroc A et al (2012) Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure. Eur J Heart Fail 14(9):1009\u20131019. https:\/\/doi.org\/10.1093\/eurjhf\/hfs085","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"3242_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1001\/jama.2017.7967","volume":"318","author":"J Yu","year":"2017","unstructured":"Yu J, Zhou Z, McEvoy RD et al (2017) Association of Positive Airway Pressure with Cardiovascular Events and death in adults with sleep apnea: a systematic review and Meta-analysis. 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Lancet Respir Med 12(2):153\u2013166. https:\/\/doi.org\/10.1016\/S2213-2600(23)00374-0","journal-title":"Lancet Respir Med"},{"issue":"4","key":"3242_CR10","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1164\/rccm.202006-2382ST","volume":"202","author":"M Macrea","year":"2020","unstructured":"Macrea M, Oczkowski S, Rochwerg B et al (2020) Long-term noninvasive ventilation in chronic stable Hypercapnic Chronic Obstructive Pulmonary Disease. An official American thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 202(4):e74\u2013e87. https:\/\/doi.org\/10.1164\/rccm.202006-2382ST","journal-title":"Am J Respir Crit Care Med"},{"key":"3242_CR11","doi-asserted-by":"publisher","unstructured":"Ergan B, Oczkowski S, Rochwerg B et al (2019) European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD. Eur Respir J 54(3). https:\/\/doi.org\/10.1183\/13993003.01003-2019","DOI":"10.1183\/13993003.01003-2019"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-024-03242-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-024-03242-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-024-03242-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:20:17Z","timestamp":1743157217000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-024-03242-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3242"],"URL":"https:\/\/doi.org\/10.1007\/s11325-024-03242-7","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"type":"print","value":"1520-9512"},{"type":"electronic","value":"1522-1709"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"3 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the four participating sleep centres in France and Germany - namely University Medical Centre Regensburg, Bethanien Hospital Solingen, Charit\u00e9 Berlin and University Medical Centre Grenoble Alpes - and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by each institution\u2019s Research Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Michael Arzt received consulting and lecture fees from ResMed, Philips Respironics, NRI, Bresotec, Boehringer-Ingelheim, Novartis, JAZZ pharmaceuticals and Bayer. Michael Arzt is supported by Else-Kroener Fresenius Foundation (2018_A159). Maria Tafelmeier is supported by Else-Kroener-Foundation (2020_EKEA.25). Jean-Louis Pepin is supported by the French National Research Agency in the framework of the \u201cInvestissements d\u2019avenir\u201d program (ANR-15-IDEX-02) and the \u201ce-health and integrated care and trajectories medicine and MIAI artificial intelligence\u201d Chairs of excellence from the Grenoble Alpes University Foundation and MIAI @ university Grenoble Alpes (ANR-19-P3IA-0003).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"79"}}