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The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patients signed a locally approved informed consent form if they sought care over the data collection period. Subjects who could not be reached during the data collection period were included in the cohort under a waiver of consent. This process was approved by the local Institutional Review Board at each participating institution (Johns Hopkins University (Baltimore, MD; coordinating site), AI DuPont Hospital for Children (Wilmington, DE), McGovern Medical School at the University of Texas Health (Houston, TX), and University of Wisconsin (Madison, WI).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This is an investigator\u2011initiated independent research study supported, in part, by BioMarin, Inc. The data presented in this paper do not pertain to the investigational pharmaceuticals under development by BioMarin, Ascendis, Therachon, or QED. These following competing activities were reviewed and approved by our institutions. J.E.H.\u2011F. has participated in Advisory Boards sponsored by BioMarin pertaining to achondroplasia. J.E.H.\u2011F. has been consulted by BioMarin, Alexion, Therachon\/Pfizer, QED, Innoskel and NovoNordisk for clinical issues related to achondroplasia and other genetic skeletal conditions and acts as a site principal investigator (PI) for clinical trials for BioMarin, Therachon\/Pfizer and QED. M.B.B. is now an employee of Tyra pharmaceuticals. J.T.H. has participated in Advisory Boards pertaining to achondroplasia sponsored by BioMarin. D.R.\u2011B. has participated in Advisory Boards pertaining to achondroplasia sponsored by BioMarin and has lectured for BioMarin. J.L. is a site PI for Ascendis and QED and is a paid speaker and consultant for BioMarin. The other authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"88"}}