{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:57:33Z","timestamp":1791593853214,"version":"4.3.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16hk0102041h0001"],"award-info":[{"award-number":["16hk0102041h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23uk1024004h0003"],"award-info":[{"award-number":["23uk1024004h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Decreased delta and increased alpha wave activity during sleep may be specific pathophysiological features of major depressive disorder; however, their usefulness as biomarkers remains unclear. We examined the use of mean alpha and delta wave power value indices during sleep to identify major depressive disorder using a portable electroencephalography device.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We compared the mean alpha and delta wave power value indices of six unmedicated patients with major depressive disorder and seven age- and sex-matched healthy controls using a portable electroencephalography device in this case-controlled study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The ratio of the mean alpha power values for the non-rapid and rapid eye movement periods was significantly lower in the major depressive disorder group (1.3\u2009\u00b1\u20090.2) than in the healthy group (2.3\u2009\u00b1\u20090.6; P\u2009=\u20090.004). The ratio of the mean delta power values for the non-rapid eye movement and rapid eye movement periods did not differ between groups but negatively correlated significantly with the Hamilton Rating Scale for Depression score (r\u2009=\u2009-0.784, P\u2009=\u20090.002). The area under the receiver operating characteristic curve (95% confidence interval) of the mean alpha power ratio for non-rapid eye movement and rapid eye movement periods for distinguishing the two groups was 0.93 (0.78\u20131.00), and both sensitivity and specificity exceeded 85% at a cut-off value\u2009\u2264\u20091.71.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The alpha- and delta-related power value indices may capture different aspects of major depressive disorder pathology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11325-025-03329-9","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T19:16:01Z","timestamp":1745262961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Objective evaluation of major depressive disorder using sleep electroencephalography measured by an in-home portable one-channel device: a preliminary study"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-2848","authenticated-orcid":false,"given":"Aoi","family":"Kawamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kadotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-4357","authenticated-orcid":false,"given":"Kenichi","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"3329_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jad.2013.10.002","volume":"152\u2013154","author":"L Ghio","year":"2014","unstructured":"Ghio L, Gotelli S, Marcenaro M, Amore M, Natta W (2014) Duration of untreated illness and outcomes in unipolar depression: a systematic review and meta-analysis. 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Secondary data were used, and an opt-out procedure was used for informed consent","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Dr. Kawamura has received speaker\u2019s honoraria from Otsuka Pharmaceutical, Takeda Pharmaceutical, and MSD outside the submitted work. Dr. Kadotani has received grant supports from the Investigator-Initiated Studies Program of Merck Sharp and Dohme LLC\/MSD K.K., Eisai, and SECOM Science and Technology Foundation; and speaker\u2019s honoraria from Sumitomo Pharma, MSD and Eisai outside the submitted work. Dr. Kadotani also reports being a president of Japanese Academy of Dental Sleep Medicine and a co-investigator on a research study funded by Kirin Holdings Company and Takeda Pharmaceutical outside the submitted work. Dr. Suzuki has received grant supports from EA Pharma, Eisai, Mochida Pharmaceutical, Meiji Seika Pharma, Otsuka Pharmaceutical, Shionogi Pharma, and Sumitomo Pharma; speaker\u2019s honoraria from EA Pharma, Eisai, Kao Corporation, Kyowa Pharmaceutical Industry, Meiji Seika Pharma, Mochida Pharmaceutical, MSD, Otsuka Pharmaceutical, Shionogi Pharma, Sumitomo Pharma, Takeda Pharmaceutical, Viatris, and Yoshitomi Pharmaceutical; and payment for expert testimony from Eisai, Kao Corporation, Mochida Pharmaceutical, and Jazz Pharmaceuticals outside the submitted work. Dr. Uchiyama reports no financial relationships with commercial interests. Dr. Yamada has received speaker\u2019s honoraria from Eisai, MSD, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, Otsuka Pharmaceutical, Takeda Pharmaceutical, and Yoshitomi Pharmaceutical outside the submitted work. Dr. Kuriyama has received grant supports from Otsuka Pharmaceutical and Eisal; personal fees from Meiji Seika Pharma, Eisai, MSD, Takeda Pharmaceutical, Tanabe Mitsubishi Pharma, Shionogi Pharma, Daiichi-Sankyo, Accuris Pharma, and Sumitomo Pharma; and advisory fees from Eisai, Shionogi Pharma, Taisho Pharmaceutical, Nobel Pharma, and Nexera Pharma outside the submitted work.Sleep EEG information in this study was obtained using the SleepScope (SS) device. SleepWell Co. Ltd., which developed the SS, participated in the study as a collaborative research facility and was responsible for improving the detection program.Conflicts of interest in this study were reported to the Conflict-of-Interest Management Committee and other appropriate departments at each collaborating institution as appropriate and were managed appropriately.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"165"}}