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Other aims were to assess retinal and optic nerve damage predictors in OSA and establish predictors of poor response to CPAP treatment in optic nerve damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study with consecutive inclusion of the first 3 patients who attended for treatment each day. All patients underwent a diagnostic polygraph, and patients with moderate-severe OSA treated with CPAP were recruited. Optical Coherence Tomography (OCT) was performed within 3 days of the patient\u2019s inclusion and 12 months after the start of CPAP treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 37 patients with OSA were analysed. After 12 months of CPAP treatment, there was a significant improvement in the thickness of the superotemporal Bruch\u2019s membrane opening-minimum rim width (BMO-MRW) (316.54 to 318.23\u00a0\u03bcm, p-value\u2009=\u20090.08). There was a non-significant improvement in the thickness of nasal, inferonasal and superonasal retinal nerve fibre layers. In a multivariate analysis, HB and Type 2 diabetes mellitus have been associated with an increased odds ratio (OR) of retinal and optical nerve damage (OR\u2009=\u20093.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03 and OR\u2009=\u20094.344,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMO-MRW thickness may assess early damage induced by OSA and the response to CPAP. HB is a predictor of retinal and optic nerve damage in patients with OSA. CPAP treatment has a long-term protective effect on the retina and optic nerve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-025-03336-w","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T02:12:11Z","timestamp":1745979131000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Benefit of continuous positive airway pressure on optic nerve damage in patients with obstructive sleep apnea"],"prefix":"10.1007","volume":"29","author":[{"given":"Teresa Diaz","family":"de Ter\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Boira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cerver\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Lopez-de-Eguileta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nebot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Banfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Solidoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-0181","authenticated-orcid":false,"given":"M\u00f3nica","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"12","key":"3336_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nrcardio.2012.141","volume":"9","author":"JP Baguet","year":"2012","unstructured":"Baguet JP, Barone-Rochette G, Tamisier R, Levy P, P\u00e9pin JL (2012) Mechanisms of cardiac dysfunction in obstructive sleep apnea. 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Written informed consent was obtained from all participants prior to enrolment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards statement"}},{"value":"The authors declare not to have any conflicts of interest that may be considered to influence directly or indirectly the content of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"In this article there is not an involvement of artificial intelligence.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Artificial intelligence"}}],"article-number":"173"}}