{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:42:53Z","timestamp":1793720573137,"version":"4.6.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","award":["Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa"],"award-info":[{"award-number":["Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa"]}],"id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13467-8"],"award-info":[{"award-number":["2020\/13467-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/09089-0"],"award-info":[{"award-number":["2021\/09089-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/05920-7"],"award-info":[{"award-number":["2021\/05920-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/13004-0"],"award-info":[{"award-number":["2021\/13004-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"],"award-info":[{"award-number":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"],"award-info":[{"award-number":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"],"award-info":[{"award-number":["Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s11325-025-03341-z","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:33:32Z","timestamp":1746621212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic overlap and immunological pathways in asthma-obstructive sleep apnea coexistence"],"prefix":"10.1007","volume":"29","author":[{"given":"Maingredy Rodrigues","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Moys\u00e9s-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Saj","family":"Porcacchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Santoro","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-6748","authenticated-orcid":false,"given":"Monica Levy","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"3341_CR1","doi-asserted-by":"crossref","unstructured":"Ragnoli B, Pochetti P, Raie A, Malerba M (2021) Interrelationship between obstructive sleep apnea syndrome and severe asthma: from Endo-Phenotype to clinical aspects. Front Med (Lausanne) 8","DOI":"10.3389\/fmed.2021.640636"},{"key":"3341_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ejcdt.2015.01.007","volume":"64","author":"M Zidan","year":"2015","unstructured":"Zidan M, Daabis R, Gharraf H (2015) Overlap of obstructive sleep apnea and bronchial asthma: effect on asthma control. Egypt J Chest Dis Tuberculosis 64:425\u2013430. https:\/\/doi.org\/10.1016\/j.ejcdt.2015.01.007","journal-title":"Egypt J Chest Dis Tuberculosis"},{"key":"3341_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.5664\/jcsm.8180","volume":"16","author":"OC Ioachimescu","year":"2020","unstructured":"Ioachimescu OC, Janocko NJ, Ciavatta M-M et al (2020) Obstructive lung disease and obstructive sleep apnea (OLDOSA) cohort study: 10-year assessment. J Clin Sleep Med 16:267\u2013277. https:\/\/doi.org\/10.5664\/jcsm.8180","journal-title":"J Clin Sleep Med"},{"key":"3341_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.sleep.2009.10.005","volume":"11","author":"S Tufik","year":"2010","unstructured":"Tufik S, Santos-Silva R, Taddei JA, Bittencourt LRA (2010) Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study. Sleep Med 11:441\u2013446. https:\/\/doi.org\/10.1016\/j.sleep.2009.10.005","journal-title":"Sleep Med"},{"key":"3341_CR5","unstructured":"American Academy of Sleep Medicine (2014) International Classification of Sleep Disorders, 3rd ed"},{"key":"3341_CR6","unstructured":"Centers for Disease Control and Prevention (2021) Asthma: most recent national asthma data. Atlanta, GA"},{"key":"3341_CR7","unstructured":"GINA GI for A (2022) Global Strategy for Asthma Management and Prevention"},{"key":"3341_CR8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/resp.12062","volume":"18","author":"OC Ioachimescu","year":"2013","unstructured":"Ioachimescu OC, Teodorescu M (2013) Integrating the overlap of obstructive lung disease and obstructive sleep apnoea: OLDOSA syndrome. Respirology 18:421\u2013431","journal-title":"Respirology"},{"key":"3341_CR9","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3390\/jcm8091476","volume":"8","author":"V Damianaki","year":"2019","unstructured":"Damianaki V, Sigala, et al (2019) \u03a4he Co-Existence of obstructive sleep apnea and bronchial asthma: revelation of a new asthma phenotype?? J Clin Med 8:1476. https:\/\/doi.org\/10.3390\/jcm8091476","journal-title":"J Clin Med"},{"key":"3341_CR10","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3349\/ymj.2013.54.4.942","volume":"54","author":"MK Byun","year":"2013","unstructured":"Byun MK, Park SC, Chang YS et al (2013) Associations of moderate to severe asthma with obstructive sleep apnea. Yonsei Med J 54:942\u2013948. https:\/\/doi.org\/10.3349\/ymj.2013.54.4.942","journal-title":"Yonsei Med J"},{"key":"3341_CR11","doi-asserted-by":"crossref","unstructured":"Saxena D, Imayama I, Adrish M (2023) Revisiting asthma obstructive sleep apnea overlap: current knowledge and future needs. J Clin Med 12","DOI":"10.3390\/jcm12206552"},{"key":"3341_CR12","doi-asserted-by":"crossref","unstructured":"Wang D, Zhou Y, Chen R et al (2023) The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis. Eur J Med Res 28","DOI":"10.1186\/s40001-023-01097-4"},{"key":"3341_CR13","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jaip.2015.04.002","volume":"3","author":"M Teodorescu","year":"2015","unstructured":"Teodorescu M, Broytman O, Curran-Everett D et al (2015) Obstructive sleep apnea risk, asthma burden, and lower airway inflammation in adults in the severe asthma research program (SARP) II. J Allergy Clin Immunology: Pract 3:566\u2013575e1. https:\/\/doi.org\/10.1016\/j.jaip.2015.04.002","journal-title":"J Allergy Clin Immunology: Pract"},{"key":"3341_CR14","doi-asserted-by":"publisher","unstructured":"Taill\u00e9 C, Rouvel-Tallec A, Stoica M et al (2016) Obstructive sleep Apnoea modulates airway inflammation and remodelling in severe asthma. PLoS ONE 11. https:\/\/doi.org\/10.1371\/journal.pone.0150042","DOI":"10.1371\/journal.pone.0150042"},{"key":"3341_CR15","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.2500\/aap.2021.42.200098","volume":"42","author":"D \u00d6zden Mat","year":"2021","unstructured":"\u00d6zden Mat D, Firat S, Aksu K et al (2021) Obstructive sleep apnea is a determinant of asthma control independent of smoking, reflux, and rhinitis. Allergy Asthma Proc 42:e25\u2013e29. https:\/\/doi.org\/10.2500\/aap.2021.42.200098","journal-title":"Allergy Asthma Proc"},{"key":"3341_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.anai.2019.11.002","volume":"124","author":"S Oka","year":"2020","unstructured":"Oka S, Goto T, Hirayama A et al (2020) Association of obstructive sleep apnea with severity of patients hospitalized for acute asthma. Annals Allergy Asthma Immunol 124:165\u2013170e4. https:\/\/doi.org\/10.1016\/j.anai.2019.11.002","journal-title":"Annals Allergy Asthma Immunol"},{"key":"3341_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.5664\/jcsm.6946","volume":"14","author":"F Sundbom","year":"2018","unstructured":"Sundbom F, Janson C, Malinovschi A, Lindberg E (2018) Effects of coexisting asthma and obstructive sleep apnea on sleep architecture, oxygen saturation, and systemic inflammation in women. J Clin Sleep Med 14:253\u2013259. https:\/\/doi.org\/10.5664\/jcsm.6946","journal-title":"J Clin Sleep Med"},{"key":"3341_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.rmed.2018.08.004","volume":"143","author":"SE Davies","year":"2018","unstructured":"Davies SE, Bishopp A, Wharton S et al (2018) Does continuous positive airway pressure (CPAP) treatment of obstructive sleep Apnoea (OSA) improve asthma-related clinical outcomes in patients with co-existing conditions?- A systematic review. Respir Med 143:18\u201330. https:\/\/doi.org\/10.1016\/j.rmed.2018.08.004","journal-title":"Respir Med"},{"key":"3341_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s13665-021-00271-5\/Published","volume":"10","author":"DL Pepito","year":"2021","unstructured":"Pepito DL, Mohammed JM, Hardin KA (2021) Obstructive sleep apnea and asthma: more than Chance? Curr Pulmonol Rep 10:84\u201391. https:\/\/doi.org\/10.1007\/s13665-021-00271-5\/Published","journal-title":"Curr Pulmonol Rep"},{"key":"3341_CR20","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1164\/ajrccm\/142.6_Pt_1.1351","volume":"142","author":"DL Duffy","year":"1990","unstructured":"Duffy DL, Martin NG, Battistutta D et al (1990) Genetics of asthma and hay fever in Australian twins. Am Rev Respir Dis 142:1351\u20131358. https:\/\/doi.org\/10.1164\/ajrccm\/142.6_Pt_1.1351","journal-title":"Am Rev Respir Dis"},{"key":"3341_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1053\/smrv.2000.0120","volume":"4","author":"S Redline","year":"2000","unstructured":"Redline S, Tishler PV (2000) The genetics of sleep apnea. Sleep Med Rev 4:583\u2013602. https:\/\/doi.org\/10.1053\/smrv.2000.0120","journal-title":"Sleep Med Rev"},{"key":"3341_CR22","doi-asserted-by":"publisher","unstructured":"Yi M, Tan Y, Pi Y et al (2022) Variants of candidate genes associated with the risk of obstructive sleep apnea. Eur J Clin Invest 52. https:\/\/doi.org\/10.1111\/eci.13673","DOI":"10.1111\/eci.13673"},{"key":"3341_CR23","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.3390\/ijms22052412","volume":"22","author":"P Ntontsi","year":"2021","unstructured":"Ntontsi P, Photiades A, Zervas E et al (2021) Genetics and epigenetics in asthma. Int J Mol Sci 22:2412. https:\/\/doi.org\/10.3390\/ijms22052412","journal-title":"Int J Mol Sci"},{"key":"3341_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-023-00795-1","author":"LNG Adami","year":"2023","unstructured":"Adami LNG, Moys\u00e9s-Oliveira M, Souza-Cunha LA et al (2023) Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea. Int J Impot Res. https:\/\/doi.org\/10.1038\/s41443-023-00795-1","journal-title":"Int J Impot Res"},{"key":"3341_CR25","doi-asserted-by":"publisher","unstructured":"Que Y, Meng H, Ding Y et al (2024) Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma. Gene 896. https:\/\/doi.org\/10.1016\/j.gene.2023.148029","DOI":"10.1016\/j.gene.2023.148029"},{"key":"3341_CR26","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1164\/rccm.201810-1838TR","volume":"201","author":"B Prasad","year":"2020","unstructured":"Prasad B, Nyenhuis SM, Imayama I et al (2020) Asthma and obstructive sleep apnea overlap: what has the evidence taught Us?? Am J Respir Crit Care Med 201:1345\u20131357. https:\/\/doi.org\/10.1164\/rccm.201810-1838TR","journal-title":"Am J Respir Crit Care Med"},{"key":"3341_CR27","doi-asserted-by":"publisher","unstructured":"Pelaia G, Vatrella A, Busceti MT et al (2015) Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma. Mediators Inflamm 2015:1\u20138. https:\/\/doi.org\/10.1155\/2015\/879783","DOI":"10.1155\/2015\/879783"},{"key":"3341_CR28","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jaip.2015.04.002","volume":"3","author":"M Teodorescu","year":"2015","unstructured":"Teodorescu M, Broytman O, Curran-Everett D et al (2015) Obstructive sleep apnea risk, asthma burden, and lower airway inflammation in adults in the severe asthma research program (SARP) II. J Allergy Clin Immunol Pract 3:566\u2013575e1. https:\/\/doi.org\/10.1016\/j.jaip.2015.04.002","journal-title":"J Allergy Clin Immunol Pract"},{"key":"3341_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3390\/jcm10020277","volume":"10","author":"A Maniaci","year":"2021","unstructured":"Maniaci A, Iannella G, Cocuzza S et al (2021) Oxidative stress and inflammation biomarker expression in obstructive sleep apnea patients. J Clin Med 10:277. https:\/\/doi.org\/10.3390\/jcm10020277","journal-title":"J Clin Med"},{"key":"3341_CR30","doi-asserted-by":"crossref","unstructured":"Wang R, Mihaicuta S, Tiotiu A et al (2022) Asthma and obstructive sleep Apnoea in adults and children\u2013 an up-to-date review. Sleep Med Rev 61","DOI":"10.1016\/j.smrv.2021.101564"},{"key":"3341_CR31","doi-asserted-by":"publisher","first-page":"100995","DOI":"10.1016\/j.mam.2021.100995","volume":"85","author":"ZI Koml\u00f3si","year":"2022","unstructured":"Koml\u00f3si ZI, van de Veen W, Kov\u00e1cs N et al (2022) Cellular and molecular mechanisms of allergic asthma. Mol Aspects Med 85:100995. https:\/\/doi.org\/10.1016\/j.mam.2021.100995","journal-title":"Mol Aspects Med"},{"key":"3341_CR32","volume-title":"Autoimmunity: from bench to bedside","author":"P Cruz-Tapias","year":"2013","unstructured":"Cruz-Tapias P, Castiblanco J, Anaya J-M (2013) Chap. 10 major histocompatibility complex: antigen processing and presentation. In: Anaya JMSYR-VA et al (eds) Autoimmunity: from bench to bedside. El Rosario University, Bogota. (Colombia)"},{"key":"3341_CR33","doi-asserted-by":"crossref","unstructured":"Momany SM, Al-Qatarneh TA, Khader YS et al (2017) The association of HLA-DQB1*0602 but not HLA-DRB1*15 with obstructive sleep apnea","DOI":"10.25011\/cim.v40i4.28494"},{"key":"3341_CR34","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1111\/crj.12945","volume":"12","author":"MY Tepeba\u015f\u0131","year":"2018","unstructured":"Tepeba\u015f\u0131 MY, \u015eahin Calapo\u011flu N, \u00d6zt\u00fcrk \u00d6 et al (2018) HLA-DRB1 allele frequency and immunological response in obstructive sleep apnea syndrome in Turkish population. Clin Respiratory J 12:2505\u20132512. https:\/\/doi.org\/10.1111\/crj.12945","journal-title":"Clin Respiratory J"},{"key":"3341_CR35","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jaci.2020.08.020","volume":"147","author":"Q Yan","year":"2021","unstructured":"Yan Q, Forno E, Herrera-Luis E et al (2021) A genome-wide association study of asthma hospitalizations in adults. J Allergy Clin Immunol 147:933\u2013940. https:\/\/doi.org\/10.1016\/j.jaci.2020.08.020","journal-title":"J Allergy Clin Immunol"},{"key":"3341_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jaci.2020.01.011","volume":"146","author":"N Vince","year":"2020","unstructured":"Vince N, Limou S, Daya M et al (2020) Association of HLA-DRB1\u221709:01 with tIgE levels among African-ancestry individuals with asthma. J Allergy Clin Immunol 146:147\u2013155. https:\/\/doi.org\/10.1016\/j.jaci.2020.01.011","journal-title":"J Allergy Clin Immunol"},{"key":"3341_CR37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.12659\/MSMBR.900193","volume":"22","author":"Y Yao","year":"2016","unstructured":"Yao Y, Zhu L, Li J et al (2016) Association of HLA-DRB1 gene polymorphism with risk of asthma: A Meta-Analysis. Med Sci Monit Basic Res 22:80\u201386. https:\/\/doi.org\/10.12659\/MSMBR.900193","journal-title":"Med Sci Monit Basic Res"},{"key":"3341_CR38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.imbio.2011.08.012","volume":"217","author":"A Kauppinen","year":"2012","unstructured":"Kauppinen A, Per\u00e4saari J, Taivainen A et al (2012) Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 217:8\u201312. https:\/\/doi.org\/10.1016\/j.imbio.2011.08.012","journal-title":"Immunobiology"},{"key":"3341_CR39","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.humimm.2019.04.018","volume":"80","author":"R Ayakannu","year":"2019","unstructured":"Ayakannu R, Abdullah NA, Radhakrishnan AK et al (2019) Relationship between various cytokines implicated in asthma. Hum Immunol 80:755\u2013763. https:\/\/doi.org\/10.1016\/j.humimm.2019.04.018","journal-title":"Hum Immunol"},{"key":"3341_CR40","doi-asserted-by":"publisher","unstructured":"Yi M, Zhao W, Fei Q et al (2022) Causal analysis between altered levels of interleukins and obstructive sleep apnea. Front Immunol 13. https:\/\/doi.org\/10.3389\/fimmu.2022.888644","DOI":"10.3389\/fimmu.2022.888644"},{"key":"3341_CR41","doi-asserted-by":"publisher","first-page":"109130","DOI":"10.1016\/j.intimp.2022.109130","volume":"111","author":"M Aliyu","year":"2022","unstructured":"Aliyu M, Zohora FT, Anka AU et al (2022) Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach. Int Immunopharmacol 111:109130. https:\/\/doi.org\/10.1016\/j.intimp.2022.109130","journal-title":"Int Immunopharmacol"},{"key":"3341_CR42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2500\/aap.2013.34.3680","volume":"34","author":"S Boonpiyathad","year":"2013","unstructured":"Boonpiyathad S, Pornsuriyasak P, Buranapraditkun S, Klaewsongkram J (2013) Interleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in nonallergic asthma. Allergy Asthma Proc 34:35\u201341. https:\/\/doi.org\/10.2500\/aap.2013.34.3680","journal-title":"Allergy Asthma Proc"},{"key":"3341_CR43","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1465-9921-11-28","volume":"11","author":"WA Neveu","year":"2010","unstructured":"Neveu WA, Allard JL, Raymond DM et al (2010) Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res 11:28. https:\/\/doi.org\/10.1186\/1465-9921-11-28","journal-title":"Respir Res"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-025-03341-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-025-03341-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-025-03341-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T13:21:24Z","timestamp":1748006484000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-025-03341-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3341"],"URL":"https:\/\/doi.org\/10.1007\/s11325-025-03341-z","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"15 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study did not involve human or animal material. All data sources are fully described in the supplemental material.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that no conflicts of interest have influenced the work presented in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"178"}}