{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:41:12Z","timestamp":1761176472508,"version":"build-2065373602"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Upper airway stimulation by means of unilateral hypoglossal nerve stimulation is an alternative therapy for patients with obstructive sleep apnea and continuous positive airway pressure intolerance or failure. Optimal device settings are essential for effective treatment of obstructive sleep apnea with this therapy. Some patients experience therapy failure, despite standard titration methods. We perform a drug induced sleep endoscopy with upper airway stimulation in these patients. This study provides an overview of this procedure and our patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective chart review of patients implanted with an upper airway stimulation device between 2015 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The drug-induced sleep endoscopy with upper airway stimulation therapy is performed in 29 non-responders of therapy. In seven patients, a change in device settings was sufficient to prevent an upper airway collapse during the drug-induced sleep endoscopy, while additional therapy was recommended for the remaining. Eventually, six patients were fitted with a change in device settings and fourteen patients were treated with additional therapy, being oral appliance therapy, barbed wire pharyngoplasty or alternative upper airway surgery. At follow-up, the apnea\u2013hypopnea index declined significantly from 41.6\u2009\u00b1\u200915.0 to 23.2\u2009\u00b1\u20099.9 events\/hour and resulted in eight additional responders to therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The drug-induced sleep endoscopy might be a valuable addition in the clinical pathway of upper airway stimulation therapy. It provides a better evaluation of the stimulation process and offers the opportunity for alterations in settings or targeted additional therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-025-03468-z","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:52:22Z","timestamp":1757764342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of drug-induced sleep endoscopy in optimizing upper airway stimulation therapy for non-responders"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-8660","authenticated-orcid":false,"given":"E.","family":"Kant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Hardeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Stokroos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Copper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"3468_CR1","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/lary.23301","volume":"122","author":"PH Van de Heyning","year":"2012","unstructured":"Van de Heyning PH, Badr MS, Baskin JZ, Cramer Bornemann MA, De Backer WA, Dotan Y, Hohenhorst W, Knaack L, Lin HS, Maurer JT, Netzer A, Odland RM, Oliven A, Strohl KP, Vanderveken OM, Verbraecken J, Woodson BT (2012) Implanted upper airway stimulation device for obstructive sleep apnea. Laryngoscope 122:1626\u20131633. https:\/\/doi.org\/10.1002\/lary.23301","journal-title":"Laryngoscope"},{"key":"3468_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/lary.26487","volume":"127","author":"C Heiser","year":"2017","unstructured":"Heiser C, Edenharter G, Bas M, Wirth M, Hofauer B (2017) Palatoglossus coupling in selective upper airway stimulation. Laryngoscope 127:378\u2013383. https:\/\/doi.org\/10.1002\/lary.26487","journal-title":"Laryngoscope"},{"issue":"11","key":"3468_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3389\/fnins.2017.00523","volume":"21","author":"OM Vanderveken","year":"2017","unstructured":"Vanderveken OM, Beyers J, Op de Beeck S, Dieltjens M, Willemen M, Verbraecken JA, De Backer WA, Van de Heyning PH (2017) Development of a clinical pathway and technical aspects of upper airway stimulation therapy for obstructive sleep apnea. 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Ethics approval for this study was obtained from the local medical ethical review board of Sint Antonius Hospital (Z23.020).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"285"}}