{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:26:22Z","timestamp":1774466782543,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11325-026-03628-9","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:51:22Z","timestamp":1771879882000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the effect of valsartan\/sacubitril on sleep parameters of patients with sleep apnea: systematic review and meta-analysis"],"prefix":"10.1007","volume":"30","author":[{"given":"Mamoon","family":"Al-Namer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safwan","family":"Al-Tahesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A. M. Y.","family":"Al-Hetar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal","family":"Taher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Al-Bakri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"2","key":"3628_CR1","first-page":"142","volume":"14","author":"A Abbasi","year":"2021","unstructured":"Abbasi A, Gupta SS, Sabharwal N, Meghrajani V, Sharma S, Kamholz S et al (2021) A comprehensive review of obstructive sleep apnea. Sleep Sci 14(2):142\u2013154","journal-title":"Sleep Sci"},{"issue":"8","key":"3628_CR2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","volume":"7","author":"AV Benjafield","year":"2019","unstructured":"Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7(8):687\u201398","journal-title":"Lancet Respir Med"},{"issue":"14","key":"3628_CR3","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1001\/jama.2020.3514","volume":"323","author":"DJ Gottlieb","year":"2020","unstructured":"Gottlieb DJ, Punjabi NM (2020) Diagnosis and management of obstructive sleep apnea: a review. JAMA 323(14):1389\u20131400","journal-title":"JAMA"},{"issue":"9918","key":"3628_CR4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","volume":"383","author":"AS Jordan","year":"2014","unstructured":"Jordan AS, McSharry DG, Malhotra A (2014) Adult obstructive sleep apnoea. Lancet 383(9918):736\u2013747","journal-title":"Lancet"},{"issue":"9","key":"3628_CR5","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1093\/aje\/kws342","volume":"177","author":"PE Peppard","year":"2013","unstructured":"Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177(9):1006\u20131014","journal-title":"Am J Epidemiol"},{"issue":"3","key":"3628_CR6","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.cger.2021.04.009","volume":"37","author":"O Ishikawa","year":"2021","unstructured":"Ishikawa O, Oks M (2021) Central sleep apnea. Clin Geriatr Med 37(3):469\u2013481","journal-title":"Clin Geriatr Med"},{"key":"3628_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac113","author":"S Javaheri","year":"2023","unstructured":"Javaheri S, Badr MS (2023) Central sleep apnea: pathophysiologic classification. Sleep. https:\/\/doi.org\/10.1093\/sleep\/zsac113","journal-title":"Sleep"},{"key":"3628_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/diseases9040088","author":"AK Mitra","year":"2021","unstructured":"Mitra AK, Bhuiyan AR, Jones EA (2021) Association and risk factors for obstructive sleep apnea and cardiovascular diseases: a systematic review. Diseases. https:\/\/doi.org\/10.3390\/diseases9040088","journal-title":"Diseases"},{"issue":"3","key":"3628_CR9","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","volume":"144","author":"Y Yeghiazarians","year":"2021","unstructured":"Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N et al (2021) Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 144(3):e56\u2013e67","journal-title":"Circulation"},{"issue":"1","key":"3628_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/kjm2.12130","volume":"36","author":"HP Chang","year":"2020","unstructured":"Chang HP, Chen YF, Du JK (2020) Obstructive sleep apnea treatment in adults. Kaohsiung J Med Sci 36(1):7\u201312","journal-title":"Kaohsiung J Med Sci"},{"issue":"6","key":"3628_CR11","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.jchf.2014.09.001","volume":"2","author":"O Vardeny","year":"2014","unstructured":"Vardeny O, Miller R, Solomon SD (2014) Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure. JACC Heart Fail 2(6):663\u2013670","journal-title":"JACC Heart Fail"},{"issue":"1","key":"3628_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s40119-021-00252-4","volume":"11","author":"E Houchen","year":"2022","unstructured":"Houchen E, Loefroth E, Schlienger R, Proudfoot C, Corda S, Saha S et al (2022) Hospitalization rates in patients with heart failure and reduced ejection fraction initiating sacubitril\/valsartan or angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers: a retrospective cohort study. Cardiol Ther 11(1):113\u201327","journal-title":"Cardiol Ther"},{"key":"3628_CR13","doi-asserted-by":"crossref","unstructured":"McMurray JJV, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR et al Angiotensin\u2013Neprilysin Inhibition versus Enalapril in Heart Failure. N Engl J Med. 2014-09-11;371(11).","DOI":"10.1056\/NEJMoa1409077"},{"issue":"4","key":"3628_CR14","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1002\/ehf2.13455","volume":"8","author":"D Jaffuel","year":"2021","unstructured":"Jaffuel D, Nogue E, Berdague P, Galinier M, Fournier P, Dupuis M et al (2021) Sacubitril-valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO-SAS study. ESC Heart Fail 8(4):2513\u201326","journal-title":"ESC Heart Fail"},{"key":"3628_CR15","doi-asserted-by":"publisher","DOI":"10.1177\/10742484211058681","volume":"27","author":"R Zhang","year":"2022","unstructured":"Zhang R, Sun X, Li Y, He W, Zhu H, Liu B et al (2022) The efficacy and safety of sacubitril\/valsartan in heart failure patients: a review. J Cardiovasc Pharmacol Ther 27:10742484211058681","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"3628_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","volume":"134","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. J Clin Epidemiol 134:103\u2013112","journal-title":"J Clin Epidemiol"},{"key":"3628_CR17","first-page":"i4919","volume":"355","author":"P J\u00fcni","year":"2016","unstructured":"J\u00fcni P, Loke Y, Pigott T, Ramsay C, Regidor D, Rothstein H et al (2016) Risk of bias in non-randomized studies of interventions (ROBINS-I): detailed guidance. Br Med J 355:i4919","journal-title":"Br Med J"},{"issue":"2","key":"3628_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/jnci\/81.2.107","volume":"81","author":"CB Begg","year":"1989","unstructured":"Begg CB, Berlin JA (1989) Publication bias and dissemination of clinical research. J Natl Cancer Inst 81(2):107\u2013115","journal-title":"J Natl Cancer Inst"},{"key":"3628_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ijcard.2021.02.012","volume":"330","author":"C Passino","year":"2021","unstructured":"Passino C, Sciarrone P, Vergaro G, Borrelli C, Spiesshoefer J, Gentile F et al (2021) Sacubitril-valsartan treatment is associated with decrease in central apneas in patients with heart failure with reduced ejection fraction. Int J Cardiol 330:112\u2013119","journal-title":"Int J Cardiol"},{"issue":"1","key":"3628_CR20","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11325-022-02623-0","volume":"27","author":"Y Wang","year":"2023","unstructured":"Wang Y, Branco RF, Salanitro M, Penzel T, Schobel C (2023) Effects of sacubitril-valsartan on central and obstructive apneas in heart failure patients with reduced ejection fraction. Sleep Breath 27(1):283\u2013289","journal-title":"Sleep Breath"},{"issue":"4","key":"3628_CR21","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1002\/ehf2.13455","volume":"8","author":"D Jaffuel","year":"2021","unstructured":"Jaffuel D, Nogue E, Berdague P, Galinier M, Fournier P, Dupuis M et al (2021) Sacubitril-valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO\u2010SAS study. ESC Heart Fail 8(4):2513\u201326","journal-title":"ESC Heart Fail"},{"key":"3628_CR22","doi-asserted-by":"publisher","first-page":"971108","DOI":"10.3389\/fcvm.2022.971108","volume":"9","author":"M Mapelli","year":"2022","unstructured":"Mapelli M, Mattavelli I, Salvioni E, Banfi C, Ghilardi S, De Martino F et al (2022) Impact of sacubitril\/valsartan on surfactant binding proteins, central sleep apneas, lung function tests and heart failure biomarkers: hemodynamic or pleiotropism? Front Cardiovasc Med 9:971108","journal-title":"Front Cardiovasc Med"},{"key":"3628_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.861663","author":"C Pelaia","year":"2022","unstructured":"Pelaia C, Armentaro G, Volpentesta M, Mancuso L, Miceli S, Caroleo B et al (2022) Effects of sacubitril-valsartan on clinical, echocardiographic, and polygraphic parameters in patients affected by heart failure with reduced ejection fraction and sleep apnea. Front Cardiovasc Med. https:\/\/doi.org\/10.3389\/fcvm.2022.861663","journal-title":"Front Cardiovasc Med"},{"issue":"SUPPL 2","key":"3628_CR24","first-page":"935","volume":"41","author":"P Sciarrone","year":"2020","unstructured":"Sciarrone P, Borrelli C, Giannoni A, Gentile F, Aimo A, Vergaro G et al (2020) Sacubitril\/valsartan improves ventilation stability in patients with chronic heart failure. Eur Heart J 41(SUPPL 2):935","journal-title":"Eur Heart J"},{"issue":"1","key":"3628_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.32552\/2022.ActaMedica.645","volume":"53","author":"E Ta\u015ftan","year":"2022","unstructured":"Ta\u015ftan E, Aslan B, Ok\u015ful M, I\u015f\u0131k F (2022) Evaluation of sleep quality with use of angiotensin receptor neprilysin inhibitor in patients with reduced ejection fraction heart failure. Acta Med 53(1):30\u201336","journal-title":"Acta Med"},{"issue":"2","key":"3628_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40256-020-00440-y","volume":"21","author":"RM Khandwalla","year":"2021","unstructured":"Khandwalla RM, Grant D, Birkeland K, Heywood JT, Fombu E, Owens RL et al (2021) The AWAKE-HF Study: Sacubitril\/Valsartan Impact on Daily Physical Activity and Sleep in Heart Failure. Am J Cardiovasc Drugs 21(2):241\u2013254","journal-title":"Am J Cardiovasc Drugs"},{"issue":"6","key":"3628_CR27","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1513\/AnnalsATS.202107-823OC","volume":"19","author":"C Gulea","year":"2022","unstructured":"Gulea C, Zakeri R, Quint JK (2022) Differences in outcomes between heart failure phenotypes in patients with coexistent chronic obstructive pulmonary disease: a cohort study. Ann Am Thorac Soc 19(6):971\u2013980","journal-title":"Ann Am Thorac Soc"},{"key":"3628_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.sleep.2021.08.029","volume":"87","author":"X Gao","year":"2021","unstructured":"Gao X, Li Y, Xu W, Han D (2021) Diagnostic accuracy of level IV portable sleep monitors versus polysomnography for pediatric obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med 87:127\u2013137","journal-title":"Sleep Med"},{"issue":"1","key":"3628_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/ejhf.1838","volume":"23","author":"S von Haehling","year":"2021","unstructured":"von Haehling S, Arzt M, Doehner W, Edelmann F, Evertz R, Ebner N et al (2021) Improving exercise capacity and quality of life using non-invasive heart failure treatments: evidence from clinical trials. Eur J Heart Fail 23(1):92\u2013113","journal-title":"Eur J Heart Fail"},{"key":"3628_CR30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005899","author":"M Arzt","year":"2017","unstructured":"Arzt M, Oldenburg O, Graml A, Erdmann E, Teschler H, Wegscheider K et al (2017) Phenotyping of sleep-disordered breathing in patients with chronic heart failure with reduced ejection fraction-the SchlaHF registry. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.116.005899","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"3628_CR31","first-page":"898","volume":"31","author":"OD Lyons","year":"2015","unstructured":"Lyons OD, Bradley TD (2015) Heart failure and sleep apnea. Can J Cardiol 31(7):898\u2013908","journal-title":"Can J Cardiol"},{"issue":"9657","key":"3628_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(08)61622-0","volume":"373","author":"TD Bradley","year":"2009","unstructured":"Bradley TD, Floras JS (2009) Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373(9657):82\u201393","journal-title":"Lancet"},{"issue":"11","key":"3628_CR33","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1001\/jama.2019.12821","volume":"322","author":"JL Januzzi Jr.","year":"2019","unstructured":"Januzzi JL Jr., Prescott MF, Butler J, Felker GM, Maisel AS, McCague K et al (2019) Association of change in N-terminal pro-B-type natriuretic peptide following initiation of sacubitril-valsartan treatment with cardiac structure and function in patients with heart failure with reduced ejection fraction. JAMA 322(11):1085\u20131095","journal-title":"JAMA"},{"key":"3628_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.754499","volume":"8","author":"D Pascual-Figal","year":"2021","unstructured":"Pascual-Figal D, Bayes-Genis A, Beltran-Troncoso P, Caravaca-Perez P, Conde-Martel A, Crespo-Leiro MG et al (2021) Sacubitril-valsartan, clinical benefits and related mechanisms of action in heart failure with reduced ejection fraction. A review. Front Cardiovasc Med 8:754499","journal-title":"Front Cardiovasc Med"},{"key":"3628_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-017-0013-4","volume":"3","author":"O Iborra-Egea","year":"2017","unstructured":"Iborra-Egea O, Galvez-Monton C, Roura S, Perea-Gil I, Prat-Vidal C, Soler-Botija C et al (2017) Mechanisms of action of sacubitril\/valsartan on cardiac remodeling: a systems biology approach. NPJ Syst Biol Appl 3:12","journal-title":"NPJ Syst Biol Appl"},{"key":"3628_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196139","volume":"12","author":"A Polecka","year":"2023","unstructured":"Polecka A, Olszewska N, Danielski L, Olszewska E (2023) Association between obstructive sleep apnea and heart failure in adults-A systematic review. J Clin Med 12:19","journal-title":"J Clin Med"},{"issue":"2","key":"3628_CR37","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jjcc.2012.05.013","volume":"60","author":"T Kasai","year":"2012","unstructured":"Kasai T (2012) Sleep apnea and heart failure. J Cardiol 60(2):78\u201385","journal-title":"J Cardiol"},{"issue":"6\u20137","key":"3628_CR38","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.acvd.2024.04.003","volume":"117","author":"LS Cardelli","year":"2024","unstructured":"Cardelli LS, Magaldi M, Agullo A, Richard G, Nogue E, Berdague P et al (2024) Sacubitril\/valsartan has an underestimated impact on the right ventricle in patients with sleep-disordered breathing, especially central sleep apnoea syndrome. Arch Cardiovasc Dis 117(6\u20137):409\u201316","journal-title":"Arch Cardiovasc Dis"},{"key":"3628_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105251","author":"T Menon","year":"2024","unstructured":"Menon T, Kalra DK (2024) Sleep apnea and heart failure-current state-of-the-art. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25105251","journal-title":"Int J Mol Sci"}],"container-title":["Sleep and Breathing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-026-03628-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11325-026-03628-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11325-026-03628-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:15:01Z","timestamp":1774462501000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11325-026-03628-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["3628"],"URL":"https:\/\/doi.org\/10.1007\/s11325-026-03628-9","relation":{},"ISSN":["1520-9512","1522-1709"],"issn-type":[{"value":"1520-9512","type":"print"},{"value":"1522-1709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"3 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study formal consent is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has not been presented at any conference.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Presentation at a conference"}}],"article-number":"62"}}