{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:05:12Z","timestamp":1792757112718,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008967","name":"Philipps-Universit\u00e4t Marburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sleep Breath"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Data on sleep-disordered breathing (SDB) in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) are sparse. Therefore, we aimed to determine the prevalence and characteristics of SDB in a large patient cohort with HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 233 patients with HFpEF were prospectively enrolled at our cardiology outpatient department after excluding patients with a history of SDB. The presence of moderate to severe SDB with an apnea-hypopnea index\u2009\u2265\u200915\/h was determined using cardiorespiratory polygraphy. All patients underwent assessment of HFpEF comorbidities, comprehensive echocardiographic studies, NT-proBNP levels and calculation of HFpEF-scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SDB was found in 97 of 233 patients (42%) with predominantly obstructive sleep apnea (OSA) in 64 patients (27%) and predominantly central sleep apnea (CSA) in 33 patients (14%). Male sex, body mass index, NYHA heart failure class III, NT-proBNP levels, HFpEF scores, chronic kidney disease, coronary artery disease, left ventricular (LV) mass index and E\/E\u2019 ratio by echocardiography were significant predictors of SDB by univariate analysis. Patients with predominantly CSA were significantly older and had higher NT-proBNP levels and a higher NYHA heart failure class than patients with OSA. Patients with OSA had a significantly higher body mass index (BMI) and a higher Epworth Sleepiness score. Multivariate analysis revealed male gender, BMI and LV mass index as significant predictors for OSA, whereas CSA was associated with a higher HFA-PEFF score and male gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate to severe SDB is a frequent comorbidity in patients with HFpEF. Predominantly OSA is more frequent than CSA with significant clinical differences between patients with OSA compared to CSA. Whereas OSA is associated with a higher BMI in addition to male gender, CSA is associated with more advanced heart failure as indicated by higher HFA-PEFF scores, NYHA heart failure class and NT-proBNP levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-026-03635-w","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:53:24Z","timestamp":1773402804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sleep-disordered breathing in patients with heart failure with preserved left ventricular ejection fraction"],"prefix":"10.1007","volume":"30","author":[{"given":"Cornelia","family":"Grimm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Viniol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikail","family":"Degerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kesper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3843-6216","authenticated-orcid":false,"given":"Wolfram","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Parahuleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"3635_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.amjcard.2023.02.020","volume":"195","author":"F Piccirillo","year":"2023","unstructured":"Piccirillo F, Crispino SP, Buzzelli L, Segreti A, Incalzi RA, Grigioni F (2023) A state-of-the-art review on sleep apnea syndrome and heart failure. 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