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Growing evidence suggests that vascular risk factors and sleep-related breathing disorders such as OSA may contribute to AD disease onset and progression. This review aims to explore astrocytes as a potential mechanistic link between OSA and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted in the PubMed database using combinations of keywords including \u201castrocytes,\u201d \u201cobstructive sleep apnea,\u201d \u201cintermittent hypoxia,\u201d \u201csleep-disordered breathing,\u201d \u201cAlzheimer\u2019s disease,\u201d and \u201cdementia\u201d.. Epidemiological, mechanistic, and clinical studies addressing the interplay between astrocyte function, sleep-disordered breathing, and neurodegeneration were reviewed and synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Astrocytes are increasingly recognized as oxygen-sensing cells capable of responding to fluctuations in oxygen availability. Under conditions of intermittent hypoxia, such as those occurring in OSA, astrocytic responses may become maladaptive, promoting oxidative stress and neuroinflammatory signalling. These processes overlap with key aspects of AD pathophysiology and may contribute to both disease initiation and progression. Although available evidence remains heterogeneous and not fully conclusive, epidemiological studies suggest a bidirectional association between OSA and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Glial maladaptation to intermittent hypoxia may represent a critical interface between sleep-disordered breathing and neurodegeneration. Targeting astrocyte-mediated mechanisms could offer new insights into the pathophysiological links between OSA and AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-026-03651-w","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:11:08Z","timestamp":1773915068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer\u2019s disease: from oxygen sensing to neurodegeneration"],"prefix":"10.1007","volume":"30","author":[{"given":"J.","family":"Cabot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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