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Kaiser Permanente Southern California Institutional Review Board approved this study (IRB #12439).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study protocol was approved by the institutional review board, which granted a waiver of informed consent due to the retrospective nature of the study.\n                      Data Availability Statement\n                      : The data analyzed in this study were derived from the Kaiser Permanente Southern California (KPSC) electronic health record and linked sleep program databases. These datasets contain identifiable patient information and cannot be shared publicly due to institutional privacy policies and legal restrictions protecting patient confidentiality. Access to the data is therefore limited to authorized KPSC investigators under institutional review board (IRB) approved research protocols. Summary-level results supporting the findings of this study are available within this article and its supplementary materials.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The sponsors did not contribute to the design, conduct, analysis of this study, nor to the development and review of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Role of the sponsors"}},{"value":"This study demonstrates that OSA is associated with increased risk of COVID-19 infection and lowered with better PAP adherence. These findings provide mechanistic insight into how sleep-disordered breathing and its treatment influence susceptibility to COVID-19 and, plausibly, to other respiratory infections. The results underscore the importance of systematically incorporating OSA severity and PAP adherence into research on OSA comorbid outcomes, exploring potential modifiable risk factors.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Impact of research"}},{"value":"Descriptor number \u2014 15.7 Sleep Disordered Breathing: Epidemiology.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Descriptor"}},{"value":"Kate Cole is an employee of Resmed Corp. All other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"137"}}