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At the therapeutic level, the reduced patient\u2019s compliance of continuous positive airway pressure (CPAP) linked with the limitations of alternative OSA treatments, emphasizes the need for novel non-invasive and effective treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This real-world interventional clinical evaluation aims to explore the viability and short-term performance of Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      in a clinically relevant OSA population representative of the routine clinical practice. Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      urge as an innovative, intelligent, non-invasive, multi-sensor and self-adaptive medical device developed to overcome the limitations of the current OSA treatments. Their clinical efficacy, under real-world conditions, was explored in this unicentric and interventional study that included 20 patients with moderate to severe OSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The clinical efficacy of Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was demonstrated by the statistically significant improvements in key OSA clinical parameters, with 55% of patients experiencing improvements\u2009&gt;\u200950% in apnea-hypopnea index (AHI). Additionally, 100% and 42.9% of patients with moderate OSA (baseline AHI\u2009\u2264\u200929) or severe OSA (baseline AHI 30\u201349) were classified as Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      responders (residual AHI\u2009&lt;\u200915). Moreover, based on investigator-defined clinical criteria (AHI+ oxygen desaturation index [ODI], AHI+ percentage of time with an oxygen saturation\u2009&lt;\u200990% [CT90], and AHI\u2009+\u2009ODI+CT90), nearly 40% of patients were categorized as good treatment responders. In addition to the clinical benefits observed with Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , 100% of patients reported satisfaction with the device ergonomics, portability, and performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Kalinix\n                      <jats:sup>\u00ae<\/jats:sup>\n                      showed promising results in the treatment OSA and offers a non-invasive, comfortable, portable, effective, and safe therapeutic option that may contribute to achieving good long-term compliance and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-026-03687-y","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:45:21Z","timestamp":1777466721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kalinix\u00ae, an innovative, intelligent, non-invasive, and self-adaptive medical device for effective OSA management"],"prefix":"10.1007","volume":"30","author":[{"given":"Juan Luis Rodr\u00edguez","family":"Hermosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam Calle","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Delgado","family":"Cidranes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis \u00c1lvarez-Sala","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Javier Montero","family":"Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngela Velacoracho","family":"Uriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldomero Fern\u00e1ndez","family":"Rond\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"3687_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.5935\/1984-0063.20200111","volume":"14","author":"A Faria","year":"2021","unstructured":"Faria A, Allen AH, Fox N et al (2021) The public health burden of obstructive sleep apnea. 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