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The outcomes of interest included the Apnea\u2013Hypopnea Index, oxygen desaturation index, treatment adherence, and quality of life. Methodological quality was assessed using AMSTAR-2, and overlap among reviews was evaluated using a citation matrix and the corrected covered area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen systematic reviews were included. CPAP demonstrated greater efficacy than mandibular advancement devices in improving objective physiological outcomes, particularly the apnea\u2013hypopnea index and oxygen desaturation indices. Both therapies showed comparable effects on daytime sleepiness, while some reviews reported better treatment adherence and more favorable patient-centered outcomes with MADs. Methodological quality was limited: no review was classified as high quality, and most were assessed as low or critically low quality. Analysis of the corrected coverage area indicated a high overlap between the primary studies included in the different reviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous positive airway pressure is more effective than mandibular advancement devices in improving the apnea\u2013hypopnea index and oxygen desaturation index. However, mandibular advancement devices were associated with positive effects on quality of life and sleep, though certainty regarding the sustainability of these outcomes and their long-term efficacy remains limited in the current literature. Treatment choice should be individualized, and evidence should be interpreted with caution due to methodological limitations and the high overlap between the included systematic reviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD2021268587.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11325-026-03784-y","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T01:48:15Z","timestamp":1787276895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative effects of CPAP and mandibular advancement devices in obstructive sleep apnea: an overview of systematic reviews"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-8880","authenticated-orcid":false,"given":"Marcela Carla Pereira","family":"do Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-2610","authenticated-orcid":false,"given":"Ana Laura Vilela","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-6727","authenticated-orcid":false,"given":"Jessica Fernanda","family":"de Oliveira Lima Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-6714","authenticated-orcid":false,"given":"S\u00e9rgio Soares","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-1489","authenticated-orcid":false,"given":"Belmiro Cavalcanti","family":"do Egito Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-5092","authenticated-orcid":false,"given":"Sandra L\u00facia Dantas","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-5004","authenticated-orcid":false,"given":"Eduardo Piza","family":"Pellizzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-192X","authenticated-orcid":false,"given":"M\u00f4nica Vilela","family":"Heimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"3784_CR1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s11325-025-03420-1","volume":"29","author":"C Antonaglia","year":"2025","unstructured":"Antonaglia C, Citton GM, Siciliano M et al (2025) Obstructive sleep apnea syndrome in women: gender in sleep respiratory medicine is a first step towards personalized medicine. 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