{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:13:57Z","timestamp":1784092437836,"version":"3.55.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s11356-012-1002-1","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T12:59:01Z","timestamp":1339073941000},"page":"3162-3177","source":"Crossref","is-referenced-by-count":18,"title":["Ready biodegradability of trifluoromethylated phenothiazine drugs, structural elucidation of their aquatic transformation products, and identification of environmental risks studied by LC-MS n and QSAR"],"prefix":"10.1007","volume":"19","author":[{"given":"Christoph","family":"Trautwein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"K\u00fcmmerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"1002_CR1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.biocel.2004.11.016","volume":"37","author":"C Bastianon","year":"2005","unstructured":"Bastianon C, Zanoni R, Miolo G et al (2005) Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine. Int J Biochem Cell Biol 37:901\u2013908. doi: 10.1016\/j.biocel.2004.11.016","journal-title":"Int J Biochem Cell Biol"},{"key":"1002_CR2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/sj.jim.7000027","volume":"26","author":"M Boersma","year":"2001","unstructured":"Boersma M, Solyanikova I, Van Berkel W et al (2001) F-19 NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols. J Ind Microbiol Biotechnol 26:22\u201334. doi: 10.1038\/sj.jim.7000027","journal-title":"J Ind Microbiol Biotechnol"},{"key":"1002_CR3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/cbic.200301023","volume":"5","author":"H Bohm","year":"2004","unstructured":"Bohm H, Banner D, Bendels S et al (2004) Fluorine in medicinal chemistry. ChemBioChem 5:637\u2013643. doi: 10.1002\/cbic.200301023","journal-title":"ChemBioChem"},{"key":"1002_CR4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1562\/0031-8655(2001)0730463POHTAM2.0.CO2","volume":"73","author":"F Bosca","year":"2001","unstructured":"Bosca F, Cuquerella M, Marin M, Miranda M (2001) Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal. Photochem Photobiol 73:463\u2013468. doi: 10.1562\/0031-8655(2001)0730463POHTAM2.0.CO2","journal-title":"Photochem Photobiol"},{"key":"1002_CR5","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-88273-2","volume-title":"Transformation products of synthetic chemicals in the environment","author":"A Boxall","year":"2009","unstructured":"Boxall A (2009) Transformation products of synthetic chemicals in the environment, 1st edn. Springer, New York","edition":"1"},{"key":"1002_CR6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-2952(74)90422-5","volume":"23","author":"U Breyer","year":"1974","unstructured":"Breyer U, Gaertner HJ, Prox A (1974) Formation of identical metabolites from piperazine- and dimethylamino-substituted phenothiazine drugs in man, rat and dog. Biochem Pharmacol 23:313\u2013322. doi: 10.1016\/0006-2952(74)90422-5","journal-title":"Biochem Pharmacol"},{"key":"1002_CR7","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1016\/0378-5173(90)90242-V","volume":"62","author":"G Burgot","year":"1990","unstructured":"Burgot G, Burgot J (1990) Water\/n-octanol thermodynamic parameters of some phenothiazines. Int J Pharm 62:R5\u2013R7. doi: 10.1016\/0378-5173(90)90242-V","journal-title":"Int J Pharm"},{"key":"1002_CR8","doi-asserted-by":"crossref","DOI":"10.1002\/9783527619337","volume-title":"Antidepressants, antipsychotics, anxiolytics: from chemistry and pharmacology to clinical application, 1","author":"H Buschmann","year":"2007","unstructured":"Buschmann H, Holenz J, P\u00e1rraga A et al (2007) Antidepressants, antipsychotics, anxiolytics: from chemistry and pharmacology to clinical application, 1. Wiley, Weinheim"},{"key":"1002_CR9","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1021\/tx700123u","volume":"20","author":"S Caffieri","year":"2007","unstructured":"Caffieri S, Miolo G, Seraglia R et al (2007) Photoaddition of fluphenazine to nucleophiles in peptides and proteins. possible cause of immune side effects. Chem Res Toxicol 20:1470\u20131476. doi: 10.1021\/tx700123u","journal-title":"Chem Res Toxicol"},{"key":"1002_CR10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1751-1097.1986.tb05635.x","volume":"43","author":"TA Ciulla","year":"1986","unstructured":"Ciulla TA, Epling GA, Kochevar IE (1986) Photoaddition of chlorpromazine to guanosine-5\u2032-monophosphate. Photochem Photobiol 43:607\u2013613. doi: 10.1111\/j.1751-1097.1986.tb05635.x","journal-title":"Photochem Photobiol"},{"key":"1002_CR11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/1097-458X(200011)38:11<951::AID-MRC762>3.0.CO;2-6","volume":"38","author":"M Dachtler","year":"2000","unstructured":"Dachtler M, H\u00e4ndel H, Glaser T et al (2000) Identification of trifluoperazine metabolites using HPLC-NMR of test mixtures. Magn Reson Chem 38:951\u2013956. doi: 10.1002\/1097-458X(200011)38:11<951::AID-MRC762>3.0.CO;2-6","journal-title":"Magn Reson Chem"},{"key":"1002_CR12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000246080","volume":"194","author":"B Eberlein-Koenig","year":"1997","unstructured":"Eberlein-Koenig B, Bindl A, Przybilla B (1997) Phototoxic properties of neuroleptic drugs. Dermatology 194:131\u2013135. doi: 10.1159\/000246080","journal-title":"Dermatology"},{"key":"1002_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1562\/0031-8655(2002)075<0011:ESPAIV>2.0.CO;2","volume":"75","author":"F Elisei","year":"2002","unstructured":"Elisei F, Latterini L, Aloisi GG et al (2002) Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives. Photochem Photobiol 75:11\u201321. doi: 10.1562\/0031-8655(2002)0750011ESPAIV2.0.CO2","journal-title":"Photochem Photobiol"},{"key":"1002_CR14","first-page":"205","volume-title":"Transformation products of synthetic chemicals in the environment","author":"B Escher","year":"2009","unstructured":"Escher B, Baumgartner R, Lienert J, Fenner K (2009) Predicting the ecotoxicological effects of transformation products. In: Boxall A (ed) Transformation products of synthetic chemicals in the environment. Springer, Heidelberg, pp 205\u2013244"},{"key":"1002_CR15","unstructured":"European Commission (2003) Technical Guidance Document on Risk Assessment Part II."},{"key":"1002_CR16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/js980206m","volume":"88","author":"U Franke","year":"1999","unstructured":"Franke U, Munk A, Wiese M (1999) Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients. J Pharm Sci 88:89\u201395. doi: 10.1021\/js980206m","journal-title":"J Pharm Sci"},{"key":"1002_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-1110(96)90004-4","volume":"366","author":"E Gocke","year":"1996","unstructured":"Gocke E (1996) Review of the genotoxic properties of chlorpromazine and related phenothiazines. Mutat Res 366:9\u201321. doi: 10.1016\/S0165-1110(96)90004-4","journal-title":"Mutat Res"},{"key":"1002_CR18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01277026","volume":"94","author":"C Harasko-van der Meer","year":"1993","unstructured":"Harasko-van der Meer C, Bruecke T, Wenger S et al (1993) Two cases of long term dopamine D2 receptor blockade after depot neuroleptics. J Neural Transm 94:217\u2013221. doi: 10.1007\/BF01277026","journal-title":"J Neural Transm"},{"key":"1002_CR19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0731-7085(85)80063-7","volume":"3","author":"WF Heyes","year":"1985","unstructured":"Heyes WF, Robinson ML (1985) HPLC procedure for the determination of some potential fluphenazine metabolites in urine. J Pharm Biomed Anal 3:477\u2013481. doi: 16\/0731-7085(85)80063-7","journal-title":"J Pharm Biomed Anal"},{"key":"1002_CR20","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/es903383a","volume":"44","author":"PH Howard","year":"2010","unstructured":"Howard PH, Muir DCG (2010) Identifying new persistent and bioaccumulative organics among chemicals in commerce. Environ Sci Technol 44:2277\u20132285. doi: 10.1021\/es903383a","journal-title":"Environ Sci Technol"},{"key":"1002_CR21","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1021\/es201196x","volume":"45","author":"PH Howard","year":"2011","unstructured":"Howard PH, Muir DCG (2011) Identifying new persistent and bioaccumulative organics among chemicals in commerce II: pharmaceuticals. Environ Sci Technol 45:6938\u20136946. doi: 10.1021\/es201196x","journal-title":"Environ Sci Technol"},{"key":"1002_CR22","unstructured":"HSDB (2011) Hazardous Substances Data Bank. US Department of Health and Human Services, National Institutes of Health, US National Library of Medicine: Bethesda, MD; http:\/\/toxnet.nlm.nih.gov\/cgi-bin\/sis\/htmlgen?HSDB ; http:\/\/toxnet.nlm.nih.gov\/cgi-bin\/sis\/htmlgen?HSDB . Accessed 23 Feb 2012"},{"key":"1002_CR23","unstructured":"Huber C, Krause C (2006) Instruction Manual Fibox 3 Software Version 5.32. PreSens GmbH Regensburg"},{"key":"1002_CR24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/jms.1790","volume":"45","author":"M Hubert-Roux","year":"2010","unstructured":"Hubert-Roux M, Bounoure F, Skiba M et al (2010) Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H\/D exchange. J Mass Spectrom 45:1121\u20131129. doi: 10.1002\/jms.1790","journal-title":"J Mass Spectrom"},{"key":"1002_CR25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0090-9556(25)07080-1","volume":"19","author":"CJ Jackson","year":"1991","unstructured":"Jackson CJ, Hubbard JW, McKay G et al (1991) Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates. Drug Metab Dispos 19:188\u2013193","journal-title":"Drug Metab Dispos"},{"key":"1002_CR26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/cbic.200300833","volume":"5","author":"P Jeschke","year":"2004","unstructured":"Jeschke P (2004) The unique role of fluorine in the design of active ingredients for modern crop protection. Chembiochem A Eur J Chem Biol 5:570\u2013589. doi: 10.1002\/cbic.200300833","journal-title":"Chembiochem A Eur J Chem Biol"},{"key":"1002_CR27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jpba.2004.07.026","volume":"36","author":"C Joyce","year":"2004","unstructured":"Joyce C, Smyth W, Ramachandran V et al (2004) The characterisation of selected drugs with amine-containing side chains using electrospray ionisation and ion trap mass spectrometry and their determination by HPLC-ESI-MS. J Pharm Biomed Anal 36:465\u2013476. doi: 10.1016\/j.jpba.2004.07.026","journal-title":"J Pharm Biomed Anal"},{"key":"1002_CR28","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/es961007c","volume":"31","author":"B Key","year":"1997","unstructured":"Key B, Howell R, Criddle C (1997) Fluorinated organics in the biosphere. Environ Sci Technol 31:2445\u20132454. doi: 10.1021\/es961007c","journal-title":"Environ Sci Technol"},{"key":"1002_CR29","first-page":"423","volume-title":"Predictive toxicology","author":"G Klopman","year":"2005","unstructured":"Klopman G, Ivanov J, Saiakhov R, Chakravarti S (2005) MC4PC\u2014an artificial intelligence approach to the discovery of structure toxic activity relationships (STAR). In: Helma C (ed) Predictive toxicology. Dekker, New York, pp 423\u2013457"},{"key":"1002_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1751-1097.1983.tb04452.x","volume":"37","author":"IE Kochevar","year":"1983","unstructured":"Kochevar IE, Hom J (1983) Photoproducts of chlorpromazine which cause red blood cell lysis. Photochem Photobiol 37:163\u2013168. doi: 10.1111\/j.1751-1097.1983.tb04452.x","journal-title":"Photochem Photobiol"},{"key":"1002_CR31","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","volume":"36","author":"DW Kolpin","year":"2002","unstructured":"Kolpin DW, Furlong ET, Meyer MT et al (2002) Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999\u20132000: a national reconnaissance. Environ Sci Technol 36:1202\u20131211","journal-title":"Environ Sci Technol"},{"key":"1002_CR32","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.trac.2008.09.010","volume":"27","author":"M Farre la","year":"2008","unstructured":"la Farre M, Perez S, Kantiani L, Barcelo D (2008) Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment. Trac-Trends Anal Chem 27:991\u20131007. doi: 10.1016\/j.trac.2008.09.010","journal-title":"Trac-Trends Anal Chem"},{"key":"1002_CR33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1021\/es0494757","volume":"39","author":"M Lam","year":"2005","unstructured":"Lam M, Young C, Mabury S (2005) Aqueous photochemical reaction kinetics and transformations of fluoxetine. Environ Sci Technol 39:513\u2013522. doi: 10.1021\/es0494757","journal-title":"Environ Sci Technol"},{"key":"1002_CR34","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","volume":"45","author":"AB Lindstrom","year":"2011","unstructured":"Lindstrom AB, Strynar MJ, Libelo EL (2011) Polyfluorinated compounds: past, present, and future. Environ Sci Technol 45:7954\u20137961. doi: 10.1021\/es2011622","journal-title":"Environ Sci Technol"},{"key":"1002_CR35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10401230591002002","volume":"17","author":"F L\u00f3pez-Mu\u00f1oz","year":"2005","unstructured":"L\u00f3pez-Mu\u00f1oz F, Alamo C, Cuenca E et al (2005) History of the discovery and clinical introduction of chlorpromazine. Ann Clin Psychiatry 17:113\u2013135. doi: 10.1080\/10401230591002002","journal-title":"Ann Clin Psychiatry"},{"key":"1002_CR36","volume-title":"Psychopharmacology: drugs, the brain and behavior","author":"JS Meyer","year":"2004","unstructured":"Meyer JS, Quenzer LF (2004) Psychopharmacology: drugs, the brain and behavior, 1st edn. Sinauer, New York","edition":"1"},{"key":"1002_CR37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/tx0502239","volume":"19","author":"G Miolo","year":"2006","unstructured":"Miolo G, Levorato L, Gallocchio F et al (2006) In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium. Chem Res Toxicol 19:156\u2013163. doi: 10.1021\/tx0502239","journal-title":"Chem Res Toxicol"},{"key":"1002_CR38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1751-1097.1985.tb03540.x","volume":"42","author":"AG Motten","year":"1985","unstructured":"Motten AG, Buettner GR, Chignell CF (1985) Spectroscopic studies of cutaneous photosensitizing agents\u2013VIII. A spin-trapping study of light induced free radicals from chlorpromazine and promazine. Photochem Photobiol 42:9\u201315. doi: 10.1111\/j.1751-1097.1985.tb03540.x","journal-title":"Photochem Photobiol"},{"key":"1002_CR39","volume-title":"Agrochemicals: composition, production, toxicology, applications","author":"F Mueller","year":"2000","unstructured":"Mueller F (2000) Agrochemicals: composition, production, toxicology, applications, 1st edn. New York, Wiley","edition":"1"},{"key":"1002_CR40","unstructured":"OECD 301D (1992) Test no. 301D: ready biodegradability: Closed Bottle test. ISBN 9789264070349. OECD guidelines for the testing of chemicals, section 3: degradation and accumulation"},{"key":"1002_CR41","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0026-895X(25)13477-9","volume":"19","author":"W Prozialeck","year":"1981","unstructured":"Prozialeck W, Cimino M, Weiss B (1981) Photoaffinity labeling of calmodulin by phenothiazine antipsychotics. Mol Pharmacol 19:264\u2013269","journal-title":"Mol Pharmacol"},{"key":"1002_CR42","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/jm00198a004","volume":"22","author":"PH Sackett","year":"1979","unstructured":"Sackett PH, McCreery RL (1979) Effect of structure on phenothiazine cation radical reactions in aqueous buffers. J Med Chem 22:1447\u20131453. doi: 10.1021\/jm00198a004","journal-title":"J Med Chem"},{"key":"1002_CR43","doi-asserted-by":"crossref","unstructured":"Schwabe U, Paffrath D (2010) Arzneiverordnungs-Report 2010: Aktuelle Daten, Kosten, Trends und Kommentare, 1st ed. Springer, Berlin","DOI":"10.1007\/978-3-642-13380-0"},{"key":"1002_CR44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-2670(02)01474-5","volume":"492","author":"WF Smyth","year":"2003","unstructured":"Smyth WF (2003) Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. Anal Chim Acta 492:1\u201316. doi: 10.1016\/S0003-2670(02)01474-5","journal-title":"Anal Chim Acta"},{"key":"1002_CR45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2005.07.018","volume":"824","author":"W Smyth","year":"2005","unstructured":"Smyth W (2005) Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr B 824:1\u201320. doi: 10.1016\/j.jchromb.2005.07.018","journal-title":"J Chromatogr B"},{"key":"1002_CR46","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.chemosphere.2011.06.057","volume":"85","author":"C Trautwein","year":"2011","unstructured":"Trautwein C, K\u00fcmmerer K (2011) Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea. Chemosphere 85:765\u2013773. doi: 10.1016\/j.chemosphere.2011.06.057","journal-title":"Chemosphere"},{"key":"1002_CR47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jchromb.2012.01.022","volume":"889\u2013890","author":"C Trautwein","year":"2012","unstructured":"Trautwein C, K\u00fcmmerer K (2012) Degradation of the tricyclic antipsychotic drug chlorpromazine under environmental conditions, identification of its main aquatic biotic and abiotic transformation products by LC\u2013MSn and their effects on environmental bacteria. J Chromatogr B 889\u2013890:24\u201338. doi: 10.1016\/j.jchromb.2012.01.022","journal-title":"J Chromatogr B"},{"key":"1002_CR48","volume-title":"Fluorine and the environment: agrochemicals, archaeology, green chemistry & water, volume 2","author":"A Tressaud","year":"2006","unstructured":"Tressaud A (2006) Fluorine and the environment: agrochemicals, archaeology, green chemistry & water, volume 2, 1st edn. Elsevier, New York","edition":"1"},{"key":"1002_CR49","unstructured":"US EPA (1999) United States Environmental Protection Agency, Federal Register: 40 CFR Part 372, Persistent bioaccumulative toxic (PBT) chemicals; final rule. 64:58665\u201358753"},{"key":"1002_CR50","unstructured":"US EPA (2004) United States Environmental Protection Agency\/OPPT\/Exposure Assessment Tools and Models\/Estimation Program Interface (EPI) Suite Version 3.12 (August 17, 2004). http:\/\/www.epa.gov\/oppt\/exposure\/pubs\/episuite.htm . Accessed 13 Dec 2011"},{"key":"1002_CR51","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2174\/138945006778226561","volume":"7","author":"G Viola","year":"2006","unstructured":"Viola G, Dall\u2019Acqua F (2006) Photosensitization of biomolecules by phenothiazine derivatives. Curr Drug Targets 7:1135\u20131154. doi: 10.2174\/138945006778226561","journal-title":"Curr Drug Targets"},{"key":"1002_CR52","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/tx025680t","volume":"16","author":"G Viola","year":"2003","unstructured":"Viola G, Latterini L, Vedaldi D et al (2003) Photosensitization of DNA strand breaks by three phenothiazine derivatives RID G-3604-2010. Chem Res Toxicol 16:644\u2013651. doi: 10.1021\/tx025680t","journal-title":"Chem Res Toxicol"},{"key":"1002_CR53","first-page":"943","volume":"23","author":"O Weso\u0142owska","year":"2009","unstructured":"Weso\u0142owska O, Molnar J, Ocsovszki I, Michalak K (2009) Differential effect of phenothiazines on MRP1 and P-glycoprotein activity. In Vivo 23:943\u2013947","journal-title":"In Vivo"},{"key":"1002_CR54","unstructured":"WHO (2011) ATC\/DDD Index, World Health Organisation Collaborating Centre for Drug Statistics Methodology. http:\/\/www.whocc.no\/atc_ddd_index . Accessed 15 Nov 2011"},{"key":"1002_CR55","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1021\/ac020176e","volume":"74","author":"OS Wolfbeis","year":"2002","unstructured":"Wolfbeis OS (2002) Fiber-optic chemical sensors and biosensors. Anal Chem 74:2663\u20132678. doi: 10.1021\/ac020176e","journal-title":"Anal Chem"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-012-1002-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-012-1002-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-012-1002-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:27:25Z","timestamp":1743287245000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-012-1002-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,8]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["1002"],"URL":"https:\/\/doi.org\/10.1007\/s11356-012-1002-1","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,8]]}}}