{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:16:22Z","timestamp":1790622982695,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s11356-014-3060-z","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T02:06:03Z","timestamp":1401933963000},"page":"10830-10839","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Behavior of sartans (antihypertensive drugs) in wastewater treatment plants, their occurrence and risk for the aquatic environment"],"prefix":"10.1007","volume":"21","author":[{"given":"Anne","family":"Bayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Asner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Sch\u00fcssler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Kopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Sengl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Letzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"3060_CR1","unstructured":"AUE (2011) Monthly report of the monitoring station at Weil am Rhein. Amt f\u00fcr Umwelt und Energie Basel-Stadt, http:\/\/www.aue.bs.ch\/2011allweil.pdf (in German)"},{"issue":"22","key":"3060_CR2","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1021\/jm960073m","volume":"39","author":"A Avdeef","year":"1996","unstructured":"Avdeef A, Barrett DA, Shaw PN, Knaggs RD, Davis SS (1996) Octanol-, chloroform-, and propylene glycol dipelargonat-water partitioning of morphine-6-glucorinide and other related opiates. J Med Chem 39(22):4377\u20134381","journal-title":"J Med Chem"},{"key":"3060_CR3","unstructured":"Bergmann A, Fohrmann R, Weber F-A (2011) Set of monitoring data of environmental concentrations of pharmaceuticals. Vol 66\/2011. Umweltbundesamt (in German)"},{"key":"3060_CR4","author":"S Berkner","year":"2013","unstructured":"Berkner S, Thierbach C (2013) Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems. Environ Sci Pollut Res Int. doi: 10.1007\/s11356-013-1868-6","journal-title":"Environ Sci Pollut Res Int"},{"key":"3060_CR5","unstructured":"BUND (2012) www.bund-bawue.de . Accessed 20 Dec 2013 (in German)"},{"key":"3060_CR6","unstructured":"ChemAxxon http:\/\/www.chemicalize.org\/ . Accessed 5 Jun 2013"},{"issue":"3","key":"3060_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4274(03)00068-7","volume":"142","author":"M Cleuvers","year":"2003","unstructured":"Cleuvers M (2003) Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142(3):185\u2013194","journal-title":"Toxicol Lett"},{"issue":"5","key":"3060_CR8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.envint.2009.01.008","volume":"35","author":"CM Coetsier","year":"2009","unstructured":"Coetsier CM, Spinelli S, Lin L, Roig B, Touraud E (2009) Discharge of pharmaceutical products (PPs) through a conventional biological sewage treatment plant: MECs vs PECs? Environ Int 35(5):787\u2013792","journal-title":"Environ Int"},{"key":"3060_CR9","unstructured":"DrugBank http:\/\/www.drugbank.ca , DrugBank 3.0. Accessed 5 Jun 2013"},{"key":"3060_CR10","unstructured":"ECB (2003) Technical guidance document on risk assessment, part II"},{"key":"3060_CR11","unstructured":"EPA US (2011) EPI Suite\u2122 v4.10. 4.10 edn. United States Environmental Protection Agency, http:\/\/www.epa.gov\/oppt\/exposure\/pubs\/episuitedl.htm"},{"issue":"1","key":"3060_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.watres.2010.08.019","volume":"45","author":"BI Escher","year":"2011","unstructured":"Escher BI, Baumgartner R, Koller M, Treyer K, Lienert J, McArdell CS (2011) Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. Water Res 45(1):75\u201392","journal-title":"Water Res"},{"key":"3060_CR13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122\u2013159","journal-title":"Aquat Toxicol"},{"key":"3060_CR14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.chroma.2012.03.059","volume":"1259","author":"I Ferrer","year":"2012","unstructured":"Ferrer I, Thurman EM (2012) Analysis of 100 pharmaceuticals and their degradates in water samples by liquid chromatography\/quadrupole time-of-flight mass spectrometry. J Chromatogr A 1259:148\u2013157","journal-title":"J Chromatogr A"},{"key":"3060_CR15","unstructured":"Fick J, Lindberg RH, Kaj L, Brorstr\u00f6m-Lund\u00e9n E (2011) Results from the Swedish National Screening Programme 2010; Subreport 3. Pharmaceuticals. Swedish Environmental Research Institute"},{"issue":"1","key":"3060_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00401706.1969.10490657","volume":"11","author":"FE Grubbs","year":"1969","unstructured":"Grubbs FE (1969) Procedures for detecting outlying observations in samples. Technometrics 11(1):1\u201321","journal-title":"Technometrics"},{"key":"3060_CR17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","volume":"131","author":"T Heberer","year":"2002","unstructured":"Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5\u201317","journal-title":"Toxicol Lett"},{"key":"3060_CR18","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1021\/es101035b","volume":"44","author":"DE Helbling","year":"2010","unstructured":"Helbling DE, Hollender J, Kohler H-PE, Fenner K (2010a) Structure-based interpretation of biotransformation pathways of amide-contaning compounds in sludge-seeded bioreactors. Environ Sci Technol 44:6628\u20136635","journal-title":"Environ Sci Technol"},{"key":"3060_CR19","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1021\/es100970m","volume":"44","author":"DE Helbling","year":"2010","unstructured":"Helbling DE, Hollender J, Kohler H-PE, Singer H, Fenner K (2010b) High-troughput identification of microbial transformation products of organic micropollutants. Environ Sci Technol 44:6621\u20136627","journal-title":"Environ Sci Technol"},{"key":"3060_CR20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","volume":"69","author":"MD Hernando","year":"2006","unstructured":"Hernando MD, Mezcua M, Fern\u00e1ndez-Alba AR, Barcel\u00f3 D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69:334\u2013342","journal-title":"Talanta"},{"key":"3060_CR21","unstructured":"Hoeger B (2008) Novartis environmental assessment: Aliskiren \/ Valsartan. Global Pharma Environment. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2009\/022217s000ea.pdf"},{"key":"3060_CR22","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1021\/es9014629","volume":"43","author":"J Hollender","year":"2009","unstructured":"Hollender J, Zimmermann SG, Koepke S, Krauss M, McArdell CS, Ort C, Singer H, von Gunten U, Siegrist H (2009) Elimination of organic micropollutants in a municipal wastewater treatment plant upgraded with a full-scale post-ozonation followed by sand filtration. Environ Sci Technol 43:7862\u20137869","journal-title":"Environ Sci Technol"},{"key":"3060_CR23","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/es048396s","volume":"39","author":"MM Huber","year":"2005","unstructured":"Huber MM, G\u00f6bel A, Joss A, Hermann N, L\u00f6ffler D, McArdell CS, Ried A, Siegrist H, Ternes TA, von Gunten U (2005) Oxidation of pharmaceuticals during ozonation of municipal wastewater effluents: a pilot study. Environ Sci Technol 39:4290\u20134299","journal-title":"Environ Sci Technol"},{"issue":"14","key":"3060_CR24","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/j.watres.2005.05.031","volume":"39","author":"A Joss","year":"2005","unstructured":"Joss A, Keller E, Alder AC, Gobel A, McArdell CS, Ternes T, Siegrist H (2005) Removal of pharmaceuticals and fragrances in biological wastewater treatment. Water Res 39(14):3139\u20133152","journal-title":"Water Res"},{"issue":"13","key":"3060_CR25","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1016\/j.watres.2008.04.026","volume":"42","author":"B Kasprzyk-Hordern","year":"2008","unstructured":"Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42(13):3498\u20133518","journal-title":"Water Res"},{"issue":"6","key":"3060_CR26","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.envpol.2009.02.019","volume":"157","author":"B Kasprzyk-Hordern","year":"2009","unstructured":"Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) Illicit drugs and pharmaceuticals in the environment\u2014forensic applications of environmental data, part 2: pharmaceuticals as chemical markers of faecal water contamination. Environ Pollut 157(6):1778\u20131786","journal-title":"Environ Pollut"},{"key":"3060_CR27","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1039\/c0em00238k","volume":"12","author":"S Kern","year":"2010","unstructured":"Kern S, Baumgartner R, Helbling DE, Hollender J, Singer H, Loos MJ, Schwarzenbach RP, Fenner K (2010) A tiered procedure for assessing the formation of biotransformation products of pharmaceuticals and biocides during activated sludge treatment. J Environ Monitor 12:2100\u20132111","journal-title":"J Environ Monitor"},{"key":"3060_CR28","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/es203495d","volume":"46","author":"L Kovalova","year":"2012","unstructured":"Kovalova L, Siegrist H, Singer H, Wittmer A, McArdell CS (2012) Hospital wastewater treatment by membrane bioreactor: performance and efficiency for organic micropollutant elimination. Environ Sci Technol 46:1536\u20131545","journal-title":"Environ Sci Technol"},{"key":"3060_CR29","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-74664-5","volume-title":"Pharmaceuticals in the environment: sources, fate, effects and risks","author":"K K\u00fcmmerer","year":"2008","unstructured":"K\u00fcmmerer K (2008) Pharmaceuticals in the environment: sources, fate, effects and risks, 3rd edn. Springer, Berlin","edition":"3"},{"key":"3060_CR30","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.jenvman.2009.01.023","volume":"90","author":"K K\u00fcmmerer","year":"2009","unstructured":"K\u00fcmmerer K (2009) The presence of pharmaceuticals in the environment due to human use\u2014present knowledge and future challenges. J Environ Manag 90:2354\u20132366","journal-title":"J Environ Manag"},{"key":"3060_CR31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-environ-052809-161223","volume":"35","author":"K K\u00fcmmerer","year":"2010","unstructured":"K\u00fcmmerer K (2010) Pharmaceuticals in the environment. Annu Rev Environ Resour 35:57\u201375","journal-title":"Annu Rev Environ Resour"},{"key":"3060_CR32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jhazmat.2007.07.008","volume":"148","author":"DGJ Larsson","year":"2007","unstructured":"Larsson DGJ, de Pedro C, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751\u2013755","journal-title":"J Hazard Mater"},{"key":"3060_CR33","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.chemosphere.2010.09.018","volume":"81","author":"M Letzel","year":"2010","unstructured":"Letzel M, Weiss K, Sch\u00fcssler W, Sengl M (2010) Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system. Chemosphere 81:1416\u20131422","journal-title":"Chemosphere"},{"key":"3060_CR34","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.scitotenv.2013.05.034","volume":"461\u2013462","author":"J Margot","year":"2013","unstructured":"Margot J, Kienle C, Magnet A, Weil M, Rossi L, De Alencastro LF, Abegglen C, Thonney D, Ch\u00e8vre N, Sch\u00e4rer M, Barry DA (2013) Treatment of micropollutants in municipal wastewater: ozone or powdered activated carbon. Sci Total Environ 461\u2013462:480\u2013498","journal-title":"Sci Total Environ"},{"key":"3060_CR35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/B978-0-444-52272-6.00457-8","volume-title":"Encyclopedia of environmental health","author":"DS Maycock","year":"2011","unstructured":"Maycock DS, Watts CD (2011) Pharmaceuticals in drinking water. In: Jerome ON (ed) Encyclopedia of environmental health. Elsevier, Burlington, pp 472\u2013484"},{"issue":"5","key":"3060_CR36","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.envpol.2008.11.045","volume":"157","author":"C Mi\u00e8ge","year":"2009","unstructured":"Mi\u00e8ge C, Choubert JM, Ribeiro L, Eusebe M, Coquery M (2009) Fate of pharmaceuticals and personal care products in wastewater treatment plants\u2014conception of a database and first results. Environ Pollut 157(5):1721\u20131726","journal-title":"Environ Pollut"},{"key":"3060_CR37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.envint.2008.10.008","volume":"35","author":"S Mompelat","year":"2009","unstructured":"Mompelat S, Le Bot B, Thomas O (2009) Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ Int 35:803\u2013814","journal-title":"Environ Int"},{"key":"3060_CR38","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00216-006-1035-8","volume":"387","author":"A Nikolaou","year":"2007","unstructured":"Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal Bioanal Chem 387:1225\u20131234","journal-title":"Anal Bioanal Chem"},{"issue":"17","key":"3060_CR39","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1016\/j.watres.2013.08.034","volume":"47","author":"K N\u00f6dler","year":"2013","unstructured":"N\u00f6dler K, Hillebrand O, Idzik K, Strathmann M, Schiperski F, Zirlewagen J, Licha T (2013) Occurrence and fate of the angiotensin II receptor antagonist transformation product valsartan acid in the water cycle\u2014a comparative study with selected \u03b2-blockers and the persistent anthropogenic wastewater indicators carbamazepine and acesulfame. Water Res 47(17):6650\u20136659","journal-title":"Water Res"},{"key":"3060_CR40","unstructured":"Scherrer RA, Crooks SL (1989) Titration in water-saturated octanol: a guide to partition coefficients of ion pairs and receptor-site interactions. In: Fauchere JL (ed) Quantitative structure-activity relationships in drug design. New York, pp 59\u201362"},{"key":"3060_CR41","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00216-006-0825-3","volume":"387","author":"M Schmitt-Jansen","year":"2007","unstructured":"Schmitt-Jansen M, Bartels P, Adler N, Altenburger R (2007) Phytotoxicity assessment of diclofenac and its phototransformation products. Anal Bioanal Chem 387:1389\u20131396","journal-title":"Anal Bioanal Chem"},{"key":"3060_CR42","volume-title":"Report of pharmaceutical prescriptions 2010","author":"U Schwabe","year":"2010","unstructured":"Schwabe U, Paffrath D (2010) Report of pharmaceutical prescriptions 2010. Springer, Berlin (in German)"},{"key":"3060_CR43","volume-title":"Report of pharmaceutical prescriptions 2013","author":"U Schwabe","year":"2013","unstructured":"Schwabe U, Paffrath D (2013) Report of pharmaceutical prescriptions 2013. Springer, Berlin (in German)"},{"key":"3060_CR44","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1021\/es030038m","volume":"37","author":"CJ Sinclair","year":"2003","unstructured":"Sinclair CJ, Boxall ABA (2003) Assessing the ecotoxicity of pesticide transformation products. Environ Sci Technol 37:4617\u20134625","journal-title":"Environ Sci Technol"},{"key":"3060_CR45","unstructured":"Statistisches Bundesamt (2012) www.destatis.de . Assessed 20 Dec 2013 (in German)"},{"key":"3060_CR46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.agwat.2006.06.015","volume":"86","author":"JT Yu","year":"2006","unstructured":"Yu JT, Bouwer EJ, Coelhan M (2006) Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent. Agric Water Manag 86:72\u201380","journal-title":"Agric Water Manag"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-3060-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-014-3060-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-3060-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T14:04:49Z","timestamp":1559397889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-014-3060-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":46,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["3060"],"URL":"https:\/\/doi.org\/10.1007\/s11356-014-3060-z","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}