{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:07:38Z","timestamp":1793160458273,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,1,10]],"date-time":"2015-01-10T00:00:00Z","timestamp":1420848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11356-014-4002-5","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T02:23:07Z","timestamp":1420770187000},"page":"8728-8737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination"],"prefix":"10.1007","volume":"22","author":[{"given":"Naima Rihane Ben","family":"Younes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Mrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Ben-Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Jeljeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Omri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaber","family":"El Ghoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassaad","family":"El Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khemais Ben","family":"Rhouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafedh","family":"Abdelmelek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sakly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,10]]},"reference":[{"issue":"8","key":"4002_CR1","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1166\/jnn.2009.1281","volume":"9","author":"S Abe","year":"2009","unstructured":"Abe S, Koyama C, Uo M et al (2009) Time-dependence and visualization of TiO2 and Pt particle biodistribution in mice. J Nanosci Nanotechnol 9(8):4988\u20134991","journal-title":"J Nanosci Nanotechnol"},{"key":"4002_CR2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/exd.12121","volume":"22","author":"K Adachi","year":"2013","unstructured":"Adachi K, Yamada N, Yoshida Y, Yamamoto O (2013) Subchronic exposure of titanium dioxide nanoparticles to hairless rat skin. Exp Dermatol 22:278\u2013283","journal-title":"Exp Dermatol"},{"issue":"2","key":"4002_CR3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1562\/2004-07-01-RA-221.1","volume":"81","author":"NS Allen","year":"2005","unstructured":"Allen NS, Edge M, Sandoval G et al (2005) Photocatalytic coatings for environmental applications. Photochem Photobiol 81(2):279\u2013290","journal-title":"Photochem Photobiol"},{"key":"4002_CR4","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jpcs.2006.01.116","volume":"67","author":"A Amlouk","year":"2006","unstructured":"Amlouk A, El Mir L, Kraiem S et al (2006) Elaboration and characterization of TiO2 nanoparticles incorporated in SiO2 host matrix. J Phys Chem Solids 67:1464\u20131468","journal-title":"J Phys Chem Solids"},{"key":"4002_CR5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/toxsci\/kfh019","volume":"77","author":"E Bermudez","year":"2004","unstructured":"Bermudez E, Mangum JB, Wong BA et al (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347\u2013357","journal-title":"Toxicol Sci"},{"key":"4002_CR6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jat.1414","volume":"29","author":"J Chen","year":"2009","unstructured":"Chen J, Dong X, Zhao J et al (2009) In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. J Appl Toxicol 29:330\u2013337","journal-title":"J Appl Toxicol"},{"key":"4002_CR7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.chemosphere.2013.07.051","volume":"96","author":"Y Cui","year":"2014","unstructured":"Cui Y, Chen X, Zhou Z, Lei Y et al (2014) Prenatal exposure to nanoparticulate titanium dioxide enhances depressive-like behaviors in adult rats. Chemosphere 96:99\u2013104","journal-title":"Chemosphere"},{"key":"4002_CR8","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1002\/aic.10472","volume":"51","author":"CR Esterkin","year":"2005","unstructured":"Esterkin CR, Negro AC, Alfano OM et al (2005) Air pollution remediation in a fixed bed photocatalytic reactor coated with TiO2. Aiche J 51:2298\u20132310","journal-title":"Aiche J"},{"key":"4002_CR9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00204-007-0253-y","volume":"82","author":"E Fabian","year":"2008","unstructured":"Fabian E, Landsiedel R, Ma-Hock L et al (2008) Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch Toxicol 82:151\u2013157","journal-title":"Arch Toxicol"},{"key":"4002_CR10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1289\/ehp.9469","volume":"115","author":"VH Grassian","year":"2007","unstructured":"Grassian VH, O\u2019Shaughnessy PT, Adamcakova-Dodd A et al (2007) Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115:397\u2013402","journal-title":"Environ Health Perspect"},{"key":"4002_CR11","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1016\/j.biomaterials.2010.07.011","volume":"31","author":"R Hu","year":"2010","unstructured":"Hu R, Gong X, Duan Y et al (2010) Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials 31:8043\u20138050","journal-title":"Biomaterials"},{"key":"4002_CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.RES.0000252802.25497.b7","volume":"100","author":"PV Hundelshausen","year":"2007","unstructured":"Hundelshausen PV, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100:27\u201340","journal-title":"Circ Res"},{"issue":"12","key":"4002_CR13","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1166\/jnn.2013.8217","volume":"13","author":"EM Kim","year":"2013","unstructured":"Kim EM, Palmer P, Howard V et al (2013) Effect of intracerebroventricular injection of TiO2 nanoparticles on complex behavior in the rat. J Nanosci Nanotechnol 13(12):8325\u20138330","journal-title":"J Nanosci Nanotechnol"},{"key":"4002_CR14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.toxlet.2010.03.1116","volume":"165","author":"N Li","year":"2010","unstructured":"Li N, Duan Y, Hong M et al (2010) Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules. Toxicol Lett 165:161\u2013168","journal-title":"Toxicol Lett"},{"key":"4002_CR15","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s11671-009-9393-8","volume":"4","author":"L Ma","year":"2009","unstructured":"Ma L, Zhao J, Wang J et al (2009) The acute liver injury in mice caused by nano-anatase TiO2. Nanoscale Res Lett 4:1275\u20131285","journal-title":"Nanoscale Res Lett"},{"key":"4002_CR16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biomaterials.2009.09.028","volume":"31","author":"L Ma","year":"2010","unstructured":"Ma L, Liu J, Li N et al (2010) Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials 31:99\u2013105","journal-title":"Biomaterials"},{"key":"4002_CR17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.physbeh.2008.10.019","volume":"96","author":"K Maaroufi","year":"2009","unstructured":"Maaroufi K, Ammari M, Jeljeli M et al (2009) Impairment of emotional behavior and spatial learning in adult Wistar rats by ferrous sulfate. Physiol Behav 96:343\u2013349","journal-title":"Physiol Behav"},{"key":"4002_CR18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.etap.2014.01.014","volume":"37","author":"A Mohammadipour","year":"2014","unstructured":"Mohammadipour A, Fazel A, Haghir A et al (2014) Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring. Environ Toxicol Pharmacol 37:617\u2013625","journal-title":"Environ Toxicol Pharmacol"},{"key":"4002_CR19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/15287390903486543","volume":"73","author":"C Moon","year":"2010","unstructured":"Moon C, Park HJ, Choi YH et al (2010) Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide. J Toxicol Environ Health A 73:396\u2013409","journal-title":"J Toxicol Environ Health A"},{"issue":"Suppl 5","key":"4002_CR20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1289\/ehp.94102s5173","volume":"102","author":"G Oberdorster","year":"1994","unstructured":"Oberdorster G, Ferin J, Lehnert BE (1994) Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102(Suppl 5):173\u2013179","journal-title":"Environ Health Perspect"},{"key":"4002_CR21","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jat.1454","volume":"29","author":"A Patri","year":"2009","unstructured":"Patri A, Umbreit T, Zheng J et al (2009) Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice. J Appl Toxicol 29:662\u2013672","journal-title":"J Appl Toxicol"},{"issue":"3","key":"4002_CR22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","volume":"14","author":"S Pellow","year":"1985","unstructured":"Pellow S, Chopin P, File SE et al (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149\u2013167","journal-title":"J Neurosci Methods"},{"key":"4002_CR23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4","volume":"12","author":"KJ Ressler","year":"2000","unstructured":"Ressler KJ, Nemeroff CB (2000) Role of sertonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12:2\u201319","journal-title":"Depress Anxiety"},{"key":"4002_CR24","first-page":"281","volume":"259","author":"I Takashima","year":"1978","unstructured":"Takashima I, Fuchimoto H, Kubota Y et al (1978) Hydrothermal alteration of Onuma geothermal area, Akita Prefecture, Northeast Japan. Rep GSJ 259:281\u2013309","journal-title":"Rep GSJ"},{"key":"4002_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4088\/JCP.0906e11","volume":"67","author":"CA Tamminga","year":"2006","unstructured":"Tamminga CA (2006) The neurobiological of cognition in schizophrenia. J Clin Psychiatry 67:9\u201313","journal-title":"J Clin Psychiatry"},{"key":"4002_CR26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.toxlet.2008.11.020","volume":"186","author":"B Ravenzwaay Van","year":"2009","unstructured":"Van Ravenzwaay B, Landsiedel R, Fabian E et al (2009) Comparing fate and effects of three particles of different surface properties: nano-TiO2, pigmentary TiO2 and quartz. Toxicol Lett 186:152\u2013159","journal-title":"Toxicol Lett"},{"issue":"2","key":"4002_CR27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.toxlet.2006.12.001","volume":"168","author":"J Wang","year":"2007","unstructured":"Wang J, Zhou G, Chen C et al (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168(2):176\u2013185","journal-title":"Toxicol Lett"},{"issue":"1\u20133","key":"4002_CR28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.toxlet.2008.10.001","volume":"183","author":"J Wang","year":"2008","unstructured":"Wang J, Chen C, Liu Y et al (2008a) Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183(1\u20133):72\u201380","journal-title":"Toxicol Lett"},{"issue":"1\u20132","key":"4002_CR29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tox.2008.09.014","volume":"254","author":"J Wang","year":"2008","unstructured":"Wang J, Liu Y, Jiao F et al (2008b) Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology 254(1\u20132):82\u201390","journal-title":"Toxicology"},{"issue":"27","key":"4002_CR30","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1016\/j.biomaterials.2009.05.008","volume":"30","author":"J Wang","year":"2009","unstructured":"Wang J, Fan Y, Gao Y et al (2009) TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection. Biomaterials 30(27):4590\u20134600","journal-title":"Biomaterials"},{"key":"4002_CR31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tox.2006.11.002","volume":"23","author":"DB Warheit","year":"2007","unstructured":"Warheit DB, Thomas RW, Kenneth LR et al (2007) Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties. Toxicology 23:90\u2013104","journal-title":"Toxicology"},{"key":"4002_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2009.05.020","volume":"191","author":"J Wu","year":"2009","unstructured":"Wu J, Liu W, Xue C et al (2009) Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191:1\u20138","journal-title":"Toxicol Lett"},{"issue":"1","key":"4002_CR33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2011.04.034","volume":"205","author":"G Xie","year":"2011","unstructured":"Xie G, Wang C, Sun J et al (2011) Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles. Toxicol Lett 205(1):55\u201361","journal-title":"Toxicol Lett"},{"issue":"8","key":"4002_CR34","doi-asserted-by":"crossref","first-page":"e70618","DOI":"10.1371\/journal.pone.0070618","volume":"8","author":"J Xu","year":"2013","unstructured":"Xu J, Shi H, Ruth M et al (2013) Acute toxicity of intravenously administered titanium dioxide nanoparticles in mice. PLoS One 8(8):e70618","journal-title":"PLoS One"},{"issue":"19","key":"4002_CR35","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1080\/15287390903091764","volume":"72","author":"J Zhao","year":"2009","unstructured":"Zhao J, Bowman L, Zhang X et al (2009) Titanium dioxide (TiO2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8\/Bid and mitochondrial pathways. J Toxicol Environ Health A 72(19):1141\u20131149","journal-title":"J Toxicol Environ Health A"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-4002-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-014-4002-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-4002-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T14:04:15Z","timestamp":1559397855000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-014-4002-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,10]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["4002"],"URL":"https:\/\/doi.org\/10.1007\/s11356-014-4002-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,10]]}}}