{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:26:34Z","timestamp":1791555994346,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FPA n\u00b02010-0009"],"award-info":[{"award-number":["FPA n\u00b02010-0009"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mexico","award":["CONACyT"],"award-info":[{"award-number":["CONACyT"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s11356-016-7398-2","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T23:12:58Z","timestamp":1472080378000},"page":"22691-22700","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Microbial biotransformation of furosemide for environmental risk assessment: identification of metabolites and toxicological evaluation"],"prefix":"10.1007","volume":"23","author":[{"given":"Hugo","family":"Olvera-Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rivard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Oturan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Oturan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-386X","authenticated-orcid":false,"given":"Didier","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"7398_CR1","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1016\/j.bmcl.2011.02.063","volume":"21","author":"E Adelin","year":"2011","unstructured":"Adelin E, Servy C, Cortial S, Levaique H, Gallard JF, Martin MT, Retailleau P, Bussaban B, Lumyong S, Ouazzani J (2011) Biotransformation of natural compounds. Oxido-reduction of Sch-642305 by Aspergillus ochraceus ATCC 1009. Bioorg Med Chem Lett 21:2456\u20132459. doi: 10.1016\/j.bmcl.2011.02.063","journal-title":"Bioorg Med Chem Lett"},{"key":"7398_CR2","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1021\/acs.est.5b00302","volume":"49","author":"M Agerstrand","year":"2015","unstructured":"Agerstrand M, Berg C, Bjorlenius B, Breitholtz M, Brunstrom B, Fick J, Gunnarsson L, Larsson DG, Sumpter JP, Tysklind M, Ruden C (2015) Improving environmental risk assessment of human pharmaceuticals. Environ Sci Technol 49:5336\u20135345. doi: 10.1021\/acs.est.5b00302","journal-title":"Environ Sci Technol"},{"key":"7398_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.scitotenv.2014.05.128","volume":"493","author":"M Al Aukidy","year":"2014","unstructured":"Al Aukidy M, Verlicchi P, Voulvoulis N (2014) A framework for the assessment of the environmental risk posed by pharmaceuticals originating from hospital effluents. Sci Total Environ 493:54\u201364. doi: 10.1016\/j.scitotenv.2014.05.128","journal-title":"Sci Total Environ"},{"key":"7398_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/J.Tox.2007.06.079","volume":"240","author":"DJ Antoine","year":"2007","unstructured":"Antoine DJ, Williams DP, Regan SL, Park BK (2007) Formation of cytotoxic protein reactive metabolites from furosemide: biological consequences of drug metabolism. Toxicology 240:157\u2013157. doi: 10.1016\/J.Tox.2007.06.079","journal-title":"Toxicology"},{"key":"7398_CR5","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.phytochem.2013.09.022","volume":"96","author":"NS Arakawa","year":"2013","unstructured":"Arakawa NS, Gobbo-Neto L, Ambrosio SR, Antonucci GA, Sampaio SV, Pupo MT, Said S, Schmidt TJ, Da Costa FB (2013) Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species. Phytochemistry 96:92\u2013100. doi: 10.1016\/j.phytochem.2013.09.022","journal-title":"Phytochemistry"},{"key":"7398_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biotechadv.2008.07.005","volume":"27","author":"S Asha","year":"2009","unstructured":"Asha S, Vidyavathi M (2009) Cunninghamella\u2014a microbial model for drug metabolism studies\u2014a review. Biotechnol Adv 27:16\u201329. doi: 10.1016\/j.biotechadv.2008.07.005","journal-title":"Biotechnol Adv"},{"key":"7398_CR7","first-page":"169","volume":"63","author":"R Azerad","year":"1999","unstructured":"Azerad R (1999) Microbial models for drug metabolism. Adv Biochem Eng Biotechnol 63:169\u2013218","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"7398_CR8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.watres.2013.11.005","volume":"49","author":"T Backhaus","year":"2014","unstructured":"Backhaus T, Karlsson M (2014) Screening level mixture risk assessment of pharmaceuticals in STP effluents. Water Res 49:157\u2013165. doi: 10.1016\/j.watres.2013.11.005","journal-title":"Water Res"},{"key":"7398_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jpba.2014.11.040","volume":"106","author":"A Barra Caracciolo","year":"2015","unstructured":"Barra Caracciolo A, Topp E, Grenni P (2015) Pharmaceuticals in the environment: biodegradation and effects on natural microbial communities a review. J Pharm Biomed Anal 106:25\u201336. doi: 10.1016\/j.jpba.2014.11.040","journal-title":"J Pharm Biomed Anal"},{"key":"7398_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/J.Toxlet.2007.10.012","volume":"176","author":"JP Besse","year":"2008","unstructured":"Besse JP, Garric J (2008) Human pharmaceuticals in surface waters implementation of a prioritization methodology and application to the French situation. Toxicol Lett 176:104\u2013123. doi: 10.1016\/J.Toxlet.2007.10.012","journal-title":"Toxicol Lett"},{"key":"7398_CR11","doi-asserted-by":"publisher","unstructured":"Bucher JR, Huff J, Haseman JK, Eustis SL, Davis WE Jr, Meierhenry EF (1990) Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice. 2. Furosemide. J Appl Toxicol 10:369\u2013378. doi: 10.1002\/jat.2550100510","DOI":"10.1002\/jat.2550100510"},{"key":"7398_CR12","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1897\/09-173.1","volume":"28","author":"MD Celiz","year":"2009","unstructured":"Celiz MD, Tso J, Aga DS (2009) Pharmaceutical metabolites in the environment: analytical challenges and ecological risks. Environ Toxicol Chem 28:2473\u20132484. doi: 10.1897\/09-173.1","journal-title":"Environ Toxicol Chem"},{"key":"7398_CR13","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1021\/tx700262z","volume":"20","author":"LJ Chen","year":"2007","unstructured":"Chen LJ, Burka LT (2007) Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts. Chem Res Toxicol 20:1741\u20131744. doi: 10.1021\/tx700262z","journal-title":"Chem Res Toxicol"},{"key":"7398_CR14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.watres.2014.10.027","volume":"72","author":"GV Jesus de","year":"2015","unstructured":"de Jesus GV, Almeida CM, Rodrigues A, Ferreira E, Benoliel MJ, Cardoso VV (2015) Occurrence of pharmaceuticals in a water supply system and related human health risk assessment. Water Res 72:199\u2013208. doi: 10.1016\/j.watres.2014.10.027","journal-title":"Water Res"},{"key":"7398_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00216-010-4441-x","volume":"400","author":"A Dirany","year":"2011","unstructured":"Dirany A, Efremova Aaron S, Oturan N, Sires I, Oturan MA, Aaron JJ (2011) Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment. Anal Bioanal Chem 400:353\u2013360. doi: 10.1007\/s00216-010-4441-x","journal-title":"Anal Bioanal Chem"},{"key":"7398_CR16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.chemosphere.2011.06.082","volume":"85","author":"D Fatta-Kassinos","year":"2011","unstructured":"Fatta-Kassinos D, Vasquez MI, Kummerer K (2011) Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes\u2014degradation, elucidation of byproducts and assessment of their biological potency. Chemosphere 85:693\u2013709. doi: 10.1016\/j.chemosphere.2011.06.082","journal-title":"Chemosphere"},{"key":"7398_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-6116-4","author":"A Felczak","year":"2016","unstructured":"Felczak A, Bernat P, Rozalska S, Lisowska K (2016) Quinoline biodegradation by filamentous fungus Cunninghamella elegans and adaptive modifications of the fungal membrane composition. Environ Sci Pollut Res Int. doi: 10.1007\/s11356-016-6116-4","journal-title":"Environ Sci Pollut Res Int"},{"key":"7398_CR18","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122\u2013159. doi: 10.1016\/j.aquatox.2005.09.009","journal-title":"Aquat Toxicol"},{"key":"7398_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.chemosphere.2014.01.016","volume":"115","author":"O Frederic","year":"2014","unstructured":"Frederic O, Yves P (2014) Pharmaceuticals in hospital wastewater: their ecotoxicity and contribution to the environmental hazard of the effluent. Chemosphere 115:31\u201339. doi: 10.1016\/j.chemosphere.2014.01.016","journal-title":"Chemosphere"},{"key":"7398_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0003-9861(02)00415-0","volume":"409","author":"FP Guengerich","year":"2003","unstructured":"Guengerich FP (2003) Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions. Arch Biochem Biophys 409:59\u201371. doi: 10.1016\/S0003-9861(02)00415-0","journal-title":"Arch Biochem Biophys"},{"key":"7398_CR21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0090-9556(25)08809-9","volume":"20","author":"M Hezari","year":"1992","unstructured":"Hezari M, Davis PJ (1992) Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans. Drug Metab Dispos 20:882\u2013888","journal-title":"Drug Metab Dispos"},{"key":"7398_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/tox.20015","volume":"19","author":"G Huschek","year":"2004","unstructured":"Huschek G, Hansen PD, Maurer HH, Krengel D, Kayser A, European C (2004) Environmental risk assessment of medicinal products for human use according to European Commission recommendations. Environ Toxicol 19:226\u2013240. doi: 10.1002\/tox.20015","journal-title":"Environ Toxicol"},{"key":"7398_CR23","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.chemosphere.2005.07.078","volume":"63","author":"M Isidori","year":"2006","unstructured":"Isidori M, Nardelli A, Parrella A, Pascarella L, Previtera L (2006) A multispecies study to assess the toxic and genotoxic effect of pharmaceuticals: furosemide and its photoproduct. Chemosphere 63:785\u2013793. doi: 10.1016\/j.chemosphere.2005.07.078","journal-title":"Chemosphere"},{"key":"7398_CR24","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1007\/s00216-014-7614-1","volume":"406","author":"A Jakimska","year":"2014","unstructured":"Jakimska A, Sliwka-Kaszynska M, Reszczynska J, Namiesnik J, Kot-Wasik A (2014) Elucidation of transformation pathway of ketoprofen, ibuprofen, and furosemide in surface water and their occurrence in the aqueous environment using UHPLC-QTOF-MS. Anal Bioanal Chem 406:3667\u20133680. doi: 10.1007\/s00216-014-7614-1","journal-title":"Anal Bioanal Chem"},{"key":"7398_CR25","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1021\/cr020441w","volume":"107","author":"SK Khetan","year":"2007","unstructured":"Khetan SK, Collins TJ (2007) Human pharmaceuticals in the aquatic environment: a challenge to green chemistry. Chem Rev 107:2319\u20132364. doi: 10.1021\/cr020441w","journal-title":"Chem Rev"},{"key":"7398_CR26","doi-asserted-by":"publisher","unstructured":"Kuster A, Adler N (2014) Pharmaceuticals in the environment: scientific evidence of risks and its regulation. Philos Trans R Soc Lond Ser B Biol Sci 369. doi: 10.1098\/rstb.2013.0587","DOI":"10.1098\/rstb.2013.0587"},{"key":"7398_CR27","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/S0968-0896(97)00094-1","volume":"5","author":"I Lacroix","year":"1997","unstructured":"Lacroix I, Biton J, Azerad R (1997) Microbial biotransformations of a synthetic immunomodulating agent, HR325. Bioorg Med Chem 5:1369\u20131380. doi: 10.1016\/S0968-0896(97)00094-1","journal-title":"Bioorg Med Chem"},{"key":"7398_CR28","doi-asserted-by":"publisher","first-page":"9518","DOI":"10.1016\/J.Tet.2011.10.006","volume":"67","author":"C Laurenc\u00e9","year":"2011","unstructured":"Laurenc\u00e9 C, Rivard M, Lachaise I, Bensemhoun J, Martens T (2011) Preparative access to transformation products (TPs) of furosemide: a versatile application of anodic oxidation. Tetrahedron 67:9518\u20139521. doi: 10.1016\/J.Tet.2011.10.006","journal-title":"Tetrahedron"},{"key":"7398_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/J.Chemosphere.2014.05.036","volume":"113","author":"C Laurenc\u00e9","year":"2014","unstructured":"Laurenc\u00e9 C, Rivard M, Martens T, Morin C, Buisson D, Bourcier S, Sablier M, Oturan MA (2014) Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide. Chemosphere 113:193\u2013199. doi: 10.1016\/J.Chemosphere.2014.05.036","journal-title":"Chemosphere"},{"key":"7398_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.aca.2013.12.012","volume":"810","author":"Z Li","year":"2014","unstructured":"Li Z, Maier MP, Radke M (2014) Screening for pharmaceutical transformation products formed in river sediment by combining ultrahigh performance liquid chromatography\/high resolution mass spectrometry with a rapid data-processing method. Anal Chim Acta 810:61\u201370. doi: 10.1016\/j.aca.2013.12.012","journal-title":"Anal Chim Acta"},{"key":"7398_CR31","doi-asserted-by":"publisher","first-page":"6475","DOI":"10.1016\/j.watres.2013.08.024","volume":"47","author":"R Loos","year":"2013","unstructured":"Loos R, Carvalho R, Antonio DC, Comero S, Locoro G, Tavazzi S, Paracchini B, Ghiani M, Lettieri T, Blaha L, Jarosova B, Voorspoels S, Servaes K, Haglund P, Fick J, Lindberg RH, Schwesig D, Gawlik BM (2013) EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents. Water Res 47:6475\u20136487. doi: 10.1016\/j.watres.2013.08.024","journal-title":"Water Res"},{"key":"7398_CR32","unstructured":"Martens T, Rivard M, Laurence C, Morin C, Lehri-Boufala S (2014) Chemical model of a neurodegenerative disease, method for preparation and uses of same. WO 2014076439"},{"key":"7398_CR33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3109\/00498254.2010.535219","volume":"41","author":"C Marvalin","year":"2011","unstructured":"Marvalin C, Azerad R (2011) Microbial production of phase I and phase II metabolites of propranolol. Xenobiotica 41:175\u2013186. doi: 10.3109\/00498254.2010.535219","journal-title":"Xenobiotica"},{"key":"7398_CR34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.envres.2015.04.003","volume":"140","author":"A Mendoza","year":"2015","unstructured":"Mendoza A, Acena J, Perez S, Lopez de Alda M, Barcelo D, Gil A, Valcarcel Y (2015) Pharmaceuticals and iodinated contrast media in a hospital wastewater: a case study to analyse their presence and characterise their environmental risk and hazard. Environ Res 140:225\u2013241. doi: 10.1016\/j.envres.2015.04.003","journal-title":"Environ Res"},{"key":"7398_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1472-8206.2011.00927.x","volume":"26","author":"SC Mondal","year":"2012","unstructured":"Mondal SC, Tripathi DN, Vikram A, Ramarao P, Jena GB (2012) Furosemide-induced genotoxicity and cytotoxicity in the hepatocytes, but weak genotoxicity in the bone marrow cells of mice. Fundam Clin Pharmacol 26:383\u2013392. doi: 10.1111\/j.1472-8206.2011.00927.x","journal-title":"Fundam Clin Pharmacol"},{"key":"7398_CR36","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.scitotenv.2014.04.082","volume":"490","author":"SA Morais","year":"2014","unstructured":"Morais SA, Delerue-Matos C, Gabarrell X (2014) An uncertainty and sensitivity analysis applied to the prioritisation of pharmaceuticals as surface water contaminants from wastewater treatment plant direct emissions. Sci Total Environ 490:342\u2013350. doi: 10.1016\/j.scitotenv.2014.04.082","journal-title":"Sci Total Environ"},{"key":"7398_CR37","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1007\/s00253-016-7304-3","volume":"100","author":"CD Murphy","year":"2016","unstructured":"Murphy CD (2016) Microbial degradation of fluorinated drugs: biochemical pathways, impacts on the environment and potential applications. Appl Microbiol Biotechnol 100:2617\u20132627. doi: 10.1007\/s00253-016-7304-3","journal-title":"Appl Microbiol Biotechnol"},{"key":"7398_CR38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.scitotenv.2015.02.104","volume":"518-519","author":"TS Oliveira","year":"2015","unstructured":"Oliveira TS, Murphy M, Mendola N, Wong V, Carlson D, Waring L (2015) Characterization of pharmaceuticals and personal care products in hospital effluent and waste water influent\/effluent by direct-injection LC-MS-MS. Sci Total Environ 518-519:459\u2013478. doi: 10.1016\/j.scitotenv.2015.02.104","journal-title":"Sci Total Environ"},{"key":"7398_CR39","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/clen.201400656","volume":"43","author":"H Olvera-Vargas","year":"2015","unstructured":"Olvera-Vargas H, Oturan N, Buisson D, van Hullebusch ED, Oturan MA (2015) Electro-oxidation of the pharmaceutical furosemide: kinetics, mechanism, and by-products. CLEAN \u2013 Soil, Air, Water 43:1455\u20131463. doi: 10.1002\/clen.201400656","journal-title":"CLEAN \u2013 Soil, Air, Water"},{"key":"7398_CR40","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.scitotenv.2015.11.047","volume":"543","author":"M Papageorgiou","year":"2016","unstructured":"Papageorgiou M, Kosma C, Lambropoulou D (2016) Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Sci Total Environ 543:547\u2013569. doi: 10.1016\/j.scitotenv.2015.11.047","journal-title":"Sci Total Environ"},{"key":"7398_CR41","doi-asserted-by":"publisher","first-page":"6971","DOI":"10.1007\/s00253-015-6765-0","volume":"99","author":"IA Parshikov","year":"2015","unstructured":"Parshikov IA, Woodling KA, Sutherland JB (2015) Biotransformations of organic compounds mediated by cultures of Aspergillus niger. Appl Microbiol Biotechnol 99:6971\u20136986. doi: 10.1007\/s00253-015-6765-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"7398_CR42","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0045-6535(02)00860-3","volume":"51","author":"D Pascoe","year":"2003","unstructured":"Pascoe D, Karntanut W, Muller CT (2003) Do pharmaceuticals affect freshwater invertebrates? A study with the cnidarian Hydra vulgaris. Chemosphere 51:521\u2013528. doi: 10.1016\/S0045-6535(02)00860-3","journal-title":"Chemosphere"},{"key":"7398_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1021\/tx3003824","volume":"26","author":"LA Peterson","year":"2013","unstructured":"Peterson LA (2013) Reactive metabolites in the biotransformation of molecules containing a furan ring. Chem Res Toxicol 26:6\u201325. doi: 10.1021\/tx3003824","journal-title":"Chem Res Toxicol"},{"key":"7398_CR44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.envint.2014.10.027","volume":"75","author":"AR Ribeiro","year":"2015","unstructured":"Ribeiro AR, Nunes OC, Pereira MF, Silva AM (2015) An overview on the advanced oxidation processes applied for the treatment of water pollutants defined in the recently launched directive 2013\/39\/EU. Environ Int 75:33\u201351. doi: 10.1016\/j.envint.2014.10.027","journal-title":"Environ Int"},{"key":"7398_CR45","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1124\/Jpet.107.125302","volume":"322","author":"DP Williams","year":"2007","unstructured":"Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK (2007) The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore. J Pharmacol Exp Ther 322:1208\u20131220. doi: 10.1124\/Jpet.107.125302","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-7398-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-016-7398-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-7398-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:40:09Z","timestamp":1749562809000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-016-7398-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":45,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["7398"],"URL":"https:\/\/doi.org\/10.1007\/s11356-016-7398-2","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}