{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:08:12Z","timestamp":1790914092235,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,10,30]],"date-time":"2016-10-30T00:00:00Z","timestamp":1477785600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["31101866"],"award-info":[{"award-number":["31101866"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s11356-016-7953-x","type":"journal-article","created":{"date-parts":[[2016,10,30]],"date-time":"2016-10-30T03:48:16Z","timestamp":1477799296000},"page":"1832-1844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Treatment of cadmium-induced renal oxidative damage in rats by administration of alpha-lipoic acid"],"prefix":"10.1007","volume":"24","author":[{"given":"Tongwang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,30]]},"reference":[{"key":"7953_CR1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.biopha.2013.08.007","volume":"68","author":"GA Adefolaju","year":"2014","unstructured":"Adefolaju GA, Theron KE, Hosie MJ (2014) Effects of HIV protease, nucleoside\/non-nucleoside reverse transcriptase inhibitors on Bax, Bcl-2 and apoptosis in two cervical cell lines. Biomed Pharmacother 68:241\u2013251","journal-title":"Biomed Pharmacother"},{"key":"7953_CR2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0147-6513(03)00063-0","volume":"57","author":"T Antonio Garcia","year":"2004","unstructured":"Antonio Garcia T, Corredor L (2004) Biochemical changes in the kidneys after perinatal intoxication with lead and\/or cadmium and their antagonistic effects when coadministered. Ecotoxicol Environ Saf 57:184\u2013189","journal-title":"Ecotoxicol Environ Saf"},{"key":"7953_CR3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4161\/oxim.3.3.11786","volume":"3","author":"P Atukeren","year":"2010","unstructured":"Atukeren P, Aydin S, Uslu E, Gumustas M, Cakatay U (2010) Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid. Oxidative Med Cell Longev 3:206\u2013213","journal-title":"Oxidative Med Cell Longev"},{"key":"7953_CR4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mehy.2005.07.020","volume":"66","author":"U Cakatay","year":"2006","unstructured":"Cakatay U (2006) Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid. Med Hypotheses 66:110\u2013117","journal-title":"Med Hypotheses"},{"key":"7953_CR5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10522-005-3462-x","volume":"6","author":"U Cakatay","year":"2005","unstructured":"Cakatay U, Kayali R (2005) Plasma protein oxidation in aging rats after alpha-lipoic acid administration. Biogerontology 6:87\u201393","journal-title":"Biogerontology"},{"key":"7953_CR6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbrc.2016.02.119","volume":"472","author":"K Chen","year":"2016","unstructured":"Chen K, Yan B, Wang F, Wen F, Xing X, Tang X, Shi Y, G. LE (2016) Type 1 5\u2032-deiodinase activity is inhibited by oxidative stress and restored by alpha-lipoic acid in HepG2 cells. Biochem Biophys Res Commun 472:496\u2013501","journal-title":"Biochem Biophys Res Commun"},{"key":"7953_CR7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jtemb.2005.10.006","volume":"19","author":"E Chwelatiuk","year":"2006","unstructured":"Chwelatiuk E, Wlostowski T, Krasowska A, Bonda E (2006) The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. J Trace Elem Med Biol 19:259\u2013265","journal-title":"J Trace Elem Med Biol"},{"key":"7953_CR8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.reprotox.2016.04.016","volume":"62","author":"P Duan","year":"2016","unstructured":"Duan P, Hu C, Butler HJ, Quan C, Chen W, Huang W, Tang S, Zhou W, Yuan M, Shi Y, Martin FL, Yang K (2016) Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways. Reprod Toxicol 62:27\u201338","journal-title":"Reprod Toxicol"},{"key":"7953_CR9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12011-014-0016-6","volume":"159","author":"OH El-habit","year":"2014","unstructured":"El-habit OH, Abdel Moneim AE (2014) Testing the genotoxicity, cytotoxicity, and oxidative stress of cadmium and nickel and their additive effect in male mice. Biol Trace Elem Res 159:364\u2013372","journal-title":"Biol Trace Elem Res"},{"key":"7953_CR10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12011-015-0453-x","volume":"170","author":"M Erboga","year":"2016","unstructured":"Erboga M, Kanter M, Aktas C, Sener U, Fidanol Erboga Z, BozdemirDonmez Y, Gurel A (2016) Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and anti-oxidant properties. Biol Trace Elem Res 170:165\u2013172","journal-title":"Biol Trace Elem Res"},{"key":"7953_CR11","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.dci.2013.08.004","volume":"41","author":"D GAO","year":"2013","unstructured":"GAO D, Xu ZE, Zhang X, Zhu C, Wang Y, Min W (2013) Cadmium triggers kidney cell apoptosis of purse red common carp (Cyprinus carpio) without caspase-8 activation. Developmental & Comparative Immunology 41:728\u2013737","journal-title":"Developmental & Comparative Immunology"},{"key":"7953_CR12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yrtph.2016.02.012","volume":"77","author":"NE Golli","year":"2016","unstructured":"Golli NE, Jrad-Lamine A, Neffati H, Dkhili H, Rahali D, Dallagi Y, El May MV, El Fazaa S (2016) Impact of e-cigarette refill liquid exposure on rat kidney. Regul Toxicol Pharmacol 77:109\u2013116","journal-title":"Regul Toxicol Pharmacol"},{"key":"7953_CR13","volume":"6","author":"MS Gregory","year":"2011","unstructured":"Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR (2011) Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One 6:e17659","journal-title":"PLoS One"},{"key":"7953_CR14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ceca.2006.08.016","volume":"40","author":"G Hajnoczky","year":"2006","unstructured":"Hajnoczky G, Csordas G, Das S, Garcia-Perez C, Saotome M, Sinha Roy S, Yi M (2006) Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 40:553\u2013560","journal-title":"Cell Calcium"},{"key":"7953_CR15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biopha.2016.02.022","volume":"80","author":"H Hu","year":"2016","unstructured":"Hu H, C. W, Jin Y, Meng Q, Liu Q, Liu K, Sun H (2016) Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs. Biomed Pharmacother 80:63\u201372","journal-title":"Biomed Pharmacother"},{"key":"7953_CR16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","volume":"238","author":"L Jarup","year":"2009","unstructured":"Jarup L, Akesson A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201\u2013208","journal-title":"Toxicol Appl Pharmacol"},{"key":"7953_CR17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/157340607780620590","volume":"3","author":"R Kayali","year":"2007","unstructured":"Kayali R, Cakatay U, Kiziler AR, Aydemir B (2007) Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats. Med Chem 3:297\u2013300","journal-title":"Med Chem"},{"key":"7953_CR18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00424-012-1157-0","volume":"464","author":"JD Klein","year":"2012","unstructured":"Klein JD, Blount MA, Sands JM (2012) Molecular mechanisms of urea transport in health and disease. Pflugers Arch 464:561\u2013572","journal-title":"Pflugers Arch"},{"key":"7953_CR19","first-page":"2302","volume":"29","author":"N Liu","year":"2008","unstructured":"Liu N, Yan B, YQ. L, Q. W, L. W (2008) Effects of Cd2+ on glutathione system of hepatopancreas and gills in freshwater crab Sinopotamon yangtsekiense. Huan Jing Ke Xue 29:2302\u20132307","journal-title":"Huan Jing Ke Xue"},{"key":"7953_CR20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.aquatox.2012.01.012","volume":"110-111","author":"VL Loro","year":"2012","unstructured":"Loro VL, Jorge MB, Silva KR, Wood CM (2012) Oxidative stress parameters and antioxidant response to sublethal waterborne zinc in a euryhaline teleost Fundulus heteroclitus: protective effects of salinity. Aquat Toxicol 110-111:187\u2013193","journal-title":"Aquat Toxicol"},{"key":"7953_CR21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ecoenv.2016.07.029","volume":"133","author":"K Manquian-Cerda","year":"2016","unstructured":"Manquian-Cerda K, Escudey M, Zuniga G, Arancibia-Miranda N, Molina M, Cruces E (2016) Effect of cadmium on phenolic compounds, antioxidant enzyme activity and oxidative stress in blueberry (Vaccinium corymbosum L.) plantlets grown in vitro. Ecotoxicol Environ Saf 133:316\u2013326","journal-title":"Ecotoxicol Environ Saf"},{"key":"7953_CR22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2005.09.006","volume":"210","author":"AI Morales","year":"2006","unstructured":"Morales AI, Vicente-Sanchez C, Jerkic M, Santiago JM, Sanchez-Gonzalez PD, Perez-Barriocanal F, Lopez-Novoa JM (2006) Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharmacol 210:128\u2013135","journal-title":"Toxicol Appl Pharmacol"},{"key":"7953_CR23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jbt.21468","volume":"27","author":"N Pathak","year":"2013","unstructured":"Pathak N, Mitra S, Khandelwal S (2013) Cadmium induces thymocyte apoptosis via caspase-dependent and caspase-independent pathways. J Biochem Mol Toxicol 27:193\u2013203","journal-title":"J Biochem Mol Toxicol"},{"key":"7953_CR24","doi-asserted-by":"crossref","unstructured":"Shi, C., Zhou, X., Zhang, J., Wang, J., Xie, H. & Wu Z. 2016. \u03b1-Lipoic acid protects against the cytotoxicity and oxidative stress induced by cadmium in HepG2 cells through regeneration of glutathione by glutathione reductase via Nrf2\/ARE signaling pathway. Environmental Toxicology and Pharmacology.","DOI":"10.1016\/j.etap.2016.06.003"},{"key":"7953_CR25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2007.03.022","volume":"236","author":"S Thijssen","year":"2007","unstructured":"Thijssen S, Cuypers A, Maringwa J, Smeets K, Horemans N, Lambrichts I, Van Kerkhove E (2007) Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 236:29\u201341","journal-title":"Toxicology"},{"key":"7953_CR26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1472-6882-11-31","volume":"11","author":"A Ugusman","year":"2011","unstructured":"Ugusman A, Zakaria Z, Hui CK, Nordin NA (2011) Piper sarmentosum inhibits ICAM-1 and Nox4 gene expression in oxidative stress-induced human umbilical vein endothelial cells. BMC Complement Altern Med 11:31","journal-title":"BMC Complement Altern Med"},{"key":"7953_CR27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12011-008-8288-3","volume":"129","author":"L Wang","year":"2009","unstructured":"Wang L, Chen D, Wang H, Liu Z (2009a) Effects of lead and\/or cadmium on the expression of metallothionein in the kidney of rats. Biol Trace Elem Res 129:190\u2013199","journal-title":"Biol Trace Elem Res"},{"key":"7953_CR28","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00244-011-9644-4","volume":"61","author":"L Wang","year":"2011","unstructured":"Wang L, Wang H, Li J, Chen D, Liu Z (2011) Simultaneous effects of lead and cadmium on primary cultures of rat proximal tubular cells: interaction of apoptosis and oxidative stress. Arch Environ Contam Toxicol 61:500\u2013511","journal-title":"Arch Environ Contam Toxicol"},{"key":"7953_CR29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cbi.2009.05.004","volume":"181","author":"SH Wang","year":"2009","unstructured":"Wang SH, Shih YL, Lee CC, Chen WL, Lin CJ, Lin YS, Wu KH, Shih CM (2009b) The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis. Chem Biol Interact 181:45\u201351","journal-title":"Chem Biol Interact"},{"key":"7953_CR30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ntt.2015.11.007","volume":"53","author":"T Wang","year":"2016","unstructured":"Wang T, Wang Q, Song R, Zhang Y, Yang J, Wang Y, Yuan Y, Bian J, Liu X, GU J, Zhu J, Liu Z (2016) Cadmium induced inhibition of autophagy is associated with microtubule disruption and mitochondrial dysfunction in primary rat cerebral cortical neurons. Neurotoxicol Teratol 53:11\u201318","journal-title":"Neurotoxicol Teratol"},{"key":"7953_CR31","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ecoenv.2007.03.014","volume":"69","author":"T Wlostowski","year":"2008","unstructured":"Wlostowski T, Krasowska A, Bonda E (2008) Joint effects of dietary cadmium and polychlorinated biphenyls on metallothionein induction, lipid peroxidation and histopathology in the kidneys and liver of bank voles. Ecotoxicol Environ Saf 69:403\u2013410","journal-title":"Ecotoxicol Environ Saf"},{"key":"7953_CR32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10646-016-1653-7","volume":"25","author":"L Xia","year":"2016","unstructured":"Xia L, Chen S, Dahms HU, Ying X, Peng X (2016) Cadmium induced oxidative damage and apoptosis in the hepatopancreas of Meretrix meretrix. Ecotoxicology 25:959\u2013969","journal-title":"Ecotoxicology"},{"key":"7953_CR33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.toxlet.2009.10.011","volume":"192","author":"Z Xie","year":"2010","unstructured":"Xie Z, Zhang Y, Li A, P L, Ji W, Huang D (2010) Cd-induced apoptosis was mediated by the release of Ca2+ from intracellular Ca storage. Toxicol Lett 192:115\u2013118","journal-title":"Toxicol Lett"},{"key":"7953_CR34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3109\/15376516.2015.1044150","volume":"25","author":"Y Xu","year":"2015","unstructured":"Xu Y, Zhou X, Shi C, Wang J, Wu Z (2015) \u03b1-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase. Toxicol Mech Methods 25:596\u2013603","journal-title":"Toxicol Mech Methods"},{"key":"7953_CR35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.aquatox.2012.05.014","volume":"122-123","author":"H Zhang","year":"2012","unstructured":"Zhang H, Cai C, Shi C, Cao H, Han Z, Jia X (2012) Cadmium-induced oxidative stress and apoptosis in the testes of frog Rana limnocharis. Aquat Toxicol 122-123:67\u201374","journal-title":"Aquat Toxicol"},{"key":"7953_CR36","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1007\/s11356-014-2801-3","volume":"21","author":"H Zhang","year":"2014","unstructured":"Zhang H, Pan L, Tao Y (2014) Antioxidant responses in clam Venerupis philippinarum exposed to environmental pollutant hexabromocyclododecane. Environ Sci Pollut Res Int 21:8206\u20138215","journal-title":"Environ Sci Pollut Res Int"},{"key":"7953_CR37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2131\/jts.40.469","volume":"40","author":"H Zou","year":"2015","unstructured":"Zou H, Liu X, Han T, Hu D, Yuan Y, Gu J, Bian J, Liu Z (2015) Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. J Toxicol Sci 40:469\u2013477","journal-title":"J Toxicol Sci"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-7953-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-016-7953-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-7953-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:46:36Z","timestamp":1718869596000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-016-7953-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,30]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["7953"],"URL":"https:\/\/doi.org\/10.1007\/s11356-016-7953-x","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,30]]}}}