{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:45:06Z","timestamp":1792086306206,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"University Grants Commission, New Delhi","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s11356-016-8196-6","type":"journal-article","created":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T19:39:18Z","timestamp":1481485158000},"page":"4537-4551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Gestational di-n-butyl phthalate exposure induced developmental and teratogenic anomalies in rats: a multigenerational assessment"],"prefix":"10.1007","volume":"24","author":[{"given":"P.","family":"Mahaboob Basha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Radha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"issue":"4","key":"8196_CR1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/0003-3472(75)90114-1","volume":"23","author":"J Altman","year":"1975","unstructured":"Altman J, Sudarshan K (1975) Postnatal development of locomotion in the laboratory rat. Anim Behav 23(4):896\u2013920","journal-title":"Anim Behav"},{"key":"8196_CR2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.envres.2014.11.011","volume":"137","author":"J Bae","year":"2015","unstructured":"Bae J, Kim S, Kannan K, Louis GMB (2015) Couples\u2019 urinary bisphenol A and phthalate metabolite concentrations and the secondary sex ratio. Environ Res 137:450\u2013457","journal-title":"Environ Res"},{"issue":"2","key":"8196_CR3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1163\/1569391053722755","volume":"19","author":"J Bailey","year":"2005","unstructured":"Bailey J, Knight A, Balcombe J (2005) The future of teratology research is in vitro. Biog Amines 19(2):97\u2013145","journal-title":"Biog Amines"},{"issue":"2","key":"8196_CR4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-4274(93)90104-6","volume":"69","author":"M Ema","year":"1993","unstructured":"Ema M, Amano H, Itami T, Kawasaki H (1993) Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicol Lett 69(2):197\u2013203","journal-title":"Toxicol Lett"},{"issue":"3","key":"8196_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0300-483X(94)90002-7","volume":"86","author":"M Ema","year":"1994","unstructured":"Ema M, Amano H, Ogawa Y (1994) Characterization of the developmental toxicity of di-n-butyl phthalate in rats. Toxicol 86(3):163\u2013174","journal-title":"Toxicol"},{"issue":"1","key":"8196_CR6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0890-6238(99)00066-0","volume":"14","author":"M Ema","year":"2000","unstructured":"Ema M, Miyawaki E, Kawashima K (2000) Effects of dibutyl phthalate on reproductive function in pregnant and pseudopregnant rats. Reprod Toxicol 14(1):13\u201319","journal-title":"Reprod Toxicol"},{"issue":"2","key":"8196_CR7","first-page":"99","volume":"40","author":"E Gilbert-Barness","year":"2010","unstructured":"Gilbert-Barness E (2010) Teratogenic causes of malformations. Ann of Clin lab Sci 40(2):99\u2013114","journal-title":"Ann of Clin lab Sci"},{"key":"8196_CR8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","volume":"29","author":"PMD Foster","year":"2006","unstructured":"Foster PMD (2006) Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl 29:140\u2013147","journal-title":"Int J Androl"},{"issue":"1","key":"8196_CR9","first-page":"1","volume":"64","author":"B Franciszek","year":"2005","unstructured":"Franciszek B, Szumi\u0142o J, Dudka J et al (2005) Morphological studies in modern teratological investigations. Folia Morphol (Warsz) 64(1):1\u20138","journal-title":"Folia Morphol (Warsz)"},{"issue":"1","key":"8196_CR10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/toxsci\/kfl035","volume":"93","author":"LE Gray Jr","year":"2006","unstructured":"Gray LE Jr, Laskey J, Ostby J (2006) Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats. Toxicol Sci 93(1):189\u2013195","journal-title":"Toxicol Sci"},{"key":"8196_CR11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1677\/JOE-07-0446","volume":"198","author":"WH James","year":"2008","unstructured":"James WH (2008) Evidence that mammalian sex ratios at birth are partially controlled by parental hormone levels around the time of conception. J Endocrinol 198:3\u201315","journal-title":"J Endocrinol"},{"key":"8196_CR12","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1111\/j.1365-2605.2010.01140.x","volume":"34","author":"MS Jobling","year":"2011","unstructured":"Jobling MS, Hutchison GR, van den Driesche S, Sharpe RM (2011) Effects of di(n-butyl) phthalate exposure on fetal rat germ cell number and differentiation: identification of age-specific windows of vulnerability. Int J Androl 34:e386\u2013e396","journal-title":"Int J Androl"},{"issue":"1526","key":"8196_CR13","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1098\/rstb.2008.0208","volume":"364","author":"HM Koch","year":"2009","unstructured":"Koch HM, Calafat AM (2009) Human body burdens of chemicals used in plastic manufacture. Phil Trans R Soc B 364(1526):2063\u20132078","journal-title":"Phil Trans R Soc B"},{"issue":"14","key":"8196_CR14","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1289\/ehp.6202","volume":"111","author":"G Latini","year":"2003","unstructured":"Latini G, De Felice C, Presta G et al (2003) In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy. Environ Health Perspect 111(14):1783\u20131785","journal-title":"Environ Health Perspect"},{"key":"8196_CR15","doi-asserted-by":"crossref","first-page":"12711","DOI":"10.1007\/s11356-015-4567-7","volume":"22","author":"C Liu","year":"2015","unstructured":"Liu C, Zhao L, Wei L, Li L (2015) DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins, deiodinases, transthyretin, receptors, and hepatic enzymes in rats. Environ Sci Pollut Res 22:12711\u201312719","journal-title":"Environ Sci Pollut Res"},{"key":"8196_CR16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jat.1447","volume":"29","author":"Y Li","year":"2009","unstructured":"Li Y, Zhuang M, Li T, Nian S (2009) Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure. J App Toxicol 29:603\u2013611","journal-title":"J App Toxicol"},{"issue":"Supplement 1","key":"8196_CR17","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1089\/105072504323024552","volume":"14","author":"AW Meikle","year":"2004","unstructured":"Meikle AW (2004) The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 14(Supplement 1):S17\u2013S25","journal-title":"Thyroid"},{"key":"8196_CR18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/43.1.47","volume":"43","author":"E Mylchreest","year":"1998","unstructured":"Mylchreest E, Cattley RC, Foster PM (1998) Male reproductive tract malformations in rats following gestational and lactational exposure to di(nbutyl) phthalate: an antiandrogenic mechanism? Toxicol Sci 43:47\u201360","journal-title":"Toxicol Sci"},{"issue":"1","key":"8196_CR19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/toxsci\/69.1.92","volume":"69","author":"JC O\u2019Connor","year":"2002","unstructured":"O\u2019Connor JC, Frame SR, Ladics GS (2002) Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicol Sci 69(1):92\u2013108","journal-title":"Toxicol Sci"},{"key":"8196_CR20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0272-0590(88)90108-X","volume":"11","author":"G Pantaleoni","year":"1988","unstructured":"Pantaleoni G, Fanini D, Mariasponta A et al (1988) Effects of maternal exposure to polychlorobiphenyls (PCBs) on Fl generation behavior in the rat. Fundam Appl Toxicol 11:440\u2013449","journal-title":"Fundam Appl Toxicol"},{"key":"8196_CR21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/58.2.339","volume":"58","author":"LG Parks","year":"2000","unstructured":"Parks LG, Ostby JS, Lambright CR et al (2000) The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 58:339\u2013349","journal-title":"Toxicol Sci"},{"key":"8196_CR22","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/sj.eye.6702858","volume":"21","author":"NK Ragge","year":"2007","unstructured":"Ragge NK, Subak-Sharpe ID, Collin JRO (2007) A practical guide to the management of anophthalmia and microphthalmia. Eye 21:1290\u20131300","journal-title":"Eye"},{"key":"8196_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2015.00066","volume":"9","author":"SJ Richardson","year":"2015","unstructured":"Richardson SJ, Wijayagunaratne RC, D\u2019Souza DG et al (2015) Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane. Front Neurosci 9:1\u20138","journal-title":"Front Neurosci"},{"key":"8196_CR24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1034\/j.1600-0773.2001.d01-143.x","volume":"89","author":"AM Saillenfait","year":"2001","unstructured":"Saillenfait AM, Langonne I, Leheup B (2001) Effects of mono-n-butyl phthalate on the development of rat embryos: in vivo and in vitro observations. Pharmacol Toxicol 89:104\u2013112","journal-title":"Pharmacol Toxicol"},{"key":"8196_CR25","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jat.1436","volume":"29","author":"AM Saillenfait","year":"2009","unstructured":"Saillenfait AM, Gallissot F, Sabat\u00e9 J-P (2009) Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats. J Appl Toxicol 29:510\u2013521","journal-title":"J Appl Toxicol"},{"issue":"1\u20132","key":"8196_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tox.2004.06.045","volume":"205","author":"V Salazar","year":"2004","unstructured":"Salazar V, Castillo C, Ariznavarreta C et al (2004) Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring. Toxicology 205(1\u20132):131\u2013137","journal-title":"Toxicology"},{"key":"8196_CR27","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1177\/0192623312474725","volume":"41","author":"S Masaru","year":"2013","unstructured":"Masaru S, Wakui S, Wempe MF et al (2013) Male Sprague-Dawley rats exposed to in utero di(n-butyl) phthalate: dose dependent and age-related morphological changes in leydig cell smooth endoplasmic reticulum. Toxicol Pathol 41:984\u2013991","journal-title":"Toxicol Pathol"},{"issue":"1","key":"8196_CR28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jps.2600610107","volume":"61","author":"AR Singh","year":"1972","unstructured":"Singh AR, Lawrence WH, Autian J (1972) Teratogenicity of phthalate esters in rats. J Pharm Sci 61(1):51\u201355","journal-title":"J Pharm Sci"},{"key":"8196_CR29","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0278-6915(02)00073-X","volume":"40","author":"T Tanaka","year":"2002","unstructured":"Tanaka T (2002) Reproductive and neurobehavioural toxicity study of bis(2-ethylhexyl) phthalate (DEHP) administered to mice in the diet. Food Chem Toxicol 40:1499\u20131506","journal-title":"Food Chem Toxicol"},{"key":"8196_CR30","first-page":"163","volume-title":"Advances in the study of birth defects: neural and behavioral teratology","author":"T Tanimura","year":"1980","unstructured":"Tanimura T, Ema M, Kihara T (1980) Effects of combined treatment with methylmercury and polychlorinated biphenyls (PCBs) on the development of mouse offspring. In: Persaud TVN (ed) Advances in the study of birth defects: neural and behavioral teratology, vol 4. University Park Press, Baltimore, pp. 163\u2013198"},{"key":"8196_CR31","doi-asserted-by":"publisher","unstructured":"Wo\u2019jtowicz Anna K, Konrad AS, Agnieszka WnukMa\u0142gorzata Kajta (2016) Dibutyl phthalate (DBP)-induced apoptosis and neurotoxicity are mediated via the aryl hydrocarbon receptor (AhR) but not by estrogen receptor alpha (ERa), estrogen receptor beta (ERb), or peroxisome proliferator-activated receptor gamma (PPARc) in mouse cortical neurons. Neurotox Res 1\u201313 doi: 10.1007\/s12640-016-9665-x","DOI":"10.1007\/s12640-016-9665-x"},{"issue":"3","key":"8196_CR32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2478\/intox-2013-0018","volume":"6","author":"ZI Harold","year":"2013","unstructured":"Harold ZI (2013) Exposure to lipophilic chemicals as a cause of neurological impairments, neurodevelopmental disorders and neurodegenerative diseases. Interdiscip Toxicol 6(3):103\u2013110","journal-title":"Interdiscip Toxicol"},{"issue":"5","key":"8196_CR33","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.reprotox.2004.04.009","volume":"18","author":"Y Zhang","year":"2004","unstructured":"Zhang Y, Jiang X, Chen B (2004) Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. Reprod Toxicol 18(5):669\u2013676","journal-title":"Reprod Toxicol"},{"key":"8196_CR34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/bdrb.21136","volume":"104","author":"MK Ziejewski","year":"2015","unstructured":"Ziejewski MK, Solomon HM, Rendemonti J, Stanislaus D (2015) Comparison of a modified mid-coronal sectioning technique and Wilson\u2019s technique when conducting eye and brain examinations in rabbit teratology studies. Birth Defects Res B 104:23\u201334","journal-title":"Birth Defects Res B"},{"key":"8196_CR35","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","volume":"16","author":"RT Zoeller","year":"2004","unstructured":"Zoeller RT, Rovet J (2004) Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol 16:809\u2013818","journal-title":"J Neuroendocrinol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-8196-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-016-8196-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-016-8196-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T08:04:15Z","timestamp":1568621055000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-016-8196-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["8196"],"URL":"https:\/\/doi.org\/10.1007\/s11356-016-8196-6","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]}}}