{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:13:36Z","timestamp":1790874816404,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"36","license":[{"start":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T00:00:00Z","timestamp":1507420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["41401570"],"award-info":[{"award-number":["41401570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Shaanxi Province, China","award":["2015JQ4098"],"award-info":[{"award-number":["2015JQ4098"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s11356-017-0413-4","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T22:11:36Z","timestamp":1507414296000},"page":"27953-27962","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Responses of growth, malformation, and thyroid hormone-dependent genes expression in Bufo gargarizans embryos following chronic exposure to Pb2+"],"prefix":"10.1007","volume":"24","author":[{"given":"Lihong","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aixia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,8]]},"reference":[{"issue":"4","key":"413_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/tox.20564","volume":"26","author":"CM Aronzon","year":"2011","unstructured":"Aronzon CM, Sandoval MT, Herkovits J, P\u00e9rez-Coll CS (2011) Stage-dependent toxicity of 2,4-dichlorophenoxyacetic on the embryonic development of a South American toad, Rhinella arenarum. Environ Toxicol 26(4):373\u2013381","journal-title":"Environ Toxicol"},{"issue":"10","key":"413_CR2","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1128\/MCB.11.10.5079","volume":"11","author":"DE Banker","year":"1991","unstructured":"Banker DE, Bigler J, Eisenman RN (1991) The thyroid hormone receptor gene (c-erbA alpha) is expressed in advance of thyroid gland maturation during the early embryonic development of Xenopus laevis. Mol Cell Biol 11(10):5079\u20135089","journal-title":"Mol Cell Biol"},{"issue":"1\u20132","key":"413_CR3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0160-4120(02)00006-5","volume":"28","author":"DW Berzins","year":"2002","unstructured":"Berzins DW, Bundy KJ (2002) Bioaccumulation of lead in Xenopus laevis tadpoles from water and sediment. Environ Int 28(1\u20132):69\u201377","journal-title":"Environ Int"},{"issue":"2","key":"413_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ygcen.2010.03.014","volume":"168","author":"RM Bonett","year":"2010","unstructured":"Bonett RM, Hoopfer ED, Denver RJ (2010) Molecular mechanisms of corticosteroid synergy with thyroid hormone during tadpole metamorphosis. Gen Comp Endocrinol 168(2):209\u2013219","journal-title":"Gen Comp Endocrinol"},{"key":"413_CR5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10886-009-9730-5","volume":"36","author":"RS Boyd","year":"2010","unstructured":"Boyd RS (2010) Heavy metal pollutants and chemical ecology: exploring new frontiers. J Chem Ecol 36:46\u201358","journal-title":"J Chem Ecol"},{"key":"413_CR6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ydbio.2007.03.021","volume":"306","author":"DD Brown","year":"2007","unstructured":"Brown DD, Cai L (2007) Amphibian metamorphosis. Dev Biol 306:20\u201333","journal-title":"Dev Biol"},{"issue":"1","key":"413_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2005.07.009","volume":"145","author":"DR Buchholz","year":"2006","unstructured":"Buchholz DR, Paul BD, Fu L, Shi YB (2006) Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog. Gen Comp Endocrinol 145(1):1\u201319","journal-title":"Gen Comp Endocrinol"},{"key":"413_CR8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ecoenv.2015.12.015","volume":"126","author":"L Chai","year":"2016","unstructured":"Chai L, Dong S, Zhao H, Deng H, Wang H (2016a) Effects of fluoride on development and growth of Rana chensinensis embryos and larvae. Ecotoxicol Environ Saf 126:129\u2013137","journal-title":"Ecotoxicol Environ Saf"},{"issue":"8","key":"413_CR9","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1007\/s10646-016-1715-x","volume":"25","author":"L Chai","year":"2016","unstructured":"Chai L, Wang H, Zhao H, Deng H (2016b) Chronic effects of triclosan on embryonic development of Chinese toad, Bufo gargarizans. Ecotoxicology 25(8):1600\u20131608","journal-title":"Ecotoxicology"},{"issue":"4","key":"413_CR10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00128-017-2036-3","volume":"98","author":"L Chai","year":"2017","unstructured":"Chai L, Wang H, Zhao H, Dong S (2017) Chronic effects of fluoride exposure on growth, metamorphosis, and skeleton development in Bufo gargarizans larvae. Bull Environ Contam Toxicol 98(4):496\u2013501","journal-title":"Bull Environ Contam Toxicol"},{"key":"413_CR11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhazmat.2011.07.106","volume":"194","author":"C Dou","year":"2011","unstructured":"Dou C, Zhang J (2011) Effects of lead on neurogenesis during zebrafish embryonic brain development. J Hazard Mater 194:277\u2013282","journal-title":"J Hazard Mater"},{"key":"413_CR12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envres.2005.10.002","volume":"101","author":"B Dundar","year":"2006","unstructured":"Dundar B, \u00d6ktem F, Arslan MK, Delibas N, Baykal B, Arslan \u00c7, Gultepe M, Ilhan IE (2006) The effect of long-term low-dose lead exposure on thyroid function in adolescents. Environ Res 101:140\u2013145","journal-title":"Environ Res"},{"key":"413_CR13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.scitotenv.2007.06.047","volume":"385","author":"NS Duzgoren-Aydin","year":"2007","unstructured":"Duzgoren-Aydin NS (2007) Sources and characteristics of lead pollution in the urban environment of Guangzhou. Sci Total Environ 385:182\u2013195","journal-title":"Sci Total Environ"},{"issue":"10","key":"413_CR14","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1210\/en.2012-1463","volume":"153","author":"JB Fini","year":"2012","unstructured":"Fini JB, Le M\u00e9vel S, Palmier K, Darras VM, Punzon I, Richardson SJ, Clerget-Froidevaux MS, Demeneix BA (2012) Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption. Endocrinology 153(10):5068\u20135081","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"413_CR15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/10408440601123545","volume":"37","author":"DJ Fort","year":"2007","unstructured":"Fort DJ, Degitz S, Tietge J, Touart LW (2007) The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction. Crit Rev Toxicol 37(1\u20132):117\u2013161","journal-title":"Crit Rev Toxicol"},{"issue":"25","key":"413_CR16","doi-asserted-by":"crossref","first-page":"26555","DOI":"10.1074\/jbc.M402847200","volume":"279","author":"JD Furlow","year":"2004","unstructured":"Furlow JD, Yang HY, Hsu M, Lim W, Ermio DJ, Chiellini G, Scanlan TS (2004) Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem 279(25):26555\u201326562","journal-title":"J Biol Chem"},{"key":"413_CR17","first-page":"183","volume":"16","author":"KL Gosner","year":"1960","unstructured":"Gosner KL (1960) A simplified table for staging anuran embryos and larvae with notes on identification. Herpetologica 16:183\u2013190","journal-title":"Herpetologica"},{"issue":"4","key":"413_CR18","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1210\/en.2013-1660","volume":"155","author":"M Heijlen","year":"2014","unstructured":"Heijlen M, Houbrechts AM, Bagci E, Van Herck SL, Kersseboom S, Esguerra CV, Blust R, Visser TJ, Knapen D, Darras VM (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology 155(4):1547\u20131559","journal-title":"Endocrinology"},{"key":"413_CR19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.scitotenv.2014.11.086","volume":"508","author":"L Hu","year":"2015","unstructured":"Hu L, Zhu J, Rotchell JM, Wu L, Gao J, Shi H (2015) Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects. Sci Total Environ 508:258\u2013265","journal-title":"Sci Total Environ"},{"key":"413_CR20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ecoenv.2014.03.027","volume":"104","author":"MY Huang","year":"2014","unstructured":"Huang MY, Duan RY, Ji X (2014) Chronic effects of environmentally-relevant concentrations of lead in Pelophylax nigromaculata tadpoles: threshold dose and adverse effects. Ecotoxicol Environ Saf 104:310\u2013316","journal-title":"Ecotoxicol Environ Saf"},{"issue":"Pt 2","key":"413_CR21","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jhazmat.2013.10.018","volume":"263","author":"IR Hutler Wolkowicz","year":"2013","unstructured":"Hutler Wolkowicz IR, Aronzon CM, P\u00e9rez Coll CS (2013) Lethal and sublethal toxicity of the industrial chemical epichlorohydrin on Rhinella arenarum (Anura, Bufonidae) embryos and larvae. J Hazard Mater 263(Pt 2):784\u2013791","journal-title":"J Hazard Mater"},{"issue":"2","key":"413_CR22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1440-169X.2010.01222.x","volume":"53","author":"A Ishizuya-Oka","year":"2011","unstructured":"Ishizuya-Oka A (2011) Amphibian organ remodeling during metamorphosis: insight into thyroid hormone-induced apoptosis. Develop Growth Differ 53(2):202\u2013212","journal-title":"Develop Growth Differ"},{"issue":"2","key":"413_CR23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/etc.5620220219","volume":"22","author":"SM James","year":"2003","unstructured":"James SM, Little EE (2003) The effects of chronic cadmium exposure on American toad (Bufo americanus) tadpoles. Environ Toxicol Chem 22(2):377\u2013380","journal-title":"Environ Toxicol Chem"},{"issue":"7","key":"413_CR24","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s11356-012-0795-2","volume":"19","author":"MB Jofr\u00e9","year":"2011","unstructured":"Jofr\u00e9 MB, Ant\u00f3n RI, Caviedes-Vidal E (2011) Lead and cadmium accumulation in anuran amphibians of a permanent water body in arid Midwestern Argentina. Environ Sci Pollut Res Int 19(7):2889\u20132897","journal-title":"Environ Sci Pollut Res Int"},{"key":"413_CR25","unstructured":"Khargarot BS, Sehgal A, Bhasin MK (1985) \u201cMan and the biosphere\u201d\u2014studies on the Sikkim Himalayas. Part 5: acute toxicity of selected heavy metals on the tadpoles of Rana hexadactyla. Acta Hydrochim et Hydrobiol 13:259\u2013263"},{"issue":"3","key":"413_CR26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/etc.3227","volume":"35","author":"J Leduc","year":"2016","unstructured":"Leduc J, Echaubard P, Trudeau V, Lesbarr\u00e8res D (2016) Copper and nickel effects on survival and growth of northern leopard frog (Lithobates pipiens) tadpoles in field-collected smelting effluent water. Environ Toxicol Chem 35(3):687\u2013694","journal-title":"Environ Toxicol Chem"},{"key":"413_CR27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10695-008-9301-7","volume":"36","author":"Q Ling","year":"2010","unstructured":"Ling Q, Hong F (2010) Antioxidative role of cerium against the toxicity of lead in the liver of silver crucian carp. Fish Physiol Biochem 36:367\u2013376","journal-title":"Fish Physiol Biochem"},{"issue":"1","key":"413_CR28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1432-0436.2002.700104.x","volume":"70","author":"YW Liu","year":"2002","unstructured":"Liu YW, Chan WK (2002) Thyroid hormones are important for embryonic to larval transitory phase in zebrafish. Differentiation 70(1):36\u201345","journal-title":"Differentiation"},{"key":"413_CR29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1006\/phrs.2000.0734","volume":"42","author":"CM Lopez","year":"2000","unstructured":"Lopez CM, Pineiro AE, Nunez N, Avagnina AM, Villaamil EC, Roses OE (2000) Thyroid hormone changes in males exposed to lead in the Buenos Aires area (Argentina). Pharmacol Res 42:599\u2013602","journal-title":"Pharmacol Res"},{"issue":"9","key":"413_CR30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00204-003-0487-2","volume":"77","author":"NS Loumbourdis","year":"2003","unstructured":"Loumbourdis NS (2003) Nephrotoxic effects of lead nitrate in Rana ridibunda. Arch Toxicol 77(9):527\u2013532","journal-title":"Arch Toxicol"},{"key":"413_CR31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cbd.2016.04.002","volume":"18","author":"SK Maher","year":"2016","unstructured":"Maher SK, Wojnarowicz P, Ichu TA, Veldhoen N, Lu L, Lesperance M, Propper CR, Helbing CC (2016) Rethinking the biological relationships of the thyroid hormones, l-thyroxine and 3,5,3\u2032-triiodothyronine. Comp Biochem Physiol Part D Genomics Proteomics 18:44\u201353","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"413_CR32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aquatox.2015.02.002","volume":"161","author":"W Miao","year":"2015","unstructured":"Miao W, Zhu B, Xiao X, Li Y, Dirbaba NB, Zhou B, Wu H (2015) Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae. Aquat Toxicol 161:117\u2013126","journal-title":"Aquat Toxicol"},{"issue":"10","key":"413_CR33","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1210\/en.2006-0609","volume":"147","author":"G Morvan Dubois","year":"2006","unstructured":"Morvan Dubois G, Sebillot A, Kuiper GG, Verhoelst CH, Darras VM, Visser TJ, Demeneix BA (2006) Deiodinase activity is present in Xenopus laevis during early embryogenesis. Endocrinology 147(10):4941\u20134949","journal-title":"Endocrinology"},{"issue":"2","key":"413_CR34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10534-006-9019-x","volume":"20","author":"F Mouchet","year":"2007","unstructured":"Mouchet F, Cren S, Cunienq C, Deydier E, Guilet R, Gauthier L (2007) Assessment of lead ecotoxicity in water using the amphibian larvae (Xenopus laevis) and preliminary study of its immobilization in meat and bone meal combustion residues. Biometals 20(2):113\u2013127","journal-title":"Biometals"},{"issue":"2","key":"413_CR35","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/toxsci\/kfm001","volume":"96","author":"S Mukhi","year":"2007","unstructured":"Mukhi S, Pati\u00f1o R (2007) Effects of prolonged exposure to perchlorate on thyroid and reproductive function in zebrafish. Toxicol Sci 96(2):246\u2013254","journal-title":"Toxicol Sci"},{"key":"413_CR36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemosphere.2015.03.078","volume":"135","author":"S Nations","year":"2015","unstructured":"Nations S, Long M, Wages M, Maul JD, Theodorakis CW, Cobb GP (2015) Subchronic and chronic developmental effects of copper oxide (CuO) nanoparticles on Xenopus laevis. Chemosphere 135:166\u2013174","journal-title":"Chemosphere"},{"issue":"8","key":"413_CR37","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.chemosphere.2011.01.061","volume":"83","author":"S Nations","year":"2011","unstructured":"Nations S, Wages M, Ca\u00f1as JE, Maul J, Theodorakis C, Cobb GP (2011) Acute effects of Fe2O3, TiO2, ZnO and CuO nanomaterials on Xenopus laevis. Chemosphere 83(8):1053\u20131061","journal-title":"Chemosphere"},{"issue":"2","key":"413_CR38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.beem.2007.04.004","volume":"21","author":"A Oetting","year":"2007","unstructured":"Oetting A, Yen PM (2007) New insights into thyroid hormone action. Best Pract Res Clin Endocrinol Metab 21(2):193\u2013208","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"413_CR39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0269-7491(90)90157-8","volume":"63","author":"C P\u00e9rez-Coll","year":"1990","unstructured":"P\u00e9rez-Coll C, Herkovits J (1990) Stage dependent susceptibility to lead in Bufo arenarum embryos. Environ Pollut 63:239\u2013245","journal-title":"Environ Pollut"},{"issue":"8","key":"413_CR40","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1128\/MCB.17.8.4738","volume":"17","author":"M Puzianowska-Kuznicka","year":"1997","unstructured":"Puzianowska-Kuznicka M, Damjanovski S, Shi YB (1997) Both thyroid hormone and 9-cis retinoic acid receptors are required to efficiently mediate the effects of thyroid hormone on embryonic development and specific gene regulation in Xenopus laevis. Mol Cell Biol 17(8):4738\u20134749","journal-title":"Mol Cell Biol"},{"issue":"3\u20134","key":"413_CR41","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.aquatox.2011.08.014","volume":"105","author":"C Rice","year":"2011","unstructured":"Rice C, Ghorai JK, Zalewski K, Weber DN (2011) Developmental lead exposure causes startle response deficits in zebrafish. Aquat Toxicol 105(3\u20134):600\u2013608","journal-title":"Aquat Toxicol"},{"key":"413_CR42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1086\/515885","volume":"71","author":"CL Rowe","year":"1998","unstructured":"Rowe CL, Kinney OM, Nagle RD, Congdon JD (1998) Elevated maintenance costs in an anuran (Rana catesbeiana) exposed to a mixture of trace elements during the embryonic and early larval periods. Physiol Zool 71:27\u201335","journal-title":"Physiol Zool"},{"key":"413_CR43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1009201426184","volume":"13","author":"B Singh","year":"2000","unstructured":"Singh B, Chandran V, Bandhu HK, Mittal BR, Bhattacharya A, Jindal SK, Varma S (2000) Impact of lead exposure on pituitary-thyroid axis in humans. Biometals 13:187\u2013192","journal-title":"Biometals"},{"issue":"3","key":"413_CR44","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00244-005-0243-0","volume":"51","author":"DW Sparling","year":"2006","unstructured":"Sparling DW, Krest S, Ortiz-Santaliestra M (2006) Effects of lead-contaminated sediment on Rana sphenocephala tadpoles. Arch Environ Contam Toxicol 51(3):458\u2013466","journal-title":"Arch Environ Contam Toxicol"},{"key":"413_CR45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/tox.10124","volume":"18","author":"NN Tchernitchin","year":"2003","unstructured":"Tchernitchin NN, Clavero A, Mena MA, Unda C, Villagra R, Cumsille M, Tchernitchin AN (2003) Effect of chronic exposure to lead on estrogen action in the prepubertal rat uterus. Environ Toxicol 18:268\u2013277","journal-title":"Environ Toxicol"},{"issue":"3","key":"413_CR46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/BC20060074","volume":"99","author":"AJ Tindall","year":"2007","unstructured":"Tindall AJ, Morris ID, Pownall ME, Isaacs HV (2007) Expression of enzymes involved in thyroid hormone metabolism during the early development of Xenopus tropicalis. Biol Cell 99(3):151\u2013163","journal-title":"Biol Cell"},{"issue":"12","key":"413_CR47","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1897\/03-696.1","volume":"23","author":"JM Unrine","year":"2004","unstructured":"Unrine JM, Jagoe CH, Hopkins WA, Brant HA (2004) Adverse effects of ecologically relevant dietary mercury exposure in southern leopard frog (Rana sphenocephala) larvae. Environ Toxicol Chem 23(12):2964\u20132970","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"413_CR48","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1210\/en.2008-0457","volume":"150","author":"CN Walpita","year":"2009","unstructured":"Walpita CN, Crawford AD, Janssens ED, Van der Geyten S, Darras VM (2009) Type 2 deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish. Endocrinology 150(1):530\u2013539","journal-title":"Endocrinology"},{"key":"413_CR49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.chemosphere.2015.07.037","volume":"139","author":"M Wang","year":"2015","unstructured":"Wang M, Chai L, Zhao H, Wu M, Wang H (2015) Effects of nitrate on metamorphosis, thyroid and iodothyronine deiodinases expression in Bufo gargarizans larvae. Chemosphere 139:402\u2013409","journal-title":"Chemosphere"},{"issue":"1","key":"413_CR50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10646-008-0262-5","volume":"18","author":"MZ Wang","year":"2009","unstructured":"Wang MZ, Jia XY (2009) Low levels of lead exposure induce oxidative damage and DNA damage in the testes of the frog Rana nigromaculata. Ecotoxicology 18(1):94\u201399","journal-title":"Ecotoxicology"},{"key":"413_CR51","first-page":"59","volume":"20","author":"X Wang","year":"2001","unstructured":"Wang X, Lu X, Li C, Gao W, Gao M (2001) Toxicity of heavy metal irons to embryos and larvae of Rana nigromaculata. Sichuan journal of zoology 20:59\u201361","journal-title":"Sichuan journal of zoology"},{"key":"413_CR52","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chemosphere.2017.03.131","volume":"179","author":"C Wu","year":"2017","unstructured":"Wu C, Zhang Y, Chai L, Wang H (2017b) Histological changes, lipid metabolism and oxidative stress in the liver of Bufo gargarizans exposed to cadmium concentrations. Chemosphere 179:337\u2013346","journal-title":"Chemosphere"},{"key":"413_CR53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.etap.2016.12.005","volume":"49","author":"C Wu","year":"2017","unstructured":"Wu C, Zhang Y, Chai L, Wang H (2017a) Oxidative stress, endocrine disruption, and malformation of Bufo gargarizans embryo exposed to sub-lethal cadmium concentrations. Environ Toxicol Pharmacol 49:97\u2013104","journal-title":"Environ Toxicol Pharmacol"},{"issue":"11","key":"413_CR54","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.chemosphere.2012.02.047","volume":"87","author":"K Xia","year":"2012","unstructured":"Xia K, Zhao H, Wu M, Wang H (2012) Chronic toxicity of copper on embryo development in Chinese toad, Bufo gargarizans. Chemosphere 87(11):1395\u20131402","journal-title":"Chemosphere"},{"issue":"3","key":"413_CR55","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.etap.2014.04.016","volume":"37","author":"X Yin","year":"2014","unstructured":"Yin X, Jiang S, Yu J, Zhu G, Wu H, Mao C (2014) Effects of spirotetramat on the acute toxicity, oxidative stress, and lipid peroxidation in Chinese toad (Bufo bufo gargarizans) tadpoles. Environ Toxicol Pharmacol 37(3):1229\u20131235","journal-title":"Environ Toxicol Pharmacol"},{"key":"413_CR56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.aquatox.2014.10.011","volume":"157","author":"B Zhu","year":"2014","unstructured":"Zhu B, Wang Q, Wang X, Zhou B (2014) Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Aquat Toxicol 157:186\u2013195","journal-title":"Aquat Toxicol"},{"key":"413_CR57","first-page":"440","volume":"3","author":"P Zhuang","year":"2009","unstructured":"Zhuang P, Wang R, Shi X, Zhang L (2009) Acute toxicity and safety assessment of fluoride to larval Siberian sturgeon Acipenser baeri. Asian J Ecotoxicol 3:440\u2013445","journal-title":"Asian J Ecotoxicol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-017-0413-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-017-0413-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-017-0413-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T06:53:45Z","timestamp":1513061625000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-017-0413-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,8]]},"references-count":57,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["413"],"URL":"https:\/\/doi.org\/10.1007\/s11356-017-0413-4","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,8]]}}}