{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:21:21Z","timestamp":1762867281167,"version":"3.37.3"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["P503-12-G147"],"award-info":[{"award-number":["P503-12-G147"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Environmental Health Sciences, National Institutes of Health","award":["ES05605","ES013661","ES012475"],"award-info":[{"award-number":["ES05605","ES013661","ES012475"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11356-017-0683-x","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T04:22:05Z","timestamp":1510201325000},"page":"16411-16419","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Atropisomers of 2,2\u2032,3,3\u2032,6,6\u2032-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro"],"prefix":"10.1007","volume":"25","author":[{"given":"Kate\u0159ina","family":"P\u011bn\u010d\u00edkov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Brenerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Svr\u017ekov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hrub\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"P\u00e1lkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Vondr\u00e1\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Lehmler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Machala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"683_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.taap.2012.05.016","volume":"263","author":"F Al-Salman","year":"2012","unstructured":"Al-Salman F, Plant N (2012) Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. Toxicol Appl Pharmacol 263:7\u201313","journal-title":"Toxicol Appl Pharmacol"},{"key":"683_CR2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1124\/dmd.109.030197","volume":"38","author":"C Anth\u00e9rieu","year":"2010","unstructured":"Anth\u00e9rieu C, Chesn\u00e9 C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C, Guillouzo A (2010) Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 38:516\u2013525","journal-title":"Drug Metab Dispos"},{"key":"683_CR3","doi-asserted-by":"crossref","unstructured":"Bonefeld-J\u00f8rgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM (2001) Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology 158:141\u2013153","DOI":"10.1016\/S0300-483X(00)00368-1"},{"key":"683_CR4","volume":"11","author":"T Chai","year":"2016","unstructured":"Chai T, Cui F, Mu X, Yang Y, Wang C, Qiu J (2016a) Exploration of stereoselectivity in embryo-larvae (Danio rerio) induced by chiral PCB149 at the bioconcentration and gene expression levels. PLoS One 11:e0155263","journal-title":"PLoS One"},{"key":"683_CR5","doi-asserted-by":"crossref","first-page":"33481","DOI":"10.1038\/srep33481","volume":"6","author":"T Chai","year":"2016","unstructured":"Chai T, Cui F, Yin Z, Yang Y, Qiu J, Wang C (2016b) Chiral PCB 91 and 149 toxicity testing in embryo and larvae (Danio rerio): application of targeted metabolomics via UPLC-MS\/MS. Sci Rep 6:33481","journal-title":"Sci Rep"},{"key":"683_CR6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2013.05.034","volume":"272","author":"M G\u00e4hrs","year":"2013","unstructured":"G\u00e4hrs M, Roos R, Andersson PL, Schrenk D (2013) Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes. Toxicol Appl Pharmacol 272:77\u201385","journal-title":"Toxicol Appl Pharmacol"},{"key":"683_CR7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10408444.2014.999365","volume":"45","author":"FA Grimm","year":"2015","unstructured":"Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW (2015) Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45:245\u2013272","journal-title":"Crit Rev Toxicol"},{"key":"683_CR8","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/0045-6535(96)00131-2","volume":"32","author":"P Haglund","year":"1996","unstructured":"Haglund P (1996) Isolation and characterisation of polychlorinated biphenyl (PCB) atropisomers. Chemosphere 32:2133\u20132140","journal-title":"Chemosphere"},{"key":"683_CR9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s002160051327","volume":"364","author":"MT Harju","year":"1999","unstructured":"Harju MT, Haglund P (1999) Determination of the rotational energy barriers of atropisomeric polychlorinated biphenyls. Fresenius J Anal Chem 364:219\u2013223","journal-title":"Fresenius J Anal Chem"},{"key":"683_CR10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/es9906958","volume":"34","author":"T Harner","year":"2000","unstructured":"Harner T, Wiberg K, Norstrom R (2000) Enantiomer fractions are preferred to enantiomer ratios for describing chiral signatures in environmental analysis. Environ Sci Technol 34:218\u2013220","journal-title":"Environ Sci Technol"},{"key":"683_CR11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfr043","volume":"121","author":"T Hamers","year":"2011","unstructured":"Hamers T, Kamstra JH, Cenijn PH, P\u011bn\u010d\u00edkov\u00e1 K, P\u00e1lkov\u00e1 L, \u0160ime\u010dkov\u00e1 P, Vondr\u00e1\u010dek J, Andersson PL, Stenberg M, Machala M (2011) In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans. Toxicol Sci 121:88\u2013100","journal-title":"Toxicol Sci"},{"key":"683_CR12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.toxlet.2011.07.011","volume":"206","author":"E Hrub\u00e1","year":"2011","unstructured":"Hrub\u00e1 E, Vondr\u00e1\u010dek J, L\u00edbalov\u00e1 H, Topinka J, Bryja V, Sou\u010dek K, Machala M (2011) Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett 206:178\u2013188","journal-title":"Toxicol Lett"},{"key":"683_CR13","first-page":"56","volume":"1","author":"E Hrub\u00e1","year":"2014","unstructured":"Hrub\u00e1 E, Pernicov\u00e1 Z, P\u00e1lkov\u00e1 L, Sou\u010dek K, Vondr\u00e1\u010dek J, Machala M (2014) Phthalates deregulate cell proliferation, but not neuroendocrine transdifferentiation, in human LNCaP prostate cancer cell model. Folia Biol (Praha) 60 Suppl 1:56\u201361","journal-title":"Folia Biol (Praha) 60 Suppl"},{"key":"683_CR14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0013-9327(74)90076-7","volume":"7","author":"KLE Kaiser","year":"1974","unstructured":"Kaiser KLE (1974) On the optical activity of polychlorinated biphenyls. Environ Pollut 7:93\u2013101","journal-title":"Environ Pollut"},{"key":"683_CR15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/chir.20342","volume":"19","author":"I Kania-Korwel","year":"2007","unstructured":"Kania-Korwel I, Shaikh NS, Hornbuckle KC, Robertson LW, Lehmler H-J (2007) Enantioselective disposition of PCB 136 (2,2\u2032,3,3\u2032,6,6\u2032-hexachlorobiphenyl) in C57BL\/6 mice after oral and intraperitoneal administration. Chirality 19:56\u201366","journal-title":"Chirality"},{"key":"683_CR16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1021\/tx800059j","volume":"21","author":"I Kania-Korwel","year":"2008","unstructured":"Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H-J (2008) 2,2\u2032,3,3\u2032,6,6\u2032-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21:1295\u20131303","journal-title":"Chem Res Toxicol"},{"key":"683_CR17","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1021\/es302810t","volume":"46","author":"I Kania-Korwel","year":"2012","unstructured":"Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler HJ (2012) 2,2\u2032,3,5\u2032,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46:11393\u201311401","journal-title":"Environ Sci Technol"},{"key":"683_CR18","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1021\/acs.chemrestox.5b00241","volume":"28","author":"I Kania-Korwel","year":"2015","unstructured":"Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H-J (2015) Effect of pregnancy on the disposition of 2,2\u2032,3,5\u2032,6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28:1774\u20131783","journal-title":"Chem Res Toxicol"},{"key":"683_CR19","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s11356-015-4150-2","volume":"23","author":"I Kania-Korwel","year":"2016","unstructured":"Kania-Korwel I, Lehmler HJ (2016a) Chiral polychlorinated biphenyls: absorption, metabolism and excretion\u2014a review. Environ Sci Pollut Res 23:2042\u20132057","journal-title":"Environ Sci Pollut Res"},{"key":"683_CR20","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s11356-015-4383-0","volume":"23","author":"I Kania-Korwel","year":"2016","unstructured":"Kania-Korwel I, Lehmler HJ (2016b) Toxicokinetics of chiral polychlorinated biphenyls across different species\u2014a review. Environ Sci Pollut Res 23:2058\u20132080","journal-title":"Environ Sci Pollut Res"},{"key":"683_CR21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/toxsci\/kfx071","volume":"158","author":"I Kania-Korwel","year":"2017","unstructured":"Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ (2017) Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: implications for PCB developmental neurotoxicity. Toxicol Sci 158:101\u2013115","journal-title":"Toxicol Sci"},{"key":"683_CR22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2133\/dmpk.23.8","volume":"23","author":"Y Konno","year":"2008","unstructured":"Konno Y, Negishi M, Kodama S (2008) The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab Pharmacokinet 23:8\u201313","journal-title":"Drug Metab Pharmacokinet"},{"key":"683_CR23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1289\/ehp.1408564","volume":"123","author":"GM Lehmann","year":"2015","unstructured":"Lehmann GM, Christensen K, Maddaloni M, Phillips LJ (2015) Evaluating health risks from inhaled polychlorinated biphenyls: research needs for addressing uncertainty. Environ Health Perspect 123:109\u2013113","journal-title":"Environ Health Perspect"},{"key":"683_CR24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.toxlet.2004.12.011","volume":"156","author":"H-J Lehmler","year":"2005","unstructured":"Lehmler H-J, Robertson LW, Garrison AW, Kodavanti PRS (2005) Effects of PCB 84 enantiomers on [3H] phorbol ester binding in rat cerebellar granule cells and 45Ca2+-uptake in rat cerebellum. Toxicol Lett 156:391\u2013400","journal-title":"Toxicol Lett"},{"key":"683_CR25","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1021\/es902208u","volume":"44","author":"H-J Lehmler","year":"2010","unstructured":"Lehmler H-J, Harrad SJ, Huhnerfuss H, Kania-Korwel I, Lee CM, Lu Z, Wong CS (2010) Chiral polychlorinated biphenyl transport, metabolism, and distribution: a review. Environ Sci Technol 44:2757\u20132766","journal-title":"Environ Sci Technol"},{"key":"683_CR26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/toxsci\/48.1.55","volume":"48","author":"J Legler","year":"1999","unstructured":"Legler J, van den Brink CE, Brouwer A, Murk AJ, van der Saag PT, Vethaak AD, van der Burg B (1999) Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol Sci 48:55\u201366","journal-title":"Toxicol Sci"},{"key":"683_CR27","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1021\/es200673q","volume":"45","author":"Z Lu","year":"2011","unstructured":"Lu Z, Wong CS (2011) Factors affecting phase I stereoselective biotransformation of chiral polychlorinated biphenyls by rat cytochrome P-450 2B1 isozyme. Environ Sci Technol 45:8298\u20138305","journal-title":"Environ Sci Technol"},{"key":"683_CR28","doi-asserted-by":"crossref","first-page":"12184","DOI":"10.1021\/es402838f","volume":"47","author":"Z Lu","year":"2013","unstructured":"Lu Z, Kania-Korwel I, Lehmler HJ, Wong CS (2013) Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environ Sci Technol 47:12184\u201312192","journal-title":"Environ Sci Technol"},{"key":"683_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/mp700103m","volume":"5","author":"A Moreau","year":"2008","unstructured":"Moreau A, Vilarem MJ, Maurel P, Pascussi JM (2008) Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. Mol Pharmacol 5:35\u201341","journal-title":"Mol Pharmacol"},{"key":"683_CR30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2003.10.005","volume":"88","author":"D Morrow","year":"2004","unstructured":"Morrow D, Qin C, Smith R, Safe S (2004) Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. J Steroid Biochem Mol Biol 88:27\u201336","journal-title":"J Steroid Biochem Mol Biol"},{"key":"683_CR31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/tx800328u","volume":"22","author":"IN Pessah","year":"2009","unstructured":"Pessah IN, Lehmler H-J, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W (2009) Enantiomeric specificity of (\u2212)-2,2\u2032,3,3\u2032,6,6\u2032-hexachlorobiphenyl toward RyRodine receptor types 1 and 2. Chem Res Toxicol 22:201\u2013207","journal-title":"Chem Res Toxicol"},{"key":"683_CR32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2009.10.009","volume":"125","author":"IN Pessah","year":"2010","unstructured":"Pessah IN, Cherednichenko G, Lein PJ (2010) Minding the calcium store: ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther 125:260\u2013285","journal-title":"Pharmacol Ther"},{"key":"683_CR33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1289\/ehp.7745","volume":"113","author":"M Pl\u00ed\u0161kov\u00e1","year":"2005","unstructured":"Pl\u00ed\u0161kov\u00e1 M, Vondr\u00e1cek J, Canton RF, Ne\u010da J, Ko\u010dan A, Petr\u00edk J, Trnovec T, Sanderson T, van den Berg M, Machala M (2005) Impact of polychlorinated biphenyls contamination on estrogenic activity in human male serum. Environ Health Perspect 113:1277\u20131284","journal-title":"Environ Health Perspect"},{"key":"683_CR34","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0006-2952(89)90342-0","volume":"38","author":"M P\u00fcttmann","year":"1989","unstructured":"P\u00fcttmann M, Mannschreck A, Oesch F, Robertson LW (1989) Chiral effects in the induction of drug-metabolizing enzymes using synthetic atropisomers of polychlorinated biphenyls (PCBs). Biochem Pharmacol 38:1345\u20131352","journal-title":"Biochem Pharmacol"},{"key":"683_CR35","unstructured":"P\u00fcttmann M, Arand M, Oesch F, Mannschreck A, Robertson LW (1990) Chirality and the induction of xenobiotic-metabolizing enzymes: effects of the atropisomers of the polychlorinated biphenyl 2,2\u2032,3,4,4\u2032,6-hexachlorobiphenyl. Chirality and Biological Activity:177\u2013184"},{"key":"683_CR36","unstructured":"Robertson LW, Hansen LG (eds) (2001) PCBs: recent advances in environmental toxicology and health effects. Lexington, KY:The University Press of Kentucky"},{"key":"683_CR37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0006-2952(91)90196-C","volume":"41","author":"LE Rodman","year":"1991","unstructured":"Rodman LE, Shedlofsky SI, Mannschreck A, P\u00fcttmann M, Swim AT, Robertson LW (1991) Differential potency of atropisomers of polychlorinated biphenyls on cytochrome P450 induction and uroporphyrin accumulation in the chick embryo hepatocyte culture. Biochem Pharmacol 41:915\u2013922","journal-title":"Biochem Pharmacol"},{"key":"683_CR38","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"683_CR39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1289\/ehp.6560","volume":"112","author":"MM Tabb","year":"2004","unstructured":"Tabb MM, Kholodovych V, Gr\u00fcn F, Zhou C, Welsh WJ, Blumberg B (2004) Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). Environ Health Perspect 112:163\u2013169","journal-title":"Environ Health Perspect"},{"key":"683_CR40","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.addr.2010.08.006","volume":"62","author":"AH Tolson","year":"2010","unstructured":"Tolson AH, Wang H (2010) Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Adv Drug Deliv Rev 62:1238\u20131249","journal-title":"Adv Drug Deliv Rev"},{"key":"683_CR41","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1021\/acs.chemrestox.6b00371","volume":"29","author":"E Uwimana","year":"2016","unstructured":"Uwimana E, Li X, Lehmler H-J (2016) 2,2\u2032,3,5\u2032,6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29:2108\u20132110","journal-title":"Chem Res Toxicol"},{"key":"683_CR42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/toxsci\/kfu083","volume":"140","author":"B Wahlang","year":"2014","unstructured":"Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC (2014) Human receptor activation by Aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140:283\u2013297","journal-title":"Toxicol Sci"},{"key":"683_CR43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/es802237u","volume":"43","author":"NA Warner","year":"2009","unstructured":"Warner NA, Martin JW, Wong CS (2009) Chiral polychlorinated biphenyls are biotransformed enantioselectively by mammalian cytochrome P-450 isozymes to form hydroxylated metabolites. Environ Sci Technol 43:114\u2013121","journal-title":"Environ Sci Technol"},{"key":"683_CR44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/carcin\/22.3.409","volume":"22","author":"N Xing","year":"2001","unstructured":"Xing N, Chen Y, Mitchell SH, Young CYF (2001) Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis 22:409\u2013414","journal-title":"Carcinogenesis"},{"key":"683_CR45","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/toxsci\/kft334","volume":"138","author":"D Yang","year":"2014","unstructured":"Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ (2014) PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138:379\u2013392","journal-title":"Toxicol Sci"},{"key":"683_CR46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.envpol.2014.03.001","volume":"189","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Lu M, Wang C, Du J, Zhou P, Zhao M (2014) Characterization of estrogen receptor \u03b1 activities in polychlorinated biphenyls by in vitro dual-luciferase reporter gene assay. Environ Pollut 189:169\u2013175","journal-title":"Environ Pollut"},{"key":"683_CR47","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/acs.est.5b04955","volume":"50","author":"J Zheng","year":"2016","unstructured":"Zheng J, Yu LH, Chen SJ, Hu GC, Chen KH, Yan X, Luo XJ, Zhang S, Yu YJ, Yang ZY, Mai BX (2016) Polychlorinated biphenyls (PCBs) in human hair and serum from e-waste recycling workers in Southern China: concentrations, chiral signatures, correlations, and source identification. Environ Sci Technol 50:1579\u20131586","journal-title":"Environ Sci Technol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-017-0683-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-017-0683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-017-0683-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T18:21:43Z","timestamp":1570299703000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-017-0683-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":47,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["683"],"URL":"https:\/\/doi.org\/10.1007\/s11356-017-0683-x","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"type":"print","value":"0944-1344"},{"type":"electronic","value":"1614-7499"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}