{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:51:20Z","timestamp":1787064680966,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21476130"],"award-info":[{"award-number":["21476130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11356-018-1894-5","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T14:01:13Z","timestamp":1523455273000},"page":"17128-17136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Low-level concentrations of aminoglycoside antibiotics induce the aggregation of cyanobacteria"],"prefix":"10.1007","volume":"25","author":[{"given":"Lin-Rui","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"1894_CR1","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.jhazmat.2007.11.058","volume":"154","author":"SS Adav","year":"2008","unstructured":"Adav SS, Lee DJ (2008) Extraction of extracellular polymeric substances from aerobic granule with compact interior structure. J Hazard Mater 154:1120\u20131126","journal-title":"J Hazard Mater"},{"key":"1894_CR2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrmicro3270","volume":"12","author":"DI Andersson","year":"2014","unstructured":"Andersson DI, Hughes D (2014) Microbiological effects of sublethal levels of antibiotics. Nat Rev Micro 12:465\u2013478","journal-title":"Nat Rev Micro"},{"key":"1894_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3389\/fmicb.2013.00246","volume":"4","author":"BM Berla","year":"2013","unstructured":"Berla BM, Saha R, Immethun CM, Maranas CD, Moon TS, Pakrasi HB (2013) Synthetic biology of cyanobacteria: unique challenges and opportunities. Front Microbiol 4:246","journal-title":"Front Microbiol"},{"key":"1894_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fmicb.2013.00020","volume":"4","author":"SP Bernier","year":"2013","unstructured":"Bernier SP, Surette MG (2013) Concentration-dependent activity of antibiotics in natural environments. Front Microbiol 4:20","journal-title":"Front Microbiol"},{"key":"1894_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrmicro3380","volume":"13","author":"JM Blair","year":"2015","unstructured":"Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ (2015) Molecular mechanisms of antibiotic resistance. Nat Rev Micro 13:42\u201351","journal-title":"Nat Rev Micro"},{"key":"1894_CR6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1894_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102879","volume":"9","author":"H Cai","year":"2014","unstructured":"Cai H, Jiang H, Krumholz LR, Yang Z (2014) Bacterial community composition of size-fractioned aggregates within the phycosphere of cyanobacterial blooms in a eutrophic freshwater lake. PLoS One 9:e102879","journal-title":"PLoS One"},{"key":"1894_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17035-4","volume":"7","author":"Y-Q Cao","year":"2017","unstructured":"Cao Y-Q, Li Q, Xia P-F, Wei L-J, Guo N, Li J-W, Wang S-G (2017) AraBAD based toolkit for gene expression and metabolic robustness improvement in Synechococcus elongatus. Sci Rep 7:18059","journal-title":"Sci Rep"},{"key":"1894_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1128\/MMBR.00036-15","volume":"79","author":"SE Cohen","year":"2015","unstructured":"Cohen SE, Golden SS (2015) Circadian rhythms in cyanobacteria. Microbiol Mol Biol Rev 79:373\u2013385","journal-title":"Microbiol Mol Biol Rev"},{"key":"1894_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ecoleng.2015.12.017","volume":"87","author":"J Deng","year":"2016","unstructured":"Deng J, Chen F, Liu X, Peng J, Hu W (2016) Horizontal migration of algal patches associated with cyanobacterial blooms in an eutrophic shallow lake. Ecol Eng 87:185\u2013193","journal-title":"Ecol Eng"},{"key":"1894_CR11","doi-asserted-by":"publisher","first-page":"E1916","DOI":"10.1073\/pnas.1504576112","volume":"112","author":"S Diamond","year":"2015","unstructured":"Diamond S, Jun D, Rubin BE, Golden SS (2015) The circadian oscillator in Synechococcus elongatus controls metabolite partitioning during diurnal growth. Proc Natl Acad Sci U S A 112:E1916\u2013E1925","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1894_CR12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1021\/ac60111a017","volume":"28","author":"M DuBois","year":"1956","unstructured":"DuBois M, Gilles KA, Hamilton JK, Rebers PA, Smith F (1956) Colorimetric method for determination of sugars and related substances. Anal Chem 28:350\u2013356","journal-title":"Anal Chem"},{"key":"1894_CR13","doi-asserted-by":"publisher","first-page":"6691","DOI":"10.1021\/la063404z","volume":"23","author":"KE Eboigbodin","year":"2007","unstructured":"Eboigbodin KE, Ojeda JJ, Biggs CA (2007) Investigating the surface properties of Escherichia coli under glucose controlled conditions and its effect on aggregation. Langmuir 23:6691\u20136697","journal-title":"Langmuir"},{"key":"1894_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1021\/bm701043c","volume":"9","author":"KE Eboigbodin","year":"2008","unstructured":"Eboigbodin KE, Biggs CA (2008) Characterization of the extracellular polymeric substances produced by Escherichia coli using infrared spectroscopic, proteomic, and aggregation studies. Biomacromolecules 9:686\u2013695","journal-title":"Biomacromolecules"},{"key":"1894_CR15","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1021\/es902240k","volume":"44","author":"AM Badawy El","year":"2010","unstructured":"El Badawy AM, Luxton TP, Silva RG, Scheckel KG, Suidan MT, Tolaymat TM (2010) Impact of environmental conditions (pH, ionic strength, and electrolyte type) on the surface charge and aggregation of silver nanoparticles suspensions. Environ Sci Technol 44:1260\u20131266","journal-title":"Environ Sci Technol"},{"key":"1894_CR16","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrmicro2415","volume":"8","author":"HC Flemming","year":"2010","unstructured":"Flemming HC, Wingender J (2010) The biofilm matrix. Nat Rev Microbiol 8:623\u2013633","journal-title":"Nat Rev Microbiol"},{"key":"1894_CR17","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/nature03912","volume":"436","author":"LR Hoffman","year":"2005","unstructured":"Hoffman LR, D'Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI (2005) Aminoglycoside antibiotics induce bacterial biofilm formation. Nature 436:1171\u20131175","journal-title":"Nature"},{"key":"1894_CR18","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1007\/s11356-015-5431-5","volume":"23","author":"J Hou","year":"2016","unstructured":"Hou J, Wang C, Mao D, Luo Y (2016) The occurrence and fate of tetracyclines in two pharmaceutical wastewater treatment plants of Northern China. Environ Sci Pollut Res 23:1722\u20131731","journal-title":"Environ Sci Pollut Res"},{"key":"1894_CR19","first-page":"364","volume":"42","author":"S Hu","year":"2014","unstructured":"Hu S, Song Y, Bai X, Jiang X, Xl Y (2014) Derivatization and solidification of floating dispersive liquid-phase microextraction for the analysis of kanamycin in wastewater and soil by HPLC with fluorescence detection. CLEAN 42:364\u2013370","journal-title":"CLEAN"},{"key":"1894_CR20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.copbio.2010.03.017","volume":"21","author":"C Jansson","year":"2010","unstructured":"Jansson C, Northen T (2010) Calcifying cyanobacteria\u2014the potential of biomineralization for carbon capture and storage. Curr Opin Biotechnol 21:365\u2013371","journal-title":"Curr Opin Biotechnol"},{"key":"1894_CR21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.2166\/wst.1998.0652","volume":"37","author":"F Jorand","year":"1998","unstructured":"Jorand F, Boue-Bigne F, Block J, Urbain V (1998) Hydrophobic\/hydrophilic properties of activated sludge exopolymeric substances. Water Sci Technol 37:307\u2013315","journal-title":"Water Sci Technol"},{"key":"1894_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.chemosphere.2008.12.006","volume":"75","author":"K Kummerer","year":"2009","unstructured":"Kummerer K (2009a) Antibiotics in the aquatic environment\u2014a review\u2014part II. Chemosphere 75:435\u2013441","journal-title":"Chemosphere"},{"key":"1894_CR23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","volume":"75","author":"K Kummerer","year":"2009","unstructured":"Kummerer K (2009b) Antibiotics in the aquatic environment\u2014a review\u2014part I. Chemosphere 75:417\u2013434","journal-title":"Chemosphere"},{"key":"1894_CR24","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1021\/la047963m","volume":"21","author":"ZA Kuznar","year":"2005","unstructured":"Kuznar ZA, Elimelech M (2005) Role of surface proteins in the deposition kinetics of Cryptosporidium parvum oocysts. Langmuir 21:710\u2013716","journal-title":"Langmuir"},{"key":"1894_CR25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/w9070462","volume":"9","author":"Q Li","year":"2017","unstructured":"Li Q, Xia P-F, Tao Z-Y, Wang S-G (2017) Modeling biofilms in water systems with new variables: a review. Water 9:462","journal-title":"Water"},{"key":"1894_CR26","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1021\/acs.est.5b05234","volume":"50","author":"R Li","year":"2016","unstructured":"Li R, Zhao C, Yao B, Li D, Yan S, O\u2019Shea KE, Song W (2016) Photochemical transformation of aminoglycoside antibiotics in simulated natural waters. Environ Sci Technol 50:2921\u20132930","journal-title":"Environ Sci Technol"},{"key":"1894_CR27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0043-1354(00)00277-3","volume":"35","author":"B Liao","year":"2001","unstructured":"Liao B, Allen D, Droppo I, Leppard G, Liss S (2001) Surface properties of sludge and their role in bioflocculation and settleability. Water Res 35:339\u2013350","journal-title":"Water Res"},{"key":"1894_CR28","doi-asserted-by":"publisher","first-page":"4355","DOI":"10.1021\/es9016766","volume":"44","author":"XM Liu","year":"2010","unstructured":"Liu XM, Sheng GP, Luo HW, Zhang F, Yuan SJ, Xu J, Zeng RJ, Wu JG, Yu HQ (2010) Contribution of extracellular polymeric substances (EPS) to the sludge aggregation. Environ Sci Technol 44:4355\u20134360","journal-title":"Environ Sci Technol"},{"key":"1894_CR29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/10643380390814479","volume":"33","author":"Y Liu","year":"2003","unstructured":"Liu Y, Fang HH (2003) Influences of extracellular polymeric substances (EPS) on flocculation, settling, and dewatering of activated sludge. Crit Rev Env Sci Tec 33:237\u2013273","journal-title":"Crit Rev Env Sci Tec"},{"key":"1894_CR30","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1007\/s12665-015-4279-9","volume":"74","author":"X Ma","year":"2015","unstructured":"Ma X, Wang Y, Feng S, Wang S (2015) Vertical migration patterns of different phytoplankton species during a summer bloom in Dianchi Lake, China. Environ Earth Sci 74:3805\u20133814","journal-title":"Environ Earth Sci"},{"key":"1894_CR31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.copbio.2017.11.008","volume":"50","author":"MM Matson","year":"2018","unstructured":"Matson MM, Atsumi S (2018) Photomixotrophic chemical production in cyanobacteria. Curr Opin Biotechnol 50:65\u201371","journal-title":"Curr Opin Biotechnol"},{"key":"1894_CR32","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1128\/AEM.03326-12","volume":"79","author":"JT McEwen","year":"2013","unstructured":"McEwen JT, Machado IM, Connor MR, Atsumi S (2013) Engineering Synechococcus elongatus PCC 7942 for continuous growth under diurnal conditions. Appl Environ Microbiol 79:1668\u20131675","journal-title":"Appl Environ Microbiol"},{"key":"1894_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002191","volume":"13","author":"NM Oliveira","year":"2015","unstructured":"Oliveira NM, Martinez-Garcia E, Xavier J, Durham WM, Kolter R, Kim W, Foster KR (2015) Biofilm formation as a response to ecological competition. PLoS Biol 13:e1002191","journal-title":"PLoS Biol"},{"key":"1894_CR34","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00248-012-0159-y","volume":"65","author":"HW Paerl","year":"2013","unstructured":"Paerl HW, Otten TG (2013) Harmful cyanobacterial blooms: causes, consequences, and controls. Microb Ecol 65:995\u20131010","journal-title":"Microb Ecol"},{"key":"1894_CR35","doi-asserted-by":"publisher","first-page":"10163","DOI":"10.1016\/j.biortech.2011.08.030","volume":"102","author":"A Parmar","year":"2011","unstructured":"Parmar A, Singh NK, Pandey A, Gnansounou E, Madamwar D (2011) Cyanobacteria and microalgae: a positive prospect for biofuels. Bioresour Technol 102:10163\u201310172","journal-title":"Bioresour Technol"},{"key":"1894_CR36","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1128\/AEM.65.7.2877-2894.1999","volume":"65","author":"RS Pembrey","year":"1999","unstructured":"Pembrey RS, Marshall KC, Schneider RP (1999) Cell surface analysis techniques: what do cell preparation protocols do to cell surface properties? Appl Environ Microbiol 65:2877\u20132894","journal-title":"Appl Environ Microbiol"},{"key":"1894_CR37","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.epsl.2005.03.006","volume":"234","author":"A Ridgwell","year":"2005","unstructured":"Ridgwell A, Zeebe R (2005) The role of the global carbonate cycle in the regulation and evolution of the Earth system. Earth Planet Sci Lett 234:299\u2013315","journal-title":"Earth Planet Sci Lett"},{"key":"1894_CR38","doi-asserted-by":"publisher","first-page":"11059","DOI":"10.1021\/nn3047605","volume":"6","author":"A Sanchez-Iglesias","year":"2012","unstructured":"Sanchez-Iglesias A, Grzelczak M, Altantzis T, Goris B, Perez-Juste J, Bals S, Van Tendeloo G, Donaldson SH Jr, Chmelka BF, Israelachvili JN, Liz-Marzan LM (2012) Hydrophobic interactions modulate self-assembly of nanoparticles. ACS Nano 6:11059\u201311065","journal-title":"ACS Nano"},{"key":"1894_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","volume":"358","author":"PS Stewart","year":"2001","unstructured":"Stewart PS, Costerton JW (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358:135\u2013138","journal-title":"Lancet"},{"key":"1894_CR40","doi-asserted-by":"publisher","first-page":"78132","DOI":"10.1039\/C6RA15025J","volume":"6","author":"L-R Tan","year":"2016","unstructured":"Tan L-R, Xia P-F, Sun X-F, Guo N, Song C, Li Q, Wang S-G (2016) Ecological insights into low-level antibiotics interfered biofilms of Synechococcus elongatus. RSC Adv 6:78132\u201378135","journal-title":"RSC Adv"},{"key":"1894_CR41","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1021\/acssynbio.7b00203","volume":"6","author":"A Taton","year":"2017","unstructured":"Taton A, Ma AT, Ota M, Golden SS, Golden JW (2017) NOT gate genetic circuits to control gene expression in cyanobacteria. ACS Synth Biol 6:2175\u20132182","journal-title":"ACS Synth Biol"},{"key":"1894_CR42","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ijheh.2017.02.003","volume":"220","author":"P V\u00e4litalo","year":"2017","unstructured":"V\u00e4litalo P, Kruglova A, Mikola A, Vahala R (2017) Toxicological impacts of antibiotics on aquatic micro-organisms: a mini-review. Int J Hyg Environ Health 220:558\u2013569","journal-title":"Int J Hyg Environ Health"},{"key":"1894_CR43","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.1021\/es400793x","volume":"47","author":"L Wang","year":"2013","unstructured":"Wang L, Liang W, Yu J, Liang Z, Ruan L, Zhang Y (2013) Flocculation of Microcystis aeruginosa using modified larch tannin. Environ Sci Technol 47:5771\u20135777","journal-title":"Environ Sci Technol"},{"key":"1894_CR44","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00253-005-1991-5","volume":"69","author":"ZW Wang","year":"2005","unstructured":"Wang ZW, Liu Y, Tay JH (2005) Distribution of EPS and cell surface hydrophobicity in aerobic granules. Appl Microbiol Biotechnol 69:469\u2013473","journal-title":"Appl Microbiol Biotechnol"},{"key":"1894_CR45","doi-asserted-by":"crossref","unstructured":"Whitton BA (2012) Ecology of cyanobacteria II: their diversity in space and time. Springer Science and Business Media","DOI":"10.1007\/978-94-007-3855-3"},{"key":"1894_CR46","doi-asserted-by":"publisher","first-page":"59438","DOI":"10.1039\/C6RA11707D","volume":"6","author":"P-F Xia","year":"2016","unstructured":"Xia P-F, Li Q, Tan L-R, Sun X-F, Song C, Wang S-G (2016) Extracellular polymeric substances protect Escherichia coli from organic solvents. RSC Adv 6:59438\u201359444","journal-title":"RSC Adv"},{"key":"1894_CR47","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1016\/j.watres.2013.01.019","volume":"47","author":"H Xu","year":"2013","unstructured":"Xu H, Cai H, Yu G, Jiang H (2013) Insights into extracellular polymeric substances of cyanobacterium Microcystis aeruginosa using fractionation procedure and parallel factor analysis. Water Res 47:2005\u20132014","journal-title":"Water Res"},{"key":"1894_CR48","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.chemosphere.2014.10.061","volume":"117","author":"H Xu","year":"2014","unstructured":"Xu H, Jiang H, Yu G, Yang L (2014) Towards understanding the role of extracellular polymeric substances in cyanobacterial Microcystis aggregation and mucilaginous bloom formation. Chemosphere 117:815\u2013822","journal-title":"Chemosphere"},{"key":"1894_CR49","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fbioe.2016.00004","volume":"4","author":"T Zhu","year":"2016","unstructured":"Zhu T, Dittrich M (2016) Carbonate precipitation through microbial activities in natural environment, and their potential in biotechnology: a review. Front Bioeng Biotechnol 4:4","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-018-1894-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-1894-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-1894-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T10:58:01Z","timestamp":1604141881000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-018-1894-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":49,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1894"],"URL":"https:\/\/doi.org\/10.1007\/s11356-018-1894-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"24 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}