{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:03:29Z","timestamp":1793333009813,"version":"4.5.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Bingol Universitesi","award":["BAP-SSHMYO.2016.00.001"],"award-info":[{"award-number":["BAP-SSHMYO.2016.00.001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s11356-018-2242-5","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T16:54:28Z","timestamp":1526403268000},"page":"20968-20984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":201,"title":["Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage"],"prefix":"10.1007","volume":"25","author":[{"given":"Cuneyt","family":"Caglayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Temel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"Kucukler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"2242_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3.","journal-title":"Methods Enzymol"},{"key":"2242_CR2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.fsi.2017.04.004","volume":"65","author":"G Alak","year":"2017","unstructured":"Alak G, Yeltekin A\u00c7, Tas IH, Ucar A, Parlak V, Topal A, Kocaman EM, Atamanalp M (2017) Investigation of 8-OHdG, CYP1A, HSP70 and transcriptional analyses of antioxidant defence system in liver tissues of rainbow trout exposed to eprinomectin. Fish Shellfish Immunol 65:136\u2013144. https:\/\/doi.org\/10.1016\/j.fsi.2017.04.004.","journal-title":"Fish Shellfish Immunol"},{"key":"2242_CR3","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3945\/an.113.005603","volume":"5","author":"MA Alam","year":"2014","unstructured":"Alam MA, Subhan N, Rahman MM, Uddin SJ, Reza HM, Sarker SD (2014) Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr 5:404\u2013417. https:\/\/doi.org\/10.3945\/an.113.005603","journal-title":"Adv Nutr"},{"key":"2242_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/4016209","volume":"2016","author":"S Alqahtani","year":"2016","unstructured":"Alqahtani S, Mahmoud AM (2016) Gamma-Glutamylcysteine ethyl Ester protects against cyclophosphamide-induced liver injury and hematologic alterations via upregulation of PPAR\u03b3 and attenuation of oxidative stress, inflammation, and apoptosis. Oxidative Med Cell Longev 2016:1\u201314. https:\/\/doi.org\/10.1155\/2016\/4016209","journal-title":"Oxidative Med Cell Longev"},{"key":"2242_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4161\/oxim.2.4.8878","volume":"2","author":"AA Al-Yahya","year":"2009","unstructured":"Al-Yahya AA, Al-Majed AA, Gado AM, Daba MH, Al-Shabanah OA, El-Azab AS, Abd-Allah AR (2009) Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. Oxidative Med Cell Longev 2:207\u2013213. https:\/\/doi.org\/10.4161\/oxim.2.4.8878","journal-title":"Oxidative Med Cell Longev"},{"key":"2242_CR6","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.etap.2015.08.035","volume":"40","author":"A Basu","year":"2015","unstructured":"Basu A, Bhattacharjee A, Samanta A, Bhattacharya S (2015) Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: effect of an l-cysteine based oxovanadium (IV) complex on oxidative stress and DNA damage. Environ Toxicol Pharmacol 40:747\u2013757. https:\/\/doi.org\/10.1016\/j.etap.2015.08.035","journal-title":"Environ Toxicol Pharmacol"},{"key":"2242_CR7","doi-asserted-by":"publisher","first-page":"e22030","DOI":"10.1002\/jbt.22030","volume":"32","author":"F Benzer","year":"2018","unstructured":"Benzer F, Kandemir FM, Ozkaraca M, Kucukler S, Caglayan C (2018a) Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. J Biochem Mol Toxicol 32:e22030. https:\/\/doi.org\/10.1002\/jbt.22030","journal-title":"J Biochem Mol Toxicol"},{"key":"2242_CR8","doi-asserted-by":"publisher","unstructured":"Benzer F, Kandemir FM, Kucukler S, Comakl\u0131 S, Caglayan C (2018b) Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage. Arch Physiol Biochem. https:\/\/doi.org\/10.1080\/13813455.2017.1422766","DOI":"10.1080\/13813455.2017.1422766"},{"key":"2242_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11010-015-2415-1","volume":"405","author":"A Bhattacharjee","year":"2015","unstructured":"Bhattacharjee A, Basu A, Biswas J, Bhattacharya S (2015) Nano-Se attenuates cyclophosphamide-induced pulmonary injury through modulation of oxidative stress and DNA damage in Swiss albino mice. Mol Cell Biochem 405:243\u2013256. https:\/\/doi.org\/10.1007\/s11010-015-2415-1","journal-title":"Mol Cell Biochem"},{"key":"2242_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cbi.2015.06.036","volume":"239","author":"Y Chtourou","year":"2015","unstructured":"Chtourou Y, Aouey B, Kebieche M, Fetoui H (2015) Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-\u03baB and P53 signaling pathways. Chem Biol Interact 239:76\u201386. https:\/\/doi.org\/10.1016\/j.cbi.2015.06.036.","journal-title":"Chem Biol Interact"},{"key":"2242_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2015.11.019","volume":"243","author":"Y Chtourou","year":"2016","unstructured":"Chtourou Y, Aouey B, Aroui S, Kebieche M, Fetoui H (2016) Anti-apoptotic and anti-inflammatory effects of naringin on cisplatin-induced renal injury in the rat. Chem Biol Interact 243:1\u20139. https:\/\/doi.org\/10.1016\/j.cbi.2015.11.019","journal-title":"Chem Biol Interact"},{"key":"2242_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1128\/MCB.00544-08","volume":"29","author":"SS Chung","year":"2009","unstructured":"Chung SS, Kim M, Youn BS, Lee NS, Park JW, Lee IK, Lee YS, Kim JB, Cho YM, Lee HK, Park KS (2009) Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor \u03b3 in human skeletal muscle cells. Mol Cell Biol 29:20\u201330","journal-title":"Mol Cell Biol"},{"key":"2242_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cbi.2015.02.016","volume":"232","author":"G Cuce","year":"2015","unstructured":"Cuce G, \u00c7etinkaya S, Koc T, Esen HH, Limandal C, Balc\u0131 T, Akoz M (2015) Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats. Chem Biol Interact 232:7\u201311. https:\/\/doi.org\/10.1016\/j.cbi.2015.02.016","journal-title":"Chem Biol Interact"},{"key":"2242_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jff.2014.11.020","volume":"12","author":"D Dong","year":"2015","unstructured":"Dong D, Xu L, Yin L, Qi Y, Peng J (2015) Naringin prevents carbon tetrachloride-induced acute liver injury in mice. J Funct Foods 12:179\u2013191. https:\/\/doi.org\/10.1016\/j.jff.2014.11.020","journal-title":"J Funct Foods"},{"key":"2242_CR15","doi-asserted-by":"publisher","first-page":"e21960","DOI":"10.1002\/jbt.21960","volume":"31","author":"E Eldutar","year":"2017","unstructured":"Eldutar E, Kandemir FM, Kucukler S, Caglayan C (2017) Restorative effects of Chrysin pretreatment on oxidant\u2013antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats: an experimental and biochemical study. J Biochem Mol Toxicol 31:e21960. https:\/\/doi.org\/10.1002\/jbt.21960","journal-title":"J Biochem Mol Toxicol"},{"key":"2242_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.biopha.2017.05.103","volume":"92","author":"AA El-Kholy","year":"2017","unstructured":"El-Kholy AA, Elkablawy MA, El-Agamy DS (2017) Lutein mitigates cyclophosphamide induced lung and liver injury via NF-\u03baB\/MAPK dependent mechanism. Biomed Pharmacother 92:519\u2013527. https:\/\/doi.org\/10.1016\/j.biopha.2017.05.103","journal-title":"Biomed Pharmacother"},{"key":"2242_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.lfs.2008.11.012","volume":"84","author":"EO Farombi","year":"2009","unstructured":"Farombi EO, Shrotriya S, Surh YJ (2009) Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-\u03baB and AP-1. Life Sci 84:149\u2013155. https:\/\/doi.org\/10.1016\/j.lfs.2008.11.012","journal-title":"Life Sci"},{"key":"2242_CR18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.etap.2016.05.031","volume":"45","author":"AA Fouad","year":"2016","unstructured":"Fouad AA, Qutub HO, Al-Melhim WN (2016) Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide. Environ Toxicol Pharmacol 45:158\u2013162. https:\/\/doi.org\/10.1016\/j.etap.2016.05.031","journal-title":"Environ Toxicol Pharmacol"},{"key":"2242_CR19","doi-asserted-by":"publisher","first-page":"781","DOI":"10.2165\/00003495-199142050-00005","volume":"42","author":"LH Fraiser","year":"1991","unstructured":"Fraiser LH, Kanekal S, Kehrer JP (1991) Cyclophosphamide toxicity. Drugs 42:781\u2013795","journal-title":"Drugs"},{"key":"2242_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0944-7113(98)80018-4","volume":"5","author":"EM Galati","year":"1998","unstructured":"Galati EM, Monforte MT, d\u2019Aquino A, Miceli N, Di Mauro D, Sanogo R (1998) Effects of naringin on experimental ulcer in rats. Phytomedicine 5:361\u2013366. https:\/\/doi.org\/10.1016\/S0944-7113(98)80018-4","journal-title":"Phytomedicine"},{"key":"2242_CR21","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00432-014-1665-8","volume":"140","author":"MO Germoush","year":"2014","unstructured":"Germoush MO, Mahmoud AM (2014) Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines. J Cancer Res Clin Oncol 140:1103\u20131109. https:\/\/doi.org\/10.1007\/s00432-014-1665-8.","journal-title":"J Cancer Res Clin Oncol"},{"key":"2242_CR22","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1210\/me.2002-0020","volume":"16","author":"GD Girnun","year":"2002","unstructured":"Girnun GD, Domann FE, Moore SA, Robbins ME (2002) Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol Endocrinol 16:2793\u20132801. https:\/\/doi.org\/10.1210\/me.2002-0020","journal-title":"Mol Endocrinol"},{"key":"2242_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3109\/13880209.2014.908399","volume":"53","author":"E Habibi","year":"2015","unstructured":"Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, Ahmadi A (2015) Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol 53:10\u201315. https:\/\/doi.org\/10.3109\/13880209.2014.908399.","journal-title":"Pharm Biol"},{"key":"2242_CR24","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/0006-2952(88)90539-4","volume":"37","author":"GR Haenen","year":"1988","unstructured":"Haenen GR, Vermeulen NP, Tsoi JNTT, Ragetli HM, Timmerman H, Bast A (1988) Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein. Biochem Pharmacol 37:1933\u20131938. https:\/\/doi.org\/10.1016\/0006-2952(88)90539-4","journal-title":"Biochem Pharmacol"},{"key":"2242_CR25","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/jbt.21570","volume":"28","author":"MH Hassan","year":"2014","unstructured":"Hassan MH, Ghobara M, Abd-Allah GM (2014) Modulator effects of meloxicam against doxorubicin-induced nephrotoxicity in mice. J Biochem Mol Toxicol 28:337\u2013346. https:\/\/doi.org\/10.1002\/jbt.21570.","journal-title":"J Biochem Mol Toxicol"},{"key":"2242_CR26","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1016\/S0024-3205(01)01363-7","volume":"69","author":"SM Jeon","year":"2001","unstructured":"Jeon SM, Bok SH, Jang MK, Lee MK, Nam KT, Park YB, Choi MS (2001) Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci 69:2855\u20132866. https:\/\/doi.org\/10.1016\/S0024-3205(01)01363-7.","journal-title":"Life Sci"},{"key":"2242_CR27","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/jphp.12016","volume":"65","author":"S Jnaneshwari","year":"2013","unstructured":"Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, Thirunavukkarasu C, Girish KS (2013) Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines. J Pharm Pharmacol 65:604\u2013614. https:\/\/doi.org\/10.1111\/jphp.12016.","journal-title":"J Pharm Pharmacol"},{"key":"2242_CR28","doi-asserted-by":"publisher","unstructured":"Kandemir FM, Kucukler S, Caglayan C, Gur C, Batil AA, G\u00fcl\u00e7in \u0130 (2017a) Therapeutic effects of silymarin and naringin on methotrexate-induced nephrotoxicity in rats: biochemical evaluation of anti-inflammatory, antiapoptotic, and antiautophagic properties. J Food Biochem 41(5). https:\/\/doi.org\/10.1111\/jfbc.12398","DOI":"10.1111\/jfbc.12398"},{"key":"2242_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.17094\/ataunivbd.347970","volume":"12","author":"FM Kandemir","year":"2017","unstructured":"Kandemir FM, K\u00fc\u00e7\u00fckler S, \u00c7a\u011flayan C (2017b) Beneficial effects of silymarin and naringin against methotrexate-induced hepatotoxicity in rats. Atat\u00fcrk \u00dcniv Vet Bil Derg 12:167\u2013177. https:\/\/doi.org\/10.17094\/ataunivbd.347970","journal-title":"Atat\u00fcrk \u00dcniv Vet Bil Derg"},{"key":"2242_CR30","doi-asserted-by":"publisher","unstructured":"Kandemir FM, Ozkaraca M, K\u00fc\u00e7\u00fckler S, Caglayan C, Hanedan B (2017c) Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-\u03b21 and oxidative DNA damage. Toxin Rev:1\u20137. https:\/\/doi.org\/10.1080\/15569543.2017.1364268","DOI":"10.1080\/15569543.2017.1364268"},{"key":"2242_CR31","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.fct.2013.11.023","volume":"64","author":"SH Kim","year":"2014","unstructured":"Kim SH, Lee IC, Baek HS, Shin IS, Moon C, Bae CS, Kim HC (2014) Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats. Food Chem Toxicol 64:110\u2013118. https:\/\/doi.org\/10.1016\/j.fct.2013.11.023","journal-title":"Food Chem Toxicol"},{"key":"2242_CR32","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","volume":"40","author":"G Kroemer","year":"2010","unstructured":"Kroemer G, Mari\u00f1o G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40:280\u2013293. https:\/\/doi.org\/10.1016\/j.molcel.2010.09.023.","journal-title":"Mol Cell"},{"key":"2242_CR33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1179\/ACB.2011.001","volume":"66","author":"N Lameire","year":"2011","unstructured":"Lameire N, Kruse VIBEKE, Rottey S (2011) Nephrotoxicity of anticancer drugs\u2014an underestimated problem? Acta Clin Belg 66:337\u2013345","journal-title":"Acta Clin Belg"},{"key":"2242_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/149185","volume":"2014","author":"G Landskron","year":"2014","unstructured":"Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA (2014) Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014:1\u201319. https:\/\/doi.org\/10.1155\/2014\/149185","journal-title":"J Immunol Res"},{"key":"2242_CR35","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/j.1460-2075.1992.tb05139.x.","volume":"11","author":"V Laudet","year":"1992","unstructured":"Laudet V, Hanni C, Coll J, Catzeflis F, Stehelin D (1992) Evolution of the nuclear receptor gene superfamily. EMBO J 11:1003\u20131013. https:\/\/doi.org\/10.1002\/j.1460-2075.1992.tb05139.x.","journal-title":"EMBO J"},{"key":"2242_CR36","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","volume":"7","author":"RA Lawrence","year":"1976","unstructured":"Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 7:952\u2013958","journal-title":"Biochem Biophys Res Commun"},{"key":"2242_CR37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"2242_CR38","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.etp.2011.01.016","volume":"64","author":"AM Mahmoud","year":"2012","unstructured":"Mahmoud AM (2012) Influence of rutin on biochemical alterations in hyperammonemia in rats. Exp Toxicol Pathol 64:783\u2013789. https:\/\/doi.org\/10.1016\/j.etp.2011.01.016","journal-title":"Exp Toxicol Pathol"},{"key":"2242_CR39","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","volume":"92","author":"AM Mahmoud","year":"2014","unstructured":"Mahmoud AM (2014) Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPAR\u03b3 and abrogation of oxidative stress and inflammation. Can J Physiol Pharmacol 92:717\u2013724. https:\/\/doi.org\/10.1139\/cjpp-2014-0204","journal-title":"Can J Physiol Pharmacol"},{"key":"2242_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-015-0491-1","volume":"10","author":"AM Mahmoud","year":"2015","unstructured":"Mahmoud AM, Al Dera HS (2015) 18\u03b2-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPAR\u03b3 and Nrf2 upregulation. Genes Nutr 10:41. https:\/\/doi.org\/10.1007\/s12263-015-0491-1","journal-title":"Genes Nutr"},{"key":"2242_CR41","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","volume":"277","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Mohammed HM, Khadrawy SM, Galaly SR (2017) Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2\/ARE\/HO-1, PPAR\u03b3 and TGF-\u03b21\/Smad3 signaling, and amelioration of oxidative stress and inflammation. Chem Biol Interact 277:146\u2013158. https:\/\/doi.org\/10.1016\/j.cbi.2017.09.015","journal-title":"Chem Biol Interact"},{"key":"2242_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.7324\/JAPS.2017.70615","volume":"7","author":"DF Mansour","year":"2017","unstructured":"Mansour DF, Salama AA, Hegazy RR, Omara EA, Nada SA (2017) Whey protein isolate protects against cyclophosphamide-induced acute liver and kidney damage in rats. J Appl Pharm Sci 7:111\u2013120. https:\/\/doi.org\/10.7324\/JAPS.2017.70615","journal-title":"J Appl Pharm Sci"},{"key":"2242_CR43","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejphar.2014.01.065","volume":"728","author":"EM Mantawy","year":"2014","unstructured":"Mantawy EM, El-Bakly WM, Esmat A, Badr AM, El-Demerdash E (2014) Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol 728:107\u2013118. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.065","journal-title":"Eur J Pharmacol"},{"key":"2242_CR44","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1053\/j.gastro.2003.08.030","volume":"125","author":"SE McKim","year":"2003","unstructured":"McKim SE, G\u00e4bele E, Isayama F, Lambert JC, Tucker LM, Wheeler MD, Arteel GE (2003) Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology 125:1834\u20131844. https:\/\/doi.org\/10.1053\/j.gastro.2003.08.030","journal-title":"Gastroenterology"},{"key":"2242_CR45","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313\u2013326. https:\/\/doi.org\/10.1016\/j.cell.2010.01.028","journal-title":"Cell"},{"key":"2242_CR46","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.canlet.2008.09.013","volume":"274","author":"DO Moon","year":"2009","unstructured":"Moon DO, Kim MO, Kang SH, Choi YH, Kim GY (2009) Sulforaphane suppresses TNF-\u03b1-mediated activation of NF-\u03baB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. Cancer Lett 274:132\u2013142. https:\/\/doi.org\/10.1016\/j.canlet.2008.09.013","journal-title":"Cancer Lett"},{"key":"2242_CR47","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/j.fct.2010.05.067","volume":"48","author":"TM Motawi","year":"2010","unstructured":"Motawi TM, Sadik NA, Refaat A (2010) Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: an experimental study on rat myocardium, testicles and urinary bladder. Food Chem Toxicol 48:2326\u20132336. https:\/\/doi.org\/10.1016\/j.fct.2010.05.067","journal-title":"Food Chem Toxicol"},{"key":"2242_CR48","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cbi.2015.02.021","volume":"231","author":"S Nafees","year":"2015","unstructured":"Nafees S, Rashid S, Ali N, Hasan SK, Sultana S (2015) Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NF\u03baB\/MAPK pathway. Chem Biol Interact 231:98\u2013107. https:\/\/doi.org\/10.1016\/j.cbi.2015.02.021","journal-title":"Chem Biol Interact"},{"key":"2242_CR49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","volume":"16","author":"ZA Placer","year":"1966","unstructured":"Placer ZA, Cushmanni LL, Johnson BC (1966) Estimation of products of lipid peroxidation (as malondialdehyde) in biochemical systems. Anal Biochem 16:359\u2013364. https:\/\/doi.org\/10.1016\/0003-2697(66)90167-9","journal-title":"Anal Biochem"},{"key":"2242_CR50","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11010-012-1250-x","volume":"365","author":"MU Rehman","year":"2012","unstructured":"Rehman MU, Tahir M, Ali F, Qamar W, Lateef A, Khan R, Sultana S (2012) Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid. Mol Cell Biochem 365:119\u2013127. https:\/\/doi.org\/10.1007\/s11010-012-1250-x","journal-title":"Mol Cell Biochem"},{"key":"2242_CR51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.taap.2014.02.022","volume":"277","author":"BD Sahu","year":"2014","unstructured":"Sahu BD, Tatireddy S, Koneru M, Borkar RM, Kumar JM, Kuncha M, Sistla R (2014) Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol 277:8\u201320. https:\/\/doi.org\/10.1016\/j.taap.2014.02.022","journal-title":"Toxicol Appl Pharmacol"},{"key":"2242_CR52","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"2242_CR53","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.urology.2012.06.053","volume":"80","author":"O Sinanoglu","year":"2012","unstructured":"Sinanoglu O, Yener AN, Ekici S, Midi A, Aksungar FB (2012) The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. Urology 80:1392\u201313e1. https:\/\/doi.org\/10.1016\/j.urology.2012.06.053","journal-title":"Urology"},{"key":"2242_CR54","first-page":"737","volume":"3","author":"M Singh","year":"2014","unstructured":"Singh M, Kumar N, Shuaib M, Garg VK, Sharma A (2014) A review on renal protective agents for cyclophosphamide induced nephrotoxicity. World J Pharm Pharmaceut Sci 3:737\u2013747","journal-title":"World J Pharm Pharmaceut Sci"},{"key":"2242_CR55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"YI Sun","year":"1988","unstructured":"Sun YI, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497\u2013500","journal-title":"Clin Chem"},{"key":"2242_CR56","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nrc1189","volume":"3","author":"YJ Surh","year":"2003","unstructured":"Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768\u2013780. https:\/\/doi.org\/10.1038\/nrc1189","journal-title":"Nat Rev Cancer"},{"key":"2242_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21995","volume":"31","author":"P Taslimi","year":"2017","unstructured":"Taslimi P, Caglayan C, Gulcin \u0130 (2017) The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and \u03b1-glycosidase enzymes: an antidiabetic, anticholinergic, and antiepileptic study. J Biochem Mol Toxicol 31:e21995. https:\/\/doi.org\/10.1002\/jbt.21995","journal-title":"J Biochem Mol Toxicol"},{"key":"2242_CR58","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.chemosphere.2017.02.047","volume":"175","author":"A Topal","year":"2017","unstructured":"Topal A, Alak G, Ozkaraca M, Yeltekin AC, Comakl\u0131 S, Ac\u0131l G, Kokturk M, Atamanalp M (2017) Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity. Chemosphere 175:186\u2013191. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.02.047","journal-title":"Chemosphere"},{"key":"2242_CR59","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.bbrc.2007.12.088","volume":"366","author":"B Vandewalle","year":"2008","unstructured":"Vandewalle B, Moerman E, Lefebvre B, Defrance F, Gmyr V, Lukowiak B, Conte JK, Pattou F (2008) PPAR\u03b3-dependent and-independent effects of rosiglitazone on lipotoxic human pancreatic islets. Biochem Biophys Res Commun 366:1096\u20131101. https:\/\/doi.org\/10.1016\/j.bbrc.2007.12.088","journal-title":"Biochem Biophys Res Commun"},{"key":"2242_CR60","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.fct.2013.03.028","volume":"57","author":"M Zarei","year":"2013","unstructured":"Zarei M, Shivanandappa T (2013) Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice. Food Chem Toxicol 57:179\u2013184. https:\/\/doi.org\/10.1016\/j.fct.2013.03.028","journal-title":"Food Chem Toxicol"},{"key":"2242_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/srep17536","volume":"5","author":"H Zhu","year":"2015","unstructured":"Zhu H, Long MH, Wu J, Wang MM, Li XY, Shen H, Li SL (2015) Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid. Sci Rep 5:17536. https:\/\/doi.org\/10.1038\/srep17536","journal-title":"Sci Rep"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-018-2242-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-2242-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-2242-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T15:00:55Z","timestamp":1661266855000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-018-2242-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":61,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2242"],"URL":"https:\/\/doi.org\/10.1007\/s11356-018-2242-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"6 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was designed and conducted according to ethical norms approved by the Animal Experimentation Ethics Committee of the Bingol University (Bingol, Turkey) (Protocol No. 2016-4\/5).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest\n                      .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}