{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:51:37Z","timestamp":1786981897402,"version":"build-2736575974"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11356-019-04155-9","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T09:29:28Z","timestamp":1547371768000},"page":"6234-6243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Do Amazon turtles exposed to environmental concentrations of the antineoplastic drug cyclophosphamide present mutagenic damages? If so, would such damages be reversible?"],"prefix":"10.1007","volume":"26","author":[{"given":"Carlos","family":"Mesak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus Flores","family":"Montalv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroliny F\u00e1tima Chaves","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna de Oliveira","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Pereira da Costa","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Chagas","family":"Quint\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Malafaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"4155_CR1","doi-asserted-by":"publisher","unstructured":"Ahlmann M, Hempel G (2016) The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy. Cancer Chemother Pharmacol 78(4):661\u2013671. https:\/\/doi.org\/10.1007\/s00280-016-3152-1","DOI":"10.1007\/s00280-016-3152-1"},{"key":"4155_CR2","volume-title":"Standard methods for the examination of water and wastewater. 20. ed","author":"American Public Health Association (APHA)","year":"1997","unstructured":"American Public Health Association (APHA) (1997) Standard methods for the examination of water and wastewater. 20. ed. APHA, AWWA, WPCR, New York 1194 p"},{"key":"4155_CR3","unstructured":"American Society of Ichthyologists and Herpetologists (ASIH) (2004) Herpetological Animal Care and Use Committee (HACC). Guidelines for use of live amphibians and reptiles in field and laboratory research. Available in: http:\/\/www.asih.org\/sites\/default\/files\/documents\/resources\/guidelinesherpsresearch2004.pdf . Access 05 May 2018"},{"issue":"1\u20132","key":"4155_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0027-5107(95)00039-L","volume":"330","author":"D Anderson","year":"1995","unstructured":"Anderson D, Bishop JB, Garner RC, Ostrosky-Wegman P, Selby PB (1995) Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res 330(1\u20132):115\u2013181","journal-title":"Mutat Res"},{"issue":"1","key":"4155_CR5","first-page":"61","volume":"5","author":"H Arikan","year":"2009","unstructured":"Arikan H, Gocmen B, Atatur M, Kumlutas Y, Cicek K (2009) Morphology of peripheral blood cells from various Turkish snake. Northwest J Zool 5(1):61\u201373","journal-title":"Northwest J Zool"},{"issue":"23","key":"4155_CR6","doi-asserted-by":"publisher","first-page":"19021","DOI":"10.1007\/s11356-017-9525-0","volume":"24","author":"T Azuma","year":"2017","unstructured":"Azuma T, Arima N, Tsukada A, Hirami S, Matsuoka R, Moriwake R, Ishiuchi H, Inoyama T, Teranishi Y, Yamaoka M, Ishida M, Hisamatsu K, Yunoki A, Mino Y (2017) Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river. Environ Sci Pollut Res 24(23):19021\u201319030","journal-title":"Environ Sci Pollut Res"},{"key":"4155_CR7","doi-asserted-by":"publisher","first-page":"109e116","DOI":"10.1897\/02-555","volume":"23","author":"D Bain","year":"2004","unstructured":"Bain D, Buttemer WA, Astheimer L, Fildes K, Hooper MJ (2004) Effects of sublethal fenitrothion ingestion on cholinesterase inhibition, standard metabolism, thermal preference and prey-capture ability in the Australian central bearded dragon (Pogonavitticeps, agamidae). Environ Toxicol Chem 23:109e116","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"4155_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.envint.2011.10.002","volume":"39","author":"JP Besse","year":"2012","unstructured":"Besse JP, Latour JF, Garric J (2012) Anticancer drugs in surface waters: what can we say about the occurrence and environmental significance of cytotoxic, cytostatic and endocrine therapy drugs? Environ Int 39(1):73\u201386. https:\/\/doi.org\/10.1016\/j.envint.2011.10.002 Epub 2011 Nov 8","journal-title":"Environ Int"},{"key":"4155_CR9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.scitotenv.2013.11.145","volume":"473\u2013474","author":"V Booker","year":"2014","unstructured":"Booker V, Halsall C, Llewellyn N, Johnson A, Williams R (2014) Prioritising anticancer drugs for environmental monitoring and risk assessment purposes. Sci Total Environ 473\u2013474:159\u2013170. https:\/\/doi.org\/10.1016\/j.scitotenv.2013.11.145 Epub 2013 Dec 22","journal-title":"Sci Total Environ"},{"issue":"3","key":"4155_CR10","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.yrtph.2014.04.006","volume":"69","author":"C Bouissou-Schurtz","year":"2014","unstructured":"Bouissou-Schurtz C, Houeto P, Guerbet M, Bachelot M, Casellas C, Mauclaire AC, Panetier P, Delval C, Masset D (2014) Ecological risk assessment of the presence of pharmaceutical residues in a French national water survey. Regul Toxicol Pharmacol 69(3):296\u2013303. https:\/\/doi.org\/10.1016\/j.yrtph.2014.04.006 Epub 2014 Apr 21","journal-title":"Regul Toxicol Pharmacol"},{"key":"4155_CR11","doi-asserted-by":"publisher","first-page":"1643e1651","DOI":"10.1016\/j.chemosphere.2003.09.030","volume":"54","author":"SM Brasfield","year":"2004","unstructured":"Brasfield SM, Bradham K, Wells JB, Talent LG, Lanno RP, Janz DM (2004) Development of a terrestrial vertebrate model for assessing bioavailability of cadmium in the fence lizard (Sceloporusundulatus) and in ovo effects on hatchling size and thyroid function. Chemosphere 54:1643e1651","journal-title":"Chemosphere"},{"issue":"23","key":"4155_CR12","doi-asserted-by":"publisher","first-page":"7242","DOI":"10.1021\/es0609405","volume":"40","author":"IJ Buerge","year":"2006","unstructured":"Buerge IJ, Buser HR, Poiger T, M\u00fcller MD (2006) Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters. Environ Sci Technol 40(23):7242\u20137250","journal-title":"Environ Sci Technol"},{"key":"4155_CR13","first-page":"495e502","volume":"55","author":"J Burger","year":"1998","unstructured":"Burger J, Carruth-Hinchey C, Ondroff J, McMahon M, Gibbons JW, Gochfeld M (1998) Effects of lead on behavior, growth, and survival of hatchling slider turtles. J Toxicol Environ Health Part A 55:495e502","journal-title":"J Toxicol Environ Health Part A"},{"issue":"1","key":"4155_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2744\/CCB-0926.1","volume":"13","author":"VH Cantarelli","year":"2014","unstructured":"Cantarelli VH, Malvasio A, Verdade LM (2014) Brazil\u2019s Podocnemis expansa Conservation Program: Retrospective and Future Directions. Chelonian Conservation and Biol 13(1):124\u2013128","journal-title":"Chelonian Conservation and Biol"},{"key":"4155_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.fct.2004.12.014","volume":"43","author":"T \u00c7avas","year":"2005","unstructured":"\u00c7avas T, Garanko NN, Arkhipchuk VV (2005) Induction of micronuclei and binuclei in blood, gill and liver cells of shes subchronically exposed to cadmium chloride and copper sulphate. Food Chem Toxicol 43:569\u2013574","journal-title":"Food Chem Toxicol"},{"key":"4155_CR16","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.envpol.2015.12.017","volume":"210","author":"M \u010cesen","year":"2016","unstructured":"\u010cesen M, Eler\u0161ek T, Novak M, \u017degura B, Kosjek T, Filipi\u010d M, Heath E (2016) Ecotoxicity and genotoxicity of cyclophosphamide, ifosfamide, their metabolites\/transformation products and their mixtures. Environ Pollut 210:192\u2013201. https:\/\/doi.org\/10.1016\/j.envpol.2015.12.017 Epub 2015 Dec 29","journal-title":"Environ Pollut"},{"issue":"2","key":"4155_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1053\/j.jepm.2009.04.006","volume":"18","author":"JA Claver","year":"2009","unstructured":"Claver JA, Quaglia AIE (2009) Comparative morphology, development and function of blood cells in nonmammalian vertebrates. J Exot Pet Med 18(2):87\u201397","journal-title":"J Exot Pet Med"},{"issue":"6335","key":"4155_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1126\/science.aal2011","volume":"356","author":"E Crist","year":"2017","unstructured":"Crist E, Mora C, Engelman R (2017) The interaction of human population, food production, and biodiversity protection. Science 356(6335):260\u2013264","journal-title":"Science"},{"issue":"3","key":"4155_CR19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/mutage\/16.3.213","volume":"16","author":"J Crott","year":"2001","unstructured":"Crott J, Fenech M (2001) Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. Mutagenesis 16(3):213\u2013217","journal-title":"Mutagenesis"},{"key":"4155_CR20","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1002\/etc.3151","volume":"34","author":"S Eggins","year":"2015","unstructured":"Eggins S, Schneider L, Krikowa F, Vogt RC, Da Silveira R, Maher W (2015) Mercury concentrations in different tissues of turtle and Caiman species from the Rio Purus, Amazonas, Brazil. Environ Toxicol Chem 34:2771\u20132781. https:\/\/doi.org\/10.1002\/etc.3151","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR21","first-page":"2016","volume":"1-12","author":"CC Eisemberg","year":"2016","unstructured":"Eisemberg CC, Balestra RAM, Farmelli S, Pereira FF, Bernardes VCD, Vogt RC (2016) Vulnerability of Giant South American Turtle(Podocnemis expansa) nesting habitat to climate-change-induced alterations to fluvial cycles. Trop Conserv Science 1-12:2016","journal-title":"Trop Conserv Science"},{"key":"4155_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0027-5107(00)00065-8","volume":"455","author":"M Fenech","year":"2000","unstructured":"Fenech M (2000) The in vitro micronucleus technique. Mutat Res Fundam Mol Mech Mutagen 455:81\u201395","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"4155_CR23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.envpol.2014.07.002","volume":"193","author":"L Ferrando-Climent","year":"2014","unstructured":"Ferrando-Climent L, Rodriguez-Mozaz S, Barcelo D (2014) Incidence of anticancer drugs in an aquatic urban system: from hospital effluents through urban wastewater to natural environment. Environ Pollut 193:216\u2013223","journal-title":"Environ Pollut"},{"issue":"4","key":"4155_CR24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/17441692.2017.1396354","volume":"13","author":"EM Fonseca","year":"2018","unstructured":"Fonseca EM (2018) How can a policy foster local pharmaceutical production and still protect public health? Lessons from the health\u2013industry complex in Brazil. Glob Public Health 13(4):489\u2013502","journal-title":"Glob Public Health"},{"key":"4155_CR25","doi-asserted-by":"publisher","first-page":"45e52","DOI":"10.1016\/0143-1471(82)90044-7","volume":"28","author":"RJ Hall","year":"1982","unstructured":"Hall RJ, Clark DR Jr (1982) Responses of the iguanid lizards Anoliscarolinensis to four organophosphorous pesticides. Environ Pollut (Series A) 28:45e52","journal-title":"Environ Pollut (Series A)"},{"key":"4155_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jwpe.2017.11.012","volume":"21","author":"P Hamon","year":"2018","unstructured":"Hamon P, Moulin P, Ercolei L, Marrot B (2018) Oncological ward wastewater treatment by membrane bioreactor: acclimation feasibility and pharmaceuticals removal performances. J Water Process Eng 21:9\u201326","journal-title":"J Water Process Eng"},{"key":"4155_CR27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/em.2850250303","volume":"25","author":"A Hartmann","year":"1995","unstructured":"Hartmann A, Herkommer K, Gl\u00fcck M, Speit G (1995) DNA-damaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single-cell gel test (comet assay). Environ Mol Mutagen 25:180\u2013187","journal-title":"Environ Mol Mutagen"},{"key":"4155_CR28","doi-asserted-by":"publisher","first-page":"14687","DOI":"10.1007\/s11356-016-7069-3","volume":"23","author":"E Heath","year":"2016","unstructured":"Heath E, Filipic M, Kosjek T, Isidori M (2016) Fate and effects of the residues of anticancer drugs in the environment. Environ Sci Pollut Res 23:14687\u201314691","journal-title":"Environ Sci Pollut Res"},{"issue":"2","key":"4155_CR29","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","volume":"69","author":"MD Hernando","year":"2006","unstructured":"Hernando MD, Mezcua M, Fern\u00e1ndez-Alba AR, Barcel\u00f3 D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69(2):334\u2013342. https:\/\/doi.org\/10.1016\/j.talanta.2005.09.037 Epub 2005 Nov 18","journal-title":"Talanta"},{"issue":"1","key":"4155_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00244-005-0099-3","volume":"51","author":"RR Holem","year":"2006","unstructured":"Holem RR, Hopkins WA, Talent LG (2006a) Effect of acute exposure to malathion and lead on sprint performance of the western fence lizard (Sceloporus occidentalis). Arch Environ Contam Toxicol 51(1):111\u2013116 Epub 2006 Feb 7","journal-title":"Arch Environ Contam Toxicol"},{"key":"4155_CR31","doi-asserted-by":"publisher","first-page":"111e116","DOI":"10.1007\/s00244-005-0099-3","volume":"51","author":"RR Holem","year":"2006","unstructured":"Holem RR, Hopkins WA, Talent LG (2006b) Effect of acute exposure to malathion and lead on sprint performance of the western fence lizard (Sceloporusoccidentalis). Arch Environ Contam Toxicol 51:111e116","journal-title":"Arch Environ Contam Toxicol"},{"issue":"1","key":"4155_CR32","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.envpol.2007.05.017","volume":"152","author":"RR Holem","year":"2008","unstructured":"Holem RR, Hopkins WA, Talent LG (2008) Effects of repeated exposure to malathion on growth, food consumption, and locomotor performance of the western fence lizard (Sceloporus occidentalis). Environ Pollut 152(1):92\u201398 Epub 2007 Jul 3","journal-title":"Environ Pollut"},{"issue":"10","key":"4155_CR33","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1002\/etc.5620191001","volume":"19","author":"WA Hopkins","year":"2000","unstructured":"Hopkins WA (2000a) Reptile toxicology: challenges and opportunities on the last frontier in vertebrate ecotoxicology. Environ Toxicol Chem 19(10):2391\u20132393","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR34","doi-asserted-by":"publisher","first-page":"2391e2393","DOI":"10.1002\/etc.5620190412","volume":"19","author":"WA Hopkins","year":"2000","unstructured":"Hopkins WA (2000b) Reptile toxicology: challenges and opportunities on the last frontier in vertebrate ecotoxicology. Environ Toxicol Chem 19:2391e2393","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR35","doi-asserted-by":"publisher","first-page":"1258e1263","DOI":"10.1002\/etc.5620180627","volume":"18","author":"WA Hopkins","year":"1999","unstructured":"Hopkins WA, Rowe CL, Cogndon JD (1999) Elevated trace element concentrations and standard metabolic rate in banded water snakes (Nerodia fasciata) exposed to coal combustion wastes. Environ Toxicol Chem 18:1258e1263","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR36","doi-asserted-by":"publisher","first-page":"906e913","DOI":"10.1002\/etc.5620210504","volume":"21","author":"WA Hopkins","year":"2002","unstructured":"Hopkins WA, Roe JH, Snodgrass JW, Staub BP, Jackson BP, Congdon JD (2002) Effects of chronic dietary exposure to trace elements on banded water snakes (Nerodia fasciata). Environ Toxicol Chem 21:906e913","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR37","doi-asserted-by":"publisher","first-page":"221e225","DOI":"10.1016\/j.ecoenv.2005.03.018","volume":"64","author":"DE Jones","year":"2006","unstructured":"Jones DE, Holladay SD (2006) Excretion of three heavy metals in the shed skin of exposed corn snakes (Elaphe guttata). Ecotoxicol Environ Saf 64:221e225","journal-title":"Ecotoxicol Environ Saf"},{"key":"4155_CR38","doi-asserted-by":"publisher","first-page":"18892","DOI":"10.1007\/s11356-016-7080-8","volume":"23","author":"R Kaur","year":"2016","unstructured":"Kaur R, Dua A (2016) Fish liver and gill cells as cytogenotoxic indicators in assessment of water quality. Environ Sci Pollut Res 23:18892\u201318900","journal-title":"Environ Sci Pollut Res"},{"key":"4155_CR39","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.trac.2011.04.007","volume":"30","author":"T Kosjek","year":"2011","unstructured":"Kosjek T, Heath E (2011) Occurrence, fate and determination of cytostatic pharmaceuticals in the environment. Trends Anal Chem 30:1065\u20131087","journal-title":"Trends Anal Chem"},{"key":"4155_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-80414-4","volume-title":"The reproductive biology of the Chelonia","author":"G Kuchling","year":"1999","unstructured":"Kuchling G (1999) The reproductive biology of the Chelonia. Springer, Vergal Berlin Heidelberg"},{"issue":"15","key":"4155_CR41","doi-asserted-by":"publisher","first-page":"14791","DOI":"10.1007\/s11356-014-3902-8","volume":"23","author":"K K\u00fcmmerer","year":"2016","unstructured":"K\u00fcmmerer K, Hai\u00df A, Schuster A, Hein A (2016) Ebert 4. Antineoplastic compounds in the environment-substances of special concern. Environ Sci Pollut Res Int 23(15):14791\u201314804. https:\/\/doi.org\/10.1007\/s11356-014-3902-8 Epub 2014 Dec 6","journal-title":"Environ Sci Pollut Res Int"},{"key":"4155_CR42","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1139\/cjz-2012-0143","volume":"90","author":"N Lara","year":"2012","unstructured":"Lara N, Marques TS, Montelo KM, Ata\u00eddes AG, Verdade LM, Malv\u00e1sio A, Camargo PB (2012) A trophic study of the sympatric Amazonian freshwater turtles Podocnemis unifilis and Podocnemis expansa (Testudines, Podocnemidae) using carbon and nitrogen stable isotope analyses. Can J Zool 90:1394\u20131401","journal-title":"Can J Zool"},{"issue":"6","key":"4155_CR43","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/mutage\/geq039","volume":"25","author":"L Hegarat Le","year":"2010","unstructured":"Le Hegarat L, Dumont J, Josse R, Huet S, Lanceleur R, Mourot A, Poul JM, Guguen-Guillouzo C, Guillouzo A, Fessard V (2010) Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays. Mutagenesis 25(6):555\u2013560. https:\/\/doi.org\/10.1093\/mutage\/geq039 Epub 2010 Jul 30","journal-title":"Mutagenesis"},{"key":"4155_CR44","unstructured":"Lovel DP (2013) Draft report on Statistical issues related to OECD in vitro genotoxicity Test Guidelines. available in: http:\/\/www.oecd.org\/env\/ehs\/testing\/Stat%20report%20TG%20473_487.pdf . Accessed 15 Nov 2016"},{"issue":"1","key":"4155_CR45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.chemosphere.2006.05.051","volume":"66","author":"SN Mahnik","year":"2007","unstructured":"Mahnik SN, Lenz K, Weissenbacher N, Mader RM, Fuerhacker M (2007) Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system. Chemosphere 66(1):30\u201337 Epub 2006 Jul 12","journal-title":"Chemosphere"},{"key":"4155_CR46","doi-asserted-by":"publisher","first-page":"1525e1534","DOI":"10.1016\/j.chemosphere.2007.03.021","volume":"68","author":"RM Mann","year":"2007","unstructured":"Mann RM, S\u00e1nchez-Hern\u00e1ndez JC, Serra EA, Soares AMVM (2007) Bioaccumulation of Cd by a European lacertid lizards after chronic exposure to Cd-contaminated food. Chemosphere 68:1525e1534","journal-title":"Chemosphere"},{"key":"4155_CR47","doi-asserted-by":"publisher","first-page":"983e990","DOI":"10.1007\/s00128-004-0340-1","volume":"72","author":"A Marco","year":"2004","unstructured":"Marco A, L\u00f3pez-Vicente M, P\u00e9rez-Mellado V (2004) Arsenic uptake by reptile flexible-shelled eggs from contaminated nest substrates and toxic effects on embryos. Bull Environ Contam Toxicol 72:983e990","journal-title":"Bull Environ Contam Toxicol"},{"issue":"3","key":"4155_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5818\/1529-9651.15.3.45","volume":"15","author":"J Mayer","year":"2005","unstructured":"Mayer J, Knoll J, Innis C, Mitchell AM (2005) Characterizing the hematologic and plasma chemistry profiles of captive Chinese water dragons. Physignathus oncincinus. J Herpetol Med Surg 15(3):16\u201323","journal-title":"J Herpetol Med Surg"},{"issue":"5","key":"4155_CR49","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1897\/07-312.1","volume":"27","author":"CA McFarland","year":"2008","unstructured":"McFarland CA, Quinn MJ Jr, Bazar MA, Remick AK, Talent LG, Johnson MS (2008) Toxicity of oral exposure to 2,4,6-trinitrotoluene in the western fence lizard (Sceloporus occidentalis). Environ Toxicol Chem 27(5):1102\u20131111. https:\/\/doi.org\/10.1897\/07-312.1","journal-title":"Environ Toxicol Chem"},{"issue":"5","key":"4155_CR50","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1897\/08-419.1","volume":"28","author":"CA McFarland","year":"2009","unstructured":"McFarland CA, Quinn MJ Jr, Bazar MA, Talent LG, Johnson MS (2009) Toxic effects of oral hexahydro-1,3,5-trinitro-1,3,5-triazine in the western fence lizard (Sceloporus occidentalis). Environ Toxicol Chem 28(5):1043\u20131050. https:\/\/doi.org\/10.1897\/08-419.1","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR51","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10646-010-0580-2","volume":"20","author":"G Mohanty","year":"2011","unstructured":"Mohanty G, Mohanty J, Nayak AK, Mohanty S, Dutta SK (2011) Application of comet assay in the study of DNA damage and recovery in rohu (Labeo rohita) fingerlings after an exposure to phorate, an organophosphate pesticide. Ecotoxicology 20:283\u2013292","journal-title":"Ecotoxicology"},{"issue":"1","key":"4155_CR52","doi-asserted-by":"publisher","first-page":"48.53","DOI":"10.2307\/1564289","volume":"24","author":"D Moll","year":"1990","unstructured":"Moll D (1990) Population sizes and foraging ecology in a tropical freshwater stream turtle community. J Herpetol 24(1):48.53","journal-title":"J Herpetol"},{"key":"4155_CR53","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195102291.001.0001","volume-title":"The ecology, exploitation and conservation of river turtles","author":"D Moll","year":"2004","unstructured":"Moll D, Moll EO (2004) The ecology, exploitation and conservation of river turtles. Oxford University Press, New York. 393 p. il"},{"issue":"29","key":"4155_CR54","doi-asserted-by":"publisher","first-page":"23411","DOI":"10.1007\/s11356-017-0124-x","volume":"24","author":"MF Montalv\u00e3o","year":"2017","unstructured":"Montalv\u00e3o MF, Malafaia G (2017) Effects of abamectin on bullfrog tadpoles: insights on cytotoxicity. Environ Sci Pollut Res Int 24(29):23411\u201323416. https:\/\/doi.org\/10.1007\/s11356-017-0124-x Epub 2017 Sep 11","journal-title":"Environ Sci Pollut Res Int"},{"key":"4155_CR55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.chemosphere.2017.05.080","volume":"183","author":"MF Montalv\u00e3o","year":"2017","unstructured":"Montalv\u00e3o MF, de Souza JM, Guimar\u00e3es ATB, de Menezes IPP, Castro ALDS, Rodrigues ASL, Malafaia G (2017) The genotoxicity and cytotoxicity of tannery effluent in bullfrog (Lithobates catesbeianus). Chemosphere 183:491\u2013502. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.05.080 Epub 2017 May 16","journal-title":"Chemosphere"},{"key":"4155_CR56","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.chemosphere.2015.05.103","volume":"139","author":"F Mouchet","year":"2015","unstructured":"Mouchet F, Teaniniuraitemoana V, Baudrimont M, Daffe G, Gauthier L, Gonzalez P (2015) Recovery capabilities of Xenopus laevis after exposure to cadmium and zinc. Chemosphere 139:117\u2013125","journal-title":"Chemosphere"},{"issue":"3","key":"4155_CR57","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/1024533031000112257","volume":"8","author":"L Novotny","year":"2003","unstructured":"Novotny L, Szekeres T (2003) Cancer therapy: new targets for chemotherapy. Hematology 8(3):129\u2013137","journal-title":"Hematology"},{"issue":"1","key":"4155_CR58","first-page":"1","volume":"61","author":"H Pendl","year":"2006","unstructured":"Pendl H (2006) Morphological changes in red blood cells of birds and reptiles and their interpretation. Isr J Vet Med 61(1):1\u201312","journal-title":"Isr J Vet Med"},{"key":"4155_CR59","doi-asserted-by":"publisher","first-page":"9852","DOI":"10.1007\/s11356-016-6153-z","volume":"23","author":"JM P\u00e9rez-Iglesias","year":"2016","unstructured":"P\u00e9rez-Iglesias JM, Franco-Belussi L, Moreno L, Tripole S, de Oliveira C, Natale GS (2016) Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus. Environ Sci Pollut Res 23:9852\u20139861","journal-title":"Environ Sci Pollut Res"},{"key":"4155_CR60","doi-asserted-by":"publisher","unstructured":"Prado-Ochoa MG, Mu\u00f1oz-Guzm\u00e1n MA, V\u00e1zquez-Valadez VH, Vel\u00e1zquez-S\u00e1nchez AM, Salazar AM, Ram\u00edrez-Noguera P, Angeles E, Alba-Hurtado F (2016) Genotoxicity and cytotoxicity assessment of new ethylcarbamates with ixodicidal activity. Mutat Res Genet Toxicol Environ Mutagen 807:8-14. https:\/\/doi.org\/10.1016\/j.mrgentox.2016.06.008","DOI":"10.1016\/j.mrgentox.2016.06.008"},{"key":"4155_CR61","unstructured":"Reavill D (2005) Selected topics in reptile clinical pathology. Lecture given at the U.C. Davis Avian\/Exotic Animal Symposium 1994:1\u201312"},{"key":"4155_CR62","doi-asserted-by":"publisher","first-page":"311e315","DOI":"10.1897\/08-035.1","volume":"28","author":"CN Rich","year":"2009","unstructured":"Rich CN, Talent LG (2009) Soil ingestion may be an important route for the uptake of contaminants by some reptiles. Environ Toxicol Chem 28:311e315","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR63","unstructured":"Ritchard PCH, Trebbau P (1984) The turtles of Venezuela. S.1p.. Society for the Study of Amphibians and Reptiles 403p"},{"key":"4155_CR64","doi-asserted-by":"publisher","first-page":"3457e3464","DOI":"10.1016\/j.envpol.2009.06.013","volume":"157","author":"CJ Salice","year":"2009","unstructured":"Salice CJ, Suski JG, Bazar MA, Talent LG (2009) Effects of inorganic lead on Western fence lizards (Sceloporusoccidentalis). Environ Pollut 157:3457e3464","journal-title":"Environ Pollut"},{"key":"4155_CR65","doi-asserted-by":"publisher","first-page":"1954e1961","DOI":"10.1002\/etc.5620160927","volume":"16","author":"JC Sanchez","year":"1997","unstructured":"Sanchez JC, Fossi MC, Focardi S (1997) Serum B esterases as a nondestructive biomarker in the lizard Gallotiagalloti experimentally treated with parathion. Environ Toxicol Chem 16:1954e1961","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR66","doi-asserted-by":"publisher","first-page":"1e12","DOI":"10.1006\/pest.1999.2471","volume":"67","author":"JC S\u00e1nchez-Hern\u00e1ndez","year":"2000","unstructured":"S\u00e1nchez-Hern\u00e1ndez JC, Walker CH (2000) In vitro and in vivo cholinesterase inhibition in lacertides by phosphonate- and phosphorothioate-type organophosphates. Pestic Biochem Physiol 67:1e12","journal-title":"Pestic Biochem Physiol"},{"key":"4155_CR67","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.chemosphere.2017.06.102","volume":"184","author":"MSF Santos","year":"2017","unstructured":"Santos MSF, Franquet-Griell H, Lacorte S, Madeira LM, Alves A (2017) Anticancer drugs in Portuguese surface waters\u2014estimation of concentrations and identification of potentially priority drugs. Chemosphere 184:1250\u20131260. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.06.102 Epub 2017 Jun 27","journal-title":"Chemosphere"},{"issue":"2","key":"4155_CR68","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00244-009-9358-z","volume":"58","author":"L Schneider","year":"2010","unstructured":"Schneider L, Belger L, Burger J, Vogt RC, Ferrara CR (2010) Mercury levels in muscle of six species of turtles eaten by people along the Rio Negro of the Amazon basin. Arch Environ Contam Toxicol 58(2):444\u2013450","journal-title":"Arch Environ Contam Toxicol"},{"key":"4155_CR69","doi-asserted-by":"publisher","unstructured":"Shields M (2017) Chapter 14\u2014chemotherapeutics. Pharmacognosy, 295-313. https:\/\/doi.org\/10.1016\/B978-0-12-802104-0.00014-7","DOI":"10.1016\/B978-0-12-802104-0.00014-7"},{"issue":"6","key":"4155_CR70","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1083\/jcb.140.6.1307","volume":"140","author":"N Shimizu","year":"1998","unstructured":"Shimizu N, Itoh N, Utiyama H, Wahl GM (1998) Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol 140(6):1307\u20131320","journal-title":"J Cell Biol"},{"key":"4155_CR71","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.chemosphere.2017.02.087","volume":"175","author":"JM Souza","year":"2017","unstructured":"Souza JM, Montalv\u00e3o MF, da Silva AR, de Lima Rodrigues AS, Malafaia G (2017) A pioneering study on cytotoxicity in Australian parakeets (Melopsittacus undulates) exposed to tannery effluent. Chemosphere 175:521\u2013533. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.02.087 Epub 2017 Feb 17","journal-title":"Chemosphere"},{"issue":"8","key":"4155_CR72","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1007\/s10646-010-0531-y","volume":"19","author":"I Strunjak-Perovic","year":"2010","unstructured":"Strunjak-Perovic I, Lisicic D, Coz-Rakovac R, Popovic NT, Jadan M, Benkovic V, Tadic Z (2010) Evaluation of micronucleus and erythrocytic nuclear abnormalities in Balkan whip snake Hierophis gemonensis. Ecotoxicology 19(8):1460\u20131465","journal-title":"Ecotoxicology"},{"issue":"2","key":"4155_CR73","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1897\/07-149R.1","volume":"27","author":"JG Suski","year":"2008","unstructured":"Suski JG, Salice C, Houpt JT, Bazar MA, Talent LG (2008) Dose-related effects following oral exposure of 2,4-dinitrotoluene on the Western fence lizard, Sceloporus occidentals. Environ Toxicol Chem 27(2):352\u2013359. https:\/\/doi.org\/10.1897\/07-149R.1","journal-title":"Environ Toxicol Chem"},{"key":"4155_CR74","doi-asserted-by":"publisher","unstructured":"Toolaram AP, K\u00fcmmerer K, Schneider M (2014) Environmental risk assessment of anti-cancer drugs and their transformation products: a focus on their genotoxicity characterization-state of knowledge and short comings. Mutat Res Rev Mutat Res.. pii: S1383\u20135742(14)00003\u20139. https:\/\/doi.org\/10.1016\/j.mrrev.2014.02.001 . [Epub ahead of print]","DOI":"10.1016\/j.mrrev.2014.02.001"},{"key":"4155_CR75","volume-title":"Amazon turtles","author":"RC Vogt","year":"2008","unstructured":"Vogt RC (2008) Amazon turtles. Grafica B\u0131blos, Lima, Peru 104pp"},{"issue":"12","key":"4155_CR76","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1016\/j.envpol.2010.08.011","volume":"158","author":"SM Weir","year":"2010","unstructured":"Weir SM, Suski JG, Salice CJ (2010) Ecological risk of anthropogenic pollutants to reptiles: evaluating assumptions of sensitivity and exposure. Environ Pollut 158(12):3596\u20133606. https:\/\/doi.org\/10.1016\/j.envpol.2010.08.011 Epub 2010 Sep 19","journal-title":"Environ Pollut"},{"issue":"1\u20132","key":"4155_CR77","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mrgentox.2011.05.007","volume":"724","author":"WM Westerink","year":"2011","unstructured":"Westerink WM, Schirris TJ, Horbach GJ, Schoonen WG (2011) Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells. Mutat Res 724(1\u20132):7\u201321. https:\/\/doi.org\/10.1016\/j.mrgentox.2011.05.007 Epub 2011 May 20","journal-title":"Mutat Res"},{"key":"4155_CR78","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s41021-015-0003-y","volume":"37","author":"M Yasui","year":"2015","unstructured":"Yasui M, Kamoshita N, Nishimura T, Honma M (2015) Mechanism of induction of binucleated cells by multiwalled carbon nanotubes as revealed by live-cell imaging analysis. Genes and Environment 37:6","journal-title":"Genes and Environment"},{"issue":"4","key":"4155_CR79","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1073\/pnas.1517650112","volume":"113","author":"HJ Zahid","year":"2016","unstructured":"Zahid HJ, Robinson E, Kelly RL (2016) Agriculture, population growth, and statistical analysis of the radiocarbon record. Proc Natl Acad Sci U S A 113(4):931\u2013935. https:\/\/doi.org\/10.1073\/pnas.1517650112 Epub 2015 Dec 22","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4155_CR80","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ecoenv.2016.01.016","volume":"127","author":"LM Zapata","year":"2016","unstructured":"Zapata LM, Bock BC, Orozco LY, Palacio JA (2016) Application of the micronucleus test and comet assay in Trachemys callirostris erythrocytes as a model for in situ genotoxic monitoring. Ecotoxicol Environ Saf 127:108\u2013116. https:\/\/doi.org\/10.1016\/j.ecoenv.2016.01.016 Epub 2016 Jan 22","journal-title":"Ecotoxicol Environ Saf"},{"key":"4155_CR81","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.scitotenv.2012.12.061","volume":"445-446","author":"J Zhang","year":"2013","unstructured":"Zhang J, Chang VW, Giannis A, Wang JY (2013) Removal of cytostatic drugs from aquatic environment: a review. Sci Total Environ 445-446:281\u2013298","journal-title":"Sci Total Environ"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-019-04155-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-04155-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-04155-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T06:28:09Z","timestamp":1606026489000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-019-04155-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,13]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4155"],"URL":"https:\/\/doi.org\/10.1007\/s11356-019-04155-9","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,13]]},"assertion":[{"value":"10 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research was approved by the Biodiversity Authorization and Information System (SISBIO\/IBAMA), under no. 61531\/2017. Our study complied with all local, state, and national regulations. Meticulous efforts were made to assure that animals were subjected to the least suffering possible, as well as to reduce external stress, pain, and discomfort sources.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical issues"}}]}}