{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:01:20Z","timestamp":1790359280085,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s11356-019-05366-w","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T02:19:36Z","timestamp":1558232376000},"page":"20731-20741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats"],"prefix":"10.1007","volume":"26","author":[{"given":"Sahar M.","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-2591","authenticated-orcid":false,"given":"Ahmed E.","family":"Abdel Moneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Qayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil A.","family":"El-Yamany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,18]]},"reference":[{"issue":"6","key":"5366_CR1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.2174\/18715273113129990081","volume":"12","author":"AE Abdel Moneim","year":"2013","unstructured":"Abdel Moneim AE (2013) The neuroprotective effects of purslane (Portulaca oleracea) on rotenone-induced biochemical changes and apoptosis in brain of rat. CNS Neurol Disord Drug Targets 12(6):830\u2013841","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"5366_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158965","volume":"11","author":"AE Abdel Moneim","year":"2016","unstructured":"Abdel Moneim AE (2016) Indigofera oblongifolia prevents lead acetate-induced hepatotoxicity, oxidative stress, fibrosis and apoptosis in rats. PLoS One 11:e0158965","journal-title":"PLoS One"},{"key":"5366_CR3","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.scitotenv.2018.09.313","volume":"650","author":"MM Abdel-Daim","year":"2019","unstructured":"Abdel-Daim MM, Dessouki AA, Abdel-Rahman HG, Eltaysh R, Alkahtani S (2019) Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: the antioxidant status and apoptotic markers expression in rats. Sci Total Environ 650:2063\u20132073","journal-title":"Sci Total Environ"},{"key":"5366_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"5366_CR5","doi-asserted-by":"publisher","unstructured":"Al Omairi NE, Al-Brakati AY, Kassab RB, Lokman MS, Elmahallawy EK, Amin HK, Abdel Moneim AE (2019) Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2\/HO-1 pathways. Metab Brain Dis. \n                    https:\/\/doi.org\/10.1007\/s11011-019-00407-2","DOI":"10.1007\/s11011-019-00407-2"},{"issue":"1","key":"5366_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11033-018-4451-x","volume":"46","author":"RS Almeer","year":"2018","unstructured":"Almeer RS, Kassab RB, AlBasher GI, Alarifi S, Alkahtani S, Ali D, Abdel Moneim AE (2018) Royal jelly mitigates cadmium-induced neuronal damage in mouse cortex. Mol Biol Rep 46(1):119\u2013131","journal-title":"Mol Biol Rep"},{"key":"5366_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1042\/bj2640863","volume":"264","author":"OI Aruoma","year":"1989","unstructured":"Aruoma OI, Laughton MJ, Halliwell B (1989) Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? Biochem J 264:863\u2013869","journal-title":"Biochem J"},{"key":"5366_CR8","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.neuint.2012.09.003","volume":"61","author":"M Astiz","year":"2012","unstructured":"Astiz M, de Alaniz MJ, Marra CA (2012) The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain. Neurochem Int 61:1231\u20131241","journal-title":"Neurochem Int"},{"issue":"3","key":"5366_CR9","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00204-019-02387-9","volume":"93","author":"P Basaure","year":"2019","unstructured":"Basaure P, Guardia-Escote L, Cabre M, Peris-Sampedro F, Sanchez-Santed F, Domingo JL, Colomina MT (2019) Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype. Arch Toxicol 93(3):693\u2013707","journal-title":"Arch Toxicol"},{"key":"5366_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11064-010-0311-3","volume":"36","author":"PM Basha","year":"2011","unstructured":"Basha PM, Poojary A (2011) Chlorpyrifos induced region specific vulnerability in rat CNS and modulation by age and cold stress: an interactive study. Neurochem Res 36:241\u2013249","journal-title":"Neurochem Res"},{"key":"5366_CR11","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s10571-014-0056-7","volume":"34","author":"PM Basha","year":"2014","unstructured":"Basha PM, Poojary A (2014) Mitochondrial dysfunction in aging rat brain regions upon chlorpyrifos toxicity and cold stress: an interactive study. Cell Mol Neurobiol 34:737\u2013756","journal-title":"Cell Mol Neurobiol"},{"key":"5366_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/brb3.208","volume":"4","author":"R Bavarsad Shahripour","year":"2014","unstructured":"Bavarsad Shahripour R, Harrigan MR, Alexandrov AV (2014) N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain Behav 4:108\u2013122","journal-title":"Brain Behav"},{"key":"5366_CR13","doi-asserted-by":"publisher","first-page":"744","DOI":"10.3389\/fneur.2017.00744","volume":"8","author":"J Bhatti","year":"2017","unstructured":"Bhatti J, Nascimento B, Akhtar U, Rhind SG, Tien H, Nathens A, da Luz LT (2017) Systematic review of human and animal studies examining the efficacy and safety of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) in traumatic brain injury: impact on neurofunctional outcome and biomarkers of oxidative stress and inflammation. Front Neurol 8:744","journal-title":"Front Neurol"},{"key":"5366_CR14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.tox.2011.10.010","volume":"290","author":"J Blanco","year":"2011","unstructured":"Blanco J, Mulero M, Lopez M, Domingo JL, Sanchez DJ (2011) BDE-99 deregulates BDNF, Bcl-2 and the mRNA expression of thyroid receptor isoforms in rat cerebellar granular neurons. Toxicology 290:305\u2013311","journal-title":"Toxicology"},{"key":"5366_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12640-009-9149-3","volume":"19","author":"D Cardona","year":"2011","unstructured":"Cardona D, Lopez-Crespo G, Sanchez-Amate MC, Flores P, Sanchez-Santed F (2011) Impulsivity as long-term sequelae after chlorpyrifos intoxication: time course and individual differences. Neurotox Res 19:128\u2013137","journal-title":"Neurotox Res"},{"key":"5366_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2131\/jts.38.193","volume":"38","author":"D Cardona","year":"2013","unstructured":"Cardona D, Lopez-Granero C, Canadas F, Llorens J, Flores P, Pancetti F, Sanchez-Santed F (2013) Dose-dependent regional brain acetylcholinesterase and acylpeptide hydrolase inhibition without cell death after chlorpyrifos administration. J Toxicol Sci 38:193\u2013203","journal-title":"J Toxicol Sci"},{"key":"5366_CR17","doi-asserted-by":"crossref","unstructured":"Chen G, Shi J, Hu Z, Hang C (2008) Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediat Inflamm 716458","DOI":"10.1155\/2008\/716458"},{"key":"5366_CR18","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.biopsych.2011.07.035","volume":"71","author":"JM das Neves Duarte","year":"2012","unstructured":"das Neves Duarte JM, Kulak A, Gholam-Razaee MM, Cuenod M, Gruetter R, Do KQ (2012) N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development. Biol Psychiatry 71:1006\u20131014","journal-title":"Biol Psychiatry"},{"key":"5366_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.toxlet.2007.05.017","volume":"172","author":"P Duramad","year":"2007","unstructured":"Duramad P, Tager IB, Holland NT (2007) Cytokines and other immunological biomarkers in children's environmental health studies. Toxicol Lett 172:48\u201359","journal-title":"Toxicol Lett"},{"key":"5366_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"5366_CR21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88\u201395","journal-title":"Biochem Pharmacol"},{"key":"5366_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0300-483X(00)00333-4","volume":"156","author":"R Farbiszewski","year":"2000","unstructured":"Farbiszewski R, Witek A, Skrzydlewska E (2000) N-acetylcysteine or trolox derivative mitigate the toxic effects of methanol on the antioxidant system of rat brain. Toxicology 156:47\u201355","journal-title":"Toxicology"},{"key":"5366_CR23","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s11064-014-1360-9","volume":"39","author":"IA Finamor","year":"2014","unstructured":"Finamor IA, Ourique GM, Pes TS, Saccol EM, Bressan CA, Scheid T, Baldisserotto B, Llesuy SF, Partata WA, Pavanato MA (2014) The protective effect of N-acetylcysteine on oxidative stress in the brain caused by the long-term intake of aspartame by rats. Neurochem Res 39:1681\u20131690","journal-title":"Neurochem Res"},{"key":"5366_CR24","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.lfs.2015.10.013","volume":"145","author":"CR Garcia-Garcia","year":"2016","unstructured":"Garcia-Garcia CR, Parron T, Requena M, Alarcon R, Tsatsakis AM, Hernandez AF (2016) Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level. Life Sci 145:274\u2013283","journal-title":"Life Sci"},{"key":"5366_CR25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1471-4159.2001.00395.x","volume":"78","author":"HM Geller","year":"2001","unstructured":"Geller HM, Cheng KY, Goldsmith NK, Romero AA, Zhang AL, Morris EJ, Grandison L (2001) Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside. J Neurochem 78:265\u2013275","journal-title":"J Neurochem"},{"key":"5366_CR26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15 N]nitrate in biological fluids. Anal Biochem 126:131\u2013138","journal-title":"Anal Biochem"},{"key":"5366_CR27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s11064-006-9040-z","volume":"31","author":"T Hicdonmez","year":"2006","unstructured":"Hicdonmez T, Kanter M, Tiryaki M, Parsak T, Cobanoglu S (2006) Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats. Neurochem Res 31:473\u2013481","journal-title":"Neurochem Res"},{"key":"5366_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041086","volume":"7","author":"A Karalija","year":"2012","unstructured":"Karalija A, Novikova LN, Kingham PJ, Wiberg M, Novikov LN (2012) Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. PLoS One 7:e41086","journal-title":"PLoS One"},{"key":"5366_CR29","doi-asserted-by":"crossref","unstructured":"Kaur S, Singla N, Dhawan DK (2019) Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats. Drug Chem Toxicol:1\u201311","DOI":"10.1080\/01480545.2019.1569022"},{"key":"5366_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1550-2783-2-2-38","volume":"2","author":"C Kerksick","year":"2005","unstructured":"Kerksick C, Willoughby D (2005) The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J Int Soc Sports Nutr 2:38\u201344","journal-title":"J Int Soc Sports Nutr"},{"key":"5366_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/jat.1677","volume":"32","author":"J Kim","year":"2012","unstructured":"Kim J, Lim W, Ko Y, Kwon H, Kim S, Kim O, Park G, Choi H (2012) The effects of cadmium on VEGF-mediated angiogenesis in HUVECs. J Appl Toxicol 32:342\u2013349","journal-title":"J Appl Toxicol"},{"key":"5366_CR32","doi-asserted-by":"publisher","first-page":"a258","DOI":"10.1289\/ehp.1104285","volume":"120","author":"PJ Landrigan","year":"2012","unstructured":"Landrigan PJ, Lambertini L, Birnbaum LS (2012) A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect 120:a258\u2013a260","journal-title":"Environ Health Perspect"},{"key":"5366_CR33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.brainresbull.2009.07.002","volume":"81","author":"TL Lassiter","year":"2010","unstructured":"Lassiter TL, Ryde IT, Levin ED, Seidler FJ, Slotkin TA (2010) Neonatal exposure to parathion alters lipid metabolism in adulthood: interactions with dietary fat intake and implications for neurodevelopmental deficits. Brain Res Bull 81:85\u201391","journal-title":"Brain Res Bull"},{"key":"5366_CR34","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.taap.2012.06.005","volume":"263","author":"JE Lee","year":"2012","unstructured":"Lee JE, Park JH, Shin IC, Koh HC (2012) Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos. Toxicol Appl Pharmacol 263:148\u2013162","journal-title":"Toxicol Appl Pharmacol"},{"key":"5366_CR35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.taap.2014.04.021","volume":"278","author":"JE Lee","year":"2014","unstructured":"Lee JE, Park JH, Jang SJ, Koh HC (2014) Rosiglitazone inhibits chlorpyrifos-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells. Toxicol Appl Pharmacol 278:159\u2013171","journal-title":"Toxicol Appl Pharmacol"},{"key":"5366_CR36","doi-asserted-by":"crossref","unstructured":"Liu J, Zhu HX, Fu WL, Xu XW, Yang JZ, Dai D, Li Y (2019) Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. Neurol Res:1\u20139","DOI":"10.1080\/01616412.2019.1576358"},{"key":"5366_CR37","first-page":"1","volume":"143","author":"M Maroni","year":"2000","unstructured":"Maroni M, Colosio C, Ferioli A, Fait A (2000) Biological monitoring of pesticide exposure: a review. Introduction Toxicology 143:1\u2013118","journal-title":"Introduction Toxicology"},{"key":"5366_CR38","first-page":"11","volume":"19","author":"V Mokhtari","year":"2017","unstructured":"Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A (2017) A review on various uses of N-acetyl cysteine. Cell J 19:11\u201317","journal-title":"Cell J"},{"key":"5366_CR39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2174\/1567205012666150325182702","volume":"12","author":"AE Moneim","year":"2015","unstructured":"Moneim AE (2015) Oxidant\/antioxidant imbalance and the risk of Alzheimer's disease. Curr Alzheimer Res 12:335\u2013349","journal-title":"Curr Alzheimer Res"},{"key":"5366_CR40","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.fct.2007.08.047","volume":"46","author":"S Ncibi","year":"2008","unstructured":"Ncibi S, Ben Othman M, Akacha A, Krifi MN, Zourgui L (2008) Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem Toxicol 46:797\u2013802","journal-title":"Food Chem Toxicol"},{"key":"5366_CR41","doi-asserted-by":"crossref","unstructured":"Nita M, Grzybowski A (2016) The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxidative Med Cell Longev 3164734","DOI":"10.1155\/2016\/3164734"},{"key":"5366_CR42","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1177\/0748233711399311","volume":"27","author":"S Ogut","year":"2011","unstructured":"Ogut S, Gultekin F, Kisioglu AN, Kucukoner E (2011) Oxidative stress in the blood of farm workers following intensive pesticide exposure. Toxicol Ind Health 27:820\u2013825","journal-title":"Toxicol Ind Health"},{"key":"5366_CR43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"5366_CR44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.expneurol.2014.04.020","volume":"257","author":"JD Pandya","year":"2014","unstructured":"Pandya JD, Readnower RD, Patel SP, Yonutas HM, Pauly JR, Goldstein GA, Rabchevsky AG, Sullivan PG (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp Neurol 257:106\u2013113","journal-title":"Exp Neurol"},{"key":"5366_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.pestbp.2018.04.001","volume":"148","author":"MM Quintana","year":"2018","unstructured":"Quintana MM, Rivero Osimani V, Magnarelli G, Rovedatti MG, Guinazu N (2018) The insecticides chlorpyrifos and acetamiprid induce redox imbalance in umbilical cord blood erythrocytes in vitro. Pestic Biochem Physiol 148:87\u201392","journal-title":"Pestic Biochem Physiol"},{"key":"5366_CR46","doi-asserted-by":"crossref","unstructured":"Repnik U, Hafner Cesen M, Turk B, 2014 Lysosomal membrane permeabilization in cell death: concepts and challenges. Mitochondrion 19 Pt A, 49-57","DOI":"10.1016\/j.mito.2014.06.006"},{"key":"5366_CR47","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/10408444.2012.738645","volume":"43","author":"SM Ross","year":"2013","unstructured":"Ross SM, McManus IC, Harrison V, Mason O (2013) Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review. Crit Rev Toxicol 43:21\u201344","journal-title":"Crit Rev Toxicol"},{"key":"5366_CR48","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature12808","volume":"505","author":"TL Roth","year":"2014","unstructured":"Roth TL, Nayak D, Atanasijevic T, Koretsky AP, Latour LL, McGavern DB (2014) Transcranial amelioration of inflammation and cell death after brain injury. Nature 505:223\u2013228","journal-title":"Nature"},{"key":"5366_CR49","first-page":"45","volume":"6","author":"A Samsel","year":"2015","unstructured":"Samsel A, Seneff S (2015) Glyphosate, pathways to modern diseases III: manganese, neurological diseases, and associated pathologies. Surg Neurol Int 6:45","journal-title":"Surg Neurol Int"},{"issue":"5","key":"5366_CR50","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/tox.22728","volume":"34","author":"L Shou","year":"2019","unstructured":"Shou L, Bei Y, Song Y, Wang L, Ai L, Yan Q, He W (2019) Nrf2 mediates the protective effect of edaravone after chlorpyrifos-induced nervous system toxicity. Environ Toxicol 34(5):626\u2013633","journal-title":"Environ Toxicol"},{"key":"5366_CR51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.reprotox.2010.07.012","volume":"31","author":"TA Slotkin","year":"2011","unstructured":"Slotkin TA (2011) Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? Reprod Toxicol 31:297\u2013301","journal-title":"Reprod Toxicol"},{"key":"5366_CR52","doi-asserted-by":"publisher","first-page":"1652S","DOI":"10.1093\/jn\/136.6.1652S","volume":"136","author":"MH Stipanuk","year":"2006","unstructured":"Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 136:1652S\u20131659S","journal-title":"J Nutr"},{"key":"5366_CR53","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1590\/S0100-879X2008000900004","volume":"41","author":"SG Suke","year":"2008","unstructured":"Suke SG, Ahmed RS, Pathak R, Tripathi AK, Banerjee BD (2008) Attenuation of phosphamidon-induced oxidative stress and immune dysfunction in rats treated with N-acetylcysteine. Braz J Med Biol Res 41:765\u2013768","journal-title":"Braz J Med Biol Res"},{"key":"5366_CR54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"Y Sun","year":"1988","unstructured":"Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497\u2013500","journal-title":"Clin Chem"},{"key":"5366_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032503","volume":"7","author":"L Sun","year":"2012","unstructured":"Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, Zhang H (2012) N-acetylcysteine protects against apoptosis through modulation of group i metabotropic glutamate receptor activity. PLoS One 7:e32503","journal-title":"PLoS One"},{"key":"5366_CR56","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1523\/JNEUROSCI.16-01-00253.1996","volume":"16","author":"CM Troy","year":"1996","unstructured":"Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML (1996) Downregulation of Cu\/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J Neurosci 16:253\u2013261","journal-title":"J Neurosci"},{"key":"5366_CR57","first-page":"136","volume":"3","author":"WY Wang","year":"2015","unstructured":"Wang WY, Tan MS, Yu JT, Tan L (2015) Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. Ann Transl Med 3:136","journal-title":"Ann Transl Med"},{"key":"5366_CR58","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neulet.2010.02.002","volume":"472","author":"X Yao","year":"2010","unstructured":"Yao X, Miao W, Li M, Wang M, Ma J, Wang Y, Miao L, Feng H (2010) Protective effect of albumin on VEGF and brain edema in acute ischemia in rats. Neurosci Lett 472:179\u2013183","journal-title":"Neurosci Lett"},{"key":"5366_CR59","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1089\/neu.2006.23.86","volume":"23","author":"JH Yi","year":"2006","unstructured":"Yi JH, Hoover R, McIntosh TK, Hazell AS (2006) Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine. J Neurotrauma 23:86\u201396","journal-title":"J Neurotrauma"},{"key":"5366_CR60","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1006\/taap.2000.9033","volume":"168","author":"ZP Yu","year":"2000","unstructured":"Yu ZP, Matsuoka M, Wispriyono B, Iryo Y, Igisu H (2000) Activation of mitogen-activated protein kinases by tributyltin in CCRF-CEM cells: role of intracellular Ca(2+). Toxicol Appl Pharmacol 168:200\u2013207","journal-title":"Toxicol Appl Pharmacol"},{"key":"5366_CR61","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1159\/000493874","volume":"49","author":"P Zhang","year":"2018","unstructured":"Zhang P, Zhong S, Wang G, Zhang SY, Chu C, Zeng S, Yan Y, Cheng X, Bao Y, Hocher B, Yang X (2018) N-acetylcysteine suppresses lps-induced pathological angiogenesis. Cell Physiol Biochem 49:2483\u20132495","journal-title":"Cell Physiol Biochem"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-05366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-019-05366-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-05366-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T23:36:20Z","timestamp":1589672180000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-019-05366-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,18]]},"references-count":61,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["5366"],"URL":"https:\/\/doi.org\/10.1007\/s11356-019-05366-w","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,18]]},"assertion":[{"value":"20 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}