{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:39:54Z","timestamp":1784374794693,"version":"3.55.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["NVKP_16-1-2016-0003"],"award-info":[{"award-number":["NVKP_16-1-2016-0003"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the fact that there are tens of thousands of thermal baths in existence, knowledge about the occurrence of pharmaceutically active compounds (PhACs) in untreated thermal wastewater is very limited. Because used thermal water is typically legally discharged into surface waters without any treatment, the effluent poses environmental risks for the receiving water bodies. The aim of this study was to show the occurrence patterns and spatiotemporal characteristics of 111 PhACs in thermal wastewater. Six thermal water outflows of different thermal baths were tested in different seasons in the Budapest metropolitan region (Hungary), and diurnal analysis was performed. After solid-phase extraction, the samples were analysed and quantified by coupling supercritical fluid chromatography and mass spectrometry to perform simultaneous multi-residue drug analysis. The results confirm that water discharge pipes directly transport pharmaceuticals into surface water bodies; 34 PhACs were measured to be over the limit of quantification at least once, and 21 of them were found in more than one water sample. The local anaesthetic drug lidocaine, antiepileptic carbamazepine, analgesic derivative tramadol and illicit drug cocaine were detected in more than half of the samples. Caffeine, metoprolol and bisoprolol (cardiovascular drugs), benzoylecgonine (cocaine metabolite), diclofenac (NSAID), citalopram (antidepressant) and certain types of hormones also have a significant frequency of 30-50%. However, the occurrence and concentrations of PhACs vary according to the season and number\/types of visitors. As demonstrated by the diurnal fluctuation, drug contamination of thermal waters can significantly vary, even for similar types of baths; furthermore, the quantity and types of some pollutants rapidly change in the discharged thermal wastewater.<\/jats:p>","DOI":"10.1007\/s11356-019-06633-6","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T16:57:56Z","timestamp":1575305876000},"page":"399-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thermal baths as sources of pharmaceutical and illicit drug contamination"],"prefix":"10.1007","volume":"27","author":[{"given":"Gergely","family":"Jakab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Szalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Michalk\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Ringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Filep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Ma\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Pirger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1rp\u00e1d","family":"Ferincz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Staszny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Dobosy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-8472","authenticated-orcid":false,"given":"Attila Csaba","family":"Kondor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"issue":"4","key":"6633_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/etc.3339","volume":"35","author":"T Aus der Beek","year":"2016","unstructured":"Aus der Beek T, Weber F-A, Bergmann A, Hickmann S, Ebert I, Hein A, K\u00fcster A (2016) Pharmaceuticals in the Environment - global occurrences and perspectives. Environ Toxicol Chem 35(4):823-835. https:\/\/doi.org\/10.1002\/etc.3339","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"6633_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/dta.1829","volume":"8","author":"P Avar","year":"2016","unstructured":"Avar P, Maasz G, Tak\u00e1cs P, Lovas S, Zrinyi Z, Svigruha R, Tak\u00e1tsy A, T\u00f3th LG, Pirger Z (2016a) HPLC-MS\/MS analysis of steroid hormones in environmental water samples. Drug Test Analysis 8(1):123-127. https:\/\/doi.org\/10.1002\/dta.1829","journal-title":"Drug Test Analysis"},{"key":"6633_CR3","doi-asserted-by":"publisher","first-page":"11630","DOI":"10.1007\/s11356-016-6276-2","volume":"23","author":"P Avar","year":"2016","unstructured":"Avar P, Zr\u00ednyi Z, Ma\u00e1sz G, Tak\u00e1tsy A, Lovas S, T\u00f3th LG, Pirger Z (2016b) \u03b2-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin. Environ Sci Pollut Res 23:11630-11638. https:\/\/doi.org\/10.1007\/s11356-016-6276-2","journal-title":"Environ Sci Pollut Res"},{"key":"6633_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.scitotenv.2017.01.139","volume":"584-585","author":"SA Benz","year":"2017","unstructured":"Benz SA, Bayer P, Blum P (2017) Identifying anthropogenic anomalies in air, surface and groundwater temperatures in Germany. Sci Total Environ 584-585:145-153. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.01.139","journal-title":"Sci Total Environ"},{"key":"6633_CR5","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.scitotenv.2018.03.363","volume":"634","author":"V B\u00f3kony","year":"2018","unstructured":"B\u00f3kony V, \u00dcveges B, Ujhegyi N, Vereb\u00e9lyi V, Nemesh\u00e1zi E, Cs\u00edkv\u00e1ri O, Hettyey A (2018) Endocrine disruptors in breeding ponds and reproductive health of toadsin agricultural, urban and natural landscapes. Sci Total Environ 634:1335-1345. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.03.363","journal-title":"Sci Total Environ"},{"key":"6633_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jhazmat.2016.08.022","volume":"320","author":"Anna Franka Bollmann","year":"2016","unstructured":"Bollmann AF, Seitz W, Prasse C, Lucke T, Schulz W, Ternes, T (2016) Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation. J Hazard Mater 320:204-215. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.08.022","journal-title":"Journal of Hazardous Materials"},{"key":"6633_CR7","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.scitotenv.2018.05.357","volume":"640-641","author":"A Capaldo","year":"2018","unstructured":"Capaldo A, Gay F, Lepretti M, Paolella G, Martucciello S, Lionetti L, Caputo I, Laforgia V (2018) Effects of environmental cocaine concentrations on the skeletal muscle of the European eel (Anguilla anguilla). Sci Total Environ 640-641:862-873. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.05.357","journal-title":"Sci Total Environ"},{"issue":"4","key":"6633_CR8","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1021\/jf404282y","volume":"62","author":"LJ Carter","year":"2014","unstructured":"Carter LJ, Harris E, Williams M, Ryan JJ, Kookana RS, Boxall ABA (2014) Fate and uptake of pharmaceuticals in soil-plant system. J Agric Food Chem 62(4):816-825","journal-title":"J Agric Food Chem"},{"key":"6633_CR9","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.watres.2017.12.047","volume":"131","author":"S Castiglioni","year":"2018","unstructured":"Castiglioni S, Davoli E, Riva F, Palmiotto M, Camporini P, Manenti A, Zuccato E (2018) Mass balance of emerging contaminants in the water cycle of a highlyurbanized and industrialized area of Italy. Water Res 131:287-298. https:\/\/doi.org\/10.1016\/j.watres.2017.12.047","journal-title":"Water Res"},{"issue":"1","key":"6633_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1515\/cjot-2017-0003","volume":"6","author":"J Csap\u00f3","year":"2017","unstructured":"Csap\u00f3 J, Marton G (2017) The Role and Importance of Spa and Wellness Tourism in Hungary\u2019s Tourism Industry. Czech Journal of Tourism 6(1):55-68. https:\/\/doi.org\/10.1515\/cjot-2017-0003","journal-title":"Czech Journal of Tourism"},{"issue":"6","key":"6633_CR11","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1289\/ehp.99107s6907","volume":"107","author":"CG Daughton","year":"1999","unstructured":"Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107(6):907-938. https:\/\/doi.org\/10.1289\/ehp.99107s6907","journal-title":"Environ Health Perspect"},{"issue":"2","key":"6633_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s40572-014-0015-y","volume":"1","author":"RP Deo","year":"2014","unstructured":"Deo RP (2014) Pharmaceuticals in the Surface Water of the USA: A review. Curr Envir Health Rpt 1(2):113-122. https:\/\/doi.org\/10.1007\/s40572-014-0015-y","journal-title":"Curr Envir Health Rpt"},{"key":"6633_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.tmp.2019.03.010","volume":"31","author":"J Duro","year":"2019","unstructured":"Duro J, Turri\u00f3n-Prats J (2019) Tourism seasonality worldwide. Tour Manag Perspect 31:38-53. https:\/\/doi.org\/10.1016\/j.tmp.2019.03.010","journal-title":"Tour Manag Perspect"},{"issue":"14","key":"6633_CR14","doi-asserted-by":"publisher","first-page":"14431","DOI":"10.1007\/s11356-016-6560-1","volume":"23","author":"Y Ekowati","year":"2016","unstructured":"Ekowati Y, Buttiglieri G, Ferrero G, Valle-Sistac J, Diaz-CruzMS PM, Villagrasa M, Kennedy MD, Rodriguez-Roda I (2016) Occurrence of pharmaceuticals and UV filters in swimming pools and spas. Environ Sci Pollut Res 23(14):14431-14441. https:\/\/doi.org\/10.1007\/s11356-016-6560-1","journal-title":"Environ Sci Pollut Res"},{"key":"6633_CR15","doi-asserted-by":"crossref","unstructured":"Erfurt-Cooper P, Cooper M (2009). Health and wellness tourism: spas and Hot Springs. Channel view publications, Bristol, UK. 362. p","DOI":"10.21832\/9781845411138"},{"key":"6633_CR16","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.watres.2014.10.048","volume":"72","author":"R Etchepare","year":"2015","unstructured":"Etchepare R, van der Hoek JP (2015) Health risk assessment of organic micropollutants in greywater for potable reuse. Water Res 72:186-198. https:\/\/doi.org\/10.1016\/j.watres.2014.10.048","journal-title":"Water Res"},{"key":"#cr-split#-6633_CR17.1","unstructured":"EU (2018). COMMISSION IMPLEMENTING DECISION"},{"key":"#cr-split#-6633_CR17.2","unstructured":"(EU) 2018\/840: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32018D0840) Accessed 10.07.2019"},{"key":"6633_CR18","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.scitotenv.2018.04.155","volume":"635","author":"G Fantuzzi","year":"2018","unstructured":"Fantuzzi G, Aggazzotti G, Righi E, Predieri G, Castiglioni S, Riva F, Zuccato E (2018) Illicit drugs and pharmaceuticals in swimming pool waters. Sci Total Environ 635:956-963. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.04.155","journal-title":"Sci Total Environ"},{"issue":"5","key":"6633_CR19","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.30638\/eemj.2015.132","volume":"14","author":"A Farsang","year":"2015","unstructured":"Farsang A, T\u00f3th TM, Balog K (2015) Environmental risks of waste thermal water disposal: long-term effects of thermal water seepage on different soil types. Environ Eng Manag J 14(5):1217-1229","journal-title":"Environ Eng Manag J"},{"key":"6633_CR20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.tourman.2018.03.015","volume":"68","author":"M Ferrante","year":"2018","unstructured":"Ferrante M, Lo Magno G, De Cantis S (2018) Measuring tourism seasonality across European countries. Tour Manag 68:220-235. https:\/\/doi.org\/10.1016\/j.tourman.2018.03.015","journal-title":"Tour Manag"},{"key":"6633_CR21","unstructured":"Global Wellness Economy Monitor (2018). Global wellness institute, global wellness economy monitor, October 2018. 113 p. www.globalwellnessinstitute.org Accessed 10.07.2019"},{"key":"6633_CR22","unstructured":"HCSO (2017). Annual reports on turnover of baths. Hungarian Central Statistical Office, 2017"},{"key":"6633_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","volume":"131","author":"T Heberer","year":"2002","unstructured":"Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5-17. https:\/\/doi.org\/10.1016\/S0378-4274(02)00041-3","journal-title":"Toxicol Lett"},{"key":"6633_CR24","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0045-6535(03)00156-5","volume":"51","author":"SJ Judd","year":"2003","unstructured":"Judd SJ, Bullock G (2003) The fate of chlorine and organic materials in swimming pools. Chemosphere 51:869-879. https:\/\/doi.org\/10.1016\/S0045-6535(03)00156-5","journal-title":"Chemosphere"},{"key":"6633_CR25","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.watres.2010.09.031","volume":"45","author":"A Kanan","year":"2011","unstructured":"Kanan A, Karanfil T (2011) Formation of disinfection by-products in indoor swimming pool water: the contribution from filling water natural organic matter and swimmer body fluids. Water Res 45:926-932. https:\/\/doi.org\/10.1016\/j.watres.2010.09.031","journal-title":"Water Res"},{"key":"6633_CR26","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1016\/j.watres.2008.04.026","volume":"42","author":"B Kasprzyk-Hordern","year":"2008","unstructured":"Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42:3498-3518. https:\/\/doi.org\/10.1016\/j.watres.2008.04.026","journal-title":"Water Res"},{"key":"6633_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.watres.2014.01.027","volume":"53","author":"MGA Keuten","year":"2014","unstructured":"Keuten MGA, Peters MCFM, Daanen HAM, de Kreuk MK, Rietveld LC, van Dijk JC (2014) Quantification of continual anthropogenic pollutants released in swimming pools. Water Res 53:259-270. https:\/\/doi.org\/10.1016\/j.watres.2014.01.027","journal-title":"Water Res"},{"key":"6633_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1023\/A:1009986606414","volume":"33","author":"B-H Kim","year":"1999","unstructured":"Kim B-H (1999) Ecology of a cyanobacterial mat community in a Korean thermal wastewater stream. Aquat Ecol 33:331-338. https:\/\/doi.org\/10.1023\/A:1009986606414","journal-title":"Aquat Ecol"},{"issue":"6","key":"6633_CR29","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.2166\/wst.2013.694","volume":"67","author":"ZL Kiss","year":"2013","unstructured":"Kiss ZL, Sz\u00e9p A, Kert\u00e9sz S, Hod\u00far C, L\u00e1szl\u00f3 Z (2013) Treatment of waste thermal waters by ozonation and nanofiltraton. Water Sci Technol 67(6):1272-1279. https:\/\/doi.org\/10.2166\/wst.2013.694","journal-title":"Water Sci Technol"},{"key":"6633_CR30","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.trac.2018.02.008","volume":"102","author":"S K\u00f6nemann","year":"2018","unstructured":"K\u00f6nemann S, Kase R, Simon E, Swart K, Buchinger S, Schl\u00fcsener M, Hollert H, Escher BI, Werner I, A\u00eft-A\u00efssa S, Vermeirssen E, Dulio V, Valsecchi S, Polesello S, Behnisch P, Javurkova B, Perceval O, Di Paolo C, Olbrich D, Sychrova E, Schlichting R, Leborgne L, Clara M, Scheffknecht C, Marneffe Y, Chalon C, Tu\u0161il P, Sold\u00e0n P, von Danwitz B, Schwaiger J, San Mart\u00edn Becares MI, Bersani F, Hilscherov\u00e1 K, Reifferscheid G, Ternes T, Carere M (2018) Effect-based and chemical analytical methods to monitor estrogens under the European water framework directive. Trends Anal Chem 102:225-235. https:\/\/doi.org\/10.1016\/j.trac.2018.02.008","journal-title":"Trends Anal Chem"},{"key":"6633_CR31","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.envpol.2016.11.011","volume":"220","author":"M K\u00f6nig","year":"2017","unstructured":"K\u00f6nig M, Escher BI, Neale PA, Krauss M, Hilscherov K, Novak J, Teodorovic I, Schulze T, Seidensticker S, Hashmi MAK, Ahlheim J, Brack W (2017) Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis. Env Poll B 220:1220-1230. https:\/\/doi.org\/10.1016\/j.envpol.2016.11.011","journal-title":"Env Poll B"},{"key":"6633_CR32","volume-title":"Pharmaceuticals in the Environment: sources, fate, effects and risks","year":"2008","unstructured":"K\u00fcmmerer K (ed) (2008) Pharmaceuticals in the Environment: sources, fate, effects and risks. Springer Verlag, Berlin-Heidelberg, Germany, 521"},{"key":"6633_CR33","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.envint.2016.06.018","volume":"94","author":"K Lees","year":"2016","unstructured":"Lees K, Fitzsimons M, Snape J, Tappin A, Comber S (2016) Pharmaceuticals in soils of lower income countries: Physico-chemical fate and risks from wastewater irrigation. Environ Int 94:712-723. https:\/\/doi.org\/10.1016\/j.envint.2016.06.018","journal-title":"Environ Int"},{"issue":"7","key":"6633_CR34","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1289\/ehp.1206244","volume":"121","author":"HW Leung","year":"2014","unstructured":"Leung HW, Jin L, Wei S, Tsui MMP, Zhou B, Jiao L, Cheung PC, Chun YK, Murphy MB, Lam PKS (2014) Pharmaceuticals in tap Water: human health risk assessment and proposed monitoring framework in China. Environ Health Perspect 121(7):839-846. https:\/\/doi.org\/10.1289\/ehp.1206244","journal-title":"Environ Health Perspect"},{"key":"6633_CR35","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.scitotenv.2018.12.048","volume":"658","author":"Y Li","year":"2019","unstructured":"Li Y, Zhang L, Liu X, Ding J (2019) Ranking and prioritizing pharmaceuticals in the aquatic environment of China. Sci Total Environ 658:333-342. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.12.048","journal-title":"Sci Total Environ"},{"issue":"4","key":"6633_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1021\/acs.estlett.7b00043","volume":"4","author":"K Lindsay","year":"2017","unstructured":"Lindsay K, Blackstock J, Wang W, Vemula S, Jaeger BT, Li X-F (2017) Sweetened swimming pools and hot tubs. Environ Sci Technol Lett 4(4):149-153. https:\/\/doi.org\/10.1021\/acs.estlett.7b00043","journal-title":"Environ Sci Technol Lett"},{"issue":"2","key":"6633_CR37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.32725\/det.2018.017","volume":"10","author":"Z L\u00f6ke","year":"2018","unstructured":"L\u00f6ke Z, Kov\u00e1cs E, Bacsi Z (2018) Assessment of service quality and consumer satisfaction in a Hungarian spa. DETUROPE 10(2):124-146","journal-title":"DETUROPE"},{"key":"6633_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/bs.coac.2017.08.009","volume-title":"Advances in the Use of Liquid Chromatography Mass Spectrometry (LC-MS) - Instrumentation Developments and Applications","author":"Ester L\u00f3pez-Garc\u00eda","year":"2018","unstructured":"L\u00f3pez-Garc\u00eda E, Postigo C, Zonja B, Barcel\u00f3 D, L\u00f3pez de Alda M (2018) Chapter Two - Analysis of Psychoactive Pharmaceuticals in Wastewater and Surface Water Using LC-MS. Compr Anal Chem 79:29-52. https:\/\/doi.org\/10.1016\/bs.coac.2017.08.009"},{"key":"6633_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ecoenv.2017.01.020","volume":"139","author":"G Ma\u00e1sz","year":"2017","unstructured":"Ma\u00e1sz G, Zr\u00ednyi Z, Tak\u00e1cs P, Lovas S, Fodor I, Kiss T, Pirger Z (2017) Complex molecular changes induced by chronic progestogens exposure inroach, Rutilus rutilus. Ecotoxicol Environ Saf 139:9-17. https:\/\/doi.org\/10.1016\/j.ecoenv.2017.01.020","journal-title":"Ecotoxicol Environ Saf"},{"key":"6633_CR40","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.scitotenv.2019.04.286","volume":"677","author":"G Maasz","year":"2019","unstructured":"Maasz G, Mayer M, Zrinyi Z, Molnar E, Kuzma M, Fodor I, Pirger Z, Tak\u00e1cs P (2019) Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination. Sci Total Environ 677:545-555. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.286","journal-title":"Sci Total Environ"},{"key":"6633_CR41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.forsciint.2016.08.016","volume":"267","author":"T Mackul\u2019ak","year":"2016","unstructured":"Mackul\u2019ak T, Bod\u00edk I, Hasan J, Grabic R, Golovko O, Vojs-Sta\u0148ova A, G\u00e1l M, Naumowicz M, Tichy J, Brandeburova P, H\u00edves J (2016) Dominant psychoactive drugs in the central European region: A wastewater study. Forensic Sci Int 267:42-51. https:\/\/doi.org\/10.1016\/j.forsciint.2016.08.016","journal-title":"Forensic Sci Int"},{"key":"6633_CR42","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.scitotenv.2014.06.089","volume":"494-495","author":"T Macku\u013eak","year":"2014","unstructured":"Macku\u013eak T, \u0160kub\u00e1k J, Grabic R, Ryba J, Biro\u0161ov\u00e1 L, Fedorova G, \u0160palkov\u00e1 V, Bod\u00edk I (2014) National study of illicit drug use in Slovakia based on wastewater analysis. Sci Total Environ 494-495:158-165. https:\/\/doi.org\/10.1016\/j.scitotenv.2014.06.089","journal-title":"Sci Total Environ"},{"key":"6633_CR43","doi-asserted-by":"publisher","first-page":"9325","DOI":"10.1021\/es5017894","volume":"48","author":"T Malchi","year":"2014","unstructured":"Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks. Environ Sci Technol 48:9325-9333. https:\/\/doi.org\/10.1021\/es5017894","journal-title":"Environ Sci Technol"},{"key":"6633_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.envint.2018.12.013","volume":"124","author":"A Margenat","year":"2019","unstructured":"Margenat A, Matamoros V, D\u00edez S, Ca\u00f1ameras N, Comas J, Bayona JM (2019) Occurrence and human health implications of chemical contaminants in vegetables grown in peri-urban agriculture. Environ Int 124:49-57. https:\/\/doi.org\/10.1016\/j.envint.2018.12.013","journal-title":"Environ Int"},{"key":"6633_CR45","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.envpol.2016.10.010","volume":"222","author":"JM Martin","year":"2017","unstructured":"Martin JM, Saaristo M, Bertram MG, Lewis PJ, Coggan TL, Clarke BO, Wong BBM (2017) The psychoactive pollutant fluoxetine compromises antipredatorbehaviour in fish. Environ Pollut 222:592-599. https:\/\/doi.org\/10.1016\/j.envpol.2016.10.010","journal-title":"Environ Pollut"},{"key":"6633_CR46","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.watres.2015.10.040","volume":"88","author":"AK McCall","year":"2016","unstructured":"McCall AK, Bade R, Kinyua J, Lai FY, Thai PK, Covaci A, Bijlsma L, van Nuijs ALN, Ort C (2016) Critical review on the stability of illicit drugs in sewers and wastewater samples. Water Res 88:933-947. https:\/\/doi.org\/10.1016\/j.watres.2015.10.040","journal-title":"Water Res"},{"key":"6633_CR47","first-page":"131","volume":"59","author":"G Michalk\u00f3","year":"2010","unstructured":"Michalk\u00f3 G, R\u00e1cz T (2010) Hungarian spa destinations in the tourism-oriented property market. Hun Geo Bull 59:131-146","journal-title":"Hun Geo Bull"},{"issue":"11","key":"6633_CR48","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1289\/ehp.1001965","volume":"118","author":"SD Richardson","year":"2010","unstructured":"Richardson SD, De Marini DM, Kogevinas M, Fernandez P, Marco E, Lourencetti C, Ballest\u00e9 C, Heederik D, Meliefste K, McKague AB (2010) What's in the pool? A comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming poolwater. Environ Health Perspect 118(11):1523-1530. https:\/\/doi.org\/10.1289\/ehp.1001965","journal-title":"Environ Health Perspect"},{"issue":"1-3","key":"6633_CR49","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.scitotenv.2005.04.031","volume":"356","author":"PH Roberts","year":"2006","unstructured":"Roberts PH, Thomas KV (2006) The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci Total Environ 356(1-3):143-153. https:\/\/doi.org\/10.1016\/j.scitotenv.2005.04.031","journal-title":"Sci Total Environ"},{"key":"6633_CR50","doi-asserted-by":"publisher","DOI":"10.4324\/9780203083772","volume-title":"Health, Tourism and Hospitality","author":"Melanie Smith","year":"2014","unstructured":"Smith, M., Puczk\u00f3, L. (2014). Health, tourism and hospitality: spas, wellness and medical travel. Routledge, New York, NY USA 508 p"},{"issue":"5","key":"6633_CR51","doi-asserted-by":"publisher","first-page":"829","DOI":"10.2166\/wh.2017.004","volume":"15","author":"L Suppes","year":"2017","unstructured":"Suppes L, Huang C-H, Lee W-N, Brockman KJ (2017) Sources of pharmaceuticals and personal care products in swimming pools. J Water Health 15(5):829-833. https:\/\/doi.org\/10.2166\/wh.2017.004","journal-title":"J Water Health"},{"issue":"2","key":"6633_CR52","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1556\/030.63.2016.2.7","volume":"63","author":"S Szur\u00f3czki","year":"2016","unstructured":"Szur\u00f3czki S, K\u00e9ki Z, K\u00e1li S, Lippai A, M\u00e1rialigeti K, T\u00f3th E (2016) Microbiological investigations on the water of a thermal bath at Budapest. Acta Microbiol Immunol Hung 63(2):229-241. https:\/\/doi.org\/10.1556\/030.63.2016.2.7","journal-title":"Acta Microbiol Immunol Hung"},{"issue":"7","key":"6633_CR53","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.1007\/s11356-015-5967-4","volume":"23","author":"TLL Teo","year":"2016","unstructured":"Teo TLL, Coleman HM, Khan SJ (2016) Occurrence and daily variability of pharmaceuticals and personal care products in swimming pools. Environ Sci Pollut Res 23(7):6972-6981. https:\/\/doi.org\/10.1007\/s11356-015-5967-4","journal-title":"Environ Sci Pollut Res"},{"key":"6633_CR54","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.chemosphere.2019.04.221","volume":"230","author":"T Thiebault","year":"2019","unstructured":"Thiebault T, Foug\u00e8re L, Destandau E, R\u00e9ty M, Jacob J (2019) Impact of meteorological and social events on human-excreted contaminant loads in raw wastewater: from daily to weekly dynamics. Chemosphere 230:107-116. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.04.221","journal-title":"Chemosphere"},{"key":"6633_CR55","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.scitotenv.2012.06.069","volume":"432","author":"KV Thomas","year":"2012","unstructured":"Thomas KV, Bijlsma L, Castiglioni S, Covaci A, Emke E, Grabic R, Hern\u00e1ndez F, Karolak S, Kasprzyk-Hordern B, Lindberg RH, Lopez de Alda M, Meierjohann A, Ort C, Pico Y, Quintana JB, Reid M, Rieckermann J, Terzic S, van Nuijs AL, de Voogt P (2012) Comparing illicit drug use in 19 European cities through sewage analysis. Sci Total Environ 432:432-439. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.06.069","journal-title":"Sci Total Environ"},{"key":"6633_CR56","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.scitotenv.2018.01.277","volume":"627","author":"R Tr\u00f6ger","year":"2018","unstructured":"Tr\u00f6ger R, Kl\u00f6ckner P, Ahrens L, Wiberg K (2018) Micropollutants in drinking water from source to tap - method development and application of a multiresidue screening method. Sci Total Environ 627:1404-1432. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.01.277","journal-title":"Sci Total Environ"},{"issue":"12","key":"6633_CR57","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1021\/ez5003133","volume":"1","author":"S Weng","year":"2014","unstructured":"Weng S, Sun P, Ben W, Huang C-H, Lee LT, Blatchley ER (2014) The presence of pharmaceuticals and personal care products in swimming pools. Environ Sci Technol Lett 1(12):495-498. https:\/\/doi.org\/10.1021\/ez5003133","journal-title":"Environ Sci Technol Lett"},{"key":"6633_CR58","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.envpol.2017.06.043","volume":"230","author":"Timothy Paul Wood","year":"2017","unstructured":"Wood TP, Du Preez C, Steenkamp A, Duvenage C, Rohwer ER (2017) Database-driven screening of South African surface water and the targeted detection of pharmaceuticals using liquid chromatography - High resolution mass spectrometry. Environ Pollut 230:453-462. https:\/\/doi.org\/10.1016\/j.envpol.2017.06.043","journal-title":"Environmental Pollution"},{"key":"6633_CR59","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.watres.2016.09.018","volume":"105","author":"E Yue","year":"2016","unstructured":"Yue E, Bai H, Lian L, Li J, Blatchley ER III (2016) Effect of chloride on the formation of volatile disinfection by products in chlorinated swimming pools. Water Res 105:413-420. https:\/\/doi.org\/10.1016\/j.watres.2016.09.018","journal-title":"Water Res"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-06633-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-019-06633-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-019-06633-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T11:32:44Z","timestamp":1665142364000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-019-06633-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["6633"],"URL":"https:\/\/doi.org\/10.1007\/s11356-019-06633-6","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"13 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no known competing financial interests or personal relationship that could have appeared to influence the results presented in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of interest"}}]}}