{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:11:00Z","timestamp":1768450260416,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330068"],"award-info":[{"award-number":["81330068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2016M592041"],"award-info":[{"award-number":["2016M592041"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Research Foundation of Anhui Provinc","award":["2016B114"],"award-info":[{"award-number":["2016B114"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s11356-020-07675-x","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T23:02:29Z","timestamp":1579820549000},"page":"11714-11723","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Urinary concentrations of phthalate metabolites during gestation and intrahepatic cholestasis of pregnancy: a population-based birth cohort study"],"prefix":"10.1007","volume":"27","author":[{"given":"Jian-Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Yong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei-Jing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Shan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Xiu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Biao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"7675_CR1","first-page":"217","volume":"39","author":"Y Ai","year":"2004","unstructured":"Ai Y, Liu SY, Yao Q (2004) Clinical characteristics of 1241 cases of intrahepatic cholestasis of pregnancy. Zhonghua Fu Chan Ke Za Zhi 39:217\u2013220","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"7675_CR2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/0148607111414021","volume":"35","author":"S Bagel","year":"2011","unstructured":"Bagel S, Dessaigne B, Bourdeaux D, Boyer A, Bouteloup C, Bazin JE, Chopineau J, Sautou V (2011) Influence of lipid type on bis (2-ethylhexyl)phthalate (DEHP) leaching from infusion line sets in parenteral nutrition. JPEN J Parenter Enteral Nutr 35:770\u2013775","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"7675_CR3","first-page":"A107","volume":"121","author":"LS Birnbaum","year":"2013","unstructured":"Birnbaum LS (2013) State of the science of endocrine disruptors. Environ Health Perspect 121:A107","journal-title":"Environ Health Perspect"},{"key":"7675_CR4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.envres.2016.08.033","volume":"151","author":"J Botton","year":"2016","unstructured":"Botton J, Philippat C, Calafat AM, Carles S, Charles MA, Slama R, The Eden Mother-Child Cohort Study G (2016) Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age. Environ Res 151:601\u2013609","journal-title":"Environ Res"},{"key":"7675_CR5","doi-asserted-by":"crossref","first-page":"e87697","DOI":"10.1371\/journal.pone.0087697","volume":"9","author":"R Cabrerizo","year":"2014","unstructured":"Cabrerizo R, Castano GO, Burgueno AL, Fernandez Gianotti T, Gonzalez Lopez Ledesma MM, Flichman D, Pirola CJ, Sookoian S (2014) Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype. PLoS One 9:e87697","journal-title":"PLoS One"},{"key":"7675_CR6","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1289\/ehp.0901108","volume":"117","author":"AM Calafat","year":"2009","unstructured":"Calafat AM, Needham LL (2009) What additional factors beyond state-of-the-art analytical methods are needed for optimal generation and interpretation of biomonitoring data? Environ Health Perspect 117:1481\u20131485","journal-title":"Environ Health Perspect"},{"key":"7675_CR7","doi-asserted-by":"crossref","first-page":"e3799","DOI":"10.1136\/bmj.e3799","volume":"344","author":"LC Chappell","year":"2012","unstructured":"Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG, Consortium PS (2012) Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ 344:e3799","journal-title":"BMJ"},{"key":"7675_CR8","first-page":"440","volume":"9","author":"ZYHL Dai","year":"1986","unstructured":"Dai ZYHL, Tao WQ (1986) The importance of intrahepatic cholestasis of pregnancy. Shanghai Med 9:440\u2013443","journal-title":"Shanghai Med"},{"key":"7675_CR9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.toxrep.2017.05.004","volume":"4","author":"L De Toni","year":"2017","unstructured":"De Toni L, Tisato F, Seraglia R, Roverso M, Gandin V, Marzano C, Padrini R, Foresta C (2017) Phthalates and heavy metals as endocrine disruptors in food: a study on pre-packed coffee products. Toxicol Rep 4:234\u2013239","journal-title":"Toxicol Rep"},{"key":"7675_CR10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00244-011-9712-9","volume":"62","author":"P Erkekoglu","year":"2012","unstructured":"Erkekoglu P, Zeybek ND, Giray B, Asan E, Hincal F (2012) The effects of di(2-ethylhexyl)phthalate exposure and selenium nutrition on sertoli cell vimentin structure and germ-cell apoptosis in rat testis. Arch Environ Contam Toxicol 62:539\u2013547","journal-title":"Arch Environ Contam Toxicol"},{"key":"7675_CR11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.taap.2009.02.008","volume":"236","author":"A Eveillard","year":"2009","unstructured":"Eveillard A, Lasserre F, de Tayrac M, Polizzi A, Claus S, Canlet C, Mselli-Lakhal L, Gotardi G, Paris A, Guillou H, Martin PG, Pineau T (2009) Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. Toxicol Appl Pharmacol 236:282\u2013292","journal-title":"Toxicol Appl Pharmacol"},{"key":"7675_CR12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.envint.2014.05.016","volume":"70","author":"KK Ferguson","year":"2014","unstructured":"Ferguson KK, McElrath TF, Ko YA, Mukherjee B, Meeker JD (2014a) Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environ Int 70:118\u2013124","journal-title":"Environ Int"},{"key":"7675_CR13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamapediatrics.2013.3699","volume":"168","author":"KK Ferguson","year":"2014","unstructured":"Ferguson KK, McElrath TF, Meeker JD (2014b) Environmental phthalate exposure and preterm birth. JAMA Pediatr 168:61\u201367","journal-title":"JAMA Pediatr"},{"key":"7675_CR14","doi-asserted-by":"crossref","first-page":"E413","DOI":"10.1111\/jpc.12244","volume":"49","author":"CJ Fischer","year":"2013","unstructured":"Fischer CJ, Bickle Graz M, Muehlethaler V, Palmero D, Tolsa JF (2013) Phthalates in the NICU: is it safe? J Paediatr Child Health 49:E413\u2013E419","journal-title":"J Paediatr Child Health"},{"key":"7675_CR15","first-page":"622","volume":"33","author":"H Gao","year":"2015","unstructured":"Gao H, Xu Y, Sun L, Jin Z, Hu H, Sheng J, Ren L, Tao F (2015) Determination of seven phthalate metabolites in human urine by high performance liquid chromatography-tandem mass spectrometry. Se Pu 33:622\u2013627","journal-title":"Se Pu"},{"key":"7675_CR16","doi-asserted-by":"crossref","first-page":"e0148732","DOI":"10.1371\/journal.pone.0148732","volume":"11","author":"X Ge","year":"2016","unstructured":"Ge X, Tao F, Huang K, Mao L, Huang S, Niu Y, Hao J, Sun Y, Rutayisire E (2016) Maternal snoring may predict adverse pregnancy outcomes: a cohort study in China. PLoS One 11:e0148732","journal-title":"PLoS One"},{"key":"7675_CR17","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3748\/wjg.15.2049","volume":"15","author":"V Geenes","year":"2009","unstructured":"Geenes V, Williamson C (2009) Intrahepatic cholestasis of pregnancy. World J Gastroenterol 15:2049\u20132066","journal-title":"World J Gastroenterol"},{"key":"7675_CR18","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/hep.26617","volume":"59","author":"V Geenes","year":"2014","unstructured":"Geenes V, Chappell LC, Seed PT, Steer PJ, Knight M, Williamson C (2014) Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 59:1482\u20131491","journal-title":"Hepatology"},{"key":"7675_CR19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/hep.20336","volume":"40","author":"A Glantz","year":"2004","unstructured":"Glantz A, Marschall HU, Mattsson LA (2004) Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 40:467\u2013474","journal-title":"Hepatology"},{"key":"7675_CR20","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1021\/jf3021128","volume":"60","author":"Y Guo","year":"2012","unstructured":"Guo Y, Zhang Z, Liu L, Li Y, Ren N, Kannan K (2012) Occurrence and profiles of phthalates in foodstuffs from China and their implications for human exposure. J Agric Food Chem 60:6913\u20136919","journal-title":"J Agric Food Chem"},{"key":"7675_CR21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1399-0004.1993.tb03826.x","volume":"43","author":"ML Hirvioja","year":"1993","unstructured":"Hirvioja ML, Kivinen S (1993) Inheritance of intrahepatic cholestasis of pregnancy in one kindred. Clin Genet 43:315\u2013317","journal-title":"Clin Genet"},{"key":"7675_CR22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.scitotenv.2018.08.149","volume":"648","author":"CJ Hsieh","year":"2019","unstructured":"Hsieh CJ, Chang YH, Hu A, Chen ML, Sun CW, Situmorang RF, Wu MT, Wang SL, group Ts (2019) Personal care products use and phthalate exposure levels among pregnant women. Sci Total Environ 648:135\u2013143","journal-title":"Sci Total Environ"},{"key":"7675_CR23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envres.2016.11.014","volume":"153","author":"HB Huang","year":"2017","unstructured":"Huang HB, Pan WH, Chang JW, Chiang HC, Guo YL, Jaakkola JJ, Huang PC (2017) Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013. Environ Res 153:63\u201372","journal-title":"Environ Res"},{"key":"7675_CR24","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.scitotenv.2017.11.048","volume":"619-620","author":"HB Huang","year":"2018","unstructured":"Huang HB, Kuo PL, Chang JW, Jaakkola JJK, Liao KW, Huang PC (2018) Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). Sci Total Environ 619-620:1058\u20131065","journal-title":"Sci Total Environ"},{"key":"7675_CR25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0140-6736(09)61495-1","volume":"375","author":"D Joshi","year":"2010","unstructured":"Joshi D, James A, Quaglia A, Westbrook RH, Heneghan MA (2010) Liver disease in pregnancy. Lancet 375:594\u2013605","journal-title":"Lancet"},{"key":"7675_CR26","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1074\/jbc.M600116200","volume":"281","author":"D Jung","year":"2006","unstructured":"Jung D, Mangelsdorf DJ, Meyer UA (2006) Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 281:19081\u201319091","journal-title":"J Biol Chem"},{"key":"7675_CR27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.envint.2016.09.013","volume":"97","author":"I Katsikantami","year":"2016","unstructured":"Katsikantami I, Sifakis S, Tzatzarakis MN, Vakonaki E, Kalantzi OI, Tsatsakis AM, Rizos AK (2016) A global assessment of phthalates burden and related links to health effects. Environ Int 97:212\u2013236","journal-title":"Environ Int"},{"key":"7675_CR28","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1289\/ehp.1003178","volume":"119","author":"Y Kim","year":"2011","unstructured":"Kim Y, Ha EH, Kim EJ, Park H, Ha M, Kim JH, Hong YC, Chang N, Kim BN (2011) Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children\u2019s Environmental Health (MOCEH) study. Environ Health Perspect 119:1495\u20131500","journal-title":"Environ Health Perspect"},{"key":"7675_CR29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.scitotenv.2014.11.019","volume":"508","author":"S Kim","year":"2015","unstructured":"Kim S, Lee J, Park J, Kim HJ, Cho G, Kim GH, Eun SH, Lee JJ, Choi G, Suh E, Choi S, Kim S, Kim YD, Kim SK, Kim SY, Kim S, Eom S, Moon HB, Kim S, Choi K (2015) Concentrations of phthalate metabolites in breast milk in Korea: estimating exposure to phthalates and potential risks among breast-fed infants. Sci Total Environ 508:13\u201319","journal-title":"Sci Total Environ"},{"key":"7675_CR30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/jech-2015-206315","volume":"70","author":"JH Kim","year":"2016","unstructured":"Kim JH, Park H, Lee J, Cho G, Choi S, Choi G, Kim SY, Eun SH, Suh E, Kim SK, Kim HJ, Kim GH, Lee JJ, Kim YD, Eom S, Kim S, Moon HB, Park J, Choi K, Kim S, Kim S (2016) Association of diethylhexyl phthalate with obesity-related markers and body mass change from birth to 3 months of age. J Epidemiol Community Health 70:466\u2013472","journal-title":"J Epidemiol Community Health"},{"key":"7675_CR31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.envres.2011.01.013","volume":"111","author":"D Koniecki","year":"2011","unstructured":"Koniecki D, Wang R, Moody RP, Zhu J (2011) Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res 111:329\u2013336","journal-title":"Environ Res"},{"key":"7675_CR32","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0168-8278(00)80139-7","volume":"33","author":"F Lammert","year":"2000","unstructured":"Lammert F, Marschall HU, Glantz A, Matern S (2000) Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol 33:1012\u20131021","journal-title":"J Hepatol"},{"key":"7675_CR33","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/acs.chemrestox.6b00186","volume":"29","author":"EM Laurenzana","year":"2016","unstructured":"Laurenzana EM, Coslo DM, Vigilar MV, Roman AM, Omiecinski CJ (2016) Activation of the constitutive androstane receptor by monophthalates. Chem Res Toxicol 29:1651\u20131661","journal-title":"Chem Res Toxicol"},{"key":"7675_CR34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/0148607107031003188","volume":"31","author":"PD Loff","year":"2007","unstructured":"Loff PD, Subotic U, Oulmi-Kagermann J, Kranzlin B, Reinecke MF, Staude C (2007) Diethylhexylphthalate extracted by typical newborn lipid emulsions from polyvinylchloride infusion systems causes significant changes in histology of rabbit liver. JPEN J Parenter Enteral Nutr 31:188\u2013193","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"7675_CR35","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1586\/17474124.2015.1083857","volume":"9","author":"HU Marschall","year":"2015","unstructured":"Marschall HU (2015) Management of intrahepatic cholestasis of pregnancy. Expert Rev Gastroenterol Hepatol 9:1273\u20131279","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"7675_CR36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejogrb.2013.12.037","volume":"176","author":"M Martineau","year":"2014","unstructured":"Martineau M, Raker C, Powrie R, Williamson C (2014) Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes. Eur J Obstet Gynecol Reprod Biol 176:80\u201385","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"7675_CR37","doi-asserted-by":"crossref","unstructured":"Martinez-Ibarra A, Martinez-Razo LD, Vazquez-Martinez ER, Martinez-Cruz N, Flores-Ramirez R, Garcia-Gomez E, Lopez-Lopez M, Ortega-Gonzalez C, Camacho-Arroyo I, Cerbon M (2019) Unhealthy Levels of Phthalates and Bisphenol A in Mexican Pregnant Women with Gestational Diabetes and Its Association to Altered Expression of miRNAs Involved with Metabolic Disease. Int J Mol Sci:20","DOI":"10.3390\/ijms20133343"},{"key":"7675_CR38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/mnfr.200800312","volume":"54","author":"AJ Martino-Andrade","year":"2010","unstructured":"Martino-Andrade AJ, Chahoud I (2010) Reproductive toxicity of phthalate esters. Mol Nutr Food Res 54:148\u2013157","journal-title":"Mol Nutr Food Res"},{"key":"7675_CR39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mam.2017.05.003","volume":"56","author":"S McIlvride","year":"2017","unstructured":"McIlvride S, Dixon PH, Williamson C (2017) Bile acids and gestation. Mol Asp Med 56:90\u2013100","journal-title":"Mol Asp Med"},{"key":"7675_CR40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5114\/ceh.2018.80122","volume":"4","author":"T Menzyk","year":"2018","unstructured":"Menzyk T, Bator M, Derra A, Kierach R, Kukla M (2018) The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy. Clin Exp Hepatol 4:217\u2013223","journal-title":"Clin Exp Hepatol"},{"key":"7675_CR41","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbadis.2010.11.001","volume":"1812","author":"G Papacleovoulou","year":"2011","unstructured":"Papacleovoulou G, Abu-Hayyeh S, Williamson C (2011) Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation. Biochim Biophys Acta 1812:879\u2013887","journal-title":"Biochim Biophys Acta"},{"key":"7675_CR42","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1172\/JCI68927","volume":"123","author":"G Papacleovoulou","year":"2013","unstructured":"Papacleovoulou G, Abu-Hayyeh S, Nikolopoulou E, Briz O, Owen BM, Nikolova V, Ovadia C, Huang X, Vaarasmaki M, Baumann M, Jansen E, Albrecht C, Jarvelin MR, Marin JJ, Knisely AS, Williamson C (2013) Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123:3172\u20133181","journal-title":"J Clin Invest"},{"key":"7675_CR43","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1210\/jc.2018-00855","volume":"103","author":"EM Philips","year":"2018","unstructured":"Philips EM, Kahn LG, Jaddoe VWV, Shao Y, Asimakopoulos AG, Kannan K, Steegers EAP, Trasande L (2018) First trimester urinary bisphenol and phthalate concentrations and time to pregnancy: a population-based cohort analysis. J Clin Endocrinol Metab 103:3540\u20133547","journal-title":"J Clin Endocrinol Metab"},{"key":"7675_CR44","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1046\/j.1537-2995.1993.33793325058.x","volume":"33","author":"SL Plonait","year":"1993","unstructured":"Plonait SL, Nau H, Maier RF, Wittfoht W, Obladen M (1993) Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. Transfusion 33:598\u2013605","journal-title":"Transfusion"},{"key":"7675_CR45","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0168-8278(00)80214-7","volume":"32","author":"H Reyes","year":"2000","unstructured":"Reyes H, Baez ME, Gonzalez MC, Hernandez I, Palma J, Ribalta J, Sandoval L, Zapata R (2000) Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile. J Hepatol 32:542\u2013549","journal-title":"J Hepatol"},{"key":"7675_CR46","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.21111","volume":"43","author":"A Ropponen","year":"2006","unstructured":"Ropponen A, Sund R, Riikonen S, Ylikorkala O, Aittomaki K (2006) Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. Hepatology 43:723\u2013728","journal-title":"Hepatology"},{"key":"7675_CR47","doi-asserted-by":"crossref","first-page":"21205","DOI":"10.1007\/s11356-018-2299-1","volume":"25","author":"IM Saadeldin","year":"2018","unstructured":"Saadeldin IM, Hussein MA, Suleiman AH, Abohassan MG, Ahmed MM, Moustafa AA, Moumen AF, Abdel-Aziz Swelum A (2018) Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats. Environ Sci Pollut Res Int 25:21205\u201321215","journal-title":"Environ Sci Pollut Res Int"},{"key":"7675_CR48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","volume":"29","author":"T Schettler","year":"2006","unstructured":"Schettler T (2006) Human exposure to phthalates via consumer products. Int J Androl 29:134\u2013139 discussion 181-5","journal-title":"Int J Androl"},{"key":"7675_CR49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00005176-199110000-00008","volume":"13","author":"B Shneider","year":"1991","unstructured":"Shneider B, Cronin J, Van Marter L, Maller E, Truog R, Jacobson M, Kevy S (1991) A prospective analysis of cholestasis in infants supported with extracorporeal membrane oxygenation. J Pediatr Gastroenterol Nutr 13:285\u2013289","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"7675_CR50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.6723","volume":"112","author":"MJ Silva","year":"2004","unstructured":"Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, Brock JW, Needham LL, Calafat AM (2004) Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 112:331\u2013338","journal-title":"Environ Health Perspect"},{"key":"7675_CR51","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1542\/peds.2008-1765","volume":"124","author":"H von Rettberg","year":"2009","unstructured":"von Rettberg H, Hannman T, Subotic U, Brade J, Schaible T, Waag KL, Loff S (2009) Use of di(2-ethylhexyl)phthalate-containing infusion systems increases the risk for cholestasis. Pediatrics 124:710\u2013716","journal-title":"Pediatrics"},{"key":"7675_CR52","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1007\/s00216-013-6779-3","volume":"405","author":"HX Wang","year":"2013","unstructured":"Wang HX, Wang B, Zhou Y, Jiang QW (2013) Rapid and sensitive analysis of phthalate metabolites, bisphenol A, and endogenous steroid hormones in human urine by mixed-mode solid-phase extraction, dansylation, and ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry. Anal Bioanal Chem 405:4313\u20134319","journal-title":"Anal Bioanal Chem"},{"key":"7675_CR53","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.envpol.2018.02.088","volume":"238","author":"W Wang","year":"2018","unstructured":"Wang W, Leung AOW, Chu LH, Wong MH (2018) Phthalates contamination in China: status, trends and human exposure-with an emphasis on oral intake. Environ Pollut 238:771\u2013782","journal-title":"Environ Pollut"},{"key":"7675_CR54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envint.2017.10.007","volume":"110","author":"AG Wenzel","year":"2018","unstructured":"Wenzel AG, Bloom MS, Butts CD, Wineland RJ, Brock JW, Cruze L, Unal ER, Kucklick JR, Somerville SE, Newman RB (2018) Influence of race on prenatal phthalate exposure and anogenital measurements among boys and girls. Environ Int 110:61\u201370","journal-title":"Environ Int"},{"key":"7675_CR55","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/1471-0528.12174","volume":"120","author":"E Wikstrom Shemer","year":"2013","unstructured":"Wikstrom Shemer E, Marschall HU, Ludvigsson JF, Stephansson O (2013) Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. BJOG 120:717\u2013723","journal-title":"BJOG"},{"key":"7675_CR56","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jhep.2015.03.010","volume":"63","author":"EA Wikstrom Shemer","year":"2015","unstructured":"Wikstrom Shemer EA, Stephansson O, Thuresson M, Thorsell M, Ludvigsson JF, Marschall HU (2015) Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: a population-based cohort study. J Hepatol 63:456\u2013461","journal-title":"J Hepatol"},{"key":"7675_CR57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chemosphere.2016.05.023","volume":"157","author":"HY Yao","year":"2016","unstructured":"Yao HY, Han Y, Gao H, Huang K, Ge X, Xu YY, Xu YQ, Jin ZX, Sheng J, Yan SQ, Zhu P, Hao JH, Tao FB (2016) Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns. Chemosphere 157:42\u201348","journal-title":"Chemosphere"},{"key":"7675_CR58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.envint.2015.12.004","volume":"88","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Wan Y, Li Y, Zhang B, Zhou A, Cai Z, Qian Z, Zhang C, Huo W, Huang K, Hu J, Cheng L, Chang H, Huang Z, Xu B, Xia W, Xu S (2016) Free and total urinary phthalate metabolite concentrations among pregnant women from the Healthy Baby Cohort (HBC), China. Environ Int 88:67\u201373","journal-title":"Environ Int"},{"key":"7675_CR59","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/en.2012-1422","volume":"153","author":"RT Zoeller","year":"2012","unstructured":"Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Vom Saal FS (2012) Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology 153:4097\u20134110","journal-title":"Endocrinology"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-07675-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-020-07675-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-07675-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T01:31:25Z","timestamp":1611279085000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-020-07675-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["7675"],"URL":"https:\/\/doi.org\/10.1007\/s11356-020-07675-x","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"assertion":[{"value":"24 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants were fully informed prior to participating in the study, and the study was ethically approved by the Anhui Medical University (number: 20131195) based on the institution\u2019s ethical standards and the ethical standards of the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}