{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:42:45Z","timestamp":1790476965773,"version":"4.1.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:00:00Z","timestamp":1584748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:00:00Z","timestamp":1584748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s11356-020-08191-8","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T03:02:29Z","timestamp":1584759749000},"page":"18592-18601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Apoptosis and DNA damage induced by silica nanoparticles and formaldehyde in human lung epithelial cells"],"prefix":"10.1007","volume":"27","author":[{"given":"Mehran","family":"Nazarparvar-Noshadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Ezzati Nazhad Dolatabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-5153","authenticated-orcid":false,"given":"Yahya","family":"Rasoulzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Mohammadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariush","family":"Shanehbandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,21]]},"reference":[{"key":"8191_CR1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0960327112459206","volume":"32","author":"M Ahamed","year":"2013","unstructured":"Ahamed M (2013) Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells. Hum Exp Toxicol 32:186\u2013195","journal-title":"Hum Exp Toxicol"},{"key":"8191_CR2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/00043764-199507000-00012","volume":"37","author":"DA Andjelkovich","year":"1995","unstructured":"Andjelkovich DA, Janszen DB, Brown MH, Richardson RB, Miller FJ (1995) Mortality of iron foundry workers: IV. Analysis of a subcohort exposed to formaldehyde. J Occup Environ Med 37:826\u2013837","journal-title":"J Occup Environ Med"},{"key":"8191_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3390\/ijerph14030289","volume":"14","author":"C Asweto","year":"2017","unstructured":"Asweto C, Wu J, Hu H, Feng L, Yang X, Duan J, Sun Z (2017) Combined effect of silica nanoparticles and benzo [a] pyrene on cell cycle arrest induction and apoptosis in human umbilical vein endothelial cells. Int J Environ Res Public Health 14:289","journal-title":"Int J Environ Res Public Health"},{"key":"8191_CR4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.toxlet.2010.07.009","volume":"198","author":"S Barillet","year":"2010","unstructured":"Barillet S, Jugan M-L, Laye M, Leconte Y, Herlin-Boime N, Reynaud C, Carri\u00e8re M (2010) In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: cyto-, genotoxicity and oxidative stress. Toxicol Lett 198:324\u2013330","journal-title":"Toxicol Lett"},{"key":"8191_CR5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ajim.10222","volume":"43","author":"N Ba\u015faran","year":"2003","unstructured":"Ba\u015faran N, Shubair M, \u00dcnde\u011fer \u00dc, Kars A (2003) Monitoring of DNA damage in foundry and pottery workers exposed to silica by the alkaline comet assay. Am J Ind Med 43:602\u2013610","journal-title":"Am J Ind Med"},{"key":"8191_CR6","doi-asserted-by":"crossref","first-page":"8385","DOI":"10.1016\/j.biomaterials.2011.07.078","volume":"32","author":"AT Bauer","year":"2011","unstructured":"Bauer AT, Strozyk EA, Gorzelanny C, Westerhausen C, Desch A, Schneider MF, Schneider SW (2011) Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells. Biomaterials 32:8385\u20138393","journal-title":"Biomaterials"},{"key":"8191_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tiv.2012.09.002","volume":"27","author":"JM Berg","year":"2013","unstructured":"Berg JM, Romoser AA, Figueroa DE, West CS, Sayes CM (2013) Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO 2. Toxicol in Vitro 27:24\u201333","journal-title":"Toxicol in Vitro"},{"key":"8191_CR8","unstructured":"Cancer IAfRo (2004) IARC classifies formaldehyde as carcinogenic to humans. Press release, 15"},{"key":"8191_CR9","first-page":"37","volume":"88","author":"Cancer IAfRo","year":"2005","unstructured":"Cancer IAfRo (2005) Formaldehyde 2-butoxyethanol and 1-tertbutoxy-2-propanol in evaluating carcinogenic. Risk Hum 88:37\u2013325","journal-title":"Risk Hum"},{"key":"8191_CR10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yexcr.2004.12.021","volume":"305","author":"M Chen","year":"2005","unstructured":"Chen M, von Mikecz A (2005) Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res 305:51\u201362","journal-title":"Exp Cell Res"},{"key":"8191_CR11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jhazmat.2008.01.036","volume":"158","author":"Y-H Cheng","year":"2008","unstructured":"Cheng Y-H, Chao Y-C, Wu C-H, Tsai C-J, Uang S-N, Shih T-S (2008) Measurements of ultrafine particle concentrations and size distribution in an iron foundry. J Hazard Mater 158:124\u2013130","journal-title":"J Hazard Mater"},{"key":"8191_CR12","doi-asserted-by":"publisher","unstructured":"Conde J, Doria G, Baptista P (2012) Noble metal nanoparticles applications in cancer. J Drug Deliv. https:\/\/doi.org\/10.1155\/2012\/751075","DOI":"10.1155\/2012\/751075"},{"key":"8191_CR13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-8977-2-10","volume":"2","author":"K Donaldson","year":"2005","unstructured":"Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V (2005) Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10","journal-title":"Part Fibre Toxicol"},{"key":"8191_CR14","doi-asserted-by":"crossref","first-page":"e62087","DOI":"10.1371\/journal.pone.0062087","volume":"8","author":"J Duan","year":"2013","unstructured":"Duan J, Yu Y, Li Y, Yu Y, Li Y, Zhou X, Huang P, Sun Z (2013) Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2\/M checkpoint. PLoS One 8:e62087","journal-title":"PLoS One"},{"key":"8191_CR15","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/dna.2013.2059","volume":"32","author":"M Eskandani","year":"2013","unstructured":"Eskandani M, Hamishehkar H, Dolatabadi JEN (2013) Cyto\/genotoxicity study of polyoxyethylene (20) sorbitan monolaurate (tween 20). DNA Cell Biol 32:498\u2013503","journal-title":"DNA Cell Biol"},{"key":"8191_CR16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.foodchem.2013.12.087","volume":"153","author":"M Eskandani","year":"2014","unstructured":"Eskandani M, Hamishehkar H, Ezzati Nazhad Dolatabadi J (2014) Cytotoxicity and DNA damage properties of tert-butylhydroquinone (TBHQ) food additive. Food Chem 153:315\u2013320","journal-title":"Food Chem"},{"key":"8191_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/annhyg\/mem056","volume":"52","author":"DE Evans","year":"2007","unstructured":"Evans DE, Heitbrink WA, Slavin TJ, Peters TM (2007) Ultrafine and respirable particles in an automotive grey iron foundry. Ann Occup Hyg 52:9\u201321","journal-title":"Ann Occup Hyg"},{"key":"8191_CR18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jddst.2018.05.017","volume":"46","author":"J Ezzati Nazhad Dolatabadi","year":"2018","unstructured":"Ezzati Nazhad Dolatabadi J, Azami A, Mohammadi A, Hamishehkar H, Panahi-Azar V, Rahbar Saadat Y, Saei AA (2018) Formulation, characterization and cytotoxicity evaluation of ketotifen-loaded nanostructured lipid carriers. J Drug Deliv Sci Technol 46:268\u2013273","journal-title":"J Drug Deliv Sci Technol"},{"key":"8191_CR19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1289\/ehp.1103750","volume":"119","author":"S Gangwal","year":"2011","unstructured":"Gangwal S, Brown JS, Wang A, Houck KA, Dix DJ, Kavlock RJ, Hubal EAC (2011) Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential. Environ Health Perspect 119:1539\u20131546","journal-title":"Environ Health Perspect"},{"key":"8191_CR20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/01480545.2013.838776","volume":"37","author":"H Hamishehkar","year":"2014","unstructured":"Hamishehkar H, Khani S, Kashanian S, Ezzati Nazhad Dolatabadi J, Eskandani M (2014) Geno- and cytotoxicity of propyl gallate food additive. Drug Chem Toxicol 37:241\u2013246","journal-title":"Drug Chem Toxicol"},{"key":"8191_CR21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nantod.2010.03.004","volume":"5","author":"WG Kreyling","year":"2010","unstructured":"Kreyling WG, Semmler-Behnke M, Chaudhry Q (2010) A complementary definition of nanomaterial. Nano Today 5:165\u2013168","journal-title":"Nano Today"},{"key":"8191_CR22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1538\/expanim.56.35","volume":"56","author":"C Kum","year":"2007","unstructured":"Kum C, Kiral F, Sekkin S, Seyrek K, Boyacioglu M (2007) Effects of xylene and formaldehyde inhalations on oxidative stress in adult and developing rats livers. Exp Anim 56:35\u201342","journal-title":"Exp Anim"},{"key":"8191_CR23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3923\/javaa.2010.396.401","volume":"9","author":"S Kum","year":"2010","unstructured":"Kum S, Sandikci M, Eren U, Metin N (2010) Effects of formaldehyde and xylene inhalations on fatty liver and kidney in adult and developing rats. J Anim Vet Adv 9:396\u2013401","journal-title":"J Anim Vet Adv"},{"key":"8191_CR24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2010.03.011","volume":"271","author":"SK Lim","year":"2010","unstructured":"Lim SK, Kim JC, Moon CJ, Kim GY, Han HJ, Park SH (2010) Formaldehyde induces apoptosis through decreased Prx 2 via p38 MAPK in lung epithelial cells. Toxicology 271:100\u2013106","journal-title":"Toxicology"},{"key":"8191_CR25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ecoenv.2015.09.030","volume":"122","author":"C-F Lu","year":"2015","unstructured":"Lu C-F, Yuan X-Y, Li L-Z, Zhou W, Zhao J, Wang Y-M, Peng S-Q (2015) Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells. Ecotoxicol Environ Saf 122:537\u2013544","journal-title":"Ecotoxicol Environ Saf"},{"key":"8191_CR26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.etap.2017.04.001","volume":"52","author":"C-F Lu","year":"2017","unstructured":"Lu C-F, Li L-Z, Zhou W, Zhao J, Wang Y-M, Peng S-Q (2017) Silica nanoparticles and lead acetate co-exposure triggered synergistic cytotoxicity in A549 cells through potentiation of mitochondria-dependent apoptosis induction. Environ Toxicol Pharmacol 52:114\u2013120","journal-title":"Environ Toxicol Pharmacol"},{"key":"8191_CR27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2754\/avb200271020163","volume":"71","author":"E Matalov\u00e1","year":"2002","unstructured":"Matalov\u00e1 E, \u0160panov\u00e1 A (2002) Detection of apoptotic DNA ladder in pig leukocytes and its precision using LM-PCR (ligation mediated polymerase chain reaction). Acta Vet Brno 71:163\u2013168","journal-title":"Acta Vet Brno"},{"key":"8191_CR28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/444267a","volume":"444","author":"AD Maynard","year":"2006","unstructured":"Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberd\u00f6rster G, Philbert MA, Ryan J, Seaton A, Stone V (2006) Safe handling of nanotechnology. Nature 444:267","journal-title":"Nature"},{"key":"8191_CR29","first-page":"21","volume":"50","author":"M Mizuki","year":"2001","unstructured":"Mizuki M, Tsuda T (2001) Relationship between atopic factors and physical symptoms induced by gaseous formaldehyde exposure during an anatomy dissection course. Arerugi 50:21\u201328","journal-title":"Arerugi"},{"key":"8191_CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.foodchem.2018.03.020","volume":"257","author":"H Mohammadzadeh-Aghdash","year":"2018","unstructured":"Mohammadzadeh-Aghdash H, Sohrabi Y, Mohammadi A, Shanehbandi D, Dehghan P, Ezzati Nazhad Dolatabadi J (2018) Safety assessment of sodium acetate, sodium diacetate and potassium sorbate food additives. Food Chem 257:211\u2013215","journal-title":"Food Chem"},{"key":"8191_CR31","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.biomaterials.2010.12.042","volume":"32","author":"H Nabeshi","year":"2011","unstructured":"Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T (2011) Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials 32:2713\u20132724","journal-title":"Biomaterials"},{"key":"8191_CR32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1743-8977-7-39","volume":"7","author":"D Napierska","year":"2010","unstructured":"Napierska D, Thomassen LC, Lison D, Martens JA, Hoet PH (2010) The nanosilica hazard: another variable entity. Part Fibre Toxicol 7:39","journal-title":"Part Fibre Toxicol"},{"key":"8191_CR33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/mutage\/gen025","volume":"23","author":"S Neuss","year":"2008","unstructured":"Neuss S, Speit G (2008) Further characterization of the genotoxicity of formaldehyde in vitro by the sister chromatid exchange test and co-cultivation experiments. Mutagenesis 23:355\u2013357","journal-title":"Mutagenesis"},{"key":"8191_CR34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"G Oberdorster","year":"2005","unstructured":"Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823\u2013839","journal-title":"Environ Health Perspect"},{"key":"8191_CR35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-8977-2-8","volume":"2","author":"G Oberd\u00f6rster","year":"2005","unstructured":"Oberd\u00f6rster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D (2005a) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2:8","journal-title":"Part Fibre Toxicol"},{"key":"8191_CR36","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"G Oberd\u00f6rster","year":"2005","unstructured":"Oberd\u00f6rster G, Oberd\u00f6rster E, Oberd\u00f6rster J (2005b) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823","journal-title":"Environ Health Perspect"},{"key":"8191_CR37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/15298668391404996","volume":"44","author":"J Oudiz","year":"1983","unstructured":"Oudiz J, Brown JW, Ayer HE, Samuels S (1983) A report on silica exposure levels in United States foundries. Am Ind Hyg Assoc J 44:374\u2013376","journal-title":"Am Ind Hyg Assoc J"},{"key":"8191_CR38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxlet.2008.10.012","volume":"184","author":"E-J Park","year":"2009","unstructured":"Park E-J, Park K (2009) Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184:18\u201325","journal-title":"Toxicol Lett"},{"key":"8191_CR39","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/annonc\/mdj125","volume":"17","author":"C Pelucchi","year":"2006","unstructured":"Pelucchi C, Pira E, Piolatto G, Coggiola M, Carta P, La Vecchia C (2006) Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996\u20132005. Ann Oncol 17:1039\u20131050","journal-title":"Ann Oncol"},{"key":"8191_CR40","first-page":"167","volume":"24","author":"N Petushok","year":"2000","unstructured":"Petushok N (2000) Activity of glutathione-related enzymes in rat tissues after formaldehyde exposure. Curr Top Biophys 24:167\u2013170","journal-title":"Curr Top Biophys"},{"key":"8191_CR41","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/toxsci\/kfj099","volume":"90","author":"KW Powers","year":"2006","unstructured":"Powers KW, Brown SC, Krishna VB, Wasdo SC, Moudgil BM, Roberts SM (2006) Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90:296\u2013303","journal-title":"Toxicol Sci"},{"key":"8191_CR42","doi-asserted-by":"crossref","unstructured":"Rezazadeh MA, Mohammadian Y, Pourahmad J, Khodagholi F, Peirovi H, Mehrabi Y, Omidi M, Rafieepour A (2019) Individual and combined toxicity of carboxylic acid functionalized multi-walled carbon nanotubes and benzo a pyrene in lung adenocarcinoma cells. Environ Sci Pollut Res Int 26(13):12709\u201312719","DOI":"10.1007\/s11356-019-04795-x"},{"key":"8191_CR43","first-page":"25","volume":"5","author":"YR Saadat","year":"2015","unstructured":"Saadat YR, Saeidi N, Vahed SZ, Barzegari A, Barar J (2015) An update to DNA ladder assay for apoptosis detection. Bioimpacts 5:25","journal-title":"Bioimpacts"},{"key":"8191_CR44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.canlet.2009.01.010","volume":"278","author":"Y Sanchez-Perez","year":"2009","unstructured":"Sanchez-Perez Y, Chirino YI, Osornio-Vargas AR, Morales-Barcenas R, Gutierrez-Ruiz C, Vazquez-Lopez I, Garcia-Cuellar CM (2009) DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants. Cancer Lett 278:192\u2013200","journal-title":"Cancer Lett"},{"key":"8191_CR45","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1021\/nl0710710","volume":"7","author":"CM Sayes","year":"2007","unstructured":"Sayes CM, Marchione AA, Reed KL, Warheit DB (2007) Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Lett 7:2399\u20132406","journal-title":"Nano Lett"},{"key":"8191_CR46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/mutage\/gel053","volume":"22","author":"O Schmid","year":"2007","unstructured":"Schmid O, Speit G (2007) Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies. Mutagenesis 22:69\u201374","journal-title":"Mutagenesis"},{"key":"8191_CR47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/carcin\/17.1.121","volume":"17","author":"J Shaham","year":"1996","unstructured":"Shaham J, Bomstein Y, Meltzer A, Kaufman Z, Palma E, Ribak J (1996) DNA-protein crosslinks, a biomarker of exposure to formaldehyde\u2014in vitro and in vivo studies. Carcinogenesis 17:121\u2013126","journal-title":"Carcinogenesis"},{"key":"8191_CR48","first-page":"406","volume":"29","author":"S S\u00f6g\u00fct","year":"2004","unstructured":"S\u00f6g\u00fct S, Songur A, \u00d6zen OA, \u00d6zyurt H, Sarsilmaz M (2004) Does the subacute (4-week) exposure to formaldehyde inhalation lead to oxidant\/antioxidant imbalance in rat liver. Eur J Gen Med 29:406\u2013409","journal-title":"Eur J Gen Med"},{"key":"8191_CR49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.15171\/apb.2018.039","volume":"8","author":"Y Sohrabi","year":"2018","unstructured":"Sohrabi Y, Mohammadzadeh-Aghdash H, Baghbani E, Dehghan P, Ezzati Nazhad Dolatabadi J (2018) Cytotoxicity and genotoxicity assessment of ascorbyl palmitate (AP) food additive. Adv Pharm Bull 8:341\u2013346","journal-title":"Adv Pharm Bull"},{"key":"8191_CR50","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.tiv.2011.06.012","volume":"25","author":"L Sun","year":"2011","unstructured":"Sun L, Li Y, Liu X, Jin M, Zhang L, Du Z, Guo C, Huang P, Sun Z (2011) Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicol in Vitro 25:1619\u20131629","journal-title":"Toxicol in Vitro"},{"key":"8191_CR51","doi-asserted-by":"crossref","unstructured":"Tong R, Cheng M, Ma X, Yang Y, Liu Y, Li J (2019) Quantitative health risk assessment of inhalation exposure to automobile foundry dust. Environ Geochem Health 41(5):2179\u20132193","DOI":"10.1007\/s10653-019-00277-8"},{"key":"8191_CR52","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.tiv.2011.05.019","volume":"25","author":"F Wang","year":"2011","unstructured":"Wang F, Jiao C, Liu J, Yuan H, Lan M, Gao F (2011) Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells. Toxicol in Vitro 25:1548\u20131556","journal-title":"Toxicol in Vitro"},{"key":"8191_CR53","first-page":"719","volume":"49","author":"H Westberg","year":"2005","unstructured":"Westberg H, Loefstedt H, Selden A, Lilja B-G, Naystroem P (2005) Exposure to low molecular weight isocyanates and formaldehyde in foundries using hot box core binders. Ann Occup Hyg 49:719\u2013725","journal-title":"Ann Occup Hyg"},{"key":"8191_CR54","doi-asserted-by":"crossref","first-page":"23134","DOI":"10.1007\/s11356-016-7559-3","volume":"23","author":"J Wu","year":"2016","unstructured":"Wu J, Shi Y, Asweto CO, Feng L, Yang X, Zhang Y, Hu H, Duan J, Sun Z (2016) Co-exposure to amorphous silica nanoparticles and benzo [a] pyrene at low level in human bronchial epithelial BEAS-2B cells. Environ Sci Pollut Res 23:23134\u201323144","journal-title":"Environ Sci Pollut Res"},{"key":"8191_CR55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00204-009-0488-x","volume":"84","author":"G Xie","year":"2010","unstructured":"Xie G, Sun J, Zhong G, Shi L, Zhang D (2010) Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch Toxicol 84:183\u2013190","journal-title":"Arch Toxicol"},{"key":"8191_CR56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jat.1710","volume":"32","author":"Z Xu","year":"2012","unstructured":"Xu Z, Chou L, Sun J (2012) Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway. J Appl Toxicol 32:358\u2013364","journal-title":"J Appl Toxicol"},{"key":"8191_CR57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-8977-7-1","volume":"7","author":"X Yang","year":"2010","unstructured":"Yang X, Liu J, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L (2010) SiO 2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol 7:1","journal-title":"Part Fibre Toxicol"},{"key":"8191_CR58","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jat.2962","volume":"34","author":"YX Yang","year":"2014","unstructured":"Yang YX, Song ZM, Cheng B, Xiang K, Chen XX, Liu JH, Cao A, Wang Y, Liu Y, Wang H (2014) Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells. J Appl Toxicol 34:424\u2013435","journal-title":"J Appl Toxicol"},{"key":"8191_CR59","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.scitotenv.2018.03.107","volume":"631","author":"X Yang","year":"2018","unstructured":"Yang X, Feng L, Zhang Y, Hu H, Shi Y, Liang S, Zhao T, Cao L, Duan J, Sun Z (2018) Co-exposure of silica nanoparticles and methylmercury induced cardiac toxicity in vitro and in vivo. Sci Total Environ 631:811\u2013821","journal-title":"Sci Total Environ"},{"key":"8191_CR60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ecoenv.2014.10.026","volume":"112","author":"Y Yu","year":"2015","unstructured":"Yu Y, Duan J, Li Y, Yu Y, Jin M, Li C, Wang Y, Sun Z (2015) Combined toxicity of amorphous silica nanoparticles and methylmercury to human lung epithelial cells. Ecotoxicol Environ Saf 112:144\u2013152","journal-title":"Ecotoxicol Environ Saf"},{"key":"8191_CR61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1191\/0748233706th260oa","volume":"22","author":"I Zararsiz","year":"2006","unstructured":"Zararsiz I, Sonmez MF, Yilmaz HR, Tas U, Kus I, Kavakli A, Sarsilmaz M (2006) Effects of v-3 essential fatty acids against formaldehyde-induced nephropathy in rats. Toxicol Ind Health 22:223\u2013229","journal-title":"Toxicol Ind Health"},{"key":"8191_CR62","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/1055-9965.EPI-09-0762","volume":"19","author":"L Zhang","year":"2010","unstructured":"Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, Qiu C, Guo W, Liu S, Reiss B (2010a) Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev 19:80\u201388","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"8191_CR63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0895-3988(10)60041-4","volume":"23","author":"M Zhang","year":"2010","unstructured":"Zhang M, Zheng Y-D, Xie-Yi D, Yang L, Wen-Jie L, Cheng Q, Zheng-Lai W (2010b) Silicosis in automobile foundry workers: a 29-year cohort study. Biomed Environ Sci 23:121\u2013129","journal-title":"Biomed Environ Sci"},{"key":"8191_CR64","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1745-7262.2006.00198.x","volume":"8","author":"DX Zhou","year":"2006","unstructured":"Zhou DX, Qiu SD, Zhang J, Tian H, Wang HX (2006) The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats. Asian J Androl 8:584\u2013588","journal-title":"Asian J Androl"},{"key":"8191_CR65","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.talanta.2013.01.037","volume":"107","author":"J Zhu","year":"2013","unstructured":"Zhu J, Liao L, Zhu L, Zhang P, Guo K, Kong J, Ji C, Liu B (2013) Size-dependent cellular uptake efficiency, mechanism, and cytotoxicity of silica nanoparticles toward HeLa cells. Talanta 107:408\u2013415","journal-title":"Talanta"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-08191-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-020-08191-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-08191-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:27:28Z","timestamp":1616286448000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-020-08191-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,21]]},"references-count":65,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["8191"],"URL":"https:\/\/doi.org\/10.1007\/s11356-020-08191-8","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,21]]},"assertion":[{"value":"28 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}