{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:35:18Z","timestamp":1772026518983,"version":"3.50.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s11356-020-10778-0","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T15:03:47Z","timestamp":1600441427000},"page":"4558-4572","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["RETRACTED ARTICLE: Synergistic effects of Ficus Carica extract and extra virgin olive oil against oxidative injury, cytokine liberation, and inflammation mediated by 5-Fluorouracil in cardiac and renal tissues of male albino rats"],"prefix":"10.1007","volume":"28","author":[{"given":"Mona M.","family":"Elghareeb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gehad E.","family":"Elshopakey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma M.","family":"Hendam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaymaa","family":"Rezk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah","family":"Lashen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"10778_CR1","doi-asserted-by":"publisher","first-page":"13502","DOI":"10.1007\/s11356-019-04780-4","volume":"26","author":"MM Abdel-Daim","year":"2019","unstructured":"Abdel-Daim MM, Abushouk AI, Donia T, Alarifi S, Alkahtani S, Aleya L, Bungau SG (2019) The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats. Environ Sci Pollut Res 26:13502\u201313509","journal-title":"Environ Sci Pollut Res"},{"key":"10778_CR2","doi-asserted-by":"publisher","unstructured":"Abdel-Daim MM, Mahmoud OM, Al Badawi MH, Alghamdi J, Alkahtani S, Salem NA (2020) Protective effects of Citrus limonia oil against cisplatin-induced nephrotoxicity. Environ Sci Pollut Res 1\u20131. https:\/\/doi.org\/10.1007\/s11356-020-10066-x","DOI":"10.1007\/s11356-020-10066-x"},{"key":"10778_CR3","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.biopha.2016.12.038","volume":"86","author":"SA Abdellatief","year":"2017","unstructured":"Abdellatief SA, Galal AA, Farouk SM, Abdel-Daim MM (2017) Ameliorative effect of parsley oil on cisplatin-induced hepato-cardiotoxicity: a biochemical, histopathological, and immunohistochemical study. Biomed Pharmacother 86:482\u2013491","journal-title":"Biomed Pharmacother"},{"key":"10778_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.9790\/3013-070401103163","volume":"7","author":"AE Al-Sanfi","year":"2017","unstructured":"Al-Sanfi AE (2017) Medicinal plants for prevention and treatment of cardiovascular review. J Pharm 7:103\u2013163. https:\/\/doi.org\/10.9790\/3013-070401103163","journal-title":"J Pharm"},{"key":"10778_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1177\/0960327115573597","volume":"35","author":"AK Al-Asmari","year":"2016","unstructured":"Al-Asmari AK, Al-Zahrani AM, Khan AQ, Al-Shahrani HM, Ali Al Amri M (2016) Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: a biochemical and histological study. Hum Exp Toxicol 35:10\u201320. https:\/\/doi.org\/10.1177\/0960327115573597","journal-title":"Hum Exp Toxicol"},{"key":"10778_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1385\/1-59259-404-2:297","volume":"21","author":"FS Apple","year":"2001","unstructured":"Apple FS (2001) Cardiac troponin: redefining the detection of myocardial infarction. Am Clin Lab 21:32\u201334. https:\/\/doi.org\/10.1385\/1-59259-404-2:297","journal-title":"Am Clin Lab"},{"key":"10778_CR7","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1159\/000489210","volume":"46","author":"HH Arab","year":"2018","unstructured":"Arab HH, Salama SA, Maghrabi IA (2018) Camel milk ameliorates 5-fluorouracil-induced renal injury in rats: targeting MAPKs, NF-\u03baB and PI3K\/Akt\/eNOS pathways. Cell Physiol Biochem 46:1628\u20131642. https:\/\/doi.org\/10.1159\/000489210","journal-title":"Cell Physiol Biochem"},{"key":"10778_CR8","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.3390\/molecules13102340","volume":"13","author":"JL Arias","year":"2008","unstructured":"Arias JL (2008) Novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems. Molecules 13:2340\u20132369. https:\/\/doi.org\/10.3390\/molecules13102340","journal-title":"Molecules"},{"key":"10778_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/b978-0-443-10279-0.50006-3","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"2008","unstructured":"Bancroft JD, Marilyn G (2008) Theory and practice of histological techniques, vol 2, 6th edn. Churchill Livingstone Elsevier, Oxford, pp 123\u2013125. https:\/\/doi.org\/10.1016\/b978-0-443-10279-0.50006-3","edition":"6"},{"key":"10778_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00244-010-9494-5","volume":"59","author":"M Banni","year":"2010","unstructured":"Banni M, Messaoudi I, Said L, El Heni J, Kerkeni A, Said K (2010) Metallothionein gene expression in liver of rats exposed to cadmium and supplemented with zinc and selenium. Arch Environ Contam Toxicol 59:513\u2013519","journal-title":"Arch Environ Contam Toxicol"},{"key":"10778_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21608\/absb.2014.25184","volume":"25","author":"MA Bashandy","year":"2014","unstructured":"Bashandy MA, Abd El-Rasheid HG, Hasan HF, Fathya AH (2014) Protective and therapeutic effects of olive oil and Ficus carica as natural antioxidants on some biochemical parameters in liver of \u03b3-irradiated male albino rats. ABSB 25:1\u201316. https:\/\/doi.org\/10.21608\/absb.2014.25184","journal-title":"ABSB"},{"key":"10778_CR12","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1182\/blood.v21.5.573.573","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888. https:\/\/doi.org\/10.1182\/blood.v21.5.573.573","journal-title":"J Lab Clin Med"},{"key":"10778_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2119\/molmed.2010.00002","volume":"16","author":"K Bhatt","year":"2010","unstructured":"Bhatt K, Zhou L, Mi QS, Huang S, She JX, Dong Z (2010) MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival. Mol Med 16:409\u2013416. https:\/\/doi.org\/10.2119\/molmed.2010.00002","journal-title":"Mol Med"},{"key":"10778_CR14","first-page":"6","volume":"2","author":"M Biswas","year":"2010","unstructured":"Biswas M, Kar B, Karan TK, Bhattacharya S, Kumar RS, Ghosh AK, Haldar PK (2010) Acute and sub-chronic toxicity study of Dregea volubilis fruit in mice. J Phytol 2:6\u201310 http:\/\/updatepublishing.com\/journal\/index.php\/jp\/article\/view\/2155","journal-title":"J Phytol"},{"key":"10778_CR15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450210108045","volume-title":"Clinical methods: the history, physical, and laboratory examinations","author":"CD Cabbinas","year":"1990","unstructured":"Cabbinas CD (1990) Creatine kinase in walker HK. In: Hall WD, Hurst JW (eds) Clinical methods: the history, physical, and laboratory examinations, 3rd edn. Butterworths, chapter 32, Boston. https:\/\/doi.org\/10.1001\/jama.1990.03450210108045","edition":"3"},{"key":"10778_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1556\/aphysiol.87.2000.1.8","volume":"87","author":"JR Canal","year":"2000","unstructured":"Canal JR, Torres DM, Romero A, Perez C (2000) A chloroform extract obtained from a decoction of Ficus carica leaves improve the cholesterolaemic status of rats with streptozotocin induced diabetes. Acta Vet Hung 87:71\u201376. https:\/\/doi.org\/10.1556\/aphysiol.87.2000.1.8","journal-title":"Acta Vet Hung"},{"key":"10778_CR17","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s13277-011-0189-y","volume":"32","author":"S Chibber","year":"2011","unstructured":"Chibber S, Farhan M, Hassan I, Naseem I (2011) White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study. Tumour Biol 32:881\u2013892. https:\/\/doi.org\/10.1007\/s13277-011-0189-y","journal-title":"Tumour Biol"},{"key":"10778_CR18","doi-asserted-by":"publisher","unstructured":"Clairborne A (1985) Catalase activity. In: Greenwald R (ed) Handbook of Methods for Oxygen Radical Research. CRC Press, pp 283\u2013284. https:\/\/doi.org\/10.1016\/0531-5565(85)90021-x","DOI":"10.1016\/0531-5565(85)90021-x"},{"key":"10778_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2217\/fca.12.73","volume":"9","author":"A Colombo","year":"2013","unstructured":"Colombo A, Cardinale D (2013) Using cardiac biomarkers and treating cardiotoxicity in cancer. Futur Cardiol 9:105\u2013118. https:\/\/doi.org\/10.2217\/fca.12.73","journal-title":"Futur Cardiol"},{"key":"10778_CR20","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.fct.2009.01.019","volume":"47","author":"RM Costa","year":"2009","unstructured":"Costa RM, Magalh\u00e3es AS, Pereira JA, Andrade PB, Valent\u00e3o P, Carvalho M, Silva BM (2009) Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: a comparative study with green tea (Camellia sinensis). Food Chem Toxicol 47:860\u2013865. https:\/\/doi.org\/10.1016\/j.fct.2009.01.019","journal-title":"Food Chem Toxicol"},{"key":"10778_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.2174\/157016111795495549","volume":"9","author":"G Kolovou","year":"2011","unstructured":"Kolovou G, Mikhailidis D, Kovar J, Lairon D, Nordestgaard B, Chye Ooi T, Perez-Martinez P, Bilianou H, Anagnostopoulou K, Panotopoulos G (2011) Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 9:258\u2013270. https:\/\/doi.org\/10.2174\/157016111795495549","journal-title":"Curr Vasc Pharmacol"},{"key":"10778_CR22","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.15373\/22778160\/june2014\/63","volume":"3","author":"K Dayan","year":"2014","unstructured":"Dayan K, Kishanchandra K (2014) Phytochemical investigation and evaluation of antihyperlipidemic activity of Ficus carica Linn. fruit extracts. Glob J Res Anal 3:2277\u20138160. https:\/\/doi.org\/10.15373\/22778160\/june2014\/63","journal-title":"Glob J Res Anal"},{"key":"10778_CR23","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1001\/jama.292.12.1440","volume":"292","author":"K Esposito","year":"2004","unstructured":"Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, D\u2019Armiento M, D\u2019Andrea F, Giugliano D (2004) Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. Jama 292:1440\u20131446. https:\/\/doi.org\/10.1001\/jama.292.12.1440","journal-title":"Jama"},{"key":"10778_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1017\/s0029665110001539","volume":"69","author":"R Estruch","year":"2010","unstructured":"Estruch R (2010) Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study. Proc Nutr Soc 69:333\u2013340. https:\/\/doi.org\/10.1017\/s0029665110001539","journal-title":"Proc Nutr Soc"},{"key":"10778_CR25","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1139\/facets-2017-0075","volume":"3","author":"AH Fathy","year":"2018","unstructured":"Fathy AH, Bashandy MA, Bashandy SA, Mansour AM (2018) The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats during diethylnitrosamine-induced carcinogenesis. FACETS 3:584\u2013597. https:\/\/doi.org\/10.1139\/facets-2017-0075","journal-title":"FACETS"},{"issue":"5","key":"10778_CR26","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/00007890-200209150-00007","volume":"74","author":"R Fernandez-Botran","year":"2002","unstructured":"Fernandez-Botran R, Gorantla V, Sun X, Ren X, Perez-Abadia G, Crespo FA, Oliver R, Orhun HI, Quan EE, Maldonado C, Ray M (2002) Targeting of glycosaminoglycan-cytokine interactions as a novel therapeutic approach in allotransplantation1. Transplantation 74(5):623\u2013629. https:\/\/doi.org\/10.1097\/00007890-200209150-00007","journal-title":"Transplantation"},{"key":"10778_CR27","doi-asserted-by":"publisher","first-page":"453","DOI":"10.18794\/aams\/65697","volume":"57","author":"S Gawe\u0142","year":"2004","unstructured":"Gawe\u0142 S, Wardas M, Niedworok E, Wardas P (2004) Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomosci Lekarskie (Warsaw, Poland: 1960) 57:453\u2013455. https:\/\/doi.org\/10.18794\/aams\/65697","journal-title":"Wiadomosci Lekarskie (Warsaw, Poland: 1960)"},{"key":"10778_CR28","doi-asserted-by":"publisher","first-page":"404","DOI":"10.22038\/IJBMS.2018.27510.6714","volume":"21","author":"V Gelen","year":"2018","unstructured":"Gelen V, \u015eeng\u00fcl E, Y\u0131ld\u0131r\u0131m S, Atila G (2018) The protective effects of naringin against 5-fluorouracil-\u0131nduced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci 21:404\u2013410. https:\/\/doi.org\/10.22038\/IJBMS.2018.27510.6714","journal-title":"Iran J Basic Med Sci"},{"key":"10778_CR29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.2478\/s11756-020-00492-0","volume":"27","author":"A Ghafoor","year":"2015","unstructured":"Ghafoor A, Tahir M, Lone KP, Faisal B, Latif W (2015) The effect of ficus carica. (Anjir) leaf extract on gentamicin induced nephrotoxicity in adult male albino mice. J Ayub Med Coll Abbottabad 27:398\u2013401. https:\/\/doi.org\/10.2478\/s11756-020-00492-0","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"10778_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2008.05.040","volume":"119","author":"AH Gilani","year":"2008","unstructured":"Gilani AH, Mehmood MH, Janbaz KH, Khan AU, Saeed SA (2008) Ethnopharmacological studies on antispasmodic and antiplatelet activities of Ficus carica. J Ethnopharmacol 119:1\u20135. https:\/\/doi.org\/10.1016\/j.jep.2008.05.040","journal-title":"J Ethnopharmacol"},{"key":"10778_CR31","doi-asserted-by":"publisher","first-page":"408","DOI":"10.2174\/1389557511313030009","volume":"13","author":"I Gulcin","year":"2013","unstructured":"Gulcin I, Beydemir S (2013) Phenolic compounds as antioxidants: carbonic anhydrase isoenzymes inhibitors. Mini-Rev Med Chem 13:408\u2013430. https:\/\/doi.org\/10.2174\/1389557511313030009","journal-title":"Mini-Rev Med Chem"},{"key":"10778_CR32","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1128\/mcb.23.7.2362-2378.2003","volume":"23","author":"G Guo","year":"2003","unstructured":"Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, Khaletskiy A, Li Z, Weydert C, Longmate JA, Huang TT (2003) Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol 23:2362\u20132378. https:\/\/doi.org\/10.1128\/mcb.23.7.2362-2378.2003","journal-title":"Mol Cell Biol"},{"key":"10778_CR33","first-page":"1201","volume":"10","author":"SY Han","year":"2011","unstructured":"Han SY, Youker S (2011) Metallic taste as a side effect of topical fluorouracil use. J Drugs Dermatol 10:1201\u20131203","journal-title":"J Drugs Dermatol"},{"key":"10778_CR34","volume-title":"Phytochemical methods","author":"JB Harborne","year":"1988","unstructured":"Harborne JB (1988) Phytochemical methods, 2nd edn. Published in USA by Chapman and Hall 29, west 35th street, New York","edition":"2"},{"key":"10778_CR35","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1253\/jcj.64.606","volume":"64","author":"N Hatori","year":"2000","unstructured":"Hatori N, Havu N, Hofman-Bang C, Clyne N, Pehrsson SK (2000) Myocardial morphology and cardiac function in rats with renal failure. Jap Circ J 64:606\u2013610. https:\/\/doi.org\/10.1253\/jcj.64.606","journal-title":"Jap Circ J"},{"key":"10778_CR36","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.5455\/njppp.2018.8.0411517042018","volume":"8","author":"TA Ismail","year":"2018","unstructured":"Ismail TA, Nassan MA, Alkhedaide AQ, Soliman MM, Mohamed DI (2018) Molecular, biochemical, and pathological impacts of energy drinks on renin\u2013angiotensin\u2013aldosterone pathway in Wistar rats. Natl J Physiol Pharm Pharmacol 8:1140\u20131146. https:\/\/doi.org\/10.5455\/njppp.2018.8.0411517042018","journal-title":"Natl J Physiol Pharm Pharmacol"},{"key":"10778_CR37","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/ptr.4994","volume":"28","author":"L Joerin","year":"2014","unstructured":"Joerin L, Kauschka M, Bonnl\u00e4nder B, Pischel I, Benedek B, Butterweck V (2014) Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C. Phytother Res 28:261\u2013267. https:\/\/doi.org\/10.1002\/ptr.4994","journal-title":"Phytother Res"},{"key":"10778_CR38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1006\/excr.1995.1211","volume":"219","author":"J Kajstura","year":"1995","unstructured":"Kajstura J, Mansukhani M, Cheng W, Reiss K, Krajewski S, Reed JC, Quaini F, Sonnenblick EH, Anversa P (1995) Programmed cell death and expression of the protooncogene bcl-2 in myocytes during postnatal maturation of the heart. Exp Cell Res 219:110\u2013121. https:\/\/doi.org\/10.1006\/excr.1995.1211","journal-title":"Exp Cell Res"},{"key":"10778_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.toxlet.2018.02.024","volume":"15","author":"SR Khalil","year":"2018","unstructured":"Khalil SR, Mohammed AT, Abd El-fattah AH, Zaglool AW (2018) Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin. Toxicol Lett 15:89\u201398. https:\/\/doi.org\/10.1016\/j.toxlet.2018.02.024","journal-title":"Toxicol Lett"},{"key":"10778_CR40","doi-asserted-by":"publisher","first-page":"397","DOI":"10.21608\/ajps.2012.7260","volume":"6","author":"RA Khudhair","year":"2014","unstructured":"Khudhair RA, Numan TI (2014) Possible cardioprotective effects of telmisartan againist 5-fluorouracil induced cadiotoxicity in wister rats. Int J Pharm Pharm Sci 6:397\u2013400. https:\/\/doi.org\/10.21608\/ajps.2012.7260","journal-title":"Int J Pharm Pharm Sci"},{"key":"10778_CR41","first-page":"109","volume":"46","author":"S Kinouchi","year":"2003","unstructured":"Kinouchi S (2003) Changes in apoptosis-related genes (Bcl-2, Bax) in the urethras of old female rats following estrogen replacement. Yonago Acta Medica 46:109\u2013115","journal-title":"Yonago Acta Medica"},{"key":"10778_CR42","doi-asserted-by":"publisher","first-page":"592","DOI":"10.21608\/ajps.2012.7260","volume":"48","author":"MRB Lemos","year":"2012","unstructured":"Lemos MRB, Siqueira EMA, Arruda SF, Zambiazi RC (2012) The effect of roasting on the phenolic compounds and antioxidant potential of baru nuts [Dipteryx alata Vog.]. Food Res Int 48:592\u2013597. https:\/\/doi.org\/10.21608\/ajps.2012.7260","journal-title":"Food Res Int"},{"key":"10778_CR43","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.bbagen.2012.06.011","volume":"1820","author":"CM Liu","year":"2012","unstructured":"Liu CM, Sun YZ, Sun JM, Ma JQ, Cheng C (2012) Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-kappaB pathway. Biochim Biophys Acta 1820:1693\u20131703. https:\/\/doi.org\/10.1016\/j.bbagen.2012.06.011","journal-title":"Biochim Biophys Acta"},{"key":"10778_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"10778_CR45","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/nu11092039","volume":"20","author":"J L\u00f3pez-Miranda","year":"2010","unstructured":"L\u00f3pez-Miranda J, P\u00e9rez-Jim\u00e9nez F, Ros E, De Caterina R, Badim\u00f3n L, Covas MI, Escrich E, Ordov\u00e1s JM, Soriguer F, Abia R, de la Lastra CA (2010) Olive oil and health: summary of the II international conference on olive oil and health consensus report, Ja\u00e9n and C\u00f3rdoba (Spain) 2008. Nutr Metab Cardiovasc Dis 20:284\u2013294. https:\/\/doi.org\/10.3390\/nu11092039","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10778_CR46","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/(sici)1099-1573(199709)11:6<463::aid-ptr130>3.0.co;2-1","volume":"3","author":"SC Manda","year":"1997","unstructured":"Manda SC, Mukherjee KP, Saha K, Das J, Pal M, Saba PB (1997) Hypoglycemic activity of Ficus carica leaves in streptozotoin-induced diabetic rats. Nat Prod Sci 3:38\u201341. https:\/\/doi.org\/10.1002\/(sici)1099-1573(199709)11:6<463::aid-ptr130>3.0.co;2-1","journal-title":"Nat Prod Sci"},{"key":"10778_CR47","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1111\/nmo.12890","volume":"28","author":"RM McQuade","year":"2016","unstructured":"McQuade RM, Stojanovska V, Donald E, Abalo R, Bornstein JC, Nurgali K (2016) Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil 28:1861\u20131875","journal-title":"Neurogastroenterol Motil"},{"key":"10778_CR48","doi-asserted-by":"publisher","unstructured":"Meunier L, Larrey D (2020, 2020) Chemotherapy-associated steatohepatitis. Annal Hepatol. https:\/\/doi.org\/10.1016\/j.aohep.2019.11.012","DOI":"10.1016\/j.aohep.2019.11.012"},{"key":"10778_CR49","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0009-8981(79)90211-0","volume":"92","author":"M Minami","year":"1979","unstructured":"Minami M, Yoshikawa H (1979) A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 92:337\u2013342. https:\/\/doi.org\/10.1016\/0009-8981(79)90211-0","journal-title":"Clin Chim Acta"},{"key":"10778_CR50","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/cancers2031717","volume":"2","author":"K Miura","year":"2010","unstructured":"Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C (2010) 5-fu metabolism in cancer and orally-administrable 5-fu drugs. Cancers 2:1717\u20131730. https:\/\/doi.org\/10.3390\/cancers2031717","journal-title":"Cancers"},{"key":"10778_CR51","doi-asserted-by":"publisher","unstructured":"Mokhtari T, Osman HE, El-Kenawy AE, Dashti N (2019) Ameliorative effect of virgin olive oil against nephrotoxicity following sub-chronic administration of ethephon in male rats. JTCM. https:\/\/doi.org\/10.1016\/j.jtcme.2019.08.005","DOI":"10.1016\/j.jtcme.2019.08.005"},{"key":"10778_CR52","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/ajh.2012.128","volume":"25","author":"R Moreno-Luna","year":"2012","unstructured":"Moreno-Luna R, Mu\u00f1oz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P (2012) Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens 25:1299\u20131304. https:\/\/doi.org\/10.1038\/ajh.2012.128","journal-title":"Am J Hypertens"},{"key":"10778_CR53","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.cbi.2008.09.034","volume":"177","author":"SN Nivitabishekam","year":"2009","unstructured":"Nivitabishekam SN, Asad M, Prasad VS (2009) Pharmacodynamic interaction of Momordica charantia with rosiglitazone in rats. Chem Biol Interact 177:247\u2013253. https:\/\/doi.org\/10.1016\/j.cbi.2008.09.034","journal-title":"Chem Biol Interact"},{"key":"10778_CR54","first-page":"66","volume":"1","author":"A Osama","year":"2014","unstructured":"Osama A, Engy R, Gehad E (2014) Immunomodulatory effect of artichoke (Cynara scolymus) on carbon tetrachloride induced immunosuppression in rats. Ann Vet Anim Sci 1:66\u201376","journal-title":"Ann Vet Anim Sci"},{"key":"10778_CR55","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s10068-013-0185-7","volume":"22","author":"S Park","year":"2013","unstructured":"Park S, Han J, Im K, Whang WK, Min H (2013) Antioxidative and anti-inflammatory activities of an ethanol extract from fig (Ficus carica) branches. Food Sci Biotechnol 22:1071\u20131075. https:\/\/doi.org\/10.1007\/s10068-013-0185-7","journal-title":"Food Sci Biotechnol"},{"key":"10778_CR56","first-page":"151","volume":"2","author":"VV Patil","year":"2011","unstructured":"Patil VV, Patil VR (2011) Evaluation of anti-inflammatory activity of Ficus carica Linn. Leaves. IJNPR 2:151\u2013155 http:\/\/hdl.handle.net\/123456789\/12134","journal-title":"IJNPR"},{"key":"10778_CR57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s005920300001","volume":"40","author":"C Perez","year":"2003","unstructured":"Perez C, Canal JR, Torres MD (2003) Experimental diabetes treated with Ficus carica extract: effect on oxidative stress parameters. Acta Diabetol 40:3\u20138. https:\/\/doi.org\/10.1007\/s005920300001","journal-title":"Acta Diabetol"},{"key":"10778_CR58","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jopr.2013.03.003","volume":"7","author":"S Rashid","year":"2013","unstructured":"Rashid S, Ali N, Nafees S, Ahmad ST, Hasan SK, Sultana S (2013) Abrogation of 5-flourouracil induced renal toxicity by bee propolis via targeting oxidative stress and inflammation in Wistar rats. J Pharm Res 7:189\u2013194. https:\/\/doi.org\/10.1016\/j.jopr.2013.03.003","journal-title":"J Pharm Res"},{"key":"10778_CR59","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.fct.2014.01.026","volume":"66","author":"S Rashid","year":"2014","unstructured":"Rashid S, Ali N, Nafees S, Hasan SK, Sultana S (2014) Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats. Food Chem Toxicol 66:185\u2013193. https:\/\/doi.org\/10.1016\/j.fct.2014.01.026","journal-title":"Food Chem Toxicol"},{"key":"10778_CR60","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.foodchem.2013.10.075","volume":"149","author":"L Rubi\u00f3","year":"2014","unstructured":"Rubi\u00f3 L, Maci\u00e0 A, Castell-Auv\u00ed A, Pinent M, Blay MT, Ard\u00e9vol A, Romero MP, Motilva MJ (2014) Effect of the co-occurring olive oil and thyme extracts on the phenolic bioaccesibility and bioavailability assessed by in vitro digestion and cell models. Food Chem 149:277\u2013284. https:\/\/doi.org\/10.1016\/j.foodchem.2013.10.075","journal-title":"Food Chem"},{"key":"10778_CR61","first-page":"270","volume-title":"Biochemical methods","author":"S Sadasivam","year":"2008","unstructured":"Sadasivam S, Manickam A (2008) Biochemical methods. New Age International Pvt. Ltd, New Delhi, p 270"},{"key":"10778_CR62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","volume":"90","author":"K Satoh","year":"1978","unstructured":"Satoh K (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 90:37\u201343. https:\/\/doi.org\/10.1016\/0009-8981(78)90081-5","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10778_CR63","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.abb.2012.05.003","volume":"527","author":"E Scoditti","year":"2012","unstructured":"Scoditti E, Calabriso N, Massaro M, Pellegrino M, Storelli C, Martines G, De Caterina R, Carluccio MA (2012) Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys 527(2):81\u201389. https:\/\/doi.org\/10.1016\/j.abb.2012.05.003","journal-title":"Arch Biochem Biophys"},{"key":"10778_CR64","doi-asserted-by":"publisher","first-page":"7717","DOI":"10.1021\/jf060497h","volume":"54","author":"A Solomon","year":"2006","unstructured":"Solomon A, Golubowicz S, Yablowicz Z, Grossman S, Bergman M, Gottlieb HE, Altman A, Kerem Z, Flaishman MA (2006) Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L). Agric Food Chem 54:7717\u20137723. https:\/\/doi.org\/10.1021\/jf060497h","journal-title":"Agric Food Chem"},{"key":"10778_CR65","doi-asserted-by":"publisher","first-page":"762","DOI":"10.17179\/excli2018-1539","volume":"17","author":"SA Vaez","year":"2018","unstructured":"Vaez SA, Ebrahimi-Barough S, Soleimani M, Kolivand S, Farzamfar S, Tafti SH, Azami M, Noorbakhsh F, Ai J (2018) The cardiac niche role in cardiomyocyte differentiation of rat bone marrow-derived stromal cells: comparison between static and microfluidic cell culture methods. EXCLI J 17:762. https:\/\/doi.org\/10.17179\/excli2018-1539","journal-title":"EXCLI J"},{"key":"10778_CR66","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3923\/rjmp.2011.246.253","volume":"5","author":"VP Vikas","year":"2011","unstructured":"Vikas VP, Vijay RP (2011) Ficus carica Linn\u2013an overview. Res J Med Plant 5:246\u2013253. https:\/\/doi.org\/10.3923\/rjmp.2011.246.253","journal-title":"Res J Med Plant"},{"key":"10778_CR67","doi-asserted-by":"publisher","first-page":"443","DOI":"10.20452\/pamw.1879","volume":"123","author":"G Wilk","year":"2013","unstructured":"Wilk G, Osmenda G, Matusik P, Nowakowski D, Jasiewicz-Honkisz B, Ignacak A, Czesnikiewicz-Guzik M, Guzik TJ (2013) Endothelial function assessment in atherosclerosis: comparison of brachial artery flow-mediated vasodilation and peripheral arterial tonometry. Pol Arch Med 123:443\u2013452. https:\/\/doi.org\/10.20452\/pamw.1879","journal-title":"Pol Arch Med"},{"key":"10778_CR68","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1021\/jf020782a","volume":"51","author":"K Wolfe","year":"2003","unstructured":"Wolfe K, Wu X, Liu R (2003) Antioxidant activity of apple peels. J Agric Food Chem 51:609\u2013614","journal-title":"J Agric Food Chem"},{"key":"10778_CR69","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.bone.2004.04.027","volume":"35","author":"CJ Xian","year":"2004","unstructured":"Xian CJ, Howarth G, Cool J, Foster B (2004) Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats. Bone 35:739\u2013749. https:\/\/doi.org\/10.1016\/j.bone.2004.04.027","journal-title":"Bone"},{"key":"10778_CR70","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.etp.2017.01.012","volume":"69","author":"HN Yousef","year":"2017","unstructured":"Yousef HN, Aboelwafa HR (2017) The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats. Exp Toxicol Pathol 69:265\u2013274. https:\/\/doi.org\/10.1016\/j.etp.2017.01.012","journal-title":"Exp Toxicol Pathol"},{"key":"10778_CR71","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12012-017-9420-4","volume":"18","author":"N Zakaria","year":"2018","unstructured":"Zakaria N, Khalil SR, Awad A, Khairy GM (2018) Quercetin reverses altered energy metabolism in the heart of rats receiving adriamycin chemotherapy. Cardiovasc Toxicol 18:109\u2013119. https:\/\/doi.org\/10.1007\/s12012-017-9420-4","journal-title":"Cardiovasc Toxicol"},{"key":"10778_CR72","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1159\/000480471","volume":"43","author":"YY Zhang","year":"2017","unstructured":"Zhang YY, Yi M, Huang YP (2017) Oxymatrine ameliorates doxorubicin-induced cardiotoxicity in rats. Cell Physiol Biochem 43:626\u2013635. https:\/\/doi.org\/10.1159\/000480471","journal-title":"Cell Physiol Biochem"},{"key":"10778_CR73","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","volume":"64","author":"J Zhishen","year":"1999","unstructured":"Zhishen J, Mengcheng T, Jianming W (1999) Research on antioxidant activity of flavonoids from natural materials. Food Chem 64:555\u2013559","journal-title":"Food Chem"}],"updated-by":[{"DOI":"10.1007\/s11356-024-35285-4","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"record-id":"57824"},{"DOI":"10.1007\/s11356-024-35285-4","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000}}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-10778-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-020-10778-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-10778-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T15:05:15Z","timestamp":1728659115000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-020-10778-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10778"],"URL":"https:\/\/doi.org\/10.1007\/s11356-020-10778-0","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"13 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11356-024-35285-4","URL":"https:\/\/doi.org\/10.1007\/s11356-024-35285-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocol was approved by the Animal Care and Use Ethics Committee of Faculty of Veterinary Medicine, Mansoura University, Egypt (Approval No. R\/7).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors voluntarily participated in this research study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have consent for the publication of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}