{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:14:59Z","timestamp":1793949299724,"version":"4.8.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"FCT","award":["UIDB\/04423\/2020 and UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDB\/04423\/2020 and UIDP\/04423\/2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11356-020-11320-y","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:06:19Z","timestamp":1604016379000},"page":"11384-11400","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Occurrence and risk assessment of pharmaceuticals and cocaine around the coastal submarine sewage outfall in Guaruj\u00e1, S\u00e3o Paulo State, Brazil"],"prefix":"10.1007","volume":"28","author":[{"given":"Vinicius","family":"Roveri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Lopes","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walber","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-025X","authenticated-orcid":false,"given":"Alberto Teodorico","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"4","key":"11320_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.15343\/0104-7809.2012364643661","volume":"36","author":"DMS Abessa","year":"2012","unstructured":"Abessa DMS, Rachid BRF, Moser GAO, Oliveira AJFC (2012) Efeitos ambientais da disposi\u00e7\u00e3o oce\u00e2nica de esgotos por meio de emiss\u00e1rios submarinos: uma revis\u00e3o. Mundo da Sa\u00fade 36(4):643\u2013661","journal-title":"Mundo da Sa\u00fade"},{"issue":"2","key":"11320_CR2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3390\/antibiotics2020274","volume":"2","author":"C Afonso-Olivares","year":"2013","unstructured":"Afonso-Olivares C, Torres-Padr\u00f3n M, Sosa-Ferrera Z, Santana-Rodr\u00edguez J (2013) Assessment of the presence of pharmaceutical compounds in seawater samples from coastal area of Gran Canaria Island (Spain). Antibiotics 2(2):274\u2013287. https:\/\/doi.org\/10.3390\/antibiotics2020274","journal-title":"Antibiotics"},{"key":"11320_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ecoenv.2013.07.002","volume":"97","author":"GV Aguirre-Mart\u00ednez","year":"2013","unstructured":"Aguirre-Mart\u00ednez GV, Del Valls TA, Mart\u00edn-D\u00edaz ML (2013a) Early responses measured in the brachyuran crab Carcinus maenas exposed to carbamazepine and novobiocin: Application of a 2-tier approach. Ecotoxicol Environ Saf 97:47\u201358. https:\/\/doi.org\/10.1016\/j.ecoenv.2013.07.002","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"11320_CR4","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/s1001-0742(12)60207-1","volume":"25","author":"GV Aguirre-Mart\u00ednez","year":"2013","unstructured":"Aguirre-Mart\u00ednez GV, Buratti S, Fabbri E, DelValls AT, Mart\u00edn-D\u00edaz ML (2013b) Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin. J Environ Sci 25(7):1408\u20131418. https:\/\/doi.org\/10.1016\/s1001-0742(12)60207-1","journal-title":"J Environ Sci"},{"key":"11320_CR5","first-page":"712","volume-title":"Farmacologia e Terap\u00eautica Cl\u00ednica","author":"JRC Almeida","year":"2013","unstructured":"Almeida JRC, Cruciol JM (2013) Farmacologia e Terap\u00eautica Cl\u00ednica, 1st edn. Atheneu, S\u00e3o Paulo, p 712","edition":"1"},{"key":"11320_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.aquatox.2014.08.002","volume":"156","author":"\u00c2 Almeida","year":"2014","unstructured":"Almeida \u00c2, Calisto V, Esteves VI, Schneider RJ, Soares AMVM, Figueira E, Freitas R (2014) Presence of the pharmaceutical drug carbamazepine in coastal systems: Effects on bivalves. Aquat Toxicol 156:74\u201387. https:\/\/doi.org\/10.1016\/j.aquatox.2014.08.002","journal-title":"Aquat Toxicol"},{"key":"11320_CR7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbpc.2015.04.004","volume":"172-173","author":"\u00c2 Almeida","year":"2015","unstructured":"Almeida \u00c2, Freitas R, Calisto V, Esteves VI, Schneider RJ, Soares AMVM, Figueira E (2015) Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum. Comp Biochem Physiol Part C Toxicol Pharmacol 172-173:26\u201335. https:\/\/doi.org\/10.1016\/j.cbpc.2015.04.004","journal-title":"Comp Biochem Physiol Part C Toxicol Pharmacol"},{"key":"11320_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.scitotenv.2015.09.145","volume":"541","author":"NA Alygizakis","year":"2016","unstructured":"Alygizakis NA, Gago-Ferrero P, Borova VL, Pavlidou A, Hatzianestis I, Thomaidis NS (2016) Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater. Sci Total Environ 541:1097\u20131105. https:\/\/doi.org\/10.1016\/j.scitotenv.2015.09.145","journal-title":"Sci Total Environ"},{"issue":"9","key":"11320_CR9","doi-asserted-by":"publisher","first-page":"6658","DOI":"10.1007\/s11356-013-1784-9","volume":"20","author":"SC Antunes","year":"2013","unstructured":"Antunes SC, Freitas R, Figueira E, Gon\u00e7alves F, Nunes B (2013) Biochemical effects of acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis philippinarum. Environ Sci Pollut Res 20(9):6658\u20136666. https:\/\/doi.org\/10.1007\/s11356-013-1784-9","journal-title":"Environ Sci Pollut Res"},{"issue":"6","key":"11320_CR10","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1007\/s11356-014-3617-x","volume":"23","author":"L Arpin-Pont","year":"2014","unstructured":"Arpin-Pont L, Bueno MJM, Gomez E, Fenet H (2014) Occurrence of PPCPs in the marine environment: a review. Environ Sci Pollut Res 23(6):4978\u20134991. https:\/\/doi.org\/10.1007\/s11356-014-3617-x","journal-title":"Environ Sci Pollut Res"},{"key":"11320_CR11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.scitotenv.2013.03.043","volume":"454-455","author":"DR Baker","year":"2013","unstructured":"Baker DR, Kasprzyk-Hordern B (2013) Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: New developments. Sci Total Environ 454-455:442\u2013456. https:\/\/doi.org\/10.1016\/j.scitotenv.2013.03.043","journal-title":"Sci Total Environ"},{"issue":"18","key":"11320_CR12","doi-asserted-by":"publisher","first-page":"10830","DOI":"10.1007\/s11356-014-3060-z","volume":"21","author":"A Bayer","year":"2014","unstructured":"Bayer A, Asner R, Sch\u00fcssler W, Kopf W, Wei\u00df K, Sengl M, Letzel M (2014) Behavior of sartans (antihypertensive drugs) in wastewater treatment plants, their occurrence and risk for the aquatic environment. Environ Sci Pollut Res 21(18):10830\u201310839. https:\/\/doi.org\/10.1007\/s11356-014-3060-z","journal-title":"Environ Sci Pollut Res"},{"issue":"20","key":"11320_CR13","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1016\/j.scitotenv.2011.07.015","volume":"409","author":"SK Behera","year":"2011","unstructured":"Behera SK, Kim HW, Oh J-E, Park H-S (2011) Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea. Sci Total Environ 409(20):4351\u20134360. https:\/\/doi.org\/10.1016\/j.scitotenv.2011.07.015","journal-title":"Sci Total Environ"},{"issue":"1","key":"11320_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2166\/ws.2011.068","volume":"12","author":"MJ Benotti","year":"2012","unstructured":"Benotti MJ, Song R, Wilson D, Snyder SA (2012) Removal of pharmaceuticals and endocrine disrupting compounds through pilot- and full-scale riverbank filtration. Water Sci Technol Water Supply 12(1):11\u201323. https:\/\/doi.org\/10.2166\/ws.2011.068","journal-title":"Water Sci Technol Water Supply"},{"issue":"7","key":"11320_CR15","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1007\/s11368-014-0884-6","volume":"14","author":"M Beretta","year":"2014","unstructured":"Beretta M, Britto V, Tavares TM, Silva SMT, Pletsch AL (2014) Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil. J Soils Sediments 14(7):1278\u20131286. https:\/\/doi.org\/10.1007\/s11368-014-0884-6","journal-title":"J Soils Sediments"},{"key":"11320_CR16","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.scitotenv.2012.11.006","volume":"443","author":"L Bijlsma","year":"2013","unstructured":"Bijlsma L, Boix C, Niessen WMA, Ib\u00e1\u00f1ez M, Sancho JV, Hern\u00e1ndez F (2013) Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment. Sci Total Environ 443:200\u2013208. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.11.006","journal-title":"Sci Total Environ"},{"key":"11320_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.aquatox.2013.06.013","volume":"140-141","author":"A Binelli","year":"2013","unstructured":"Binelli A, Marisa I, Fedorova M, Hoffmann R, Riva C (2013) First evidence of protein profile alteration due to the main cocaine metabolite (benzoylecgonine) in a freshwater biological model. Aquat Toxicol 140-141:268\u2013278. https:\/\/doi.org\/10.1016\/j.aquatox.2013.06.013","journal-title":"Aquat Toxicol"},{"issue":"2","key":"11320_CR18","doi-asserted-by":"publisher","first-page":"29","DOI":"10.14210\/bjast.v10n2.p29-51","volume":"10","author":"C Blaise","year":"2006","unstructured":"Blaise C, Gagn\u00e9 F, Eullaffroy P, F\u00e9rard JF (2006) Ecotoxicity of selected pharmaceuticals of urban origin discharged to the Saint-Lawrence river (Qu\u00e9bec, Canada): a review. Ecotoxicity of selected pharmaceuticals of urban origin discharged to the Saint-Lawrence river (Qu\u00e9bec, Canada): a review. Braz J Aquat Sci Technol 10(2):29\u201351","journal-title":"Braz J Aquat Sci Technol"},{"key":"11320_CR19","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.scitotenv.2017.09.146","volume":"613-614","author":"B Bonnefille","year":"2018","unstructured":"Bonnefille B, Gomez E, Alali M, Rosain D, Fenet H, Courant F (2018) Metabolomics assessment of the effects of diclofenac exposure on Mytilus galloprovincialis: Potential effects on osmoregulation and reproduction. Sci Total Environ 613-614:611\u2013618. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.09.146","journal-title":"Sci Total Environ"},{"issue":"1","key":"11320_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.aquatox.2004.06.011","volume":"70","author":"RA Brain","year":"2004","unstructured":"Brain RA, Johnson DJ, Richards SM, Hanson ML, Sanderson H, Lam MW, Solomon KR (2004) Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum. Aquat Toxicol 70(1):23\u201340. https:\/\/doi.org\/10.1016\/j.aquatox.2004.06.011","journal-title":"Aquat Toxicol"},{"issue":"1","key":"11320_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/tox.20774","volume":"29","author":"FP Brand\u00e3o","year":"2011","unstructured":"Brand\u00e3o FP, Pereira JL, Gon\u00e7alves F, Nunes B (2011) The impact of paracetamol on selected biomarkers of the mollusc species Corbicula fluminea. Environ Toxicol 29(1):74\u201383. https:\/\/doi.org\/10.1002\/tox.20774","journal-title":"Environ Toxicol"},{"issue":"8","key":"11320_CR22","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1016\/j.ecoenv.2010.08.031","volume":"73","author":"EJ Brandhof","year":"2010","unstructured":"Brandhof EJ, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac and metoprolol. Ecotoxicol Environ Saf 73(8):1862\u20131866. https:\/\/doi.org\/10.1016\/j.ecoenv.2010.08.031","journal-title":"Ecotoxicol Environ Saf"},{"key":"11320_CR23","first-page":"364","volume-title":"Relat\u00f3rio Brasileiro sobre Drogas","author":"Brazil \u2013 Senad: Secretaria Nacional de Pol\u00edticas Sobre Drogas","year":"2009","unstructured":"Brazil \u2013 Senad: Secretaria Nacional de Pol\u00edticas Sobre Drogas (2009) Relat\u00f3rio Brasileiro sobre Drogas. IME\/USP, Bras\u00edlia, p 364 ISBN 978-85-60662-29-6"},{"key":"11320_CR24","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.envpol.2017.07.082","volume":"229","author":"M Brumovsk\u00fd","year":"2017","unstructured":"Brumovsk\u00fd M, Be\u010danov\u00e1 J, Kohoutek J, Borghini M, Nizzetto L (2017) Contaminants of emerging concern in the open seawaters of the Western Mediterranean. Environ Pollut 229:976\u2013983. https:\/\/doi.org\/10.1016\/j.envpol.2017.07.082","journal-title":"Environ Pollut"},{"issue":"1","key":"11320_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.talanta.2011.03.051","volume":"85","author":"MJM Bueno","year":"2011","unstructured":"Bueno MJM, Ucl\u00e9s S, Hernando MD, Fernad\u00e9z-Alba AR (2011) Development of a solvent-free method for the simultaneous identification\/quantification of drugs of abuse and their metabolites in environmental water by LC\u2013MS\/MS. Talanta 85(1):157\u2013166. https:\/\/doi.org\/10.1016\/j.talanta.2011.03.051","journal-title":"Talanta"},{"issue":"1","key":"11320_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/bf00212796","volume":"26","author":"MC Calleja","year":"1994","unstructured":"Calleja MC, Persoone G, Geladi P (1994) Comparative acute toxicity of the first 50 multicentre evaluation of in vitro cytotoxicity chemicals to aquatic non-vertebrates. Arch Environ Contam Toxicol 26(1):69\u201378. https:\/\/doi.org\/10.1007\/bf00212796","journal-title":"Arch Environ Contam Toxicol"},{"key":"11320_CR27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ecoenv.2018.11.010","volume":"169","author":"A Capaldo","year":"2019","unstructured":"Capaldo A, Gay F, Laforgia V (2019) Changes in the gills of the European eel (Anguilla anguilla) after chronic exposure to environmental cocaine concentration. Ecotoxicol Environ Saf 169:112\u2013119. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.11.010","journal-title":"Ecotoxicol Environ Saf"},{"key":"11320_CR28","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.scitotenv.2016.04.125","volume":"563-564","author":"M Capolupo","year":"2016","unstructured":"Capolupo M, Valbonesi P, Kiwan A, Buratti S, Franzellitti S, Fabbri E (2016) Use of an integrated biomarker-based strategy to evaluate physiological stress responses induced by environmental concentrations of caffeine in the Mediterranean mussel Mytilus galloprovincialis. Sci Total Environ 563-564:538\u2013548. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.04.125","journal-title":"Sci Total Environ"},{"key":"11320_CR29","unstructured":"Cetesb - Companhia Estadual de Tecnologia e Saneamento ambiental (2017) Relat\u00f3rio de qualidade das \u00e1guas costeiras no estado de S\u00e3o Paulo 2016. S\u00e9rie Relat\u00f3rios\/Cetesb, p 178 ISSN 0103-4103"},{"issue":"1-2","key":"11320_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.marpolbul.2013.03.039","volume":"71","author":"M Claessens","year":"2013","unstructured":"Claessens M, Vanhaecke L, Wille K, Janssen CR (2013) Emerging contaminants in Belgian marine waters: single toxicant and mixture risks of pharmaceuticals. Mar Pollut Bull 71(1-2):41\u201350. https:\/\/doi.org\/10.1016\/j.marpolbul.2013.03.039","journal-title":"Mar Pollut Bull"},{"issue":"3","key":"11320_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/s0378-4274(03)00068-7","volume":"142","author":"M Cleuvers","year":"2003","unstructured":"Cleuvers M (2003) Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142(3):185\u2013194. https:\/\/doi.org\/10.1016\/s0378-4274(03)00068-7","journal-title":"Toxicol Lett"},{"key":"11320_CR32","volume-title":"Anu\u00e1rio Estat\u00edstico do Mercado Farmac\u00eautico","author":"CMED - C\u00e2mara de Regula\u00e7\u00e3o do Mercado de Medicamentos","year":"2017","unstructured":"CMED - C\u00e2mara de Regula\u00e7\u00e3o do Mercado de Medicamentos (2017) Anu\u00e1rio Estat\u00edstico do Mercado Farmac\u00eautico. ANVISA, Bras\u00edlia http:\/\/portal.anvisa.gov.br\/. (Accessed Jun 9 2019)"},{"key":"11320_CR33","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.chemosphere.2016.09.077","volume":"166","author":"S Comtois-Marotte","year":"2017","unstructured":"Comtois-Marotte S, Chappuis T, Vo Duy S, Gilbert N, Lajeunesse A, Taktek S, Sauv\u00e9 S (2017) Analysis of emerging contaminants in water and solid samples using high resolution mass spectrometry with a Q Exactive orbital ion trap and estrogenic activity with YES-assay. Chemosphere 166:400\u2013411. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.09.077","journal-title":"Chemosphere"},{"key":"11320_CR34","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.scitotenv.2018.05.069","volume":"637-638","author":"FS Cortez","year":"2018","unstructured":"Cortez FS, Souza L d S, Guimar\u00e3es LL, Almeida JE, Pusceddu FH, Maranho LA, Pereira CDS (2018) Ecotoxicological effects of losartan on the brown mussel Perna perna and its occurrence in seawater from Santos Bay (Brazil). Sci Total Environ 637-638:1363\u20131371. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.05.069","journal-title":"Sci Total Environ"},{"issue":"7","key":"11320_CR35","doi-asserted-by":"publisher","first-page":"6087","DOI":"10.1007\/s11356-017-9228-6","volume":"25","author":"F Courant","year":"2017","unstructured":"Courant F, Arpin-Pont L, Bonnefille B, Vacher S, Picot-Groz M, Gomez E, Fenet H (2017) Exposure of marine mussels to diclofenac: modulation of prostaglandin biosynthesis. Environ Sci Pollut Res 25(7):6087\u20136094. https:\/\/doi.org\/10.1007\/s11356-017-9228-6","journal-title":"Environ Sci Pollut Res"},{"key":"11320_CR36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.chemosphere.2016.06.068","volume":"160","author":"D Cruz","year":"2016","unstructured":"Cruz D, Almeida \u00c2, Calisto V, Esteves VI, Schneider RJ, Wrona FJ, Freitas R (2016) Caffeine impacts in the clam Ruditapes philippinarum: alterations on energy reserves, metabolic activity and oxidative stress biomarkers. Chemosphere 160:95\u2013103. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.06.068","journal-title":"Chemosphere"},{"key":"11320_CR37","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.scitotenv.2017.09.155","volume":"615","author":"R Dafouz","year":"2018","unstructured":"Dafouz R, C\u00e1ceres N, Rodr\u00edguez-Gil JL, Mastroianni N, L\u00f3pez de Alda M, Barcel\u00f3 D, Valc\u00e1rcel Y (2018) Does the presence of caffeine in the marine environment represent an environmental risk? A regional and global study. Sci Total Environ 615:632\u2013642. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.09.155","journal-title":"Sci Total Environ"},{"issue":"6","key":"11320_CR38","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1590\/s0102-311x2004000600025","volume":"20","author":"AI de Loyola Filho","year":"2004","unstructured":"de Loyola Filho AI, Lima-Costa MF, Uch\u00f4a E (2004) Bambu\u00ed Project: a qualitative approach to self-medication. Cad Sa\u00fade P\u00fablica 20(6):1661\u20131669. https:\/\/doi.org\/10.1590\/s0102-311x2004000600025","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"4","key":"11320_CR39","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s10646-011-0649-6","volume":"20","author":"ZR Del Rey","year":"2011","unstructured":"Del Rey ZR, Granek EF, Buckley BA (2011) Expression of HSP70 in Mytilus californianus following exposure to caffeine. Ecotoxicology 20(4):855\u2013861. https:\/\/doi.org\/10.1007\/s10646-011-0649-6","journal-title":"Ecotoxicology"},{"issue":"2","key":"11320_CR40","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00244-007-9032-2","volume":"54","author":"ME DeLorenzo","year":"2007","unstructured":"DeLorenzo ME, Fleming J (2007) Individual and mixture effects of selected pharmaceuticals and personal care products on the marine Phytoplankton species Dunaliella tertiolecta. Arch Environ Contam Toxicol 54(2):203\u2013210. https:\/\/doi.org\/10.1007\/s00244-007-9032-2","journal-title":"Arch Environ Contam Toxicol"},{"key":"11320_CR41","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.scitotenv.2018.04.351","volume":"639","author":"F Desbiolles","year":"2018","unstructured":"Desbiolles F, Malleret L, Tiliacos C, Wong-Wah-Chung P, Laffont-Schwob I (2018) Occurrence and ecotoxicological assessment of pharmaceuticals: Is there a risk for the Mediterranean aquatic environment? Sci Total Environ 639:1334\u20131348. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.04.351","journal-title":"Sci Total Environ"},{"key":"11320_CR42","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.scitotenv.2019.06.173","volume":"685","author":"K Diamanti","year":"2019","unstructured":"Diamanti K, Aalizadeh R, Alygizakis N, Galani A, Mardal M, Thomaidis NS (2019) Wide-scope target and suspect screening methodologies to investigate the occurrence of new psychoactive substances in influent wastewater from Athens. Sci Total Environ 685:1058\u20131065. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.06.173","journal-title":"Sci Total Environ"},{"issue":"20","key":"11320_CR43","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1016\/j.watres.2009.08.033","volume":"43","author":"X Dom\u00e8nech","year":"2009","unstructured":"Dom\u00e8nech X, Peral J, Mu\u00f1oz I (2009) Predicted environmental concentrations of cocaine and benzoylecgonine in a model environmental system. Water Res 43(20):5236\u20135242. https:\/\/doi.org\/10.1016\/j.watres.2009.08.033","journal-title":"Water Res"},{"key":"11320_CR44","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.scitotenv.2012.11.059","volume":"443","author":"E Donner","year":"2013","unstructured":"Donner E, Kosjek T, Qualmann S, Kusk KO, Heath E, Revitt DM, Andersen HR (2013) Ecotoxicity of carbamazepine and its UV photolysis transformation products. Sci Total Environ 443:870\u2013876. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.11.059","journal-title":"Sci Total Environ"},{"issue":"1","key":"11320_CR45","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.marpolbul.2018.02.048","volume":"129","author":"DM Dos Santos","year":"2018","unstructured":"Dos Santos DM, Buruaem L, Gon\u00e7alves RM, Williams M, Abessa DMS, Kookana R, de Marchi MRR (2018) Multiresidue determination and predicted risk assessment of contaminants of emerging concern in marine sediments from the vicinities of submarine sewage outfalls. Mar Pollut Bull 129(1):299\u2013307. https:\/\/doi.org\/10.1016\/j.marpolbul.2018.02.048","journal-title":"Mar Pollut Bull"},{"key":"11320_CR46","first-page":"108","volume":"II","author":"ECB","year":"2003","unstructured":"ECB (2003) Technical guidance document on risk assessment for existing substances. Part II:108\u2013110","journal-title":"Part"},{"key":"11320_CR47","unstructured":"ECHA (2008) Guidance on information requirements and chemical safety assessment. Chapter R.10: Characterisation of dose [concentration]-response for environment, pp 7\u201329"},{"key":"11320_CR48","unstructured":"EMA - European Medicines Agency, Committee for Medicinal Products for Human use (CHMP) (2006) Guideline on the environmental risk assessment of medicinal products for guman use. Doc. Ref.: EMEA\/CHMP\/SWP\/4447\/00 corr 1, London, UK"},{"issue":"4","key":"11320_CR49","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/etc.3131","volume":"35","author":"E Fabbri","year":"2015","unstructured":"Fabbri E, Franzellitti S (2015) Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species. Environ Toxicol Chem 35(4):799\u2013812. https:\/\/doi.org\/10.1002\/etc.3131","journal-title":"Environ Toxicol Chem"},{"key":"11320_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.marenvres.2014.05.007","volume":"99","author":"R Fabbri","year":"2014","unstructured":"Fabbri R, Montagna M, Balbi T, Raffo E, Palumbo F, Canesi L (2014) Adaptation of the bivalve embryotoxicity assay for the high throughput screening of emerging contaminants in Mytilus galloprovincialis. Mar Environ Res 99:1\u20138. https:\/\/doi.org\/10.1016\/j.marenvres.2014.05.007","journal-title":"Mar Environ Res"},{"key":"11320_CR51","unstructured":"FDA \u2013 U.S. Food and Drug Administration (2002) Center for drug evaluation and research. Approach Package for: Application number 20-386\/S-019 and 029. Environment Assessment\/ Fonsi, p 8"},{"issue":"3","key":"11320_CR52","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/s0147-6513(02)00082-9","volume":"55","author":"B Ferrari","year":"2003","unstructured":"Ferrari B, Pax\u00e9us N, Giudice RL, Pollio A, Garric J (2003) Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicol Environ Saf 55(3):359\u2013370. https:\/\/doi.org\/10.1016\/s0147-6513(02)00082-9","journal-title":"Ecotoxicol Environ Saf"},{"issue":"7","key":"11320_CR53","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1021\/es903440m","volume":"44","author":"J Fick","year":"2010","unstructured":"Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Tysklind M, Larsson DGJ (2010) Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol 44(7):2661\u20132666. https:\/\/doi.org\/10.1021\/es903440m","journal-title":"Environ Sci Technol"},{"key":"11320_CR54","doi-asserted-by":"publisher","first-page":"110545","DOI":"10.1016\/j.marpolbul.2019.110545","volume":"149","author":"MK Fontes","year":"2019","unstructured":"Fontes MK, Campos BG, Cortez FS, Pusceddu FH, Moreno BB, Maranho LA, Lebre DT, Guimar\u00e3es LL, Pereira CDS (2019) Seasonal monitoring of cocaine and benzoylecgonine in a subtropical coastal zone (Santos Bay, Brazil). Mar Pollut Bull 149:110545. https:\/\/doi.org\/10.1016\/j.marpolbul.2019.110545","journal-title":"Mar Pollut Bull"},{"issue":"10","key":"11320_CR55","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1897\/04-541r.1","volume":"24","author":"B Fraysse","year":"2005","unstructured":"Fraysse B, Garric J (2005) Prediction and experimental validation of acute toxicity of \u03b2-blockers in Ceriodaphinia dubia. Environ Toxicol Chem 24(10):2470\u20132476. https:\/\/doi.org\/10.1897\/04-541r.1","journal-title":"Environ Toxicol Chem"},{"key":"11320_CR56","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.aquatox.2012.12.021","volume":"132-133","author":"M Galus","year":"2013","unstructured":"Galus M, Kirischian N, Higgins S, Purdy J, Chow J, Rangaranjan S, Wilson JY (2013) Chronic, low concentration exposure to pharmaceuticals impacts multiple organ systems in zebrafish. Aquat Toxicol 132-133:200\u2013211. https:\/\/doi.org\/10.1016\/j.aquatox.2012.12.021","journal-title":"Aquat Toxicol"},{"issue":"1","key":"11320_CR57","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s11356-014-3400-z","volume":"22","author":"AJ Ghoshdastidar","year":"2015","unstructured":"Ghoshdastidar AJ, Fox S, Tong AZ (2015) The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada. Environ Sci Pollut Res 22(1):689\u2013700. https:\/\/doi.org\/10.1007\/s11356-014-3400-z","journal-title":"Environ Sci Pollut Res"},{"issue":"16","key":"11320_CR58","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1080\/10643389.2017.1370991","volume":"47","author":"AA Godoy","year":"2017","unstructured":"Godoy AA, Kummrow F (2017) What do we know about the ecotoxicology of pharmaceutical and personal care product mixtures? A critical review. Crit Rev Environ Sci Technol 47(16):1453\u20131496. https:\/\/doi.org\/10.1080\/10643389.2017.1370991","journal-title":"Crit Rev Environ Sci Technol"},{"issue":"5","key":"11320_CR59","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1007\/s10646-015-1455-3","volume":"24","author":"AA Godoy","year":"2015","unstructured":"Godoy AA, Kummrow F, Pamplin PAZ (2015a) Ecotoxicological evaluation of propranolol hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in binary mixtures. Ecotoxicology 24(5):1112\u20131123. https:\/\/doi.org\/10.1007\/s10646-015-1455-3","journal-title":"Ecotoxicology"},{"key":"11320_CR60","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.chemosphere.2015.06.024","volume":"138","author":"AA Godoy","year":"2015","unstructured":"Godoy AA, Kummrow F, Pamplin PAZ (2015b) Occurrence, ecotoxicological effects and risk assessment of antihypertensive pharmaceutical residues in the aquatic environment - a review. Chemosphere 138:281\u2013291. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.06.024","journal-title":"Chemosphere"},{"key":"11320_CR61","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.chroma.2012.05.084","volume":"1248","author":"M Gros","year":"2012","unstructured":"Gros M, Rodr\u00edguez-Mozaz S, Barcel\u00f3 D (2012) Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. J Chromatogr A 1248:104\u2013121. https:\/\/doi.org\/10.1016\/j.chroma.2012.05.084","journal-title":"J Chromatogr A"},{"issue":"2","key":"11320_CR62","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","volume":"69","author":"MD Hernando","year":"2006","unstructured":"Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69(2):334\u2013342. https:\/\/doi.org\/10.1016\/j.talanta.2005.09.037","journal-title":"Talanta"},{"key":"11320_CR63","unstructured":"Ibge \u2013 Instituto brasileiro de Geografia e Estat\u00edstica (2018) Estimativa da popula\u00e7\u00e3o brasileira. Rio de Janeiro. Brazilhtftp:\/\/ftp.ibge.gov.br\/Estimativas_de_Populacao\/Estimativas_2018\/Estimativadou_2018_20181019.pdf. Accessed 24 Oct 2020"},{"key":"11320_CR64","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbr.2017.05.069","volume":"332","author":"A Imeh-Nathaniel","year":"2017","unstructured":"Imeh-Nathaniel A, Rincon N, Orfanakos VB, Brechtel L, Wormack L, Richardson E, Nathaniel TI (2017) Effects of chronic cocaine, morphine and methamphetamine on the mobility, immobility and stereotyped behaviors in crayfish. Behav Brain Res 332:120\u2013125. https:\/\/doi.org\/10.1016\/j.bbr.2017.05.069","journal-title":"Behav Brain Res"},{"key":"11320_CR65","volume-title":"Instituto Nacional de Metrologia, Normaliza\u00e7\u00e3o e Qualidade Industrial","author":"INMETRO","year":"2011","unstructured":"INMETRO (2011) Instituto Nacional de Metrologia, Normaliza\u00e7\u00e3o e Qualidade Industrial. Orienta\u00e7\u00e3o sobre valida\u00e7\u00e3o de m\u00e9todos de ensaios qu\u00edmicos, Rio de Janeiro DOQ-CGCRE-008. <http:\/\/www.inmetro.gov.br\/Sidoq\/Arquivos\/CGCRE\/DOQ\/DOQ-CGCRE-8_04.pdf>"},{"issue":"3","key":"11320_CR66","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.watres.2010.11.010","volume":"45","author":"A Jelic","year":"2011","unstructured":"Jelic A, Gros M, Ginebreda A, Cespedes-S\u00e1nchez R, Ventura F, Petrovic M, Barcelo D (2011) Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Res 45(3):1165\u20131176. https:\/\/doi.org\/10.1016\/j.watres.2010.11.010","journal-title":"Water Res"},{"issue":"5","key":"11320_CR67","first-page":"524","volume":"16","author":"M Kaza","year":"2007","unstructured":"Kaza M, Na\u0142\u0119cz-Jawecki G, Sawicki J (2007) The toxicity of selected pharmacelticals to the aquatic plant Lemna minor. Fresenius Environ Bull 16(5):524\u2013531","journal-title":"Fresenius Environ Bull"},{"issue":"3","key":"11320_CR68","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.envint.2006.11.017","volume":"33","author":"Y Kim","year":"2007","unstructured":"Kim Y, Choi K, Jung J, Park S, Kim P-G, Park J (2007) Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ Int 33(3):370\u2013375. https:\/\/doi.org\/10.1016\/j.envint.2006.11.017","journal-title":"Environ Int"},{"issue":"2","key":"11320_CR69","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2131\/jts.34.227","volume":"34","author":"J-W Kim","year":"2009","unstructured":"Kim J-W, Ishibashi H, Yamauchi R, Ichikawa N, Takao Y, Hirano M, Arizono K (2009) Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). J Toxicol Sci 34(2):227\u2013232. https:\/\/doi.org\/10.2131\/jts.34.227","journal-title":"J Toxicol Sci"},{"key":"11320_CR70","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.envint.2013.01.009","volume":"54","author":"SL Klosterhaus","year":"2013","unstructured":"Klosterhaus SL, Grace R, Hamilton MC, Yee D (2013) Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary. Environ Int 54:92\u201399. https:\/\/doi.org\/10.1016\/j.envint.2013.01.009","journal-title":"Environ Int"},{"key":"11320_CR71","doi-asserted-by":"publisher","unstructured":"K\u00fcster A, Alder AC, Escher B, Duis K, Fenner K, Garric J, Knacker T (2007) Environmental risk assessment of human pharmaceuticals in the European Union - a case study with the \u03b2-blocker atenolol. Integr Environ Assess Manag 1. https:\/\/doi.org\/10.1897\/ieam_2009-050.1","DOI":"10.1897\/ieam_2009-050.1"},{"key":"11320_CR72","volume-title":"II Levantamento Nacional de \u00c1lcool e Drogas - Consumo de \u00c1lcool no Brasil: Tend\u00eancias entre 2006\/2012","author":"R Laranjeira","year":"2012","unstructured":"Laranjeira R, Madruga CS, Pinsky I, Caetano R, Ribeiro M, Mitsuhiro S (2012) II Levantamento Nacional de \u00c1lcool e Drogas - Consumo de \u00c1lcool no Brasil: Tend\u00eancias entre 2006\/2012. INPAD, Brazil, S\u00e3o Paulo http:\/\/inpad.org.br (Accessed 11 Jun 2019)"},{"issue":"5","key":"11320_CR73","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.ecoenv.2011.03.014","volume":"74","author":"J Lee","year":"2011","unstructured":"Lee J, Ji K, Lim Kho Y, Kim P, Choi K (2011) Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka. Ecotoxicol Environ Saf 74(5):1216\u20131225. https:\/\/doi.org\/10.1016\/j.ecoenv.2011.03.014","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"11320_CR74","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1007\/s10661-012-2702-1","volume":"185","author":"Y Li","year":"2012","unstructured":"Li Y, Zhang X, Li W, Lu X, Liu B, Wang J (2012) The residues and environmental risks of multiple veterinary antibiotics in animal faeces. Environ Monit Assess 185(3):2211\u20132220. https:\/\/doi.org\/10.1007\/s10661-012-2702-1","journal-title":"Environ Monit Assess"},{"issue":"1-3","key":"11320_CR75","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.jhazmat.2009.01.108","volume":"167","author":"AY-C Lin","year":"2009","unstructured":"Lin AY-C, Yu T-H, Lateef SK (2009) Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan. J Hazard Mater 167(1-3):1163\u20131169. https:\/\/doi.org\/10.1016\/j.jhazmat.2009.01.108","journal-title":"J Hazard Mater"},{"issue":"18","key":"11320_CR76","doi-asserted-by":"publisher","first-page":"5875","DOI":"10.1007\/s00216-013-6944-8","volume":"405","author":"R Loos","year":"2013","unstructured":"Loos R, Tavazzi S, Paracchini B, Canuti E, Weissteiner C (2013) Analysis of polar organic contaminants in surface water of the northern Adriatic Sea by solid-phase extraction followed by ultrahigh-pressure liquid chromatography\u2013QTRAP\u00ae MS using a hybrid triple-quadrupole linear ion trap instrument. Anal Bioanal Chem 405(18):5875\u20135885. https:\/\/doi.org\/10.1007\/s00216-013-6944-8","journal-title":"Anal Bioanal Chem"},{"key":"11320_CR77","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.scitotenv.2018.01.274","volume":"627","author":"ASC L\u00f6ve","year":"2018","unstructured":"L\u00f6ve ASC, Baz-Lomba JA, Reid MJ, Kankaanp\u00e4\u00e4 A, Gunnar T, Dam M, Thomas KV (2018) Analysis of stimulant drugs in the wastewater of five Nordic capitals. Sci Total Environ 627:1039\u20131047. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.01.274","journal-title":"Sci Total Environ"},{"key":"11320_CR78","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.scitotenv.2016.07.210","volume":"572","author":"KC Machado","year":"2016","unstructured":"Machado KC, Grassi MT, Vidal C, Pescara IC, Jardim WF, Fernandes AN, Severo FJR (2016) A preliminary nationwide survey of the presence of emerging contaminants in drinking and source waters in Brazil. Sci Total Environ 572:138\u2013146. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.07.210","journal-title":"Sci Total Environ"},{"key":"11320_CR79","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ecoenv.2015.04.010","volume":"118","author":"LA Maranho","year":"2015","unstructured":"Maranho LA, Andr\u00e9 C, DelValls TA, Gagn\u00e9 F, Mart\u00edn-D\u00edaz ML (2015a) Toxicological evaluation of sediment samples spiked with human pharmaceutical products: energy status and neuroendocrine effects in marine polychaetes Hediste diversicolor. Ecotoxicol Environ Saf 118:27\u201336. https:\/\/doi.org\/10.1016\/j.ecoenv.2015.04.010","journal-title":"Ecotoxicol Environ Saf"},{"key":"11320_CR80","doi-asserted-by":"publisher","unstructured":"Maranho LA, Garrido-P\u00e9rez MC, DelValls TA, Mart\u00edn-D\u00edaz ML (2015b) Suitability of standardized acute toxicity tests for marine sediment assessment: pharmaceutical contamination. Water Air Soil Pollut 226(3). https:\/\/doi.org\/10.1007\/s11270-014-2273-6","DOI":"10.1007\/s11270-014-2273-6"},{"issue":"5","key":"11320_CR81","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/jez.672","volume":"315A","author":"A Massarsky","year":"2011","unstructured":"Massarsky A, Trudeau VL, Moon TW (2011) \u03b2-blockers as endocrine disruptors: the potential effects of human \u03b2-blockers on aquatic organisms. J Exp Zool A Ecol Genet Physiol 315A(5):251\u2013265. https:\/\/doi.org\/10.1002\/jez.672","journal-title":"J Exp Zool A Ecol Genet Physiol"},{"key":"11320_CR82","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.marenvres.2016.03.005","volume":"121","author":"M Mezzelani","year":"2016","unstructured":"Mezzelani M, Gorbi S, Da Ros Z, Fattorini D, d\u2019Errico G, Milan M, Regoli F (2016) Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis. Mar Environ Res 121:31\u201339. https:\/\/doi.org\/10.1016\/j.marenvres.2016.03.005","journal-title":"Mar Environ Res"},{"issue":"6","key":"11320_CR83","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1080\/00450618.2016.1212270","volume":"49","author":"S Milione","year":"2016","unstructured":"Milione S, Mercurio I, Troiano G, Melai P, Agostinelli V, Nante N, Bacci M (2016) Drugs and psychoactive substances in the Tiber River. Aust J Forensic Sci 49(6):679\u2013686. https:\/\/doi.org\/10.1080\/00450618.2016.1212270","journal-title":"Aust J Forensic Sci"},{"issue":"6","key":"11320_CR84","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1007\/s11356-014-3662-5","volume":"23","author":"L Minguez","year":"2014","unstructured":"Minguez L, Pedelucq J, Farcy E, Ballandonne C, Budzinski H, Halm-Lemeille M-P (2014) Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France. Environ Sci Pollut Res 23(6):4992\u20135001. https:\/\/doi.org\/10.1007\/s11356-014-3662-5","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"11320_CR85","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00244-007-9059-4","volume":"54","author":"MT Moore","year":"2008","unstructured":"Moore MT, Greenway SL, Farris JL, Guerra B (2008) Assessing caffeine as an emerging environmental concern using conventional approaches. Arch Environ Contam Toxicol 54(1):31\u201335. https:\/\/doi.org\/10.1007\/s00244-007-9059-4","journal-title":"Arch Environ Contam Toxicol"},{"key":"11320_CR86","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.envres.2015.02.016","volume":"138","author":"R Moreno-Gonz\u00e1lez","year":"2015","unstructured":"Moreno-Gonz\u00e1lez R, Rodriguez-Mozaz S, Gros M, Barcel\u00f3 D, Le\u00f3n VM (2015) Seasonal distribution of pharmaceuticals in marine water and sediment from a mediterranean coastal lagoon (SE Spain). Environ Res 138:326\u2013344. https:\/\/doi.org\/10.1016\/j.envres.2015.02.016","journal-title":"Environ Res"},{"issue":"42","key":"11320_CR87","doi-asserted-by":"publisher","first-page":"6511","DOI":"10.1016\/j.chroma.2010.08.048","volume":"1217","author":"K Nodler","year":"2010","unstructured":"Nodler K, Licha T, Bester K, Sauter M (2010) Development of a multi-residue analytical method, based on liquid chromatography\u2013tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples. J Chromatogr A 1217(42):6511\u20136521. https:\/\/doi.org\/10.1016\/j.chroma.2010.08.048","journal-title":"J Chromatogr A"},{"issue":"15","key":"11320_CR88","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.1007\/s11356-015-4329-6","volume":"22","author":"B Nunes","year":"2015","unstructured":"Nunes B, Verde MF, Soares AMVM (2015) Biochemical effects of the pharmaceutical drug paracetamol on Anguilla anguilla. Environ Sci Pollut Res 22(15):11574\u201311584. https:\/\/doi.org\/10.1007\/s11356-015-4329-6","journal-title":"Environ Sci Pollut Res"},{"key":"11320_CR89","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.scitotenv.2012.10.046","volume":"442","author":"M Oosterhuis","year":"2013","unstructured":"Oosterhuis M, Sacher F, ter Laak TL (2013) Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data. Sci Total Environ 442:380\u2013388. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.10.046","journal-title":"Sci Total Environ"},{"key":"11320_CR90","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4322\/dae.2016.015","volume":"64","author":"JP Ortiz","year":"2016","unstructured":"Ortiz JP, Braulio A, Yanes JP (2016) Wastewater marine disposal through outfalls on the coast of S\u00e3o Paulo State Brazil: an overview. Revista DAE 64:29\u201346. https:\/\/doi.org\/10.4322\/dae.2016.015","journal-title":"Revista DAE"},{"key":"11320_CR91","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.scitotenv.2015.11.047","volume":"543","author":"M Papageorgiou","year":"2016","unstructured":"Papageorgiou M, Kosma C, Lambropoulou D (2016) Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Sci Total Environ 543:547\u2013569. https:\/\/doi.org\/10.1016\/j.scitotenv.2015.11.047","journal-title":"Sci Total Environ"},{"key":"11320_CR92","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","volume":"548-549","author":"CDS Pereira","year":"2016","unstructured":"Pereira CDS, Maranho LA, Cortez FS, Pusceddu FH, Santos AR, Ribeiro DA, Guimar\u00e3es LL (2016) Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone. Sci Total Environ 548-549:148\u2013154. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.01.051","journal-title":"Sci Total Environ"},{"key":"11320_CR93","volume-title":"Ecotoxicity of hospital wastewater. Hospital Wastewaters, 33\u201347","author":"Y Perrodin","year":"2017","unstructured":"Perrodin Y, Orias F (2017) Ecotoxicity of hospital wastewater. Hospital Wastewaters, 33\u201347. Springer, Cham"},{"key":"11320_CR94","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.watres.2014.08.053","volume":"72","author":"B Petrie","year":"2015","unstructured":"Petrie B, Barden R, Kasprzyk-Hordern B (2015) A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring. Water Res 72:3\u201327. https:\/\/doi.org\/10.1016\/j.watres.2014.08.053","journal-title":"Water Res"},{"issue":"1","key":"11320_CR95","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/toxsci\/kfm291","volume":"102","author":"F Pomati","year":"2007","unstructured":"Pomati F, Orlandi C, Clerici M, Luciani F, Zuccato E (2007) Effects and interactions in an environmentally relevant mixture of pharmaceuticals. Toxicol Sci 102(1):129\u2013137. https:\/\/doi.org\/10.1093\/toxsci\/kfm291","journal-title":"Toxicol Sci"},{"issue":"2","key":"11320_CR96","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1007\/s11356-016-7789-4","volume":"24","author":"GR Quadra","year":"2016","unstructured":"Quadra GR, Oliveira de Souza H, Costa R d S, Fernandez MA d S (2016) Do pharmaceuticals reach and affect the aquatic ecosystems in Brazil? A critical review of current studies in a developing country. Environ Sci Pollut Res 24(2):1200\u20131218. https:\/\/doi.org\/10.1007\/s11356-016-7789-4","journal-title":"Environ Sci Pollut Res"},{"issue":"3","key":"11320_CR97","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.etap.2014.04.005","volume":"37","author":"AS Ramos","year":"2014","unstructured":"Ramos AS, Correia AT, Antunes SC, Gon\u00e7alves F, Nunes B (2014) Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative defence system and peroxidative damage. Environ Toxicol Pharmacol 37(3):1221\u20131228. https:\/\/doi.org\/10.1016\/j.etap.2014.04.005","journal-title":"Environ Toxicol Pharmacol"},{"key":"11320_CR98","first-page":"255","volume-title":"Baixada Santista: uma contribui\u00e7\u00e3o \u00e0 an\u00e1lise geoambiental","author":"ALPM Ribeiro","year":"2015","unstructured":"Ribeiro ALPM, Oliveira RC (2015) Baixada Santista: uma contribui\u00e7\u00e3o \u00e0 an\u00e1lise geoambiental, 1st edn. UNESP, S\u00e3o Paulo, p 255","edition":"1"},{"key":"11320_CR99","doi-asserted-by":"publisher","DOI":"10.2166\/9781780401669","volume-title":"Marine wastewater outfalls and treatment systems","author":"PJW Roberts","year":"2010","unstructured":"Roberts PJW, Salas JH, Reiff FM, Libhaber M, Labbe A, Thomsom JC (2010) Marine wastewater outfalls and treatment systems. IWA Publishing, London"},{"issue":"8","key":"11320_CR100","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1021\/es991059c","volume":"34","author":"TP Rodgers-Gray","year":"2000","unstructured":"Rodgers-Gray TP, Jobling S, Morris S, Kelly C, Kirby S, Janbakhsh A, Harries JE, Waldock MJ, Sumpter JP, Tyler CR (2000) Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish. Environ Sci Technol 34(8):1521\u20131528. https:\/\/doi.org\/10.1021\/es991059c","journal-title":"Environ Sci Technol"},{"issue":"2-3","key":"11320_CR101","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jhazmat.2008.09.073","volume":"164","author":"JL Santos","year":"2009","unstructured":"Santos JL, Aparicio I, Callej\u00f3n M, Alonso E (2009) Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain). J Hazard Mater 164(2-3):1509\u20131516. https:\/\/doi.org\/10.1016\/j.jhazmat.2008.09.073","journal-title":"J Hazard Mater"},{"key":"11320_CR102","doi-asserted-by":"publisher","DOI":"10.11606\/T.85.2015.tde-28042015-095207","volume-title":"Desenvolvimento e Valida\u00e7\u00e3o de Metodologia SPE-LC-MS\/MS para determina\u00e7\u00e3o de F\u00e1rmacos e Droga de Abuso nas \u00c1guas da Represa Guarapiranga","author":"HM Shihomatzu","year":"2015","unstructured":"Shihomatzu HM (2015) Desenvolvimento e Valida\u00e7\u00e3o de Metodologia SPE-LC-MS\/MS para determina\u00e7\u00e3o de F\u00e1rmacos e Droga de Abuso nas \u00c1guas da Represa Guarapiranga. IPEN\/USP, S\u00e3o Paulo. https:\/\/doi.org\/10.11606\/T.85.2015.tde-28042015-095207"},{"key":"11320_CR103","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cej.2013.11.094","volume":"240","author":"JL Sotelo","year":"2014","unstructured":"Sotelo JL, Ovejero G, Rodr\u00edguez A, \u00c1lvarez S, Gal\u00e1n J, Garc\u00eda J (2014) Competitive adsorption studies of caffeine and diclofenac aqueous solutions by activated carbon. Chem Eng J 240:443\u2013453. https:\/\/doi.org\/10.1016\/j.cej.2013.11.094","journal-title":"Chem Eng J"},{"key":"11320_CR104","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jhazmat.2018.04.043","volume":"372","author":"MCVM Starling","year":"2018","unstructured":"Starling MCVM, Amorim CC, Le\u00e3o MMD (2018) Occurrence, control and fate of contaminants of emerging concern in environmental compartments in Brazil. J Hazard Mater 372:17\u201336. https:\/\/doi.org\/10.1016\/j.jhazmat.2018.04.043","journal-title":"J Hazard Mater"},{"issue":"2","key":"11320_CR105","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.watres.2009.07.010","volume":"44","author":"Q Sui","year":"2010","unstructured":"Sui Q, Huang J, Deng S, Yu G, Fan Q (2010) Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Res 44(2):417\u2013426. https:\/\/doi.org\/10.1016\/j.watres.2009.07.010","journal-title":"Water Res"},{"key":"11320_CR106","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jhazmat.2013.11.056","volume":"277","author":"Q Sun","year":"2014","unstructured":"Sun Q, Lv M, Hu A, Yang X, Yu C-P (2014) Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in a wastewater treatment plant in Xiamen, China. J Hazard Mater 277:69\u201375. https:\/\/doi.org\/10.1016\/j.jhazmat.2013.11.056","journal-title":"J Hazard Mater"},{"key":"11320_CR107","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.jhazmat.2014.10.023","volume":"283","author":"VS Thomaidi","year":"2015","unstructured":"Thomaidi VS, Stasinakis AS, Borova VL, Thomaidis NS (2015) Is there a risk for the aquatic environment due to the existence of emerging organic contaminants in treated domestic wastewater? Greece as a case-study. J Hazard Mater 283:740\u2013747. https:\/\/doi.org\/10.1016\/j.jhazmat.2014.10.023","journal-title":"J Hazard Mater"},{"key":"11320_CR108","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.aquatox.2016.03.017","volume":"175","author":"E Toufexi","year":"2016","unstructured":"Toufexi E, Dailianis S, Vlastos D, Manariotis ID (2016) Mediated effect of ultrasound treated Diclofenac on mussel hemocytes: first evidence for the involvement of respiratory burst enzymes in the induction of DCF-mediated unspecific mode of action. Aquat Toxicol 175:144\u2013153. https:\/\/doi.org\/10.1016\/j.aquatox.2016.03.017","journal-title":"Aquat Toxicol"},{"key":"11320_CR109","volume-title":"World drug report","author":"UNODC - United Nations Office on Drugs and Crime","year":"2016","unstructured":"UNODC - United Nations Office on Drugs and Crime (2016) World drug report. United Nations publication, Sales No. E.16.XI.7, New York http:\/\/www.unodc.org. (Accessed Jun 12 2019)"},{"key":"11320_CR110","unstructured":"USEPA - United States Environmental Protection Agency (2007) Method 1684: pharmaceuticals and personal care products in water, soil sediment, and biosolids by HPLC\/MS\/MS. Washington"},{"key":"11320_CR111","unstructured":"USEPA - United States Environmental Protection Agency (2017) Ecological structure-activity relationship model (ECOSAR) class program. MS-Windows Version 2.0. https:\/\/www.epa.gov\/tsca-screening-tools\/ecological-structure-activity-relationships-ecosarcpredictive-model. Accessed 24 Oct 2020"},{"key":"11320_CR112","unstructured":"USEPA - United States Environmental Protection Agency (2019) ECOTOX user guide: ecotoxicology database system, Version 4.0. http:\/\/www.epa.gov\/ecotox\/. Accessed 24 Oct 2020"},{"issue":"12","key":"11320_CR113","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/etc.2004","volume":"31","author":"DE Vidal-Dorsch","year":"2012","unstructured":"Vidal-Dorsch DE, Bay SM, Maruya K, Snyder SA, Trenholm RA, Vanderford BJ (2012) Contaminants of emerging concern in municipal wastewater effluents and marine receiving water. Environ Toxicol Chem 31(12):2674\u20132682. https:\/\/doi.org\/10.1002\/etc.2004","journal-title":"Environ Toxicol Chem"},{"key":"11320_CR114","volume-title":"World Health Day 2011: policy briefs. Regulate and promote rational use of medicines, including in animal husbandry, and ensure proper patient care","author":"Who \u2013 World Health Organization","year":"2011","unstructured":"Who \u2013 World Health Organization (2011) World Health Day 2011: policy briefs. Regulate and promote rational use of medicines, including in animal husbandry, and ensure proper patient care. World Health Organization, Geneva"},{"issue":"5","key":"11320_CR115","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00216-010-3702-z","volume":"397","author":"K Wille","year":"2010","unstructured":"Wille K, Noppe H, Verheyden K, Vanden Bussche J, De Wulf E, Van Caeter P, Vanhaecke L (2010) Validation and application of an LC-MS\/MS method for the simultaneous quantification of 13 pharmaceuticals in seawater. Anal Bioanal Chem 397(5):1797\u20131808. https:\/\/doi.org\/10.1007\/s00216-010-3702-z","journal-title":"Anal Bioanal Chem"},{"issue":"5","key":"11320_CR116","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1007\/s00216-011-4878-6","volume":"400","author":"K Wille","year":"2011","unstructured":"Wille K, Kiebooms JAL, Claessens M, Rapp\u00e9 K, Vanden Bussche J, Noppe H, Vanhaecke L (2011) Development of analytical strategies using U-HPLC-MS\/MS and LC-ToF-MS for the quantification of micropollutants in marine organisms. Anal Bioanal Chem 400(5):1459\u20131472. https:\/\/doi.org\/10.1007\/s00216-011-4878-6","journal-title":"Anal Bioanal Chem"},{"issue":"3","key":"11320_CR117","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.aquatox.2007.11.017","volume":"86","author":"MJ Winter","year":"2008","unstructured":"Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Hutchinson TH (2008) Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquat Toxicol 86(3):361\u2013369. https:\/\/doi.org\/10.1016\/j.aquatox.2007.11.017","journal-title":"Aquat Toxicol"},{"key":"11320_CR118","first-page":"27","volume":"3","author":"NS Yamamoto","year":"2014","unstructured":"Yamamoto NS, Pereira CDS, Cortez FS, Pusceddu FH, Santos AR, Toma W, Guimar\u00e3es LL (2014) Avalia\u00e7\u00e3o dos efeitos biol\u00f3gicos adversos dos f\u00e1rmacos anti-hipertensivos Losartan e Valsartan em ouri\u00e7o-do-mar Lytechinus variegatus (Echinodermata: Echinoidea). Unisanta BioScience 3:27\u201332","journal-title":"Unisanta BioScience"},{"issue":"4-5","key":"11320_CR119","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.watres.2007.09.010","volume":"42","author":"E Zuccato","year":"2008","unstructured":"Zuccato E, Castiglioni S, Bagnati R, Chiabrando C, Grassi P, Fanelli R (2008) Illicit drugs, a novel group of environmental contaminants. Water Res 42(4-5):961\u2013968. https:\/\/doi.org\/10.1016\/j.watres.2007.09.010","journal-title":"Water Res"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-11320-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-020-11320-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-020-11320-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T11:51:13Z","timestamp":1613735473000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-020-11320-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":119,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["11320"],"URL":"https:\/\/doi.org\/10.1007\/s11356-020-11320-y","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"11 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"We declare that this work has not been published previously, that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors authorise the publication of this manuscript following its final acceptance.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}