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Until a vaccine is available, personal protection, social distancing, and disinfection are the main tools against SARS-CoV-2. Although it is quite infectious, the SARS-CoV-2 virus itself is an enveloped virus that is relatively fragile because its protective fatty layer is sensitive to heat, ultraviolet radiation, and certain chemicals. However, heat and liquid treatments can damage some materials, and ultraviolet light is not efficient in shaded areas, so other disinfection alternatives are required to allow safe re-utilization of materials and spaces. As of this writing, evidences are still accumulating for the use of ozone gas as a disinfectant for sanitary materials and ambient disinfection in indoor areas. This paper reviews the most relevant results of virus disinfection by the application of gaseous ozone. The review covers disinfection treatments of both air and surfaces carried out in different volumes, which varies from small boxes and controlled chambers to larger rooms, as a base to develop future ozone protocols against COVID-19. Published papers have been critically analyzed to evaluate trends in the required ozone dosages, as a function of relative humidity (RH), contact time, and viral strains. The data have been classified depending on the disinfection objective and the volume and type of the experimental set-up. Based on these data, conservative dosages and times to inactivate the SARS-CoV-2 are estimated. In small chambers, 10\u201320\u00a0mg ozone\/m<jats:sup>3<\/jats:sup>over 10 to 50\u00a0min can be sufficient to significantly reduce the virus load of personal protection equipment. In large rooms, 30 to 50\u00a0mg ozone\/m<jats:sup>3<\/jats:sup>would be required for treatments of 20\u201330\u00a0min. Maximum antiviral activity of ozone is achieved at high humidity, while the same ozone concentrations under low RH could result inefficient. At these ozone levels, safety protocols must be strictly followed. These data can be used for reducing significantly the viral load although for assuring a safe disinfection, the effective dosages under different conditions need to be confirmed with experimental data.<\/jats:p>","DOI":"10.1007\/s11356-020-12036-9","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T20:02:39Z","timestamp":1609617759000},"page":"16517-16531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Ozone potential to fight against SAR-COV-2 pandemic: facts and research needs"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6820-7698","authenticated-orcid":false,"given":"Angeles","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco de Borja","family":"Ojembarrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Clavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Negro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"12036_CR1","doi-asserted-by":"publisher","first-page":"1800369","DOI":"10.1183\/13993003.00369-2018","volume":"51","author":"ST Ali","year":"2018","unstructured":"Ali ST, Wu P, Cauchemez S, He D, Fang VJ, Cowling BJ, Tian L (2018) Ambient ozone and influenza transmissibility in Hong Kong. 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