{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:47:46Z","timestamp":1778622466094,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Capes","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Capes","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"cnpq","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"cnpq","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"cnpq","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"cnpq","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11356-021-12617-2","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T07:03:26Z","timestamp":1612335806000},"page":"14285-14292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genotoxicity, oxidative stress, and inflammatory response induced by crack-cocaine: relevance to carcinogenesis"],"prefix":"10.1007","volume":"28","author":[{"given":"Ingra Tais","family":"Malacarne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Vitor","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Dos Anjos","family":"Rosario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena De Barros","family":"Viana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo Dias Seabra","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Estadella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-4983","authenticated-orcid":false,"given":"Daniel Araki","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"issue":"suppl 5","key":"12617_CR1","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1590\/0034-7167-2017-0444","volume":"71","author":"\u00c2MM Abreu","year":"2018","unstructured":"Abreu \u00c2MM, Jomar RT, Taets GGC, Souza MHDN, Fernandes DB (2018) Screening and brief intervention for the use of alcohol and other drugs. Rev Bras Enferm 71(suppl 5):2258\u20132263","journal-title":"Rev Bras Enferm"},{"issue":"2","key":"12617_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000465518","volume":"23","author":"MB Albini","year":"2017","unstructured":"Albini MB, Malacarne IT, Batista TBD, de Lima AAS, Machado MAN, Johann ACBR, Rosa EAR, Azevedo-Alanis LR (2017) Cytopathological changes induced by the crack use in oral mucosa. Eur Addict Res 23(2):77\u201386","journal-title":"Eur Addict Res"},{"issue":"11-12","key":"12617_CR3","first-page":"1269","volume":"58","author":"TC Almeida","year":"2012","unstructured":"Almeida TC, Stefanon EB, Rech VC, Sagrillo MR, Bohrer PL (2012) Analysis of oral mucosa of users of crack through micronucleus technique. Clin Lab 58(11-12):1269\u20131275","journal-title":"Clin Lab"},{"issue":"10","key":"12617_CR4","first-page":"5383","volume":"37","author":"F Angelieri","year":"2017","unstructured":"Angelieri F, Yujra VQ, Oshima CTF, Ribeiro DA (2017) do dental x-rays induce genotoxicity and cytotoxicity in oral mucosa cells? A critical review. Anticancer Res 37(10):5383\u20135388","journal-title":"Anticancer Res"},{"issue":"12","key":"12617_CR5","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1902\/jop.2016.150732","volume":"87","author":"RP Antoniazzi","year":"2016","unstructured":"Antoniazzi RP, Zanatta FB, R\u00f6sing CK, Feldens CA (2016) Association among periodontitis and the use of crack-cocaine and other illicit drugs. J Periodontol 87(12):1396\u20131405","journal-title":"J Periodontol"},{"issue":"7","key":"12617_CR6","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.ijom.2017.12.005","volume":"47","author":"RP Antoniazzi","year":"2018","unstructured":"Antoniazzi RP, Lago FB, Jardim LC, Sagrillo MR, Ferrazzo KL, Feldens CA (2018) Impact of crack-cocaine use on the occurrence of oral lesions and micronuclei. Int J Oral Maxillofac Surg 47(7):888\u2013895","journal-title":"Int J Oral Maxillofac Surg"},{"key":"12617_CR7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fncir.2013.00152","volume":"7","author":"J Baik","year":"2013","unstructured":"Baik J (2013) Dopamine signaling in reward-related behaviors. Front Neural Circuit 7:152","journal-title":"Front Neural Circuit"},{"key":"12617_CR8","doi-asserted-by":"publisher","first-page":"110614","DOI":"10.1016\/j.nut.2019.110614","volume":"71","author":"MPP Coelho","year":"2020","unstructured":"Coelho MPP, Diniz KGD, Bering T, Ferreira LDSA, Vieira DA, Castro MRC, Correia MITD, Rocha GA, Teixeira R, Garcia FD, Silva LD (2020) Skeletal muscle mass index and phase angle are decreased in individuals with dependence on alcohol and other substances. Nutrition 71:110614","journal-title":"Nutrition"},{"issue":"4","key":"12617_CR9","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1007\/s11356-016-7918-0","volume":"24","author":"PR Cury","year":"2017","unstructured":"Cury PR, Oliveira MG, Dos Santos JN (2017) Periodontal status in crack and cocaine addicted men: a cross-sectional study. Environ Sci Pollut Res Int 24(4):3423\u20133429","journal-title":"Environ Sci Pollut Res Int"},{"issue":"20","key":"12617_CR10","doi-asserted-by":"publisher","first-page":"19801","DOI":"10.1007\/s11356-018-2120-1","volume":"25","author":"PR Cury","year":"2018","unstructured":"Cury PR, Araujo NS, das Gra\u00e7as Alonso Oliveira M, Dos Santos JN (2018) Association between oral mucosal lesions and crack and cocaine addiction in men: a cross-sectional study. Environ Sci Pollut Res Int 25(20):19801\u201319807","journal-title":"Environ Sci Pollut Res Int"},{"issue":"3","key":"12617_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0740-5472(01)00192-1","volume":"21","author":"CA Dackis","year":"2001","unstructured":"Dackis CA, O\u2019Brien CP (2001) Cocaine dependence: a disease of the brain\u2019s reward centers. J Subst Abuse Treat 21(3):111\u2013117","journal-title":"J Subst Abuse Treat"},{"issue":"8","key":"12617_CR12","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1007\/s11356-013-2447-6","volume":"21","author":"M das Gra\u00e7as Alonso de Oliveira","year":"2014","unstructured":"das Gra\u00e7as Alonso de Oliveira M, Dos Santos JN, Cury PR, da Silva VH, Oliveira NR, da Costa Padovani R, Tucci AM, Ribeiro DA (2014) Cytogenetic biomonitoring of oral mucosa cells of crack-cocaine users. Environ Sci Pollut Res Int 21(8):5760\u20135764","journal-title":"Environ Sci Pollut Res Int"},{"issue":"10","key":"12617_CR13","doi-asserted-by":"publisher","first-page":"10003","DOI":"10.3390\/ijerph111010003","volume":"11","author":"TA de Freitas","year":"2014","unstructured":"de Freitas TA, Palazzo RP, de Andrade FM, Reichert CL, Pechansky F, Kessler F, de Farias CB, de Andrade GG, Leistner-Segal S, Maluf SW (2014) Genomic instability in human lymphocytes from male users of crack-cocaine. Int J Environ Res Public Health 11(10):10003\u201310015","journal-title":"Int J Environ Res Public Health"},{"issue":"27","key":"12617_CR14","doi-asserted-by":"publisher","first-page":"27569","DOI":"10.1007\/s11356-018-1600-7","volume":"26","author":"A Dos Santos Barbosa Ortega","year":"2019","unstructured":"Dos Santos Barbosa Ortega A, Maranho LA, Nobre CR, Moreno BB, Guimar\u00e3es RS, Lebre DT, de Souza Abessa DM, Ribeiro DA, Pereira CDS (2019) Detoxification, oxidative stress, and genotoxicity of crack-cocaine in the brown mussel Perna perna. Environ Sci Pollut Res Int 26(27):27569\u201327578","journal-title":"Environ Sci Pollut Res Int"},{"key":"12617_CR15","unstructured":"Florence AT, Attwood D (2006) Physicochemical principles of pharmacy, 6th edn. Pharmaceutical Press, London, pp 148\u2013154"},{"issue":"1","key":"12617_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/toxsci\/kfs140","volume":"128","author":"RC Garcia","year":"2012","unstructured":"Garcia RC, Dati LM, Fukuda S, Torres LH, Moura S, de Carvalho ND, Carrettiero DC, Camarini R, Levada-Pires AC, Yonamine M, Negrini-Neto O, Abdalla FM, Sandoval MR, Afeche SC, Marcourakis T (2012) Neurotoxicity of anhydroecgonine methyl ester, a crack-cocaine pyrolysis product. Toxicol Sci 128(1):223\u2013234","journal-title":"Toxicol Sci"},{"key":"12617_CR17","doi-asserted-by":"publisher","first-page":"17555","DOI":"10.1038\/srep17555","volume":"5","author":"RC Garcia","year":"2015","unstructured":"Garcia RC, Dati LM, Torres LH, da Silva MA, Udo MS, Abdalla FM, da Costa JL, Gorj\u00e3o R, Afeche SC, Yonamine M, Niswender CM, Conn PJ, Camarini R, Sandoval MR, Marcourakis T (2015) M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product. Sci Rep 5:17555","journal-title":"Sci Rep"},{"key":"12617_CR18","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.toxrep.2019.11.001","volume":"6","author":"RCT Garcia","year":"2019","unstructured":"Garcia RCT, Torres LL, Dati LMM, Loureiro APM, Afeche SC, Sandoval MRL, Marcourakis T (2019) Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture. Toxicol Rep 6:1223\u20131229","journal-title":"Toxicol Rep"},{"key":"12617_CR19","doi-asserted-by":"publisher","first-page":"108041","DOI":"10.1016\/j.drugalcdep.2020.108041","volume":"212","author":"RE Gicquelais","year":"2020","unstructured":"Gicquelais RE, Jannausch M, Bohnert ASB, Thomas L, Sen S, Fernandez AC (2020) Links between suicidal intent, polysubstance use, and medical treatment after non-fatal opioid overdose. Drug Alcohol Depend In press 212:108041","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"12617_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1007\/s12640-017-9813-y","volume":"34","author":"EF Gomes","year":"2018","unstructured":"Gomes EF, Lipaus IFS, Martins CW, Ara\u00fajo AM, Mendon\u00e7a JB, Peli\u00e7\u00e3o FS, Lebarch EC, de Melo Rodrigues LC, Nakamura-Palacios EM (2018) Anhydroecgonine methyl ester (AEME), a product of cocaine pyrolysis, impairs spatial working memory and induces striatal oxidative stress in rats. Neurotox Res 34(4):834\u2013847","journal-title":"Neurotox Res"},{"issue":"5","key":"12617_CR21","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"7","key":"12617_CR22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/md18070347","volume":"18","author":"MA Hannan","year":"2020","unstructured":"Hannan MA, Dash R, Haque MN, Mohibbullah M, Sohag AAM, Rahman MA, Uddin MJ, Alam M, Moon IS (2020) neuroprotective potentials of marine algae and their bioactive metabolites: pharmacological insights and therapeutic advances. Mar Drugs 18(7):347","journal-title":"Mar Drugs"},{"issue":"Suppl 1","key":"12617_CR23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1289\/ehp.98106s1289","volume":"106","author":"JE Klaunig","year":"1998","unstructured":"Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg EF Jr (1998) The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect 106(Suppl 1):289\u2013295","journal-title":"Environ Health Perspect"},{"issue":"9","key":"12617_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222611","volume":"14","author":"V Knerich","year":"2019","unstructured":"Knerich V, Jones AA, Seyedin S, Siu C, Dinh L, Mostafavi S, Barr AM, Panenka WJ, Thornton AE, Honer WG (2019) Rutherford AR (2019) Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada. PLoS One 14(9):e0222611","journal-title":"PLoS One"},{"issue":"1","key":"12617_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11845-016-1464-0","volume":"186","author":"A Korniluk","year":"2017","unstructured":"Korniluk A, Koper O, Kemona H, Dymicka-Piekarska V (2017) From inflammation to cancer. Ir J Med Sci 186(1):57\u201362","journal-title":"Ir J Med Sci"},{"key":"12617_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neulet.2016.06.023","volume":"628","author":"ML Levandowski","year":"2016","unstructured":"Levandowski ML, Hess AR, Grassi-Oliveira R, de Almeida RM (2016) Plasma interleukin-6 and executive function in crack-cocaine-dependent women. Neurosci Lett 628:85\u201390","journal-title":"Neurosci Lett"},{"key":"12617_CR27","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.bbr.2018.06.020","volume":"359","author":"IFS Lipaus","year":"2019","unstructured":"Lipaus IFS, Gomes EF, Martins CW, E Silva CM, RGW P, Malgarin F, Schuck PF, Palacios EMN, de Melo Rodrigues LC (2019) Impairment of spatial working memory and oxidative stress induced by repeated crack-cocaine inhalation in rats. Behav Brain Res 359:910\u2013917","journal-title":"Behav Brain Res"},{"issue":"1-2","key":"12617_CR28","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.marpolbul.2017.08.043","volume":"123","author":"LA Maranho","year":"2017","unstructured":"Maranho LA, Fontes MK, Kamimura ASS, Nobre CR, Moreno BB, Pusceddu FH, Cortez FS, Lebre DT, Marques JR, Abessa DMS, Ribeiro DA, Pereira CDS (2017) Exposure to crack-cocaine causes adverse effects on marine mussels Perna perna. Mar Pollut Bull 123(1-2):410\u2013414","journal-title":"Mar Pollut Bull"},{"issue":"8","key":"12617_CR29","doi-asserted-by":"publisher","first-page":"8104","DOI":"10.1007\/s11356-016-6141-3","volume":"23","author":"EG Moretti","year":"2016","unstructured":"Moretti EG, Yujra VQ, Claudio SR, Silva MJ, Vilegas W, Pereira CD, de Oliveira F, Ribeiro DA (2016) Acute crack-cocaine exposure induces genetic damage in multiple organs of rats. Environ Sci Pollut Res Int 23(8):8104\u20138112","journal-title":"Environ Sci Pollut Res Int"},{"key":"12617_CR30","first-page":"109","volume":"1","author":"W Morton","year":"1999","unstructured":"Morton W (1999) Cocaine and psychiatric symptoms. Prim care companion. J Clin Psychiatr 1:109\u2013113","journal-title":"J Clin Psychiatr"},{"key":"12617_CR31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neulet.2013.03.045","volume":"544","author":"JC Narvaez","year":"2013","unstructured":"Narvaez JC, Magalh\u00e3es PV, Fries GR, Colpo GD, Czepielewski LS, Vianna P, Chies JA, Rosa AR, Von Diemen L, Vieta E, Pechansky F, Kapczinski F (2013) Peripheral toxicity in crack-cocaine use disorders. Neurosci Lett 544:80\u201384","journal-title":"Neurosci Lett"},{"issue":"12","key":"12617_CR32","first-page":"535","volume":"44","author":"N Noda","year":"2001","unstructured":"Noda N, Wakasugi H (2001) Cancer and oxidative stress. Japan Med Assoc J 44(12):535\u2013539","journal-title":"Japan Med Assoc J"},{"issue":"1","key":"12617_CR33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00213-017-4759-6","volume":"235","author":"RR Parcianello","year":"2018","unstructured":"Parcianello RR, Mardini V, Ceres\u00e9r KMM, Langleben DD, Xavier F, Zavaschi MLS, Rhode LAP, Pechansky F, Gubert C, Szobot CM (2018) Increased cocaine and amphetamine-regulated transcript cord blood levels in the newborns exposed to crack-cocaine in utero. Psychopharmacology 235(1):215\u2013222","journal-title":"Psychopharmacology"},{"issue":"11","key":"12617_CR34","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","volume":"49","author":"S Reuter","year":"2010","unstructured":"Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49(11):1603\u20131616","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"12617_CR35","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1590\/S1516-44462006000300010","volume":"28","author":"M Ribeiro","year":"2006","unstructured":"Ribeiro M, Dunn J, Sesso R, Dias AC, Laranjeira R (2006) Causes of death among crack-cocaine users. Braz J Psychiatry 28(3):196\u2013202","journal-title":"Braz J Psychiatry"},{"issue":"1","key":"12617_CR36","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1515\/revneuro-2018-0118","volume":"31","author":"BDA Ros\u00e1rio","year":"2019","unstructured":"Ros\u00e1rio BDA, de Nazar\u00e9 MFS, Estadella D, Ribeiro DA, Viana MB (2019) Behavioral and neurobiological alterations induced by chronic use of crack-cocaine. Rev Neurosci 31(1):59\u201375","journal-title":"Rev Neurosci"},{"issue":"20","key":"12617_CR37","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1007\/s00213-014-3542-1","volume":"231","author":"AO Sordi","year":"2014","unstructured":"Sordi AO, Pechansky F, Kessler FH, Kapczinski F, Pfaffenseller B, Gubert C, de Aguiar BW, de Magalh\u00e3es Narvaez JC, Ornell F, von Diemen L (2014) Oxidative stress and BDNF as possible markers for the severity of crack-cocaine use in early withdrawal. Psychopharmacology 231(20):4031\u20134039","journal-title":"Psychopharmacology"},{"issue":"2","key":"12617_CR38","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1590\/1516-4446-2019-0532","volume":"42","author":"AO Sordi","year":"2020","unstructured":"Sordi AO, von Diemen L, Kessler FH, Schuch S, Ornell F, Kapczinski F, Pfaffenseller B, Gubert C, Wollenhaupt-Aguiar B, Salum GA, Pechansky F (2020) Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal. Braz J Psychiatry 42(2):214\u2013217","journal-title":"Braz J Psychiatry"},{"issue":"4","key":"12617_CR39","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0960327119891219","volume":"39","author":"EM Souza-Silva","year":"2020","unstructured":"Souza-Silva EM, Alves RB, Simon KA, Hueza IM (2020) Crack-cocaine smoke on pregnant rats: maternal evaluation and teratogenic effect. Hum Exp Toxicol 39(4):411\u2013422","journal-title":"Hum Exp Toxicol"},{"issue":"4","key":"12617_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/13556219971443","volume":"4","author":"M Stefanidou","year":"1999","unstructured":"Stefanidou M, Alevisopoulos G, Maravelias C, Loutsidis C, Koutselinis A (1999) Phagocytosis of the protozoon Tetrahymena pyriformis as an endpoint in the estimation of cocaine salt and cocaine freebase toxicity. Addict Biol 4(4):449\u2013452","journal-title":"Addict Biol"},{"issue":"3","key":"12617_CR41","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1248\/bpb.25.332","volume":"25","author":"M Stefanidou","year":"2002","unstructured":"Stefanidou M, Chatziioannou A, Livaditou A, Rellaki A, Alevisopoulos G, Spiliopoulou H, Koutselinis A (2002) DNA toxicity of cocaine hydrochloride and cocaine freebase by means of DNA image analysis on Tetrahymena pyriformis. Biol Pharm Bull 25(3):332\u2013334","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"12617_CR42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10616-010-9318-5","volume":"63","author":"ME Stefanidou","year":"2011","unstructured":"Stefanidou ME, Hatzi VI, Terzoudi GI, Loutsidou AC, Maravelias CP (2011) Effect of cocaine and crack on the ploidy status of Tetrahymena pyriformis: a study using DNA image analysis. Cytotechnology. 63(1):35\u201340","journal-title":"Cytotechnology."},{"key":"12617_CR43","doi-asserted-by":"crossref","unstructured":"Uddin MS, Kabir MT (2019) Oxidative stress in Alzheimer\u2019s Disease: molecular hallmarks of underlying vulnerability. In: Ashraf G, Alexiou A (eds) Biological, diagnostic and therapeutic advances in Alzheimer\u2019s disease, 1st edn. Springer Nature, pp 91\u2013115","DOI":"10.1007\/978-981-13-9636-6_5"},{"key":"12617_CR44","doi-asserted-by":"publisher","first-page":"106479","DOI":"10.1016\/j.intimp.2020.106479","volume":"84","author":"MS Uddin","year":"2020","unstructured":"Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM (2020a) Pharmacological approaches to mitigate neuroinflammation in Alzheimer\u2019s disease. Int Immunopharmacol 84:106479","journal-title":"Int Immunopharmacol"},{"key":"12617_CR45","doi-asserted-by":"publisher","unstructured":"Uddin MS, Hasana S, Ahmad J, Hossain MF, Rahman MM, Behl T, Rauf A, Ahmad A, Hafeez A, Perveen A, Md Ashraf G (2020b) Anti-neuroinflammatory potential of polyphenols by inhibiting NF-kappaB to halt Alzheimer\u2019s disease. Curr Pharm Des. https:\/\/doi.org\/10.2174\/1381612826666201118092422","DOI":"10.2174\/1381612826666201118092422"},{"key":"12617_CR46","unstructured":"UNODC (2019) Available from: https:\/\/www.unodc.org\/lpo-brazil\/pt\/frontpage\/2014\/06\/26-world-drug-report-2014.html. Assessed July, 24, 2019."},{"issue":"2","key":"12617_CR47","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0960327115579430","volume":"35","author":"LP Webber","year":"2016","unstructured":"Webber LP, Pellicioli AC, Magnusson AS, Danilevicz CK, Bueno CC, Sant\u2019Ana Filho M, Rados PV, Carrard VC (2016) Nuclear changes in oral mucosa of alcoholics and crack-cocaine users. Hum Exp Toxicol 35(2):184\u2013913","journal-title":"Hum Exp Toxicol"},{"issue":"4","key":"12617_CR48","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3109\/01480545.2015.1126843","volume":"39","author":"VQ Yujra","year":"2016","unstructured":"Yujra VQ, Moretti EG, Claudio SR, Silva MJ, Oliveira F, Oshima CT, Ribeiro DA (2016) Genotoxicity and mutagenicity induced by acute crack-cocaine exposure in mice. Drug Chem Toxicol 39(4):388\u2013391","journal-title":"Drug Chem Toxicol"},{"issue":"8","key":"12617_CR49","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s00213-014-3779-8","volume":"232","author":"A Zaparte","year":"2015","unstructured":"Zaparte A, Viola TW, Grassi-Oliveira R, da Silva Morrone M, Moreira JC, Bauer ME (2015) Early abstinence of crack-cocaine is effective to attenuate oxidative stress and to improve antioxidant defences. Psychopharmacology 232(8):1405\u20131413","journal-title":"Psychopharmacology"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12617-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-12617-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12617-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T23:20:23Z","timestamp":1674948023000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-12617-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["12617"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-12617-2","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"assertion":[{"value":"3 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}