{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:19:27Z","timestamp":1782015567816,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"33","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s11356-021-12672-9","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T21:05:59Z","timestamp":1618952759000},"page":"45739-45744","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of sulfur dioxide exposure on histopathology and morphometry of pancreatic islet cells and glycemic indices in Wistar rats"],"prefix":"10.1007","volume":"28","author":[{"given":"Razieh Musapour","family":"Soltan-Abad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-4462","authenticated-orcid":false,"given":"Sorayya","family":"Kheirouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran Mesgari","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Khordadmehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"issue":"1","key":"12672_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s12291-010-0014-1","volume":"25","author":"TA Ajith","year":"2010","unstructured":"Ajith TA (2010) Ameliorating reactive oxygen species-induced in vitro lipid peroxidation in brain, liver, mitochondria and DNA damage by Zingiber officinale Roscoe. Indian J Clin Biochem 25(1):67\u201373. https:\/\/doi.org\/10.1007\/s12291-010-0014-1","journal-title":"Indian J Clin Biochem"},{"key":"12672_CR2","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.2337\/db16-1416","volume":"66","author":"TL Alderete","year":"2017","unstructured":"Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD (2017) Longitudinal associations between ambient air pollution with insulin sensitivity, beta-cell function, and adiposity in Los Angeles Latino children. Diabetes 66:1789\u20131796","journal-title":"Diabetes"},{"key":"12672_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s40471-018-0140-5","volume":"5","author":"TL Alderete","year":"2018","unstructured":"Alderete TL, Chen Z, Toledo-Corral CM, Contreras ZA, Kim JS, Habre R, Chatzi L, Bastain T, Breton CV, Gilliland FD (2018) Ambient and traffic-related air pollution exposures as novel risk factors for metabolic dysfunction and type 2 diabetes. Curr Epidemiol Rep 5:79\u201391","journal-title":"Curr Epidemiol Rep"},{"key":"12672_CR4","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41569-020-0371-2","volume":"17","author":"SG Al-Kindi","year":"2020","unstructured":"Al-Kindi SG, Brook RD, Biswal S, Rajagopalan S (2020) Environmental determinants of cardiovascular disease: lessons learned from air pollution. Nat Rev Cardiol 17:656\u2013672. https:\/\/doi.org\/10.1038\/s41569-020-0371-2","journal-title":"Nat Rev Cardiol"},{"key":"12672_CR5","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2018.02.016","volume":"27","author":"J Alma\u00e7a","year":"2018","unstructured":"Alma\u00e7a J, Jonathan W, Rayner R, Elizabeth P, Alejandro C (2018) The pericyte of the pancreatic islet regulates capillary diameter and local blood flow. Cell Metab 27:630\u2013644. e4","journal-title":"Cell Metab"},{"key":"12672_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2012.05.002","volume":"46","author":"RE Dales","year":"2012","unstructured":"Dales RE, Cakmak S, Vidal CB, Rubio MA (2012) Air pollution and hospitalization for acute complications of diabetes in Chile. Environ Int 46:1\u20135","journal-title":"Environ Int"},{"issue":"11","key":"12672_CR7","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3390\/ijerph15112593","volume":"15","author":"J Dang","year":"2018","unstructured":"Dang J, Yang M, Zhang X, Ruan H, Qin G, Fu J, Shen Z, Tan A, Li R, Moore J (2018) Associations of exposure to air pollution with insulin resistance: a systematic review and meta-analysis. Int J Environ Res Public Health 15(11):2593","journal-title":"Int J Environ Res Public Health"},{"key":"12672_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/ijerph15010078","volume":"15","author":"T Dendup","year":"2018","unstructured":"Dendup T, Feng X, Clingan S, Astell-Burt T (2018) Environmental risk factors for developing type 2 diabetes mellitus: a systematic review. Int J Environ Res Public Health 15:78","journal-title":"Int J Environ Res Public Health"},{"key":"12672_CR9","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1159\/000494239","volume":"50","author":"Y Gao","year":"2018","unstructured":"Gao Y, Liang C, Zhang J, Ma J, Wang J, Niu R, Tikka C, Wang Y, Wang J (2018) Combination of fluoride and SO2 induce DNA damage and morphological alterations in male rat kidney. Cell Physiol Biochem 50:734\u2013744","journal-title":"Cell Physiol Biochem"},{"key":"12672_CR10","first-page":"665","volume":"20","author":"G George","year":"1950","unstructured":"George G (1950) Aldehyde-fuchsin: a new stain for elastic tissue. AJCP 20:665\u2013666","journal-title":"AJCP"},{"issue":"10","key":"12672_CR11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4103\/1995-7645.291036","volume":"13","author":"M Ghasemi-Dehnoo","year":"2020","unstructured":"Ghasemi-Dehnoo M, Amini-Khoei H, Lorigooini Z, Rafieian-Kopaei M (2020) Oxidative stress and antioxidants in diabetes mellitus. Asian Pac J Trop Med 13(10):431\u2013438","journal-title":"Asian Pac J Trop Med"},{"key":"12672_CR12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/1735-1995.189646","volume":"21","author":"A Ghorani-Azam","year":"2016","unstructured":"Ghorani-Azam A, Riahi-Zanjani B, Balali-Mood M (2016) Effects of air pollution on human health and practical measures for prevention in Iran. J Res Med Sci 21:65","journal-title":"J Res Med Sci"},{"key":"12672_CR13","unstructured":"IDF DIABETES ATLAS. Eighth edition 2017.\u00a0http:\/\/www.idf.org\/diabetesatlas\/data-visualisations. Accessed 19\/4\/2021"},{"key":"12672_CR14","unstructured":"International Diabetes Federation. IDF Diabetes Atlas 9th Edition. 2019. \u00a0Available online at:https:\/\/www.diabetesatlas.org\/en\/resources\/. Accessed 19\/4\/2021"},{"key":"12672_CR15","first-page":"605","volume":"25","author":"S Javadi","year":"2014","unstructured":"Javadi S, Eftekhariand A, Farshid AA (2014) The effects of grape seed oil on histopathological changes of the pancreas, liver and plasma lipids in streptozotine induced diabetic rats. Urmia Med J 25:605\u2013615","journal-title":"Urmia Med J"},{"key":"12672_CR16","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2337\/dc12-0388","volume":"36","author":"MA Khafaie","year":"2013","unstructured":"Khafaie MA, Salvi SS, Ojha A, Khafaie B, Gore SS, Yajnik CS (2013) Systemic inflammation (C-reactive protein) in type 2 diabetic patients is associated with ambient air pollution in Pune City, India. Diabetes Care 36:625\u2013630","journal-title":"Diabetes Care"},{"key":"12672_CR17","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1289\/ehp.1104406","volume":"120","author":"JH Kim","year":"2012","unstructured":"Kim JH, Hong YC (2012) GSTM1, GSTT1, and GSTP1 polymorphisms and associations between air pollutants and markers of insulin resistance in elderly Koreans. Environ Health Perspect 120:1378\u20131384","journal-title":"Environ Health Perspect"},{"key":"12672_CR18","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.5897\/AJMR2014.6742","volume":"8","author":"YJ Kim","year":"2014","unstructured":"Kim YJ, Ahmed ST, Islam MM, Yang C (2014) Evaluation of Bacillus amyloliquefaciens as manure additive for control of odorous gas emissions from pig slurry. Afr J Microbiol Res 8:2540\u20132546","journal-title":"Afr J Microbiol Res"},{"issue":"2","key":"12672_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cdtm.2018.03.003","volume":"4","author":"D Kim","year":"2018","unstructured":"Kim D, Chen Z, Zhou LF, Huang SX (2018) Air pollutants and early origins of respiratory diseases. Chronic Dis Transl Med 4(2):75\u201394. https:\/\/doi.org\/10.1016\/j.cdtm.2018.03.003","journal-title":"Chronic Dis Transl Med"},{"key":"12672_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1746-6148-9-123","volume":"9","author":"R Klopfleisch","year":"2013","unstructured":"Klopfleisch R (2013) Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review. BMC Vet Res 9:123","journal-title":"BMC Vet Res"},{"issue":"8","key":"12672_CR21","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1080\/00207450600934531","volume":"117","author":"V Kucukatay","year":"2007","unstructured":"Kucukatay V, A\u011far A, Gumuslu S, Yargi\u00e7o\u011flu P (2007) Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: relation to oxidant stress and antioxidant enzymes. Int J Neurosci 117(8):1091\u20131107. https:\/\/doi.org\/10.1080\/00207450600934531","journal-title":"Int J Neurosci"},{"key":"12672_CR22","doi-asserted-by":"publisher","first-page":"204201881989704","DOI":"10.1177\/2042018819897046","volume":"10","author":"Y Li","year":"2019","unstructured":"Li Y, Xu L, Shan Z, Teng W, Han C (2019) Association between air pollution and type 2 diabetes: an updated review of the literature. Ther Adv Endocrinol Metab 10:2042018819897046. https:\/\/doi.org\/10.1177\/2042018819897046","journal-title":"Ther Adv Endocrinol Metab"},{"key":"12672_CR23","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.envint.2016.03.028","volume":"92-93","author":"C Liu","year":"2016","unstructured":"Liu C, Yang C, Zhao Y, Ma Z, Bi J, Liu Y, Meng X, Wang Y, Cai J, Kan H, Chen R (2016) Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China. Environ Int 92-93:416\u2013421","journal-title":"Environ Int"},{"key":"12672_CR24","doi-asserted-by":"publisher","unstructured":"Longnecker DS (2014) Anatomy and histology of the pancreas. Pancreapedia: The Exocrine Pancreas Knowledge Base.\u00a0American Pancreatic Association. https:\/\/doi.org\/10.3998\/panc.2021.01","DOI":"10.3998\/panc.2021.01"},{"key":"12672_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fpubh.2020.00014","volume":"8","author":"I Manisalidis","year":"2020","unstructured":"Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E (2020) Environmental and health impacts of air pollution: a review. Front Public Health 8:14. https:\/\/doi.org\/10.3389\/fpubh.2020.00014","journal-title":"Front Public Health"},{"key":"12672_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118700","volume":"10","author":"M Otero-Losada","year":"2015","unstructured":"Otero-Losada M, Cao G, Gonz\u00e1lez J, Muller A, Ottaviano G, Lillig C, Capani F, Ambrosio G, Milei J (2015) Functional and morphological changes in endocrine pancreas following cola drink consumption in rats. PLoS One 10:e0118700","journal-title":"PLoS One"},{"key":"12672_CR27","doi-asserted-by":"publisher","first-page":"105333","DOI":"10.1016\/j.envint.2019.105333","volume":"134","author":"LA Paul","year":"2020","unstructured":"Paul LA, Burnett RT, Kwong JC, Hystad P, Donkelaar AV, Bai L et al (2020) The impact of air pollution on the incidence of diabetes and survival among prevalent diabetes cases. Environ Int 134:105333. https:\/\/doi.org\/10.1016\/j.envint.2019.105333","journal-title":"Environ Int"},{"key":"12672_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.tox.2012.05.026","volume":"300","author":"G Qin","year":"2012","unstructured":"Qin G, Wang J, Huo Y, Yan H, Jiang C, Zhou J, Wang X, Sang N (2012) Sulfur dioxide inhalation stimulated mitochondrial biogenesis in rat brains. Toxicology 300:67\u201374","journal-title":"Toxicology"},{"key":"12672_CR29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.envint.2018.07.034","volume":"120","author":"M Riant","year":"2018","unstructured":"Riant M, Meirhaeghe A, Giovannelli J, Occelli F, Havet A, Cuny D, Amouyel P, Dauchet L (2018) Associations between long-term exposure to air pollution, glycosylated hemoglobin, fasting blood glucose and diabetes mellitus in northern France. Environ Int 120:121\u2013129","journal-title":"Environ Int"},{"key":"12672_CR30","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001093","volume":"94","author":"MY Sade","year":"2015","unstructured":"Sade MY, Kloog I, Liberty IF, Katra I, Novack L, Novack V (2015) Air pollution and serum glucose levels: a population-based study. Medicine (Baltimore) 94:e1093","journal-title":"Medicine (Baltimore)"},{"key":"12672_CR31","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1001\/jama.295.14.1688","volume":"295","author":"CD Saudek","year":"2006","unstructured":"Saudek CD, Derr RL, Kalyani RR (2006) Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c. Jama 295:1688\u20131697","journal-title":"Jama"},{"key":"12672_CR32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0165-1110(77)90020-3","volume":"39","author":"R Shapiro","year":"1977","unstructured":"Shapiro R (1977) Genetic effects of bisulfite (sulfur dioxide). Mutat Res 39:149\u2013175","journal-title":"Mutat Res"},{"key":"12672_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s12889-020-8354-0","volume":"20","author":"S Shen","year":"2020","unstructured":"Shen S, Li X, Yuan C, Huang Q, Liu D, Ma S, Hui J, Liu R, Wu T, Chen Q (2020) Association of short-term exposure to sulfur dioxide and hospitalization for ischemic and hemorrhagic stroke in Guangzhou, China. BMC Public Health 20:263. https:\/\/doi.org\/10.1186\/s12889-020-8354-0","journal-title":"BMC Public Health"},{"key":"12672_CR34","first-page":"293","volume":"46","author":"D Sohn","year":"2017","unstructured":"Sohn D, Oh H (2017) Gender-dependent differences in the relationship between diabetes mellitus and ambient air pollution among adults in South Korean Cities. Iran J Public Health 46:293\u2013300","journal-title":"Iran J Public Health"},{"key":"12672_CR35","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1186\/s12889-019-7849-z","volume":"19","author":"S Su","year":"2019","unstructured":"Su S, Liaw Y, Jhuang J et al (2019) Associations between ambient air pollution and cancer incidence in Taiwan: an ecological study of geographical variations. BMC Public Health 19:1496. https:\/\/doi.org\/10.1186\/s12889-019-7849-z","journal-title":"BMC Public Health"},{"key":"12672_CR36","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.tem.2015.05.002","volume":"26","author":"E Thiering","year":"2015","unstructured":"Thiering E, Heinrich J (2015) Epidemiology of air pollution and diabetes. Trends Endocrinol Metab 26:384\u2013394","journal-title":"Trends Endocrinol Metab"},{"key":"12672_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/ijpo.12188","volume":"13","author":"CM Toledo-Corral","year":"2018","unstructured":"Toledo-Corral CM, Alderete TL, Habre R, Berhane K, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD (2018) Effects of air pollution exposure on glucose metabolism in Los Angeles minority children. Pediatr Obes 13:54\u201362","journal-title":"Pediatr Obes"},{"key":"12672_CR38","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","volume":"27","author":"TM Wallace","year":"2004","unstructured":"Wallace TM, Levy JC, Matthews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27:1487\u20131495","journal-title":"Diabetes Care"},{"key":"12672_CR39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2337\/diab.47.1.50","volume":"47","author":"Z Wang","year":"1998","unstructured":"Wang Z, Gleichmann H (1998) GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes 47:50\u201356","journal-title":"Diabetes"},{"key":"12672_CR40","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.2337\/diab.36.9.1014","volume":"36","author":"SA Wohaieb","year":"1987","unstructured":"Wohaieb SA, Odin DV (1987) Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Diabetes 36:1014\u20131018","journal-title":"Diabetes"},{"key":"12672_CR41","unstructured":"World Health Organization, Ambient (outdoor) air pollution (2018)\u00a0Available online at:\u00a0https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-(outdoor)-air-quality-and-health.\u00a0Accessed 19\/4\/2021"},{"key":"12672_CR42","unstructured":"World Health Organization, The Global Health Observatory, Explore a world of health data, Air pollution. Available online at:\u00a0https:\/\/www.who.int\/data\/gho\/data\/themes\/theme-details\/GHO\/air-pollution. Accessed 19\/4\/2021"},{"key":"12672_CR43","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1016\/S2542-5196(18)30001-9","volume":"2","author":"BY Yang","year":"2018","unstructured":"Yang BY, Qian ZM, Li S et al (2018) Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study. Lancet Planet Health 2:e64\u2013e73","journal-title":"Lancet Planet Health"},{"key":"12672_CR44","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ajpath.2018.05.022","volume":"189","author":"Y Zen","year":"2019","unstructured":"Zen Y, Deshpandey V (2019) Tumefactive inflammatory diseases of the pancreas. Am J Pathol 189:82\u201393","journal-title":"Am J Pathol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12672-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-12672-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12672-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T07:36:43Z","timestamp":1628926603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-12672-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,20]]},"references-count":44,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["12672"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-12672-9","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,20]]},"assertion":[{"value":"5 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Tabriz University of Medical Sciences, Animal Investigational Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}