{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:41:37Z","timestamp":1776991297993,"version":"3.51.4"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s11356-021-12781-5","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T17:06:29Z","timestamp":1614791189000},"page":"19601-19614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of UPP pathway in amelioration of diabetes-associated complications"],"prefix":"10.1007","volume":"28","author":[{"given":"Amit","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotfi","family":"Aleya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Habibur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlokesh Narayan","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giridhari","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishnoor","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"6","key":"12781_CR1","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.2337\/db12-0677","volume":"62","author":"T Abe","year":"2013","unstructured":"Abe T, Hirasaka K, Kagawa S, Kohno S, Ochi A, Utsunomiya K, Sakai A, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M (2013) Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice. Diabetes. 62(6):1957\u20131969","journal-title":"Diabetes."},{"issue":"2","key":"12781_CR2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1172\/JCI16269","volume":"113","author":"Y Asano","year":"2004","unstructured":"Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K (2004) Impaired Smad7-Smurf\u2013mediated negative regulation of TGF-\u03b2 signaling in scleroderma fibroblasts. J Clin Invest 113(2):253\u2013264","journal-title":"J Clin Invest"},{"issue":"9","key":"12781_CR3","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/embor.2011.140","volume":"12","author":"BS Atanassov","year":"2011","unstructured":"Atanassov BS, Dent SY (2011) USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1. EMBO Rep 12(9):924\u2013930","journal-title":"EMBO Rep"},{"issue":"7","key":"12781_CR4","doi-asserted-by":"publisher","first-page":"E473","DOI":"10.1152\/ajpendo.00467.2015","volume":"310","author":"T Bai","year":"2016","unstructured":"Bai T, Wang F, Mellen N, Zheng Y, Cai L (2016) Diabetic cardiomyopathy: role of the E3 ubiquitin ligase. Am J Physiol-Endocrinol Metab 310(7):E473\u2013E483","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"1-2","key":"12781_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11010-005-1083-y","volume":"275","author":"M Balasubramanyam","year":"2005","unstructured":"Balasubramanyam M, Sampathkumar R, Mohan V (2005) Is insulin signaling molecules misguided in diabetes for ubiquitin\u2013proteasome mediated degradation? Mol Cell Biochem 275(1-2):117\u2013125","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"12781_CR6","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nsmb.2066","volume":"18","author":"C Behrends","year":"2011","unstructured":"Behrends C, Harper JW (2011) Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol 18(5):520","journal-title":"Nat Struct Mol Biol"},{"issue":"6","key":"12781_CR7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.molcel.2008.05.014","volume":"30","author":"MJ Bertrand","year":"2008","unstructured":"Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 30(6):689\u2013700","journal-title":"Mol Cell"},{"issue":"8","key":"12781_CR8","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1681\/ASN.2015010111","volume":"27","author":"K Bhatt","year":"2016","unstructured":"Bhatt K, Lanting LL, Jia Y, Yadav S, Reddy MA, Magilnick N, Boldin M, Natarajan R (2016) Anti-inflammatory role of microRNA-146a in the pathogenesis of diabetic nephropathy. J Am Soc Nephrol 27(8):2277\u20132288","journal-title":"J Am Soc Nephrol"},{"issue":"27","key":"12781_CR9","doi-asserted-by":"publisher","first-page":"14392","DOI":"10.1074\/jbc.A113.529925","volume":"291","author":"S Bonala","year":"2016","unstructured":"Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R (2016) Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) in response to high calorie diet intake. J Biol Chem 291(27):14392","journal-title":"J Biol Chem"},{"key":"12781_CR10","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3389\/fphys.2018.01514","volume":"9","author":"G Borghetti","year":"2018","unstructured":"Borghetti G, von Lewinski D, Eaton DM, Sourij H, Houser SR, Wallner M (2018) Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control. Front Physiol 9:1514","journal-title":"Front Physiol"},{"issue":"3","key":"12781_CR11","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.celrep.2013.02.014","volume":"3","author":"K Brinkmann","year":"2013","unstructured":"Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Sch\u00fcll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM (2013) Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep 3(3):881\u2013891","journal-title":"Cell Rep"},{"key":"12781_CR12","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1007\/s12035-012-8391-5","volume":"47","author":"L Campello","year":"2013","unstructured":"Campello L, Esteve-Rudd J, Cuenca N et al (2013) The ubiquitin\u2013proteasome system in retinal health and disease. Mol Neurobiol 47:790\u2013810","journal-title":"Mol Neurobiol"},{"key":"12781_CR13","doi-asserted-by":"crossref","unstructured":"Cardaci TD, Machek SB, Wilburn DT, Hwang PS, Willoughby DS. (2020) Ubiquitin proteasome system activity is suppressed by curcumin following exercise-induced muscle damage in human skeletal muscle. J Am Coll Nutr 1-1","DOI":"10.1080\/07315724.2020.1783721"},{"key":"12781_CR14","first-page":"2014","volume-title":"National diabetes statistics report: estimates of diabetes and its burden in the United States","author":"Centers for Disease Control and Prevention","year":"2014","unstructured":"Centers for Disease Control and Prevention (2014) National diabetes statistics report: estimates of diabetes and its burden in the United States. US Department of Health and Human Services, Atlanta, p 2014"},{"key":"12781_CR15","first-page":"2020","volume-title":"Centers for Disease Control and Prevention","author":"Centers for Disease Control and Prevention. National Diabetes Statistics Report","year":"2020","unstructured":"Centers for Disease Control and Prevention. National Diabetes Statistics Report (2020) Centers for Disease Control and Prevention. US Dept of Health and Human Services, Atlanta, p 2020"},{"issue":"1","key":"12781_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07882-8","volume":"10","author":"H Chen","year":"2019","unstructured":"Chen H, Moreno-Moral A, Pesce F, Devapragash N, Mancini M, Heng EL, Rotival M, Srivastava PK, Harmston N, Shkura K, Rackham OJ (2019) WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling. Nat Commun 10(1):1\u20139","journal-title":"Nat Commun"},{"issue":"16","key":"12781_CR17","doi-asserted-by":"publisher","first-page":"7525","DOI":"10.1016\/S0021-9258(19)43856-8","volume":"255","author":"A Ciechanover","year":"1980","unstructured":"Ciechanover A, Elias S, Heller H, Ferber S, Hershko A (1980a) Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. J Biol Chem 255(16):7525\u20137528","journal-title":"J Biol Chem"},{"issue":"3","key":"12781_CR18","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1073\/pnas.77.3.1365","volume":"77","author":"A Ciechanover","year":"1980","unstructured":"Ciechanover A, Heller H, Elias S, Haas AL, Hershko A (1980b) ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci 77(3):1365\u20131368","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"12781_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cell.2010.11.012","volume":"143","author":"MJ Clague","year":"2010","unstructured":"Clague MJ, Urb\u00e9 S (2010) Ubiquitin: same molecule, different degradation pathways. Cell 143(5):682\u2013685","journal-title":"Cell"},{"issue":"5","key":"12781_CR20","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1083\/jcb.201304167","volume":"204","author":"S Cohen","year":"2014","unstructured":"Cohen S, Lee D, Zhai B, Gygi SP, Goldberg AL (2014) Trim32 reduces PI3K\u2013Akt\u2013FoxO signaling in muscle atrophy by promoting plakoglobin\u2013PI3K dissociation. J Cell Biol 204(5):747\u2013758","journal-title":"J Cell Biol"},{"issue":"1","key":"12781_CR21","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1053\/j.ajkd.2009.10.009","volume":"55","author":"AJ Collins","year":"2010","unstructured":"Collins AJ, Foley RN, Herzog C, Chavers BM, Gilbertson D, Ishani A, Kasiske BL, Liu J, Mau LW, McBean M, Murray A (2010) Excerpts from the US renal data system 2009 annual data report. Am J Kidney Dis 55(1):A6\u2013A7","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"12781_CR22","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.4161\/auto.28478","volume":"10","author":"S Costes","year":"2014","unstructured":"Costes S, Gurlo T, Rivera JF, Butler PC (2014) UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in \u03b2-cells: evidence of interplay between the ubiquitin\/proteasome system and autophagy. Autophagy. 10(6):1004\u20131014","journal-title":"Autophagy."},{"issue":"1","key":"12781_CR23","doi-asserted-by":"publisher","first-page":"E87","DOI":"10.1152\/ajpendo.00430.2012","volume":"304","author":"W Cui","year":"2013","unstructured":"Cui W, Li B, Bai Y, Miao X, Chen Q, Sun W, Tan Y, Luo P, Zhang C, Zheng S, Epstein PN (2013) Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. Am J Physiol-Endocrinol Metab 304(1):E87\u2013E99","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"3","key":"12781_CR24","first-page":"203","volume":"43","author":"S Das","year":"2020","unstructured":"Das S, Ramakrishna S, Kim KS (2020) Critical roles of deubiquitinating enzymes in the nervous system and neurodegenerative disorders. Mol Cell 43(3):203","journal-title":"Mol Cell"},{"issue":"1","key":"12781_CR25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/cdd.2016.78","volume":"24","author":"MC De Almagro","year":"2017","unstructured":"De Almagro MC, Goncharov T, Izrael-Tomasevic A, Duttler S, Kist M, Varfolomeev E, Wu X, Lee WP, Murray J, Webster JD (2017) Yu K. Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death. Cell Death Differ 24(1):26\u201337","journal-title":"Cell Death Differ"},{"issue":"12","key":"12781_CR26","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/md16120467","volume":"16","author":"G Della Sala","year":"2018","unstructured":"Della Sala G, Agriesti F, Mazzoccoli C, Tataranni T, Costantino V, Piccoli C (2018) Clogging the ubiquitin-proteasome machinery with marine natural products: last decade update. Mar Drugs 16(12):467","journal-title":"Mar Drugs"},{"issue":"1","key":"12781_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1210\/er.2007-0015","volume":"29","author":"DL Eizirik","year":"2008","unstructured":"Eizirik DL, Cardozo AK, Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29(1):42\u201361","journal-title":"Endocr Rev"},{"key":"12781_CR28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2147\/IBPC.S188869","volume":"12","author":"BT Enslow","year":"2019","unstructured":"Enslow BT, Stockand JD, Berman JM (2019) Liddle\u2019s syndrome mechanisms, diagnosis and management. Integrated Blood Pressure Control 12:13","journal-title":"Integrated Blood Pressure Control"},{"key":"12781_CR29","first-page":"800","volume":"25","author":"M Esquerdo-Barrag\u00e1n","year":"2019","unstructured":"Esquerdo-Barrag\u00e1n M, Brooks MJ, Toulis V, Swaroop A, Marfany G (2019) Expression of deubiquitinating enzyme genes in the developing mammal retina. Mol Vis 25:800","journal-title":"Mol Vis"},{"issue":"3","key":"12781_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11892-017-0842-y","volume":"17","author":"Y Fan","year":"2017","unstructured":"Fan Y, Lee K, Wang N, He JC (2017) The role of endoplasmic reticulum stress in diabetic nephropathy. Curr Diabetes Rep 17(3):17","journal-title":"Curr Diabetes Rep"},{"issue":"19","key":"12781_CR31","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1038\/onc.2011.443","volume":"31","author":"JM Fraile","year":"2012","unstructured":"Fraile JM, Quesada V, Rodr\u00edguez D, Freije JM, L\u00f3pez-Ot\u00edn C (2012) Deubiquitinases in cancer: new functions and therapeutic options. Oncogene. 31(19):2373\u20132388","journal-title":"Oncogene."},{"issue":"1","key":"12781_CR32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","volume":"65","author":"N Frey","year":"2003","unstructured":"Frey N, Olson EN (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65(1):45\u201379","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"12781_CR33","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.celrep.2018.03.047","volume":"23","author":"Z Ge","year":"2018","unstructured":"Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J (2018) Integrated genomic analysis of the ubiquitin pathway across cancer types. Cell Rep 23(1):213\u2013226","journal-title":"Cell Rep"},{"key":"12781_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-biochem-052110-120012","volume":"81","author":"F Geng","year":"2012","unstructured":"Geng F, Wenzel S, Tansey WP (2012) Ubiquitin and proteasomes in transcription. Annu Rev Biochem 81:177\u2013201","journal-title":"Annu Rev Biochem"},{"issue":"44","key":"12781_CR35","doi-asserted-by":"publisher","first-page":"27280","DOI":"10.1074\/jbc.271.44.27280","volume":"271","author":"AL Goldberg","year":"1996","unstructured":"Goldberg AL (1996) Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J Biol Chem 271(44):27280\u201327284","journal-title":"J Biol Chem"},{"key":"12781_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2016.02.006","volume":"106","author":"SK Goru","year":"2016","unstructured":"Goru SK, Pandey A, Gaikwad AB (2016) E3 ubiquitin ligases as novel targets for inflammatory diseases. Pharmacol Res 106:1\u20139","journal-title":"Pharmacol Res"},{"key":"12781_CR37","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.phrs.2017.03.024","volume":"120","author":"SK Goru","year":"2017","unstructured":"Goru SK, Kadakol A, Gaikwad AB (2017) Hidden targets of ubiquitin proteasome system: to prevent diabetic nephropathy. Pharmacol Res 120:170\u2013179","journal-title":"Pharmacol Res"},{"key":"12781_CR38","doi-asserted-by":"publisher","first-page":"100183","DOI":"10.1016\/j.obmed.2020.100183","volume":"17","author":"A Gupta","year":"2020","unstructured":"Gupta A, Behl T, Sachdeva M (2020) Key milestones in the diabetes research: a comprehensive update. Obes Med 17:100183","journal-title":"Obes Med"},{"issue":"52","key":"12781_CR39","doi-asserted-by":"publisher","first-page":"53899","DOI":"10.1074\/jbc.R400021200","volume":"279","author":"RS Hilgarth","year":"2004","unstructured":"Hilgarth RS, Murphy LA, Skaggs HS, Wilkerson DC, Xing H, Sarge KD (2004) Regulation and function of SUMO modification. J Biol Chem 279(52):53899\u201353902","journal-title":"J Biol Chem"},{"key":"12781_CR40","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.2337\/db06-1768","volume":"56","author":"K Hirasaka","year":"2007","unstructured":"Hirasaka K, Kohno S, Goto J et al (2007) Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 56:2511\u20132522","journal-title":"Diabetes"},{"key":"12781_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.dci.2017.04.010","volume":"74","author":"CT Hoang","year":"2017","unstructured":"Hoang CT, Hong Y, Truong AD, Lee J, Lee K, Hong YH (2017) Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-\u03baB signaling pathway. Dev Comp Immunol 74:40\u201348","journal-title":"Dev Comp Immunol"},{"issue":"1","key":"12781_CR42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0014-5793(97)01480-4","volume":"420","author":"R Honda","year":"1997","unstructured":"Honda R, Tanaka H, Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420(1):25\u201327","journal-title":"FEBS Lett"},{"issue":"4","key":"12781_CR43","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/cr.2016.31","volume":"26","author":"X Huang","year":"2016","unstructured":"Huang X, Dixit VM (2016) Drugging the undruggables: exploring the ubiquitin system for drug development. Cell Res 26(4):484\u2013498","journal-title":"Cell Res"},{"issue":"7194","key":"12781_CR44","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature06926","volume":"453","author":"K Husnjak","year":"2008","unstructured":"Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I (2008) Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 453(7194):481\u2013488","journal-title":"Nature."},{"key":"12781_CR45","unstructured":"IDF (2020) data (https:\/\/diabetesatlas.org\/data\/en\/world\/). Accessed on 22-March-2020"},{"issue":"12","key":"12781_CR46","doi-asserted-by":"publisher","first-page":"11680","DOI":"10.1074\/jbc.M310369200","volume":"279","author":"NR Jana","year":"2004","unstructured":"Jana NR, Dikshit P, Goswami A, Nukina N (2004) Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 279(12):11680\u201311685","journal-title":"J Biol Chem"},{"issue":"18","key":"12781_CR47","doi-asserted-by":"publisher","first-page":"16287","DOI":"10.18632\/oncotarget.3843","volume":"6","author":"HJ Kim","year":"2015","unstructured":"Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ (2015) Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4. Oncotarget. 6(18):16287","journal-title":"Oncotarget."},{"issue":"6","key":"12781_CR48","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/jb\/mvq044","volume":"147","author":"Y Kimura","year":"2010","unstructured":"Kimura Y, Tanaka K (2010) Regulatory mechanisms involved in the control of ubiquitin homeostasis. J Biochem 147(6):793\u2013798","journal-title":"J Biochem"},{"issue":"4","key":"12781_CR49","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.cell.2010.04.026","volume":"141","author":"A K\u00f6hler","year":"2010","unstructured":"K\u00f6hler A, Zimmerman E, Schneider M, Hurt E, Zheng N (2010) Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell. 141(4):606\u2013617","journal-title":"Cell."},{"issue":"48","key":"12781_CR50","doi-asserted-by":"publisher","first-page":"34301","DOI":"10.1074\/jbc.274.48.34301","volume":"274","author":"P Komalavilas","year":"1999","unstructured":"Komalavilas P, Shah PK, Jo H, Lincoln TM (1999) Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells. J Biol Chem 274(48):34301\u201334309","journal-title":"J Biol Chem"},{"issue":"8","key":"12781_CR51","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nrm2731","volume":"10","author":"D Komander","year":"2009","unstructured":"Komander D, Clague MJ, Urb\u00e9 S (2009) Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 10(8):550\u2013563","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"12781_CR52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrd.2016.211","volume":"16","author":"AC Lai","year":"2017","unstructured":"Lai AC, Crews CM (2017) Induced protein degradation: an emerging drug discovery paradigm. Nat Rev Drug Discov 16(2):101","journal-title":"Nat Rev Drug Discov"},{"issue":"19","key":"12781_CR53","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1038\/emboj.2009.241","volume":"28","author":"E Laplantine","year":"2009","unstructured":"Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, Veron M, Agou F, Isra\u00ebl A (2009) NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J 28(19):2885\u20132895","journal-title":"EMBO J"},{"issue":"2","key":"12781_CR54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cardiores.2006.07.012","volume":"74","author":"A Leask","year":"2007","unstructured":"Leask A (2007) TGF\u03b2, cardiac fibroblasts, and the fibrotic response. Cardiovasc Res 74(2):207\u2013212","journal-title":"Cardiovasc Res"},{"issue":"3","key":"12781_CR55","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1128\/MCB.25.3.1173-1182.2005","volume":"25","author":"KK Lee","year":"2005","unstructured":"Lee KK, Florens L, Swanson SK, Washburn MP, Workman JL (2005) The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complex. Mol Cell Biol 25(3):1173\u20131182","journal-title":"Mol Cell Biol"},{"issue":"8","key":"12781_CR56","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI200422220","volume":"114","author":"HH Li","year":"2004","unstructured":"Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C (2004) Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest 114(8):1058\u20131071","journal-title":"J Clin Invest"},{"issue":"1","key":"12781_CR57","doi-asserted-by":"publisher","first-page":"e1487","DOI":"10.1371\/journal.pone.0001487","volume":"3","author":"W Li","year":"2008","unstructured":"Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, Chanda SK, Batalov S, Joazeiro CA (2008) Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle\u2019s dynamics and signaling. PLoS One 3(1):e1487","journal-title":"PLoS One"},{"issue":"4","key":"12781_CR58","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1210\/en.2014-1909","volume":"156","author":"JJ Li","year":"2015","unstructured":"Li JJ, Ferry RJ, Diao S, Xue B, Bahouth SW, Liao FF (2015) Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity. Endocrinology. 156(4):1283\u20131291","journal-title":"Endocrinology."},{"issue":"10","key":"12781_CR59","doi-asserted-by":"publisher","first-page":"e120362","DOI":"10.1172\/jci.insight.120362","volume":"3","author":"S Li","year":"2018","unstructured":"Li S, Zhao J, Shang D, Kass DJ, Zhao Y (2018) Ubiquitination and deubiquitination emerge as players in idiopathic pulmonary fibrosis pathogenesis and treatment. JCI insight 3(10):e120362","journal-title":"JCI insight"},{"key":"12781_CR60","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3389\/fphys.2020.612927","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Zou J, Littlejohn R, Liu J, Su H (2020) Neddylation, an emerging mechanism regulating cardiac development and function. Front Physiol 11:1624","journal-title":"Front Physiol"},{"issue":"1","key":"12781_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms1776","volume":"3","author":"JH Lim","year":"2012","unstructured":"Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W (2012) Park SH. CYLD negatively regulates transforming growth factor-\u03b2-signalling via deubiquitinating Akt. Nat Commun 3(1):1\u20132","journal-title":"Nat Commun"},{"issue":"4","key":"12781_CR62","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.molcel.2012.03.024","volume":"46","author":"Z Lin","year":"2012","unstructured":"Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, Fang D (2012) USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell 46(4):484\u2013494","journal-title":"Mol Cell"},{"issue":"3","key":"12781_CR63","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/jso.21802","volume":"103","author":"YL Liu","year":"2011","unstructured":"Liu YL, Yang YM, Xu H, Dong XS (2011) Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer. J Surg Oncol 103(3):283\u2013289","journal-title":"J Surg Oncol"},{"issue":"9","key":"12781_CR64","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1161\/ATVBAHA.112.253385","volume":"32","author":"H Liu","year":"2012","unstructured":"Liu H, Yu S, Xu W (2012) Xu J. Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus. Arterioscler Thromb Vasc Biol 32(9):2131\u20132140","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"12781_CR65","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/CIRCULATIONAHA.114.012285","volume":"131","author":"F Liu","year":"2015","unstructured":"Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C (2015) Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor \u03b1. Circulation. 131(9):795\u2013804","journal-title":"Circulation."},{"issue":"11-12","key":"12781_CR66","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.lfs.2010.12.023","volume":"88","author":"ZF Luo","year":"2011","unstructured":"Luo ZF, Qi W, Feng B, Mu J, Zeng W, Guo YH, Pang Q, Ye ZL, Liu L, Yuan FH (2011) Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome. Life Sci 88(11-12):512\u2013520","journal-title":"Life Sci"},{"issue":"4","key":"12781_CR67","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.bbrc.2007.11.092","volume":"365","author":"M Majetschak","year":"2008","unstructured":"Majetschak M, Patel MB, Sorell LT, Liotta C, Li S, Pham SM (2008) Cardiac proteasome dysfunction during cold ischemic storage and reperfusion in a murine heart transplantation model. Biochem Biophys Res Commun 365(4):882\u2013888","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"12781_CR68","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2337\/db13-0802","volume":"63","author":"A Marino","year":"2014","unstructured":"Marino A, Menghini R, Fabrizi M, Casagrande V, Mavilio M, Stoehr R, Candi E, Mauriello A, Moreno-Navarrete JM, G\u00f3mez-Serrano M, Peral B (2014) ITCH deficiency protects from diet-induced obesity. Diabetes. 63(2):550\u2013561","journal-title":"Diabetes."},{"issue":"8","key":"12781_CR69","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.2337\/db14-0893","volume":"64","author":"T Matsubara","year":"2015","unstructured":"Matsubara T, Araki M, Abe H, Ueda O, Jishage KI, Mima A, Goto C, Tominaga T, Kinosaki M, Kishi S, Nagai K (2015) Bone morphogenetic protein 4 and Smad1 mediate extracellular matrix production in the development of diabetic nephropathy. Diabetes. 64(8):2978\u20132990","journal-title":"Diabetes."},{"issue":"6","key":"12781_CR70","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1210\/en.2004-1074","volume":"146","author":"EA Medina","year":"2005","unstructured":"Medina EA, Afsari RR, Ravid T, Castillo SS, Erickson KL, Goldkorn T (2005) Tumor necrosis factor-\u03b1 decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology. 146(6):2726\u20132735","journal-title":"Endocrinology."},{"issue":"28","key":"12781_CR71","doi-asserted-by":"publisher","first-page":"44848","DOI":"10.18632\/oncotarget.8602","volume":"7","author":"J Melo-Cardenas","year":"2016","unstructured":"Melo-Cardenas J, Zhang Y, Zhang DD, Fang D (2016) Ubiquitin-specific peptidase 22 functions and its involvement in disease. Oncotarget. 7(28):44848","journal-title":"Oncotarget."},{"key":"12781_CR72","doi-asserted-by":"crossref","unstructured":"Meyer-Schwesinger C (2019) The ubiquitin\u2013proteasome system in kidney physiology and disease. Nat Rev Nephrol 1","DOI":"10.1038\/s41581-019-0148-1"},{"issue":"2","key":"12781_CR73","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1007\/PL00002934","volume":"44","author":"NJ Morrish","year":"2001","unstructured":"Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H, WHO Multinational Study Group (2001) Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia. 44(2):S14","journal-title":"Diabetologia."},{"key":"12781_CR74","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.canlet.2018.07.018","volume":"434","author":"SF Nabavi","year":"2018","unstructured":"Nabavi SF, Atanasov AG, Khan H, Barreca D, Trombetta D, Testai L, Sureda A, Tejada S, Vacca RA, Pittal\u00e0 V, Gulei D (2018) Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: lessons learned from clinical trials. Cancer Lett 434:101\u2013113","journal-title":"Cancer Lett"},{"issue":"1","key":"12781_CR75","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2337\/dc08-9025","volume":"32","author":"DM Nathan","year":"2009","unstructured":"Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32(1):193\u2013203","journal-title":"Diabetes Care"},{"issue":"5","key":"12781_CR76","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.cell.2005.11.007","volume":"123","author":"SM Nijman","year":"2005","unstructured":"Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R (2005) A genomic and functional inventory of deubiquitinating enzymes. Cell. 123(5):773\u2013786","journal-title":"Cell."},{"issue":"3","key":"12781_CR77","first-page":"9","volume":"23","author":"F Nurwidya","year":"2016","unstructured":"Nurwidya F, Andarini S, Takahashi F, Syahruddin E, Takahashi K (2016) Implications of insulin-like growth factor 1 receptor activation in lung cancer. Malays J Med Sci: MJMS 23(3):9","journal-title":"Malays J Med Sci: MJMS"},{"issue":"4","key":"12781_CR78","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1054\/mehy.1999.0895","volume":"54","author":"J Pallares-Trujillo","year":"2000","unstructured":"Pallares-Trujillo J, Carbo N, Lopez-Soriano FJ, Argiles JM (2000) Does the mechanism responsible for TNF-mediated insulin resistance involve the proteasome? Med Hypotheses 54(4):565\u2013569","journal-title":"Med Hypotheses"},{"issue":"6467","key":"12781_CR79","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.aax3769","volume":"366","author":"C Pohl","year":"2019","unstructured":"Pohl C, Dikic I (2019) Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 366(6467):818\u2013822","journal-title":"Science."},{"issue":"3","key":"12781_CR80","doi-asserted-by":"publisher","first-page":"181","DOI":"10.5483\/BMBRep.2019.52.3.048","volume":"52","author":"N Poondla","year":"2019","unstructured":"Poondla N, Chandrasekaran AP, Kim KS, Ramakrishna S (2019) Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities? BMB Rep 52(3):181","journal-title":"BMB Rep"},{"issue":"1","key":"12781_CR81","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.kint.2017.05.016","volume":"93","author":"V Rad\u00f3n","year":"2018","unstructured":"Rad\u00f3n V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop JH, Wiech T, Wenzel UO, Sachs M, Reinicke AT (2018) Ubiquitin C-terminal hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney. Kidney Int 93(1):110\u2013127","journal-title":"Kidney Int"},{"issue":"2","key":"12781_CR82","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bbrc.2006.01.163","volume":"342","author":"P Razeghi","year":"2006","unstructured":"Razeghi P, Baskin KK, Sharma S, Young ME, Stepkowski S, Essop MF, Taegtmeyer H (2006) Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. Biochem Biophys Res Commun 342(2):361\u2013364","journal-title":"Biochem Biophys Res Commun"},{"key":"12781_CR83","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.mce.2015.06.008","volume":"413","author":"JE Rodr\u00edguez","year":"2015","unstructured":"Rodr\u00edguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DJ, Frederick CB, Yoder BC, Lalush DS, Patterson C (2015) The ubiquitin ligase MuRF1 regulates PPAR\u03b1 activity in the heart by enhancing nuclear export via monoubiquitination. Mol Cell Endocrinol 413:36\u201348","journal-title":"Mol Cell Endocrinol"},{"key":"12781_CR84","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2015.12.031","volume":"98","author":"O Rom","year":"2016","unstructured":"Rom O, Reznick AZ (2016) The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass. Free Radic Biol Med 98:218\u2013230","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"12781_CR85","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/nrm2690","volume":"10","author":"D Rotin","year":"2009","unstructured":"Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10(6):398","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"44","key":"12781_CR86","doi-asserted-by":"publisher","first-page":"42394","DOI":"10.1074\/jbc.C200444200","volume":"277","author":"L Rui","year":"2002","unstructured":"Rui L, Yuan M, Frantz D, Shoelson S, White MF (2002) SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 277(44):42394\u201342398","journal-title":"J Biol Chem"},{"issue":"2","key":"12781_CR87","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cellsig.2013.11.005","volume":"26","author":"F Scheufele","year":"2014","unstructured":"Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Muehlich S, Pfeiffer AF, Field LJ, Charron MJ, Pan ZQ, Engelhardt S (2014) Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling. Cell Signal 26(2):233\u2013239","journal-title":"Cell Signal"},{"issue":"6","key":"12781_CR88","doi-asserted-by":"publisher","first-page":"F1348","DOI":"10.1152\/ajprenal.00028.2010","volume":"299","author":"M Sedeek","year":"2010","unstructured":"Sedeek M, Callera G, Montezano A, Gutsol A, Heitz F, Szyndralewiez C, Page P, Kennedy CR, Burns KD, Touyz RM, Hebert RL (2010) Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am J Physiol-Renal Physiol 299(6):F1348\u2013F1358","journal-title":"Am J Physiol-Renal Physiol"},{"issue":"2","key":"12781_CR89","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrc.2017.105","volume":"18","author":"D Senft","year":"2018","unstructured":"Senft D, Qi J, Ze\u2019ev AR (2018) Ubiquitin ligases in oncogenic transformation and cancer therapy. Nat Rev Cancer 18(2):69","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"12781_CR90","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.devcel.2011.09.011","volume":"21","author":"J Shi","year":"2011","unstructured":"Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (2011) The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Dev Cell 21(5):835\u2013847","journal-title":"Dev Cell"},{"issue":"7437","key":"12781_CR91","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nature11834","volume":"494","author":"R Song","year":"2013","unstructured":"Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M (2013) Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 494(7437):375\u2013379","journal-title":"Nature."},{"issue":"1","key":"12781_CR92","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/cdd.2009.43","volume":"17","author":"SC Sun","year":"2010","unstructured":"Sun SC (2010) CYLD: a tumor suppressor deubiquitinase regulating NF-\u03ba B activation and diverse biological processes. Cell Death Differ 17(1):25\u201334","journal-title":"Cell Death Differ"},{"issue":"7","key":"12781_CR93","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1074\/jbc.M117.811471","volume":"293","author":"S Sun","year":"2018","unstructured":"Sun S, Tan P, Huang X, Zhang W, Kong C, Ren F, Ubiquitinated SX (2018) CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. J Biol Chem 293(7):2383\u20132394","journal-title":"J Biol Chem"},{"issue":"1","key":"12781_CR94","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","volume":"55","author":"K Susztak","year":"2006","unstructured":"Susztak K, Raff AC, Schiffer M, B\u00f6ttinger EP (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 55(1):225\u2013233","journal-title":"Diabetes."},{"issue":"4","key":"12781_CR95","doi-asserted-by":"publisher","first-page":"397","DOI":"10.5155\/eurjchem.7.4.397-404.1478","volume":"7","author":"MA Taher","year":"2016","unstructured":"Taher MA, Dawood DH, Sanad MI, Hassan RA (2016) Searching for anti-hyperglycemic phytomolecules of Tecoma stans. Eur J Chem 7(4):397\u2013404","journal-title":"Eur J Chem"},{"issue":"2","key":"12781_CR96","doi-asserted-by":"publisher","first-page":"460","DOI":"10.2337\/db07-1119","volume":"57","author":"V Thallas-Bonke","year":"2008","unstructured":"Thallas-Bonke V, Thorpe SR, Coughlan MT, Fukami K, Yap FY, Sourris KC, Penfold SA, Bach LA, Cooper ME, Forbes JM (2008) Inhibition of NADPH oxidase prevents advanced glycation end product\u2013mediated damage in diabetic nephropathy through a protein kinase C-\u03b1\u2013dependent pathway. Diabetes. 57(2):460\u2013469","journal-title":"Diabetes."},{"issue":"1","key":"12781_CR97","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/emboj\/19.1.94","volume":"19","author":"JS Thrower","year":"2000","unstructured":"Thrower JS, Hoffman L, Rechsteiner M, Pickart CM (2000) Recognition of the polyubiquitin proteolytic signal. EMBO J 19(1):94\u2013102","journal-title":"EMBO J"},{"issue":"1","key":"12781_CR98","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bmcl.2004.10.012","volume":"15","author":"S Tsukamoto","year":"2005","unstructured":"Tsukamoto S, Hirota H, Imachi M, Fujimuro M, Onuki H, Ohta T, Yokosawa H (2005) Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp. Bioorg Med Chem Lett 15(1):191\u2013194","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"12781_CR99","first-page":"726","volume":"5","author":"Y Tu","year":"2012","unstructured":"Tu Y, Chen C, Pan J, Xu J, Zhou ZG, Wang CY (2012) The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis. Int J Clin Exp Pathol 5(8):726","journal-title":"Int J Clin Exp Pathol"},{"issue":"12","key":"12781_CR100","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41419-020-03246-7","volume":"11","author":"B Udayan","year":"2020","unstructured":"Udayan B, Fiifi NA, Priyabrata M, Resham B (2020) When the chains do not break: the role of USP10 in physiology and pathology. Cell Death Dis 11(12):1033","journal-title":"Cell Death Dis"},{"issue":"2","key":"12781_CR101","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/glia.23251","volume":"66","author":"JJ VerPlank","year":"2018","unstructured":"VerPlank JJ, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L (2018) Impairment of protein degradation and proteasome function in hereditary neuropathies. Glia. 66(2):379\u2013395","journal-title":"Glia."},{"issue":"3","key":"12781_CR102","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/0022-2836(87)90679-6","volume":"194","author":"S Vijay-Kumar","year":"1987","unstructured":"Vijay-Kumar S, Bugg CE, Cook WJ (1987) Structure of ubiquitin refined at 1.8 \u00c5resolution. J Mol Biol 194(3):531\u2013544","journal-title":"J Mol Biol"},{"issue":"9","key":"12781_CR103","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1210\/en.2006-0251","volume":"147","author":"X Wang","year":"2006","unstructured":"Wang X, Hu Z, Hu J, Du J, Mitch WE (2006) Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 147(9):4160\u20134168","journal-title":"Endocrinology."},{"issue":"4","key":"12781_CR104","first-page":"H567","volume":"304","author":"Y Wang","year":"2013","unstructured":"Wang Y, Sun W, Du B, Miao X, Bai Y, Xin Y, Tan Y, Cui W, Liu B, Cui T, Epstein PN (2013) Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-\u03baB. Am J Phys Heart Circ Phys 304(4):H567\u2013H578","journal-title":"Am J Phys Heart Circ Phys"},{"key":"12781_CR105","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mrfmmm.2017.07.001","volume":"803","author":"Z Wang","year":"2017","unstructured":"Wang Z, Zhu WG, Xu X (2017) Ubiquitin-like modifications in the DNA damage response. Mutation Res\/Fundam Mol Mech Mutagen 803:56\u201375","journal-title":"Mutation Res\/Fundam Mol Mech Mutagen"},{"issue":"3","key":"12781_CR106","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/35056563","volume":"2","author":"AM Weissman","year":"2001","unstructured":"Weissman AM (2001) Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2(3):169\u2013178","journal-title":"Nat Rev Mol Cell Biol"},{"key":"12781_CR107","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ddtec.2019.02.003","volume":"31","author":"IE Wertz","year":"2019","unstructured":"Wertz IE, Murray JM (2019) Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms. Drug Discov Today Technol 31:109\u2013123","journal-title":"Drug Discov Today Technol"},{"issue":"6","key":"12781_CR108","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.immuni.2014.11.013","volume":"41","author":"S Yang","year":"2014","unstructured":"Yang S, Wang B, Humphries F, Hogan AE, O\u2019Shea D, Moynagh PN (2014) The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance. Immunity. 41(6):973\u2013987","journal-title":"Immunity."},{"issue":"2","key":"12781_CR109","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbadis.2014.05.006","volume":"1852","author":"L Yang","year":"2015","unstructured":"Yang L, Zhao D, Ren J, Yang J (2015) Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852(2):209\u2013218","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"8","key":"12781_CR110","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/dom.12677","volume":"18","author":"XD Yang","year":"2016","unstructured":"Yang XD, Xiang DX, Yang YY (2016) Role of E3 ubiquitin ligases in insulin resistance. Diabetes Obes Metab 18(8):747\u2013754","journal-title":"Diabetes Obes Metab"},{"key":"12781_CR111","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1038\/ncomms3354","volume":"4","author":"JS Yi","year":"2013","unstructured":"Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, Kim BW, Lee H, Lee CS, Jeong BC, Song HK (2013) MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun 4:2354","journal-title":"Nat Commun"},{"issue":"3","key":"12781_CR112","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/sj.embor.7401158","volume":"9","author":"LP Zalmas","year":"2008","unstructured":"Zalmas LP, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB (2008) DNA-damage response control of E2F7 and E2F8. EMBO Rep 9(3):252\u2013259","journal-title":"EMBO Rep"},{"issue":"13","key":"12781_CR113","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1161\/01.CIR.101.13.1539","volume":"101","author":"G Zeng","year":"2000","unstructured":"Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, Quon MJ (2000) Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 101(13):1539\u20131545","journal-title":"Circulation."},{"issue":"9","key":"12781_CR114","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3390\/ijms17091404","volume":"17","author":"H Zhang","year":"2016","unstructured":"Zhang H, Luo W, Sun Y, Qiao Y, Zhang L, Zhao Z, Lv S (2016) Wnt\/\u03b2-catenin signaling mediated-UCH-L1 expression in podocytes of diabetic nephropathy. Int J Mol Sci 17(9):1404","journal-title":"Int J Mol Sci"},{"key":"12781_CR115","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3389\/fnagi.2016.00303","volume":"8","author":"Q Zheng","year":"2016","unstructured":"Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X (2016) Dysregulation of ubiquitin-proteasome system in neurodegenerative diseases. Front Aging Neurosci 8:303","journal-title":"Front Aging Neurosci"},{"key":"12781_CR116","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3389\/fendo.2018.00624","volume":"9","author":"Y Zhong","year":"2018","unstructured":"Zhong Y, Lee K, He JC (2018) SIRT1 Is a potential drug target for treatment of diabetic kidney disease. Front Endocrinol 9:624","journal-title":"Front Endocrinol"},{"key":"12781_CR117","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-981-15-1025-0_14","volume-title":"Cullin-RING Ligases and Protein Neddylation","author":"P Zhou","year":"2020","unstructured":"Zhou P, Yan F (2020) CRL4 ubiquitin pathway and DNA damage response. In: Cullin-RING Ligases and Protein Neddylation. Springer, Singapore, pp 225\u2013239"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12781-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-12781-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-12781-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T19:21:46Z","timestamp":1675020106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-12781-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":117,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["12781"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-12781-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"20 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors approved the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}