{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:59:44Z","timestamp":1789862384695,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"26","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012456","name":"National Social Science Foundation of China","doi-asserted-by":"crossref","award":["20BRK037"],"award-info":[{"award-number":["20BRK037"]}],"id":[{"id":"10.13039\/501100012456","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Key Research and Development Program of Shaanxi","award":["2019SF-100"],"award-info":[{"award-number":["2019SF-100"]}]},{"name":"The Science and Technology Project of Xi'an City","award":["201805098YX6SF32(1)"],"award-info":[{"award-number":["201805098YX6SF32(1)"]}]},{"name":"The Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University, China","award":["XJTU1AF-CRF-2019-023"],"award-info":[{"award-number":["XJTU1AF-CRF-2019-023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal exposure to air pollution during pregnancy is associated with adverse outcomes in the offspring, but limited studies focused on the impacts of gaseous air pollution on newborn congenital hypothyroidism (CH). Therefore, a national data-based analysis was conducted to explore the association between maternal exposure to gaseous air pollution and the incidence of CH in China. Annual average exposure levels of SO<jats:sub>2<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, CO, and O<jats:sub>3<\/jats:sub> from January 1, 2014, to December 30, 2014, were acquired from the Chinese Air Quality Online Monitoring and Analysis Platform. The annual incidence of newborn CH from October 1, 2014, to September 30, 2015, was collected from the Chinese Maternal and Child Health Surveillance Network. Temperature and toxic metal in wastewater in 2014 were also collected as covariates. Maternal exposure to O<jats:sub>3<\/jats:sub> and NO<jats:sub>2<\/jats:sub> in 1 \u03bcg\/m<jats:sup>3<\/jats:sup> level increment was positively associated with newborn CH, with an OR of 1.055 (95% CI 1.011, 1.102) and 1.097 (95% CI 1.019, 1.182) after adjusting for covariates completely. Compared with the lowest level of O<jats:sub>3<\/jats:sub>, maternal exposure to the 4th quartile of O<jats:sub>3<\/jats:sub> was positively associated with newborn CH (OR 1.393, 95% CI 1.081, 1.794) after adjusting for covariates completely. And the 3rd and 4th quartiles of NO<jats:sub>2<\/jats:sub> were associated positively with CH (OR 1.576, 95% CI 1.025, 2.424, and OR 1.553, 95% CI 0.999, 2.414, respectively) compared with the lowest level of NO<jats:sub>2<\/jats:sub>. By fitting the ROC curve, 93.688 \u03bcg\/m<jats:sup>3<\/jats:sup> in O<jats:sub>3<\/jats:sub> might be used as cutoff to predict the incidence of newborn CH in China.<\/jats:p>","DOI":"10.1007\/s11356-021-13083-6","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T20:02:45Z","timestamp":1614715365000},"page":"34621-34629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maternal exposure to O3 and NO2 may increase the risk of newborn congenital hypothyroidism: a national data-based analysis in China"],"prefix":"10.1007","volume":"28","author":[{"given":"Cuifang","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liren","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Chun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"issue":"9","key":"13083_CR1","doi-asserted-by":"publisher","first-page":"CD012192","DOI":"10.1002\/14651858.CD012192.pub2","volume":"9","author":"NA Baak","year":"2019","unstructured":"Baak NA, Cantineau AE, Farquhar C, Brison DR (2019) Temperature of embryo culture for assisted reproduction. Cochrane Database Syst Rev 9(9):CD012192. https:\/\/doi.org\/10.1002\/14651858.CD012192.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"13083_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-069X-9-6","volume":"9","author":"F Ballester","year":"2010","unstructured":"Ballester F, Estarlich M, I\u00f1iguez C, Llop S, Ram\u00f3n R, Esplugues A, Lacasa\u00f1a M, Rebagliato M (2010) Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain. Environ Health 9:6. https:\/\/doi.org\/10.1186\/1476-069X-9-6","journal-title":"Environ Health"},{"issue":"6","key":"13083_CR3","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1162\/00335530360698513","volume":"118","author":"KY Chay","year":"2003","unstructured":"Chay KY, Greenstone M (2003) The impact of air pollution on infant mortality: evidence from geographic variation in pollution shocks induced by a recession. Q J Econ 118(6):1121\u20131167. https:\/\/doi.org\/10.1162\/00335530360698513","journal-title":"Q J Econ"},{"issue":"4","key":"13083_CR4","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1164\/rccm.200611-1627OC","volume":"176","author":"KJ Chuang","year":"2007","unstructured":"Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS (2007) The effect of urban air pollution on inflammation, oxidative stress, coagulation and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176(4):370\u2013376. https:\/\/doi.org\/10.1164\/rccm.200611-1627OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"13083_CR5","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1289\/ehp.0800219","volume":"117","author":"R Dallaire","year":"2009","unstructured":"Dallaire R, Muckle G, Dewailly \u00c9, Jacobson SW, Jacobson JL, Sandanger TM, Sandau CD, Ayotte P (2009) Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants. Environ Health Perspect 117(6):1014\u20131020. https:\/\/doi.org\/10.1289\/ehp.0800219","journal-title":"Environ Health Perspect"},{"issue":"6","key":"13083_CR6","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.1007\/s11356-017-0692-9","volume":"25","author":"M Dastoorpoor","year":"2018","unstructured":"Dastoorpoor M, Idani E, Goudarzi G, Khanjani N (2018) Acute effects of air pollution on spontaneous abortion, premature delivery, and stillbirth in Ahvaz, Iran: a time-series study. Environ Sci Pollut Res Int 25(6):5447\u20135458. https:\/\/doi.org\/10.1007\/s11356-017-0692-9","journal-title":"Environ Sci Pollut Res Int"},{"issue":"11","key":"13083_CR7","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s00431-018-3230-y","volume":"177","author":"J David","year":"2018","unstructured":"David J, Chrastina P, Vinohradska H, al Taji E, Holubova A, Hlidkova E, Kozich V, Votava F (2018) Neonatal screening in the Czech Republic: increased prevalence of selected diseases in low birthweight neonates. Eur J Pediatr 177(11):1697\u20131704. https:\/\/doi.org\/10.1007\/s00431-018-3230-y","journal-title":"Eur J Pediatr"},{"issue":"6","key":"13083_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1515\/jpem-2017-0361","volume":"31","author":"K Deng","year":"2018","unstructured":"Deng K, He C, Zhu J, Liang J, Li X, Xie X, Yu P, Li N, Li Q, Wang Y (2018) Incidence of congenital hypothyroidism in China: data from the national newborn screening program, 2013-2015. J Pediatr Endocrinol Metab 31(6):601\u2013608. https:\/\/doi.org\/10.1515\/jpem-2017-0361","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"6","key":"13083_CR9","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1289\/ehp.0901623","volume":"118","author":"AV Donkelaar","year":"2010","unstructured":"Donkelaar AV, Martin RV, Brauer M, Kahn R, Levy R, Verduzco C, Villeneuve PJ (2010) Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application. Environ Health Perspect 118(6):847\u2013855. https:\/\/doi.org\/10.1289\/ehp.0901623","journal-title":"Environ Health Perspect"},{"issue":"4","key":"13083_CR10","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1289\/ehp.1307065","volume":"122","author":"AF Fleisch","year":"2014","unstructured":"Fleisch AF, Gold DR, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, Coull BA, Zanobetti A, Gillman MW, Oken E (2014) Air pollution exposure and abnormal glucose tolerance during pregnancy: the project Viva cohort. Environ Health Perspect 122(4):378\u2013383. https:\/\/doi.org\/10.1289\/ehp.1307065","journal-title":"Environ Health Perspect"},{"issue":"8","key":"13083_CR11","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1530\/EC-17-0289","volume":"6","author":"C Fu","year":"2017","unstructured":"Fu C, Luo S, Li Y, Li Q, Hu X, Li M, Zhang Y, Su J, Hu X, Chen Y, Wang J, Xie B, Luo J, Fan X, Chen S, Shen Y (2017) The incidence of congenital hypothyroidism (CH) in Guangxi, China and the predictors of permanent and transient CH. Endocr Connect 6(8):926\u2013934. https:\/\/doi.org\/10.1530\/EC-17-0289","journal-title":"Endocr Connect"},{"key":"13083_CR12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.10.231","volume":"578","author":"J Gao","year":"2016","unstructured":"Gao J, Woodward A, Vardoulakis S, Kovats S, Wilkinson P, Li L, Xu L, Li J, Yang J, Li J, Cao L, Liu X, Wu H, Liu Q (2016) Haze, public health and mitigation measures in China: a review of the current evidence for further policy response. Sci Total Environ 578:148\u2013157. https:\/\/doi.org\/10.1016\/j.scitotenv.2016.10.231","journal-title":"Sci Total Environ"},{"issue":"11","key":"13083_CR13","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1080\/10962247.2012.707632","volume":"62","author":"LA Geer","year":"2012","unstructured":"Geer LA, Weedon J, Bell ML (2012) Ambient air pollution and term birth weight in Texas from 1998 to 2004. J Air Waste Manage Assoc 62(11):1285\u20131295. https:\/\/doi.org\/10.1080\/10962247.2012.707632","journal-title":"J Air Waste Manage Assoc"},{"key":"13083_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envres.2015.12.010","volume":"146","author":"MS Girguis","year":"2016","unstructured":"Girguis MS, Strickland MJ, Hu X, Liu Y, Bartell SM, Vieira VM (2016) Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res 146:1\u20139. https:\/\/doi.org\/10.1016\/j.envres.2015.12.010","journal-title":"Environ Res"},{"issue":"1","key":"13083_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1476-069X-13-4","volume":"13","author":"SC Gray","year":"2014","unstructured":"Gray SC, Edwards SE, Schultz BD, Miranda ML (2014) Assessing the impact of race, social factors and air pollution on birth outcomes: a population-based study. Environ Health 13(1):4. https:\/\/doi.org\/10.1186\/1476-069X-13-4","journal-title":"Environ Health"},{"key":"13083_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1476-069X-9-46","volume":"9","author":"CE Herr","year":"2010","unstructured":"Herr CE et al (2010) Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths. Environ Health 9:46. https:\/\/doi.org\/10.1186\/1476-069X-9-46","journal-title":"Environ Health"},{"issue":"3","key":"13083_CR17","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1161\/HYPERTENSIONAHA.110.164087","volume":"57","author":"EHVD Hooven","year":"2011","unstructured":"Hooven EHVD et al (2011) Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study. Hypertension 57(3):406\u2013412. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.110.164087","journal-title":"Hypertension"},{"issue":"5","key":"13083_CR18","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.2172","volume":"1","author":"CG Howe","year":"2018","unstructured":"Howe CG, Eckel SP, Habre R, Girguis MS, Gao L, Lurmann FW, Gilliland FD, Breton CV (2018) Association of prenatal exposure to ambient and traffic-related air pollution with newborn thyroid function: findings from the children\u2019s health study. JAMA Netw Open 1(5):e182172. https:\/\/doi.org\/10.1001\/jamanetworkopen.2018.2172","journal-title":"JAMA Netw Open"},{"issue":"8","key":"13083_CR19","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S2213-8587(19)30153-6","volume":"7","author":"TA Jansen","year":"2019","unstructured":"Jansen TA, Korevaar TIM, Mulder TA, White T, Muetzel RL, Peeters RP, Tiemeier H (2019) Maternal thyroid function during pregnancy and child brain morphology: a time window-specific analysis of a prospective cohort. Lancet Diabetes Endocrinol 7(8):629\u2013637. https:\/\/doi.org\/10.1016\/S2213-8587(19)30153-6","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"13083_CR20","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1289\/EHP508","volume":"125","author":"BG Janssen","year":"2017","unstructured":"Janssen BG, Saenen ND, Roels HA, Madhloum N, Gyselaers W, Lefebvre W, Penders J, Vanpoucke C, Vrijens K, Nawrot TS (2017) Fetal thyroid function, birth weight, and in utero exposure to fine particle air pollution: a birth cohort study. Environ Health Perspect 125(4):699\u2013705. https:\/\/doi.org\/10.1289\/EHP508","journal-title":"Environ Health Perspect"},{"issue":"1","key":"13083_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S2213-8587(15)00327-7","volume":"4","author":"TI Korevaar","year":"2016","unstructured":"Korevaar TI et al (2016) Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol 4(1):35\u201343. https:\/\/doi.org\/10.1016\/S2213-8587(15)00327-7","journal-title":"Lancet Diabetes Endocrinol"},{"key":"13083_CR22","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.scitotenv.2017.11.058","volume":"619-620","author":"DK Lamichhane","year":"2018","unstructured":"Lamichhane DK, Ryu J, Leem JH, Ha M, Hong YC, Park H, Kim Y, Jung DY, Lee JY, Kim HC, Ha EH (2018) Air pollution exposure during pregnancy and ultrasound and birth measures of fetal growth: a prospective cohort study in Korea. Sci Total Environ 619-620:834\u2013841. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.11.058","journal-title":"Sci Total Environ"},{"key":"13083_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.envint.2016.03.013","volume":"92-93","author":"KJ Lane","year":"2016","unstructured":"Lane KJ, Levy JI, Scammell MK, Peters JL, Patton AP, Reisner E, Lowe L, Zamore W, Durant JL, Brugge D (2016) Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers. Environ Int 92-93:173\u2013182. https:\/\/doi.org\/10.1016\/j.envint.2016.03.013","journal-title":"Environ Int"},{"issue":"1","key":"13083_CR24","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1186\/s12889-019-7790-1","volume":"19","author":"S Li","year":"2019","unstructured":"Li S et al (2019) Maternal exposure to PM2.5 may increase the risk of congenital hypothyroidism in the offspring: a national database based study in China. BMC Public Health 19(1):1412. https:\/\/doi.org\/10.1186\/s12889-019-7790-1","journal-title":"BMC Public Health"},{"issue":"4","key":"13083_CR25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1289\/ehp.1205736","volume":"121","author":"E Malmqvist","year":"2013","unstructured":"Malmqvist E, Jakobsson K, Tinnerberg H, Rignellhydbom A, Rylander L (2013) Gestational diabetes and preeclampsia in association with air pollution at levels below current air quality guidelines. Environ Health Perspect 121(4):488\u2013493. https:\/\/doi.org\/10.1289\/ehp.1205736","journal-title":"Environ Health Perspect"},{"issue":"10","key":"13083_CR26","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.5455\/JPMA.35858","volume":"70","author":"S Mansoor","year":"2020","unstructured":"Mansoor S (2020) Congenital hypothyroidism: diagnosis and management of patients. J Pak Med Assoc 70(10):1845\u20131847. https:\/\/doi.org\/10.5455\/JPMA.35858","journal-title":"J Pak Med Assoc"},{"issue":"10","key":"13083_CR27","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1289\/EHP243","volume":"124","author":"RM Nachman","year":"2016","unstructured":"Nachman RM, Mao G, Zhang X, Hong X, Chen Z, Soria CS, He H, Wang G, Caruso D, Pearson C, Biswal S, Zuckerman B, Wills-Karp M, Wang X (2016) Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston Birth Cohort. Environ Health Perspect 124(10):1608\u20131615. https:\/\/doi.org\/10.1289\/EHP243","journal-title":"Environ Health Perspect"},{"issue":"11-12","key":"13083_CR28","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3109\/00365548.2010.498020","volume":"42","author":"CM Nascimento Carvalho","year":"2010","unstructured":"Nascimento Carvalho CM et al (2010) Seasonal patterns of viral and bacterial infections among children hospitalized with community-acquired pneumonia in a tropical region. Scand J Infect Dis 42(11-12):839\u2013844. https:\/\/doi.org\/10.3109\/00365548.2010.498020","journal-title":"Scand J Infect Dis"},{"key":"13083_CR29","unstructured":"National Bureau of Statistics of China (2015) China\u00a0Statistical\u00a0Yearbook in 2014. National Bureau of Statistics of China. http:\/\/www.stats.gov.cn\/tjsj\/ndsj\/2015\/indexch.htm. Accessed 26 June 2019"},{"key":"13083_CR30","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.envpol.2017.06.052","volume":"230","author":"X Nie","year":"2017","unstructured":"Nie X, Chen Y, Chen Y, Chen C, Han B, Li Q, Zhu C, Xia F, Zhai H, Wang N, Lu Y (2017) Lead and cadmium exposure, higher thyroid antibodies and thyroid dysfunction in Chinese women. Environ Pollut 230:320\u2013328. https:\/\/doi.org\/10.1016\/j.envpol.2017.06.052","journal-title":"Environ Pollut"},{"key":"13083_CR31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-069X-12-6","volume":"12","author":"MJ Nieuwenhuijsen","year":"2013","unstructured":"Nieuwenhuijsen MJ, Dadvand P, Grellier J, Martinez D, Vrijheid M (2013) Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies. Environ Health 12:6. https:\/\/doi.org\/10.1186\/1476-069X-12-6","journal-title":"Environ Health"},{"issue":"3","key":"13083_CR32","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1161\/HYPERTENSIONAHA.114.03545","volume":"64","author":"M Pedersen","year":"2014","unstructured":"Pedersen M, Stayner L, Slama R, S\u00f8rensen M, Figueras F, Nieuwenhuijsen MJ, Raaschou-Nielsen O, Dadvand P (2014) Ambient air pollution and pregnancy-induced hypertensive disorders: a systematic review and meta-analysis. Hypertension 64(3):494\u2013500. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03545","journal-title":"Hypertension"},{"key":"13083_CR33","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.envres.2014.12.020","volume":"137","author":"CA Robledo","year":"2015","unstructured":"Robledo CA, Mendola P, Yeung E, M\u00e4nnist\u00f6 T, Sundaram R, Liu D, Ying Q, Sherman S, Grantz KL (2015) Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus. Environ Res 137:316\u2013322. https:\/\/doi.org\/10.1016\/j.envres.2014.12.020","journal-title":"Environ Res"},{"issue":"8","key":"13083_CR34","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1289\/ehp.1408549","volume":"123","author":"ND Saenen","year":"2015","unstructured":"Saenen ND, Plusquin M, Bijnens E, Janssen BG, Gyselaers W, Cox B, Fierens F, Molenberghs G, Penders J, Vrijens K, de Boever P, Nawrot TS (2015) In utero fine particle air pollution and placental expression of genes in the brain-derived neurotrophic factor signaling pathway: an ENVIRONAGE Birth Cohort Study. Environ Health Perspect 123(8):834\u2013840. https:\/\/doi.org\/10.1289\/ehp.1408549","journal-title":"Environ Health Perspect"},{"issue":"3","key":"13083_CR35","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1289\/ehp.1306802","volume":"122","author":"A Schembari","year":"2014","unstructured":"Schembari A, Nieuwenhuijsen MJ, Salvador J, de Nazelle A, Cirach M, Dadvand P, Beelen R, Hoek G, Basaga\u00f1a X, Vrijheid M (2014) Traffic-related air pollution and congenital anomalies in Barcelona. Environ Health Perspect 122(3):317\u2013323. https:\/\/doi.org\/10.1289\/ehp.1306802","journal-title":"Environ Health Perspect"},{"issue":"2","key":"13083_CR36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.6065\/apem.2017.22.2.102","volume":"22","author":"MK Seo","year":"2017","unstructured":"Seo MK, Yoon JS, So CH, Lee HS, Hwang JS (2017) Intellectual development in preschool children with early treated congenital hypothyroidism. Ann Pediatric Endocrinol Metab 22(2):102\u2013107. https:\/\/doi.org\/10.6065\/apem.2017.22.2.102","journal-title":"Ann Pediatric Endocrinol Metab"},{"issue":"16","key":"13083_CR37","doi-asserted-by":"publisher","first-page":"9069","DOI":"10.1021\/acs.est.8b02864","volume":"52","author":"G Shaddick","year":"2018","unstructured":"Shaddick G, Thomas ML, Amini H (2018) Data integration for the assessment of population exposure to ambient air pollution for global burden of disease assessment. Environ Sci Technol 52(16):9069\u20139078. https:\/\/doi.org\/10.1021\/acs.est.8b02864","journal-title":"Environ Sci Technol"},{"issue":"6","key":"13083_CR38","doi-asserted-by":"publisher","first-page":"E934","DOI":"10.1210\/jc.2010-2814","volume":"96","author":"BM Shields","year":"2011","unstructured":"Shields BM, Knight BA, Hill A, Hattersley AT, Vaidya B (2011) Fetal thyroid hormone level at birth is associated with fetal growth. J Clin Endocrinol Metab 96(6):E934\u2013E938. https:\/\/doi.org\/10.1210\/jc.2010-2814","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"13083_CR39","doi-asserted-by":"publisher","first-page":"e015895","DOI":"10.1136\/bmjopen-2017-015895","volume":"7","author":"J Song","year":"2017","unstructured":"Song J, Chen Y, Wei L, Ma Y, Tian N, Huang SY, Dai YM, Zhao LH, Kong YY (2017) Early-life exposure to air pollutants and adverse pregnancy outcomes: protocol for a prospective cohort study in Beijing. BMJ Open 7(9):e015895. https:\/\/doi.org\/10.1136\/bmjopen-2017-015895","journal-title":"BMJ Open"},{"issue":"6","key":"13083_CR40","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1530\/EJE-17-1017","volume":"178","author":"F Sun","year":"2018","unstructured":"Sun F, Zhang JX, Yang CY, Gao GQ, Zhu WB, Han B, Zhang LL, Wan YY, Ye XP, Ma YR, Zhang MM, Yang L, Zhang QY, Liu W, Guo CC, Chen G, Zhao SX, Song KY, Song HD (2018) The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes. Eur J Endocrinol 178(6):623\u2013633. https:\/\/doi.org\/10.1530\/EJE-17-1017","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"13083_CR41","doi-asserted-by":"publisher","first-page":"e91966","DOI":"10.1371\/journal.pone.0091966","volume":"9","author":"D Tang","year":"2014","unstructured":"Tang D, Lee J, Muirhead L, Li TY, Qu L, Yu J, Perera F (2014) Molecular and neurodevelopmental benefits to children of closure of a coal burning power plant in China. PLoS One 9(3):e91966. https:\/\/doi.org\/10.1371\/journal.pone.0091966","journal-title":"PLoS One"},{"issue":"5","key":"13083_CR42","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1289\/ehp.1002946","volume":"119","author":"M Vrijheid","year":"2011","unstructured":"Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J, Nieuwenhuijsen M (2011) Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis. Environ Health Perspect 119(5):598\u2013606. https:\/\/doi.org\/10.1289\/ehp.1002946","journal-title":"Environ Health Perspect"},{"issue":"1","key":"13083_CR43","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2337\/dc12-0702","volume":"36","author":"X Wang","year":"2013","unstructured":"Wang X, Bao W, Liu J, OuYang YY, Wang D, Rong S, Xiao X, Shan ZL, Zhang Y, Yao P, Liu LG (2013) Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 36(1):166\u2013175. https:\/\/doi.org\/10.2337\/dc12-0702","journal-title":"Diabetes Care"},{"issue":"1","key":"13083_CR44","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41467-017-00918-5","volume":"8","author":"H Wang","year":"2017","unstructured":"Wang H, Zhang Y, Zhao H, Lu X, Zhang Y, Zhu W, Nielsen CP, Li X, Zhang Q, Bi J, McElroy MB (2017) Trade-driven relocation of air pollution and health impacts in China. Nat Commun 8(1):738. https:\/\/doi.org\/10.1038\/s41467-017-00918-5","journal-title":"Nat Commun"},{"issue":"5","key":"13083_CR45","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.envres.2011.03.008","volume":"111","author":"J Wu","year":"2011","unstructured":"Wu J, Wilhelm M, Chung J, Ritz B (2011) Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study. Environ Res 111(5):685\u2013692. https:\/\/doi.org\/10.1016\/j.envres.2011.03.008","journal-title":"Environ Res"},{"key":"13083_CR46","unstructured":"Yang Q, Mou H, Wang J (2017) Progress in newborn genetic metabolic disease screening of China. Zhong Guo Fu You Wei Sheng Za Zhi 8(4):1-4. (in Chinese)"},{"issue":"3","key":"13083_CR47","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.ijheh.2018.01.014","volume":"221","author":"S Yang","year":"2018","unstructured":"Yang S, Tan Y, Mei H, Wang F, Li N, Zhao J, Zhang Y, Qian Z, Chang JJ, Syberg KM, Peng A, Mei H, Zhang D, Zhang Y, Xu S, Li Y, Zheng T, Zhang B (2018) Ambient air pollution the risk of stillbirth: a prospective birth cohort study in Wuhan, China. Int J Hyg Environ Health 221(3):502\u2013509. https:\/\/doi.org\/10.1016\/j.ijheh.2018.01.014","journal-title":"Int J Hyg Environ Health"},{"key":"13083_CR48","doi-asserted-by":"publisher","first-page":"108687","DOI":"10.1016\/j.envres.2019.108687","volume":"178","author":"P Yang","year":"2019","unstructured":"Yang P, Zhang Y, Wang K, Doraiswamy P, Cho SH (2019) Health impacts and cost-benefit analyses of surface O3 and PM2.5 over the U.S. under future climate and emission scenarios. Environ Res 178:108687. https:\/\/doi.org\/10.1016\/j.envres.2019.108687","journal-title":"Environ Res"},{"key":"13083_CR49","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jhazmat.2018.12.078","volume":"367","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Cao Z, Li H, Su X, Yang Y, Liu C, Hua J (2019) Air pollution exposure in association with maternal thyroid function during early pregnancy. J Hazard Mater 367:188\u2013193. https:\/\/doi.org\/10.1016\/j.jhazmat.2018.12.078","journal-title":"J Hazard Mater"},{"issue":"26","key":"13083_CR50","doi-asserted-by":"publisher","first-page":"e20838","DOI":"10.1097\/MD.0000000000020838","volume":"99","author":"J Zhou","year":"2020","unstructured":"Zhou J, Luo J, Lin Y, Zeng Y, Qiu X, Zhu W, Liu G (2020) Perinatal risk factors for congenital hypothyroidism: a retrospective cohort study performed at a tertiary hospital in China. Medicine 99(26):e20838. https:\/\/doi.org\/10.1097\/MD.0000000000020838","journal-title":"Medicine"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-13083-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T16:18:04Z","timestamp":1626106684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-13083-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":50,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["13083"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-13083-6","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,2]]},"assertion":[{"value":"24 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was approved by the Ethics Committee of Science of Medical Center, the First Affiliated Hospital of Xi\u2019an Jiaotong University (XJTU1AF2018LSK-245).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}