{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:53:11Z","timestamp":1789267991735,"version":"build-2803163510"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"28","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771640"],"award-info":[{"award-number":["81771640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800587"],"award-info":[{"award-number":["81800587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s11356-021-13396-6","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T17:02:52Z","timestamp":1615654972000},"page":"37482-37497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Meta-analysis and experimental validation identified atrazine as a toxicant in the male reproductive system"],"prefix":"10.1007","volume":"28","author":[{"given":"Shenhao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,13]]},"reference":[{"key":"13396_CR1","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1177\/0748233714555389","volume":"32","author":"S Abarikwu","year":"2016","unstructured":"Abarikwu S, Farombi E (2016) Quercetin ameliorates atrazine-induced changes in the testicular function of rats. Toxicol Ind Health 32:1278\u20131285. https:\/\/doi.org\/10.1177\/0748233714555389","journal-title":"Toxicol Ind Health"},{"key":"13396_CR2","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1007\/s00244-009-9371-2","volume":"58","author":"SO Abarikwu","year":"2010","unstructured":"Abarikwu SO, Adesiyan AC, Oyeloja TO, Oyeyemi MO, Farombi EO (2010) Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine. Arch Environ Contam Toxicol 58:874\u2013882. https:\/\/doi.org\/10.1007\/s00244-009-9371-2","journal-title":"Arch Environ Contam Toxicol"},{"key":"13396_CR3","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.biopha.2018.03.136","volume":"102","author":"RL Abdel Aziz","year":"2018","unstructured":"Abdel Aziz RL, Abdel-Wahab A, Abo El-Ela FI, Hassan NEHY, El-Nahass ES, Ibrahim MA, Khalil ATAY (2018) Dose- dependent ameliorative effects of quercetin and L-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats. Biomed Pharmacother 102:855\u2013864. https:\/\/doi.org\/10.1016\/j.biopha.2018.03.136","journal-title":"Biomed Pharmacother"},{"key":"13396_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.etp.2009.11.008","volume":"63","author":"AC Adesiyan","year":"2011","unstructured":"Adesiyan AC, Oyejola TO, Abarikwu SO, Oyeyemi MO, Farombi EO (2011) Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity. Exp Toxicol Pathol 63:201\u2013207. https:\/\/doi.org\/10.1016\/j.etp.2009.11.008","journal-title":"Exp Toxicol Pathol"},{"key":"13396_CR5","doi-asserted-by":"publisher","first-page":"292","DOI":"10.22074\/cellj.2016.490","volume":"19","author":"HR Agdam","year":"2017","unstructured":"Agdam HR, Razi M, Amniattalab A, Malekinejad H, Molavi M (2017) Co-administration of vitamin E and testosterone attenuates the atrazine-induced toxic effects on sperm quality and testes in rats. Cell J 19:292\u2013305. https:\/\/doi.org\/10.22074\/cellj.2016.490","journal-title":"Cell J"},{"key":"13396_CR6","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.1021\/acsami.8b20355","volume":"11","author":"I Akpinar","year":"2019","unstructured":"Akpinar I, Drout RJ, Islamoglu T, Kato S, Lyu J, Farha OK (2019) Exploiting pi-pi interactions to design an efficient sorbent for atrazine removal from water. ACS Appl Mater Interfaces 11:6097\u20136103. https:\/\/doi.org\/10.1021\/acsami.8b20355","journal-title":"ACS Appl Mater Interfaces"},{"issue":"9","key":"13396_CR7","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.3390\/ijerph15091889","volume":"15","author":"KS Almberg","year":"2018","unstructured":"Almberg KS, Turyk ME, Jones RM, Rankin K, Freels S, Stayner LT (2018) Atrazine contamination of drinking water and adverse birth outcomes in community water systems with elevated atrazine in Ohio, 2006(-)2008. Int J Environ Res Public Health 15(9):1889. https:\/\/doi.org\/10.3390\/ijerph15091889","journal-title":"Int J Environ Res Public Health"},{"key":"13396_CR8","volume-title":"Review of atrazine\u2014technical report: environmental assessment","author":"Australian Pesticides and Veterinary Medicines Authority","year":"2004","unstructured":"Australian Pesticides and Veterinary Medicines Authority (2004) Review of atrazine\u2014technical report: environmental assessment. Canberra, Australia"},{"key":"13396_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1071\/RD09300","volume":"23","author":"D Balabanic","year":"2011","unstructured":"Balabanic D, Rupnik M, Klemencic AK (2011) Negative impact of endocrine-disrupting compounds on human reproductive health. Reprod Fertil Dev 23:403\u2013416. https:\/\/doi.org\/10.1071\/RD09300","journal-title":"Reprod Fertil Dev"},{"key":"13396_CR10","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1289\/ehp.10141","volume":"115","author":"DB Barr","year":"2007","unstructured":"Barr DB, Panuwet P, Nguyen JV, Udunka S, Needham LL (2007) Assessing exposure to atrazine and its metabolites using biomonitoring. Environ Health Perspect 115:1474\u20131478. https:\/\/doi.org\/10.1289\/ehp.10141","journal-title":"Environ Health Perspect"},{"key":"13396_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.tox.2010.07.002","volume":"279","author":"V Belloni","year":"2011","unstructured":"Belloni V, Dess\u00ec-Fulgheri F, Zaccaroni M, di Consiglio E, de Angelis G, Testai E, Santochirico M, Alleva E, Santucci D (2011) Early exposure to low doses of atrazine affects behavior in juvenile and adult CD1 mice. Toxicology 279:19\u201326. https:\/\/doi.org\/10.1016\/j.tox.2010.07.002","journal-title":"Toxicology"},{"key":"13396_CR12","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.2134\/jeq2007.0568","volume":"37","author":"M Bridges","year":"2008","unstructured":"Bridges M, Henry WB, Shaner DL, Khosla R, Westra P, Reich R (2008) Spatial variability of atrazine and metolachlor dissipation on dryland no-tillage crop fields in Colorado. J Environ Qual 37:2212\u20132220. https:\/\/doi.org\/10.2134\/jeq2007.0568","journal-title":"J Environ Qual"},{"key":"13396_CR13","first-page":"53","volume":"L78","author":"Commission of the European Communities","year":"2004","unstructured":"Commission of the European Communities (2004) Commission decision of 10 March 2004 concerning the non-inclusion of atrazine in Annex I to Council Directive 91\/414\/EEC and the withdrawal of authorisations for plant protection products containing this active substance (2004\/248\/EC). Off J Eur Union L78:53\u201355","journal-title":"Off J Eur Union"},{"key":"13396_CR14","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1071\/RD18505","volume":"31","author":"LE Cook","year":"2019","unstructured":"Cook LE, Finger BJ, Green MP, Pask AJ (2019) Exposure to atrazine during puberty reduces sperm viability, increases weight gain and alters the expression of key metabolic genes in the liver of male mice. Reprod Fertil Dev 31:920\u2013931. https:\/\/doi.org\/10.1071\/RD18505","journal-title":"Reprod Fertil Dev"},{"key":"13396_CR15","doi-asserted-by":"publisher","first-page":"8526","DOI":"10.1007\/s11356-014-4010-5","volume":"22","author":"TA Dantas","year":"2015","unstructured":"Dantas TA, Cancian G, Neodini DNR, Mano DRS, Capucho C, Predes FS, Pulz RB, Pigoso AA, Dolder H, Severi-Aguiar GDC (2015) Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health. Environ Sci Pollut Res 22:8526\u20138535. https:\/\/doi.org\/10.1007\/s11356-014-4010-5","journal-title":"Environ Sci Pollut Res"},{"key":"13396_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.reprotox.2011.04.004","volume":"32","author":"LK Davis","year":"2011","unstructured":"Davis LK, Murr AS, Best DS, Fraites MJP, Zorrilla LM, Narotsky MG, Stoker TE, Goldman JM, Cooper RL (2011) The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat. Reprod Toxicol 32:43\u201351. https:\/\/doi.org\/10.1016\/j.reprotox.2011.04.004","journal-title":"Reprod Toxicol"},{"key":"13396_CR17","doi-asserted-by":"publisher","first-page":"134868","DOI":"10.1016\/j.scitotenv.2019.134868","volume":"700","author":"FP de Albuquerque","year":"2020","unstructured":"de Albuquerque FP, de Oliveira JL, Moschini-Carlos V, Fraceto LF (2020) An overview of the potential impacts of atrazine in aquatic environments: perspectives for tailored solutions based on nanotechnology. Sci Total Environ 700:134868. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134868","journal-title":"Sci Total Environ"},{"key":"13396_CR18","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.1007\/s11356-020-10693-4","volume":"28","author":"AR de Souza","year":"2021","unstructured":"de Souza AR, Guerra ACS, de Andrade MB, Nishi L, Baptista ATA, Bergamasco R, Vieira AMS (2021) Application of graphene nanosheet oxide for atrazine adsorption in aqueous solution: synthesis, material characterization, and comprehension of the adsorption mechanism. Environ Sci Pollut Res 28:5731\u20135741. https:\/\/doi.org\/10.1007\/s11356-020-10693-4","journal-title":"Environ Sci Pollut Res"},{"key":"13396_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/bdrb.21106","volume":"101","author":"JM DeSesso","year":"2014","unstructured":"DeSesso JM, Scialli AR, White TE, Breckenridge CB (2014) Multigeneration reproduction and male developmental toxicity studies on atrazine in rats. Birth Defects Res B Dev Reprod Toxicol 101:237\u2013253. https:\/\/doi.org\/10.1002\/bdrb.21106","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"13396_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/01480545.2011.642380","volume":"36","author":"M Ekor","year":"2013","unstructured":"Ekor M, Odewabi AO, Kale OE, Adesanoye OA, Bamidele TO (2013) Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride-associated hepatotoxicity in rats. Drug Chem Toxicol 36:1\u20138. https:\/\/doi.org\/10.3109\/01480545.2011.642380","journal-title":"Drug Chem Toxicol"},{"key":"13396_CR21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1289\/ehp.9758","volume":"115","author":"W Fan","year":"2007","unstructured":"Fan W, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi KI, Hayes TB, Takayanagi R, Nawata H (2007) Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115:720\u2013727. https:\/\/doi.org\/10.1289\/ehp.9758","journal-title":"Environ Health Perspect"},{"key":"13396_CR22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.29252\/ijrm.16.8.519","volume":"16","author":"M Fani","year":"2018","unstructured":"Fani M, Mohammadipour A, Ebrahimzadeh-Bideskan A (2018) The effect of crocin on testicular tissue and sperm parameters of mice offspring from mothers exposed to atrazine during pregnancy and lactation periods: an experimental study. Int J Reprod Biomed 16:519\u2013528. https:\/\/doi.org\/10.29252\/ijrm.16.8.519","journal-title":"Int J Reprod Biomed"},{"key":"13396_CR23","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/and.12001","volume":"45","author":"EO Farombi","year":"2013","unstructured":"Farombi EO, Abarikwu SO, Adesiyan AC, Oyejola TO (2013) Quercetin exacerbates the effects of subacute treatment of atrazine on reproductive tissue antioxidant defence system, lipid peroxidation and sperm quality in rats. Andrologia 45:256\u2013265. https:\/\/doi.org\/10.1111\/and.12001","journal-title":"Andrologia"},{"issue":"1","key":"13396_CR24","first-page":"19","volume":"3","author":"S Feyzi-Dehkhargani","year":"2012","unstructured":"Feyzi-Dehkhargani S, Shahrooz R, Malekinejad H, Sadrkhanloo RA (2012) Atrazine in sub-acute exposure results in sperm DNA disintegrity and nuclear immaturity in rats. Vet Res Forum 3(1):19\u201326","journal-title":"Vet Res Forum"},{"key":"13396_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.reprotox.2011.04.003","volume":"32","author":"MJ Fraites","year":"2011","unstructured":"Fraites MJ et al (2011) Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate. Reprod Toxicol 32:52\u201363. https:\/\/doi.org\/10.1016\/j.reprotox.2011.04.003","journal-title":"Reprod Toxicol"},{"key":"13396_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/ps.1000","volume":"61","author":"DW Gammon","year":"2005","unstructured":"Gammon DW, Aldous CN, Carr WC Jr, Sanborn JR, Pfeifer KF (2005) A risk assessment of atrazine use in California: human health and ecological aspects. Pest Manag Sci 61:331\u2013355. https:\/\/doi.org\/10.1002\/ps.1000","journal-title":"Pest Manag Sci"},{"issue":"1","key":"13396_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-015-2095-y","volume":"16","author":"A Gely-Pernot","year":"2015","unstructured":"Gely-Pernot A, Hao C, Becker E, Stuparevic I, Kervarrec C, Chalmel F, Primig M, J\u00e9gou B, Smagulova F (2015) The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine. BMC Genomics 16(1):1\u201322. https:\/\/doi.org\/10.1186\/s12864-015-2095-y","journal-title":"BMC Genomics"},{"issue":"1","key":"13396_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-03738-1","volume":"7","author":"A Gely-Pernot","year":"2017","unstructured":"Gely-Pernot A, Saci S, Kernanec PY, Hao C, Giton F, Kervarrec C, Tevosian S, Mazaud-Guittot S, Smagulova F (2017) Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice. Sci Rep 7(1):1\u201314. https:\/\/doi.org\/10.1038\/s41598-017-03738-1","journal-title":"Sci Rep"},{"issue":"6","key":"13396_CR29","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1210\/er.2015-1010","volume":"36","author":"AC Gore","year":"2015","unstructured":"Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT (2015) EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev 36(6):593\u2013602. https:\/\/doi.org\/10.1210\/er.2015-1010","journal-title":"Endocr Rev"},{"issue":"3","key":"13396_CR30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1017\/S2040174419000473","volume":"11","author":"LC Govers","year":"2019","unstructured":"Govers LC, Harper AP, Finger BJ, Mattiske DM, Pask AJ, Green MP (2019) Atrazine induces penis abnormalities including hypospadias in mice. J Dev Orig Health Dis 11(3):246\u2013249. https:\/\/doi.org\/10.1017\/S2040174419000473","journal-title":"J Dev Orig Health Dis"},{"key":"13396_CR31","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.jclinepi.2011.01.012","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, Jaeschke R, Williams JW Jr, Murad MH, Sinclair D, Falck-Ytter Y, Meerpohl J, Whittington C, Thorlund K, Andrews J, Sch\u00fcnemann HJ (2011) GRADE guidelines 6. Rating the quality of evidence\u2014imprecision. J Clin Epidemiol 64:1283\u20131293. https:\/\/doi.org\/10.1016\/j.jclinepi.2011.01.012","journal-title":"J Clin Epidemiol"},{"key":"13396_CR32","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.freeradbiomed.2010.01.017","volume":"48","author":"SS Hamdulay","year":"2010","unstructured":"Hamdulay SS, Wang B, Birdsey GM, Ali F, Dumont O, Evans PC, Haskard DO, Wheeler-Jones CP, Mason JC (2010) Celecoxib activates PI-3K\/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium. Free Radic Biol Med 48:1013\u20131023. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.01.017","journal-title":"Free Radic Biol Med"},{"key":"13396_CR33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbrc.2007.11.107","volume":"366","author":"Y Hase","year":"2008","unstructured":"Hase Y, Tatsuno M, Nishi T, Kataoka K, Kabe Y, Yamaguchi Y, Ozawa N, Natori M, Handa H, Watanabe H (2008) Atirazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm. Biochem Biophys Res Commun 366:66\u201372. https:\/\/doi.org\/10.1016\/j.bbrc.2007.11.107","journal-title":"Biochem Biophys Res Commun"},{"key":"13396_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jsbmb.2011.03.015","volume":"127","author":"TB Hayes","year":"2011","unstructured":"Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Mu\u00f1oz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E (2011) Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol 127:64\u201373. https:\/\/doi.org\/10.1016\/j.jsbmb.2011.03.015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"13396_CR35","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/15376510601166384","volume":"17","author":"M Hong","year":"2007","unstructured":"Hong M, Ping Z, Jian X (2007) Testicular toxicity and mechanisms of chlorotoluron compounds in the mouse. Toxicol Mech Methods 17:483\u2013488. https:\/\/doi.org\/10.1080\/15376510601166384","journal-title":"Toxicol Mech Methods"},{"key":"13396_CR36","doi-asserted-by":"publisher","first-page":"676013","DOI":"10.1155\/2014\/676013","volume":"2014","author":"DB Jestadi","year":"2014","unstructured":"Jestadi DB, Phaniendra A, Babji U, Shanmuganathan B, Periyasamy L (2014) Effects of atrazine on reproductive health of nondiabetic and diabetic male rats. Int Sch Res Notices 2014:676013\u2013676017. https:\/\/doi.org\/10.1155\/2014\/676013","journal-title":"Int Sch Res Notices"},{"key":"13396_CR37","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.toxlet.2014.01.006","volume":"225","author":"Y Jin","year":"2014","unstructured":"Jin Y, Lin X, Miao W, Wu T, Shen H, Chen S, Li Y, Pan Q, Fu Z (2014a) Chronic exposure of mice to environmental endocrine-disrupting chemicals disturbs their energy metabolism. Toxicol Lett 225:392\u2013400. https:\/\/doi.org\/10.1016\/j.toxlet.2014.01.006","journal-title":"Toxicol Lett"},{"key":"13396_CR38","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.etap.2014.02.014","volume":"37","author":"Y Jin","year":"2014","unstructured":"Jin Y, Wang L, Chen G, Lin X, Miao W, Fu Z (2014b) Exposure of mice to atrazine and its metabolite diaminochlorotriazine elicits oxidative stress and endocrine disruption. Environ Toxicol Pharmacol 37:782\u2013790. https:\/\/doi.org\/10.1016\/j.etap.2014.02.014","journal-title":"Environ Toxicol Pharmacol"},{"key":"13396_CR39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ygcen.2013.01.010","volume":"184","author":"Y Jin","year":"2013","unstructured":"Jin Y, Wang L, Fu Z (2013) Oral exposure to atrazine modulates hormone synthesis and the transcription of steroidogenic genes in male peripubertal mice. Gen Comp Endocrinol 184:120\u2013127. https:\/\/doi.org\/10.1016\/j.ygcen.2013.01.010","journal-title":"Gen Comp Endocrinol"},{"key":"13396_CR40","unstructured":"Julian PT Higgins, Green S (2017) Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0. The Cochrane Collaboration,"},{"key":"13396_CR41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.etap.2017.12.026","volume":"58","author":"OE Kale","year":"2018","unstructured":"Kale OE, Oyesola TO, Raji FS (2018) Celecoxib, a cyclooxygenase-2 inhibitor, offers chemoprevention against reproductive and neurobehavioural abnormalities induced by atrazine in male Wistar rats. Environ Toxicol Pharmacol 58:84\u201397. https:\/\/doi.org\/10.1016\/j.etap.2017.12.026","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"13396_CR42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/(SICI)1099-1263(200001\/02)20:1<61::AID-JAT628>3.0.CO;2-3","volume":"20","author":"J Kniewald","year":"2000","unstructured":"Kniewald J, Jakominic M, Tomljenovic A, Simic B, Romac P, Vranesic D, Kniewald Z (2000) Disorders of male rat reproductive tract under the influence of atrazine. J Appl Toxicol 20(1):61\u201368. https:\/\/doi.org\/10.1002\/(SICI)1099-1263(200001\/02)20:1<61::AID-JAT628>3.0.CO;2-3","journal-title":"J Appl Toxicol"},{"key":"13396_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/jat.2550150312","volume":"15","author":"J Kniewald","year":"1995","unstructured":"Kniewald J, Osredecki V, Gojmerac T, Zechner V, Kniewald Z (1995) Effect of s-triazine compounds on testosterone metabolism in the rat prostate. J Appl Toxicol : JAT 15:215\u2013218. https:\/\/doi.org\/10.1002\/jat.2550150312","journal-title":"J Appl Toxicol : JAT"},{"key":"13396_CR44","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.aca.2020.03.045","volume":"1116","author":"EY Kwon","year":"2020","unstructured":"Kwon EY, Ruan X, Wang L, Lin Y, Du D, Van Wie BJ (2020) Mesoporous Pd@Pt nanoparticle-linked immunosorbent assay for detection of atrazine. Anal Chim Acta 1116:36\u201344. https:\/\/doi.org\/10.1016\/j.aca.2020.03.045","journal-title":"Anal Chim Acta"},{"issue":"4","key":"13396_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005186","volume":"4","author":"S Lim","year":"2009","unstructured":"Lim S, Ahn SY, Song IC, Chung MH, Jang HC, Park KS, Lee KU, Pak YK, Lee HK (2009) Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One 4(4):e5186. https:\/\/doi.org\/10.1371\/journal.pone.0005186","journal-title":"PLoS One"},{"key":"13396_CR46","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.envres.2012.12.007","volume":"122","author":"V Migeot","year":"2013","unstructured":"Migeot V, Albouy-Llaty M, Carles C, Limousi F, Strezlec S, Dupuis A, Rabouan S (2013) Drinking-water exposure to a mixture of nitrate and low-dose atrazine metabolites and small-for-gestational age (SGA) babies: a historic cohort study. Environ Res 122:58\u201364. https:\/\/doi.org\/10.1016\/j.envres.2012.12.007","journal-title":"Environ Res"},{"key":"13396_CR47","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/toxsci\/kfj087","volume":"90","author":"K Mizota","year":"2006","unstructured":"Mizota K, Ueda H (2006) Endocrine disrupting chemical atrazine causes degranulation through Gq\/11 protein-coupled neurosteroid receptor in mast cells. Toxicol Sci 90:362\u2013368. https:\/\/doi.org\/10.1093\/toxsci\/kfj087","journal-title":"Toxicol Sci"},{"issue":"9","key":"13396_CR48","doi-asserted-by":"publisher","first-page":"889","DOI":"10.3736\/jcim20090918","volume":"7","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement(Chinese edition). Chin J Integr Med 7(9):889\u2013896. https:\/\/doi.org\/10.3736\/jcim20090918","journal-title":"Chin J Integr Med"},{"key":"13396_CR49","volume-title":"Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals","author":"NASEM (National Academies of Sciences E, and Medicine)","year":"2017","unstructured":"NASEM (National Academies of Sciences E, and Medicine) (2017) Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals. The National Academies Press, Washington"},{"key":"13396_CR50","unstructured":"NTP (National Toxicology Program). Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration. (2015) Office of Health Assessment and Translation, Division, National Toxicology Program, National Institute of Environmental Health Sciences 1 9, 2015 [online]. http:\/\/ntp.niehs.nih.gov\/ntp\/ohat\/pubs\/handbookjan2015_508.pdf. Accessed May 14, 2020"},{"key":"13396_CR51","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1289\/ehp.0900784","volume":"117","author":"H Ochoa-Acuna","year":"2009","unstructured":"Ochoa-Acuna H, Frankenberger J, Hahn L, Carbajo C (2009) Drinking-water herbicide exposure in Indiana and prevalence of small-for-gestational-age and preterm delivery. Environ Health Perspect 117:1619\u20131624. https:\/\/doi.org\/10.1289\/ehp.0900784","journal-title":"Environ Health Perspect"},{"issue":"1","key":"13396_CR52","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.reprotox.2006.08.005","volume":"23","author":"MJ Perry","year":"2007","unstructured":"Perry MJ, Venners SA, Barr DB, Xu X (2007) Environmental pyrethroid and organophosphorus insecticide exposures and sperm concentration. Reprod Toxicol 23(1):113\u2013118. https:\/\/doi.org\/10.1016\/j.reprotox.2006.08.005","journal-title":"Reprod Toxicol"},{"key":"13396_CR53","doi-asserted-by":"publisher","first-page":"154","DOI":"10.5935\/1518-0557.20190016","volume":"23","author":"MJ Piazza","year":"2019","unstructured":"Piazza MJ, Urbanetz AA (2019) Environmental toxins and the impact of other endocrine disrupting chemicals in women\u2019s reproductive health. JBRA Assist Reprod 23:154\u2013164. https:\/\/doi.org\/10.5935\/1518-0557.20190016","journal-title":"JBRA Assist Reprod"},{"key":"13396_CR54","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.reprotox.2014.05.008","volume":"47","author":"BW Riffle","year":"2014","unstructured":"Riffle BW, Klinefelter GR, Cooper RL, Winnik WM, Swank A, Jayaraman S, Suarez J, Best D, Laws SC (2014) Novel molecular events associated with altered steroidogenesis induced by exposure to atrazine in the intact and castrate male rat. Reprod Toxicol 47:59\u201369. https:\/\/doi.org\/10.1016\/j.reprotox.2014.05.008","journal-title":"Reprod Toxicol"},{"key":"13396_CR55","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.toxlet.2004.07.005","volume":"154","author":"M Roberge","year":"2004","unstructured":"Roberge M, Hakk H, Larsen G (2004) Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor. Toxicol Lett 154:61\u201368. https:\/\/doi.org\/10.1016\/j.toxlet.2004.07.005","journal-title":"Toxicol Lett"},{"key":"13396_CR56","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1289\/ehp.1307972","volume":"122","author":"AA Rooney","year":"2014","unstructured":"Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA (2014) Systematic review and evidence integration for literature-based environmental health science assessments. Environ Health Perspect 122:711\u2013718. https:\/\/doi.org\/10.1289\/ehp.1307972","journal-title":"Environ Health Perspect"},{"key":"13396_CR57","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1007\/s11356-017-0657-z","volume":"25","author":"GQ Saalfeld","year":"2018","unstructured":"Saalfeld GQ, Varela Junior AS, Castro T, Pereira FA, Gheller SMM, da Silva AC, Corcini CD, da Rosa CE, Colares EP (2018) Low atrazine dosages reduce sperm quality of Calomys laucha mice. Environ Sci Pollut Res 25:2924\u20132931. https:\/\/doi.org\/10.1007\/s11356-017-0657-z","journal-title":"Environ Sci Pollut Res"},{"key":"13396_CR58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/aja.2012.87","volume":"15","author":"S Safe","year":"2013","unstructured":"Safe S (2013) Endocrine disruptors and falling sperm counts: lessons learned or not! Asian J Androl 15:191\u2013194. https:\/\/doi.org\/10.1038\/aja.2012.87","journal-title":"Asian J Androl"},{"key":"13396_CR59","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1179\/oeh.2006.12.3.260","volume":"12","author":"JB Sass","year":"2006","unstructured":"Sass JB, Colangelo A (2006) European Union bans atrazine, while the United States negotiates continued use. Int J Occup Environ Health 12:260\u2013267. https:\/\/doi.org\/10.1179\/oeh.2006.12.3.260","journal-title":"Int J Occup Environ Health"},{"key":"13396_CR60","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.etap.2017.02.024","volume":"51","author":"S Sifakis","year":"2017","unstructured":"Sifakis S, Androutsopoulos VP, Tsatsakis AM, Spandidos DA (2017) Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems. Environ Toxicol Pharmacol 51:56\u201370. https:\/\/doi.org\/10.1016\/j.etap.2017.02.024","journal-title":"Environ Toxicol Pharmacol"},{"key":"13396_CR61","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/etc.2050","volume":"32","author":"KR Solomon","year":"2013","unstructured":"Solomon KR, Giesy JP, LaPoint TW, Giddings JM, Richards RP (2013) Ecological risk assessment of atrazine in North American surface waters. Environ Toxicol Chem 32:10\u201311. https:\/\/doi.org\/10.1002\/etc.2050","journal-title":"Environ Toxicol Chem"},{"key":"13396_CR62","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3967\/bes2014.050","volume":"27","author":"Y Song","year":"2014","unstructured":"Song Y, Jia ZC, Chen JY, Hu JX, Zhang LS (2014) Toxic effects of atrazine on reproductive system of male rats. Biomed Environ Sci 27:281\u2013288. https:\/\/doi.org\/10.3967\/bes2014.050","journal-title":"Biomed Environ Sci"},{"key":"13396_CR63","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.envres.2016.10.022","volume":"152","author":"LT Stayner","year":"2017","unstructured":"Stayner LT, Almberg K, Jones R, Graber J, Pedersen M, Turyk M (2017) Atrazine and nitrate in drinking water and the risk of preterm delivery and low birth weight in four Midwestern states. Environ Res 152:294\u2013303. https:\/\/doi.org\/10.1016\/j.envres.2016.10.022","journal-title":"Environ Res"},{"key":"13396_CR64","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00253-012-4495-0","volume":"96","author":"N Udikovic-Kolic","year":"2012","unstructured":"Udikovic-Kolic N, Scott C, Martin-Laurent F (2012) Evolution of atrazine-degrading capabilities in the environment. Appl Microbiol Biotechnol 96:1175\u20131189. https:\/\/doi.org\/10.1007\/s00253-012-4495-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"13396_CR65","unstructured":"US Environmental Protection Agency (EPA) (2003) Interim Reregistration Eligibility Decision for Atrazine. US Environmental Protection Agency"},{"key":"13396_CR66","doi-asserted-by":"publisher","first-page":"126533","DOI":"10.1016\/j.chemosphere.2020.126533","volume":"252","author":"A Wang","year":"2020","unstructured":"Wang A, Hu X, Wan Y, Mahai G, Jiang Y, Huo W, Zhao X, Liang G, He Z, Xia W, Xu S (2020) A nationwide study of the occurrence and distribution of atrazine and its degradates in tap water and groundwater in China: assessment of human exposure potential. Chemosphere 252:126533. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126533","journal-title":"Chemosphere"},{"key":"13396_CR67","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1536\/ihj.17-114","volume":"59","author":"Y Wang","year":"2018","unstructured":"Wang Y, Wang Q, Yu W, Du H (2018) Crocin attenuates oxidative stress and myocardial infarction injury in rats. Int Heart J 59:387\u2013393. https:\/\/doi.org\/10.1536\/ihj.17-114","journal-title":"Int Heart J"},{"issue":"1","key":"13396_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12940-016-0161-9","volume":"15","author":"JJ Winston","year":"2016","unstructured":"Winston JJ et al (2016) Hypospadias and maternal exposure to atrazine via drinking water in the National Birth Defects Prevention study. Environ Health 15(1):1\u20139. https:\/\/doi.org\/10.1186\/s12940-016-0161-9","journal-title":"Environ Health"},{"issue":"6","key":"13396_CR69","first-page":"2780","volume":"7","author":"F Zhao","year":"2014","unstructured":"Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S (2014) Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response. Int J Clin Exp Pathol 7(6):2780\u20132789","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13396-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-13396-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13396-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T06:44:40Z","timestamp":1627022680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-13396-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,13]]},"references-count":69,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["13396"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-13396-6","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,13]]},"assertion":[{"value":"22 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were performed according to the protocols and approved by the Institutional Animal Care and Use Committee Of Nanjing Medical University (Approval No. IACUC-2101037).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}