{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:54:14Z","timestamp":1792367654791,"version":"4.4.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"34","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s11356-021-13969-5","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T11:08:27Z","timestamp":1619089707000},"page":"47046-47055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["The protective effects of hesperidin and curcumin on 5-fluorouracil\u2013induced nephrotoxicity in mice"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-1262","authenticated-orcid":false,"given":"Volkan","family":"Gelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"\u015eeng\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samet","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsamed","family":"K\u00fck\u00fcrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"13969_CR1","first-page":"379","volume":"17","author":"MM Abdel-Daim","year":"2015","unstructured":"Abdel-Daim MM, Abdou RH (2015) Protective effects of diallyl sulfide and curcumin separately against thallium-induced toxicity in rats. Cell J 17:379\u2013388","journal-title":"Cell J"},{"key":"13969_CR2","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1007\/s11356-018-3907-9","volume":"26","author":"MM Abdel-Diam","year":"2019","unstructured":"Abdel-Diam MM, Samak DH, El-Sayed YS, Aleya L, Alarifi S, Alkahtani S (2019) Curcumin and quercetin synergistically attenuate subacute diazinon-induced inflammation and oxidative neurohepatic damage, and acetylcholinesterase inhibition in albino rats. Environ Sci Pollut Res Int 26:3659\u20133665","journal-title":"Environ Sci Pollut Res Int"},{"key":"13969_CR3","first-page":"276","volume-title":"Methods in enzymatic analysis","author":"H Aebi","year":"1983","unstructured":"Aebi H (1983) Catalase. In: Bergmeyer HU (ed) Methods in enzymatic analysis. Academic Press, New York, pp 276\u2013286"},{"key":"13969_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","volume":"208","author":"ST Ahmad","year":"2012","unstructured":"Ahmad ST, Arjumand W, Nafees S, Seth A, Ali N, Rashid S, Sultana S (2012) Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 208:149\u2013161","journal-title":"Toxicol Lett"},{"key":"13969_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-2006-960004","volume":"57","author":"HPT Ammon","year":"1991","unstructured":"Ammon HPT, Wahl MA (1991) Pharmacology of Curcuma longa. Planta Med 57:1\u20137","journal-title":"Planta Med"},{"key":"13969_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1158\/1055-9965.EPI-06-0769","volume":"16","author":"C Bosetti","year":"2007","unstructured":"Bosetti C, Rossi M, McLaughlin JK, Negri E, Talamini R, Lagiou P, Montella M, Ramazzotti V, Franceschi S, LaVecchia C (2007) Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomark Prev 16:98\u2013101","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"13969_CR7","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.freeradbiomed.2014.10.598","volume":"75","author":"J Cadet","year":"2016","unstructured":"Cadet J (2016) Oxidative degradation pathways of cellular DNA: product formation and mechanistic insights. Free Radic Biol Med 75:S2","journal-title":"Free Radic Biol Med"},{"key":"13969_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.mrfmmm.2003.09.001","volume":"531","author":"J Cadet","year":"2003","unstructured":"Cadet J, Douki T, Gasparutto D, Ravanat JL (2003) Oxidative damage to DNA: formation, measurement and biochemical features. Mutat Res Fund Mol M 531:5\u201323","journal-title":"Mutat Res Fund Mol M"},{"key":"13969_CR9","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","volume":"250","author":"I Carlberg","year":"1975","unstructured":"Carlberg I, Mannervik B (1975) Glutathione reductase levels in rat brain. J Biol Chem 250:5475\u20135480","journal-title":"J Biol Chem"},{"key":"13969_CR10","doi-asserted-by":"publisher","first-page":"8809","DOI":"10.1021\/jf300669s","volume":"60","author":"A Chanet","year":"2012","unstructured":"Chanet A, Milenkovic D, Manach C, Mazur A, Morand C (2012) Citrus flavanones: what is their role in cardiovascular protection? J Agric Food Chem 60:8809\u20138822","journal-title":"J Agric Food Chem"},{"key":"13969_CR11","doi-asserted-by":"publisher","first-page":"e31808","DOI":"10.1371\/journal.pone.0031808","volume":"7","author":"CT Chang","year":"2012","unstructured":"Chang CT, Ho TY, Lin H, Liang JA, Huang HC, Li CC, Lo HY, Wu SL, Huang YF, Hsiang CY (2012) 5-Fluorouracil induced intestinal mucositis via nuclear factor-kB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One 7:e31808","journal-title":"PLoS One"},{"key":"13969_CR12","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s13277-011-0189-y","volume":"32","author":"S Chibber","year":"2011","unstructured":"Chibber S, Farhan M, Hassan I, Naseem I (2011) White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study. Tumour Biol 32:881\u2013892","journal-title":"Tumour Biol"},{"key":"13969_CR13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.curtheres.2011.11.003","volume":"72","author":"T David","year":"2011","unstructured":"David T, Peter HC, Gregory T, Catherine B, Saurabh S (2011) In vivo effects of immunomodulators in a murine model of fluorouracil-induced mucositis. Curr. Therapeutic Res 72:262\u2013272","journal-title":"Therapeutic Res"},{"key":"13969_CR14","doi-asserted-by":"publisher","first-page":"35151","DOI":"10.1007\/s11356-019-06660-3","volume":"26","author":"AE Elhelaly","year":"2019","unstructured":"Elhelaly AE, AlBasher G, Alfarraj S, Almeer R, Bahbah EI, Fouda MMA, Bung\u0103u SG, Aleya L, Abdel-Daim MM (2019) Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res 26:35151\u201335162","journal-title":"Environ Sci Pollut Res"},{"key":"13969_CR15","first-page":"45","volume":"1","author":"IH El-Sayyad","year":"2013","unstructured":"El-Sayyad IH, Hassan A (2013) Effects of adriamycin, cisplatin, and 5-fluorouracil on the testes of albino rats. Br J Med Health Sci 1:45\u201362 49","journal-title":"Br J Med Health Sci"},{"key":"13969_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1742-7843.2007.00005.x","volume":"100","author":"EO Farombi","year":"2007","unstructured":"Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO (2007) Kolaviron and curcumin ameliorate di-n-Butylphthalate-induced testicular toxicity in rats. Basic Clin Pharmacol Toxicol 100:43\u201348","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"13969_CR17","first-page":"127","volume":"3","author":"V Gelen","year":"2018","unstructured":"Gelen V, \u015eeng\u00fcl E (2018) Hematoprotective effect of naringin on 5-FU toxicity in rats. Chem Res J 3:127\u2013130","journal-title":"Chem Res J"},{"key":"13969_CR18","first-page":"459","volume":"19","author":"V Gelen","year":"2020","unstructured":"Gelen V, \u015eeng\u00fcl E (2020) Antioxidant, antiinflammatory and antiapoptotic effects of naringin on cardiac damage induced by cisplatin. Indian J Tradit Knowl 19:459\u2013465","journal-title":"Indian J Tradit Knowl"},{"key":"13969_CR19","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.apjtb.2017.06.013","volume":"7","author":"V Gelen","year":"2017","unstructured":"Gelen V, \u015eeng\u00fcl E, Gedikli S, Atila G, Uslu H, Makav M (2017a) The protective effect of rutin and quercetin on 5-FU-induced hepatotoxicity in rats. Asian Pac J Trop Biomed 7:647\u2013653","journal-title":"Asian Pac J Trop Biomed"},{"key":"13969_CR20","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.biopha.2017.02.057","volume":"89","author":"V Gelen","year":"2017","unstructured":"Gelen V, \u015eeng\u00fcl E, Gedikli S, G\u00fcr C, \u00d6zkanlar S (2017b) Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. Biomed Pharmacother 89:524\u2013528","journal-title":"Biomed Pharmacother"},{"key":"13969_CR21","first-page":"404","volume":"21","author":"V Gelen","year":"2018","unstructured":"Gelen V, \u015eeng\u00fcl E, Y\u0131ld\u0131r\u0131m S, Atila G (2018) The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci 21:404\u2013410","journal-title":"Iran J Basic Med Sci"},{"key":"13969_CR22","unstructured":"Gelen V, Gelen S.U, Celebi F, Cinar A, Yildirim S, Eser G (2019) The protective effect of Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus brevis against cisplatin-induced hepatic damage in rats. Fresenius Environ Bull 28:7583\u20137592."},{"key":"13969_CR23","first-page":"19","volume":"3","author":"M Hussein","year":"2011","unstructured":"Hussein M, Othman S (2011) Structure activity relationship of antioxidative property of hesperidin. International Journal of Pharmaceutical Research and Development 3:19\u201329","journal-title":"International Journal of Pharmaceutical Research and Development"},{"key":"13969_CR24","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1093\/carcin\/21.10.1835","volume":"21","author":"H Inano","year":"2000","unstructured":"Inano H, Onoda M, Inafuku N, Kubota M, Kamada Y, Osawa T, Kobayashi H, Wakabayashi K (2000) Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21:1835\u20131841","journal-title":"Carcinogenesis"},{"key":"13969_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.fct.2014.07.022","volume":"72","author":"S Ince","year":"2014","unstructured":"Ince S, Arslan Acaroz D, Neuwirth O, Demirel HH, Denk B, Kucukkurt I, Turkmen R (2014) Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin induced toxicity in rats. Food Chem Toxicol 72:147\u2013153","journal-title":"Food Chem Toxicol"},{"key":"13969_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cbi.2011.03.009","volume":"192","author":"R Khan","year":"2011","unstructured":"Khan R, Sultana S (2011) Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem Biol Interact 192:193\u2013200","journal-title":"Chem Biol Interact"},{"key":"13969_CR27","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/02841860310004409","volume":"42","author":"S Kinhult","year":"2003","unstructured":"Kinhult S, Albertsson M, Eskilsson J, Cwikiel M (2003) Effects of probucol on endothelial damage by 5-fluorouracil. Acta Oncol 42:304\u2013308","journal-title":"Acta Oncol"},{"key":"13969_CR28","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1681\/ASN.2019080827","volume":"31","author":"BM Klinkhammer","year":"2020","unstructured":"Klinkhammer BM, Djudjaj S, Kunter U, Palsson R, Edvardsson VO, Wiech T, Thorsteinsdottir M, Hardarson S, Foresto-Neto O, Mulay SR, Moeller MJ, Jahnen-Dechent W, Floege J, Anders HJ, Boor P (2020) Cellular and molecular mechanisms of kidney injury in 2,8-dihydroxyadenine nephropathy. J Am Soc Nephrol 31:799\u2013816","journal-title":"J Am Soc Nephrol"},{"key":"13969_CR29","first-page":"31","volume":"19","author":"M Lamberti","year":"2012","unstructured":"Lamberti M, Porto S, Marra M, Zappavigna S, Grimaldi A, Feola D, Pesce D, Naviglio S, Spina A, Sannolo N, Caraglia M (2012) 5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress. J Exp Clin Cancer Res 19:31\u201360","journal-title":"J Exp Clin Cancer Res"},{"key":"13969_CR30","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","volume":"71","author":"RA Lawrence","year":"1976","unstructured":"Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71:952\u2013958","journal-title":"Biochem Biophys Res Commun"},{"key":"13969_CR31","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s00210-018-1514-4","volume":"391","author":"F Mercantepe","year":"2018","unstructured":"Mercantepe F, Mercantepe T, Topcu A, Y\u0131lmaz A, Tumkaya L (2018) Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn Schmiedeberg's Arch Pharmacol 391:915\u2013931","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"13969_CR32","first-page":"673","volume":"52","author":"E Middleton Jr","year":"2000","unstructured":"Middleton E Jr, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673\u2013751","journal-title":"Pharmacol Rev"},{"key":"13969_CR33","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/cancers2031717","volume":"2","author":"K Miura","year":"2010","unstructured":"Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ti A, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I (2010) 5-FU metabolism in cancer and orally-administrable 5-FU drugs. Cancers 2:1717\u20131730","journal-title":"Cancers"},{"key":"13969_CR34","first-page":"1","volume":"2","author":"O Nada","year":"2010","unstructured":"Nada O (2010) A review of propolis antitumour action in vivo and in vitro. J. Api Product ApMed Sci 2:1\u201320","journal-title":"Api Product ApMed Sci"},{"key":"13969_CR35","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1593\/neo.04169","volume":"6","author":"MU Naidu","year":"2004","unstructured":"Naidu MU, Ramana GV, Rani PU, Mohan IK, Suman A, Pb R (2004) Chemotherapy-induced and\/or radiation therapy-induced oral mucositis complicating the treatment of cancer. Neoplasia 6:423\u2013431","journal-title":"Neoplasia"},{"key":"13969_CR36","unstructured":"Nora E, Ali (2012) Protective effect of captopril against 5-fluorouracil-induced hepato and nephrotoxicity in male albino rats. J Am Sci:8"},{"key":"13969_CR37","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","volume":"16","author":"ZA Placer","year":"1966","unstructured":"Placer ZA, Cushmanni LL, Johnson BC (1966) Estimation of products of lipid peroxidation (as malondialdehyde) in biochemical systems. Anal Biochem 16:359\u2013364","journal-title":"Anal Biochem"},{"key":"13969_CR38","doi-asserted-by":"crossref","unstructured":"Ramadori G, Cameron S (2010) Effects of systemic chemotherapy on the liver. Ann Hepatol 9:133\u2013143.","DOI":"10.1016\/S1665-2681(19)31651-5"},{"key":"13969_CR39","doi-asserted-by":"crossref","unstructured":"Rashid S, Ali N, Nafees S, Ahmad S. Tanveer Arjumand W, Hasan S, Kazim Sultana S (2012) Alleviation of doxorubicin induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats. Toxicol Mech Methods 23:337\u2013345.","DOI":"10.3109\/15376516.2012.759306"},{"key":"13969_CR40","first-page":"189","volume":"7","author":"S Rashid","year":"2013","unstructured":"Rashid S, Ali N, Nafees S, Ahmad S, Tanveer Hasan S, Kazim Sultana S (2013) Abrogation of 5-flourouracil induced renal toxicity by bee propolis via targeting oxidative stress and inflammation in Wistar rats. J Pharm Res 7:189\u2013194","journal-title":"J Pharm Res"},{"key":"13969_CR41","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.bjorl.2018.07.007","volume":"85","author":"MS Sakat","year":"2019","unstructured":"Sakat MS, Kilic K, Akdemir FNE, Yildirim S, Eser G, Kiziltunc A (2019) The effectiveness of eugenol against cisplatin-induced ototoxicity. Braz J Otorhinolaryngoly 85:766\u2013773","journal-title":"Braz J Otorhinolaryngoly"},{"key":"13969_CR42","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205","journal-title":"Anal Biochem"},{"key":"13969_CR43","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.etp.2010.10.012","volume":"64","author":"P Selvaraj","year":"2012","unstructured":"Selvaraj P, Pugalendi KV (2012) Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity. Exp Toxicol Pathol 64:449\u2013452","journal-title":"Exp Toxicol Pathol"},{"key":"13969_CR44","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biopha.2017.05.047","volume":"92","author":"E \u015eeng\u00fcl","year":"2017","unstructured":"\u015eeng\u00fcl E, Gelen V, Gedikli S, \u00d6zkanlar S, G\u00fcr C, \u00c7elebi F, \u00c7\u0131nar A (2017) The protective effect of quercetin on cyclophosphamide-induced lung toxicity in rats. Biomed Pharmacother 92:303\u2013307","journal-title":"Biomed Pharmacother"},{"key":"13969_CR45","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4103\/2221-1691.254605","volume":"9","author":"E Sengul","year":"2019","unstructured":"Sengul E, Gelen SU, Y\u0131ld\u0131r\u0131m S, \u00c7elebi F, \u00c7\u0131nar A (2019) Probiotic bacteria attenuates cisplatin-induced nephrotoxicity through modulation of oxidative stress, inflammation and apoptosis in rats. Asian Pac J Trop Biomed 9:116","journal-title":"Asian Pac J Trop Biomed"},{"key":"13969_CR46","first-page":"423","volume":"31","author":"E Sengul","year":"2021","unstructured":"Sengul E, Gelen V, Gedikli S (2021a) Cardioprotect\u0131ve activities of quercetin and rutin in Sprague-Dawley rats treated w\u0131th 5-fluorouracil. J Anim Plant Sci 31:423\u2013443","journal-title":"J Anim Plant Sci"},{"key":"13969_CR47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12011-020-02111-0","volume":"199","author":"E Sengul","year":"2021","unstructured":"Sengul E, Gelen V, Yildirim S, Tekin S, Dag Y (2021b) The effects of selenium in acrylamide-induced nephrotoxicity in rats: roles of oxidative stress, inflammation, apoptosis, and DNA damage. Biol Trace Elem Res 199:173\u2013184","journal-title":"Biol Trace Elem Res"},{"key":"13969_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/19396368.2015.1101510","volume":"62","author":"J Stepniak","year":"2016","unstructured":"Stepniak J, Karbownik-Lewinska M (2016) 17 \u03b2-estradiol prevents experimentally-induced oxidative damage to membrane lipids and nuclear DNA in porcine ovary. Syst Biol Reprod Med 62:17\u201321","journal-title":"Syst Biol Reprod Med"},{"key":"13969_CR49","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0944-7113(98)80044-5","volume":"5","author":"J Suarez","year":"1998","unstructured":"Suarez J, Herrera MD, Marhuenda E (1998) In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone. Phytomedicine 5:469\u2013473","journal-title":"Phytomedicine"},{"key":"13969_CR50","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"Y Sun","year":"1988","unstructured":"Sun Y, Larry WO, Ying L (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497\u2013500","journal-title":"Clin Chem"},{"key":"13969_CR51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0027-5107(01)00183-X","volume":"1","author":"YJ Surh","year":"2001","unstructured":"Surh YJ, Chun KS, Cha HH (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: downregulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 1:243\u2013268","journal-title":"Mutat Res"},{"key":"13969_CR52","first-page":"3579","volume":"28","author":"AA Thant","year":"2008","unstructured":"Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV (2008) Role of caspases in 5-FU and selenium-induced growth inhibition of colorectalcancer cells. Anticancer Res 28:3579\u20133592","journal-title":"Anticancer Res"},{"key":"13969_CR53","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1124\/dmd.106.011684","volume":"35","author":"X Wang","year":"2007","unstructured":"Wang X, Morris ME (2007) Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 35:268\u2013274","journal-title":"Drug Metab Dispos"},{"key":"13969_CR54","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s12011-018-1434-7","volume":"188","author":"S Yildirim","year":"2019","unstructured":"Yildirim S, Ozkan C, Huyut Z, \u00c7\u0131nar A (2019) Detection of Se, vit. E, vit. A, MDA, 8-OHdG, and CoQ10 levels and histopathological changes in heart tissue in sheep with white muscle disease. Biol Trace Elem Res 188:419\u2013423","journal-title":"Biol Trace Elem Res"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13969-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-13969-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-13969-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T09:52:36Z","timestamp":1629798756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-13969-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":54,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["13969"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-13969-5","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"23 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was designed and conducted according to ethical norms approved by the Atat\u00fcrk University Rectorate Animal Experiments Local Ethics Committee (Erzurum, Turkey) (Protocol No. 2019\/16).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}