{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:49:12Z","timestamp":1775026152425,"version":"3.50.1"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"35","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s11356-021-14089-w","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:43:50Z","timestamp":1619581430000},"page":"48517-48534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose\/streptozotocin diabetic rat model"],"prefix":"10.1007","volume":"28","author":[{"given":"Rasha M.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahany E.","family":"Kholief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa H. M.","family":"Hassanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehan A.","family":"Gafer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-2250","authenticated-orcid":false,"given":"Yasser A.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"issue":"3","key":"14089_CR1","first-page":"159","volume":"10","author":"HA Abd El-Rahim","year":"2017","unstructured":"Abd El-Rahim HA, Abd-Elmoneim OM, Hafiz NA (2017) Assessment of antigenotoxic effect of nanoselenium and metformin on diabetic rats. Jordan Journal of Biological Sciences 10(3):159\u2013165","journal-title":"Jordan Journal of Biological Sciences"},{"issue":"7","key":"14089_CR2","first-page":"1","volume":"7","author":"NS Abd El-Rahman","year":"2016","unstructured":"Abd El-Rahman NS, Reda SM, Al Ghannam MS (2016) Synthesis and characterization of nano-doped zinc oxide and its application as protective oxidative changes in the retina of diabetic rats. Journal of Diabetes & Metabolism 7(7):1\u20136","journal-title":"Journal of Diabetes & Metabolism"},{"issue":"6","key":"14089_CR3","first-page":"1","volume":"2018","author":"AN Abdella","year":"2018","unstructured":"Abdella AN, Mojiminiyi AO (2018) Clinical applications of adiponectin measurements in type 2 diabetes mellitus. Screening Diagnosis and Marker of Diabetes Control 2018(6):1\u20136","journal-title":"Screening Diagnosis and Marker of Diabetes Control"},{"issue":"8","key":"14089_CR4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/iub.84","volume":"60","author":"A Abdourahman","year":"2008","unstructured":"Abdourahman A, Edwards JG (2008) Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats. IUBMB Life 60(8):541\u2013548","journal-title":"IUBMB Life"},{"issue":"1","key":"14089_CR5","doi-asserted-by":"publisher","first-page":"266","DOI":"10.21608\/bvmj.2015.32661","volume":"28","author":"RA Abou Zaid","year":"2015","unstructured":"Abou Zaid RA, El-sonbaty MS, Afifi FWM (2015) The biochemical effect of chromium nanoparticles administration on adiponectin secretion, oxidative stress and metabolic disordered in streptozotocin induced diabetic rats. Benha Veterinary Medical Journal 28(1):266\u2013275","journal-title":"Benha Veterinary Medical Journal"},{"issue":"7","key":"14089_CR6","first-page":"271","volume":"27","author":"M Afifi","year":"2020","unstructured":"Afifi M, Alkaladi A, Abomughaid M, Abdelazim AM (2020) Nanocurcumin improved glucose metabolism in streptozotocin-induced diabetic rats: a comparison study with Gliclazide. Environ Sci Pollut Res 27(7):271\u2013277","journal-title":"Environ Sci Pollut Res"},{"issue":"2","key":"14089_CR7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s12011-016-0876-z","volume":"177","author":"HH Ahmed","year":"2017","unstructured":"Ahmed HH, Abd El-Maksoud MD, AbdelMoneim AE, Aglan HA (2017) Pre-clinical study for the antidiabetic potential of selenium nanoparticles. Biol Trace Elem Res 177(2):267\u2013280","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"14089_CR8","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"C Allain","year":"1974","unstructured":"Allain C, Poon L, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20(4):470\u2013475","journal-title":"Clin Chem"},{"issue":"6","key":"14089_CR9","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1080\/07315724.1998.10718802","volume":"17","author":"RA Anderson","year":"1998","unstructured":"Anderson RA (1998) Chromium, glucose intolerance and diabetes. J Am Coll Nutr 17(6):548\u2013555","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"14089_CR10","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/ajcn\/54.5.909","volume":"54","author":"RA Anderson","year":"1991","unstructured":"Anderson RA, Polansky MM, Bryden NA, Canary JJ (1991) Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets. Am J Clin Nutr 54(5):909\u2013916","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"14089_CR11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.arcmed.2013.03.004","volume":"44","author":"DL Avila","year":"2013","unstructured":"Avila DL, Araujo GR, Silva M, Miranda PHA, Diniz MF, Pedrosa ML, Silva ME, Lima WG, Costaa DC (2013) Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats. Archives of Medical Research 44(3):194\u2013202","journal-title":"Archives of Medical Research"},{"key":"14089_CR12","doi-asserted-by":"publisher","unstructured":"Attia AY, Attia YS, Essa R, Mohamed S (2020) Photosynthesis of chromium oxide\/reduced graphene oxide nanocomposites and its application in water desalination and purification. nanoscience & nanotechnology-Asia 10 (5). https:\/\/doi.org\/10.2174\/2210681209666190627155956","DOI":"10.2174\/2210681209666190627155956"},{"key":"14089_CR13","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12011-017-1192-y","volume":"184","author":"A Berenjian","year":"2018","unstructured":"Berenjian A, Sharifi DS, Abdollah MSA, Ghazanfari A (2018) Effect of chromium nanoparticles on physiological stress induced by exogenous dexamethasone in Japanese quails. Biol Trace Elem Res 184:474\u2013481","journal-title":"Biol Trace Elem Res"},{"key":"14089_CR14","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1373\/clinchem.2004.037556","volume":"50","author":"A Brehm","year":"2004","unstructured":"Brehm A, Pfeiler G, Pacini G, Vierhapper H, Roden M (2004) Relationship between serum lipoprotein ratios and insulin resistance in obesity. Clin Chem 50:2316\u20132322","journal-title":"Clin Chem"},{"key":"14089_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1152\/ajplung.00076.2006","volume":"292","author":"P Bulau","year":"2007","unstructured":"Bulau P, Zakrzewicz D, Kitowska K, Leiper J, Gunther A, Grimminger F, Eickelberg O (2007) Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am J Physiol Lung Cell Mol Physiol 292:18\u201324","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"14089_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0009-8981(75)90033-9","volume":"59","author":"AR Butler","year":"1975","unstructured":"Butler AR (1975) The Jaffe reaction identification of the colored species. Clin Chim Acta 59:227\u2013232","journal-title":"Clin Chim Acta"},{"issue":"2","key":"14089_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/07315724.1998.10718735","volume":"17","author":"AB Chausmer","year":"1998","unstructured":"Chausmer AB (1998) Zinc, insulin and diabetes. J Am Coll Nutr 17(2):109\u2013115","journal-title":"J Am Coll Nutr"},{"issue":"2","key":"14089_CR18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1289\/ehp.7861","volume":"114","author":"C Chen","year":"2006","unstructured":"Chen C, Yu H, Zhao J, Li B, Qu L, Liu S, Zhang P, Chai Z (2006) The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure. Environ Health Perspect 114(2):297\u2013301","journal-title":"Environ Health Perspect"},{"issue":"4","key":"14089_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1463-1326.2008.00936.x","volume":"11","author":"WY Chen","year":"2009","unstructured":"Chen WY, Chen CJ, Liu CH, Mao FC (2009) Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK\/HlJ diabetic mice. Diabetes Obes Metab 11(4):293\u2013303","journal-title":"Diabetes Obes Metab"},{"key":"14089_CR20","first-page":"532","volume":"15","author":"P Chomczynski","year":"1993","unstructured":"Chomczynski P (1993) A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 15:532\u2013537","journal-title":"BioTechniques"},{"key":"14089_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156\u2013159","journal-title":"Anal Biochem"},{"issue":"2","key":"14089_CR22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.2307\/1941207","volume":"76","author":"S Collins","year":"1995","unstructured":"Collins S, Glenn SM, Gibson DJ (1995) Experimental Analysis of Intermediate Disturbance and Initial Floristic Composition: Decoupling Cause and Effect. Ecology 76(2):486\u2013492","journal-title":"Ecology"},{"issue":"22","key":"14089_CR23","doi-asserted-by":"publisher","first-page":"4225","DOI":"10.1002\/adma.200703183","volume":"20","author":"M De","year":"2008","unstructured":"De M, Ghosh PS, Rotello VM (2008) Applications of nanoparticles in biology. Adv Mater 20(22):4225\u20134241","journal-title":"Adv Mater"},{"key":"14089_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ymeth.2009.11.001","volume":"50","author":"S Derveaux","year":"2010","unstructured":"Derveaux S, Jo V, Jan H (2010) How to do successful gene expression analysis using real-time PCR. Methods. 50:227\u2013230","journal-title":"Methods."},{"key":"14089_CR25","doi-asserted-by":"crossref","unstructured":"Dobi\u00e1sov\u00e1 M, Frohlich J (2001) The plasma parameter log (TG\/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoBlipoprotein-depleted plasma (FER(HDL)). Clin Biochem 34(7):583\u2013588","DOI":"10.1016\/S0009-9120(01)00263-6"},{"key":"14089_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","volume":"31","author":"BT Doumas","year":"1971","unstructured":"Doumas BT, Watson WA, Biggs HG (1971) Albumin standards and measurements of serum albumin with bromocresol green. Clin Chim Acta 31:87\u201396","journal-title":"Clin Chim Acta"},{"key":"14089_CR27","volume-title":"Carletons histology technique","author":"RA Drury","year":"1980","unstructured":"Drury RA, Wallington EA (1980) Carletons histology technique, 4th edn. Oxford university press, New York","edition":"4"},{"issue":"5","key":"14089_CR28","first-page":"2282","volume":"11","author":"G Elankani","year":"2020","unstructured":"Elankani G, Reddy D, Kabilan N, Kumar P, Ganesan R, Kumar N, Pitchaiah D (2020) Evaluation of the anti-diabetic activity of the tran vidhai kudineer on fructose and streptozotocin induced diabetic rats. IJPSR. 11(5):2282\u20132292","journal-title":"IJPSR."},{"issue":"2","key":"14089_CR29","first-page":"065","volume":"7","author":"SM El-Megharbel","year":"2015","unstructured":"El-Megharbel SM (2015) Synthesis, characterization and antidiabetic activity of chromium (III) metformin complex. Journal of Microbial & Biochemical Technology 7(2):065\u2013075","journal-title":"Journal of Microbial & Biochemical Technology"},{"key":"14089_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2174\/2212796814666200818111849","volume":"14","author":"M Emam","year":"2020","unstructured":"Emam M, Keshta TA, Mohamed AMY, Attia AY (2020) Insight on ameliorative role of selenium nanoparticles and niacin in wound healing on adult female albino mice. Curr Chem Biol 14:169\u2013186. https:\/\/doi.org\/10.2174\/2212796814666200818111849","journal-title":"Curr Chem Biol"},{"key":"14089_CR31","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1093\/clinchem\/28.10.2077","volume":"28","author":"P Fassati","year":"1982","unstructured":"Fassati P, Prencipe L (1982) Measurement of serum TG calorimetrically with an enzyme that produce H2O2. Clin Chem 28:2077\u20132080","journal-title":"Clin Chem"},{"key":"14089_CR32","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1136\/jcp.13.2.156","volume":"13","author":"JK Fawcett","year":"1960","unstructured":"Fawcett JK, Scott JE (1960) A rapid and precise of method for the determination of urea. J Clin Pathol 13:156\u2013160","journal-title":"J Clin Pathol"},{"issue":"16","key":"14089_CR33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Robert IL, Donald SF (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(16):499\u2013502","journal-title":"Clin Chem"},{"key":"14089_CR34","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S2221-1691(12)60023-9","volume":"2","author":"GR Gandhi","year":"2012","unstructured":"Gandhi GR, Sasikumar P (2012) Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pac J Trop Biomed 2:281\u2013286","journal-title":"Asian Pac J Trop Biomed"},{"issue":"11","key":"14089_CR35","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/S0955-2863(02)00220-6","volume":"13","author":"D Ghosh","year":"2002","unstructured":"Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, Chowdhury S (2002) Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem 13(11):690\u2013697","journal-title":"J Nutr Biochem"},{"key":"14089_CR36","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1177\/0300985813485099","volume":"50","author":"KN Gibson-Corley","year":"2013","unstructured":"Gibson-Corley KN, Olivier AK, Meyerholz DK (2013) Principles for Valid histopathologic scoring in research. Vet Pathol 50:1007\u20131015","journal-title":"Vet Pathol"},{"key":"14089_CR37","first-page":"197","volume-title":"The cytokine. Handbook 3rd edition","author":"T Hirano","year":"1998","unstructured":"Hirano T (1998) c. In: Thomson AE (ed) The cytokine. Handbook 3rd edition. Academic Press, San Diego, pp 197\u2013227"},{"issue":"4","key":"14089_CR38","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jnutbio.2011.11.001","volume":"23","author":"Y Hua","year":"2012","unstructured":"Hua Y, Clark S, Ren J, Sreejayan N (2012) Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem 23(4):313\u2013319","journal-title":"J Nutr Biochem"},{"issue":"1","key":"14089_CR39","first-page":"166","volume":"27","author":"SA Hussein","year":"2014","unstructured":"Hussein SA, YA EL-S, El-Dawy K, Hind AB (2014) Evaluation of zinc oxide nanoparticles for insulin, insulin receptors and insulin receptors substrates gene expression in streptozotocin-induced diabetic rats. Benha Veterinary Medical Journal 27(1):166\u2013174","journal-title":"Benha Veterinary Medical Journal"},{"issue":"6","key":"14089_CR40","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jnutbio.2009.01.009","volume":"20","author":"J Jansen","year":"2009","unstructured":"Jansen J, Karges W, Rink L (2009) Zinc and diabetes \u2013 clinical links and molecular mechanisms. J Nutr Biochem 20(6):399\u2013417","journal-title":"J Nutr Biochem"},{"issue":"1","key":"14089_CR41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-5996-4-13","volume":"4","author":"R Jayawardena","year":"2012","unstructured":"Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P (2012) Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr 4(1):13","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"14089_CR42","first-page":"196","volume":"3","author":"C Kumar","year":"2014","unstructured":"Kumar C, Kumar R, Nehar S (2014) Induction of type 2 diabetes by high \u2013fructose diet and low dose of intraperioneal injection of STZ in albion rats. Int J Pharm Res Sch 3(1):196\u2013202","journal-title":"Int J Pharm Res Sch"},{"key":"14089_CR43","unstructured":"Levesque R (2007) SPSSS programming and data management: a guide for SPSS and SAS user. 3rd edition, United States of America."},{"key":"14089_CR44","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/clinchem\/23.5.882","volume":"23","author":"MF Lopes-Virella","year":"1977","unstructured":"Lopes-Virella MF, Stone P, Ellis S, Colwell JA (1977) Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem 23:882\u2013884","journal-title":"Clin Chem"},{"key":"14089_CR45","doi-asserted-by":"crossref","unstructured":"Majeed W, Zafar M, Bhatti A, john P (2018) Therapeutic potential of selenium nanoparticles. Journal of Nanomedicine & Nanotechnology 9:1.","DOI":"10.4172\/2157-7439.1000487"},{"issue":"7","key":"14089_CR46","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"D Matthews","year":"1985","unstructured":"Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412\u2013419","journal-title":"Diabetologia"},{"issue":"9","key":"14089_CR47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/aoc.5758","volume":"34","author":"AMY Mohamed","year":"2020","unstructured":"Mohamed AMY, Attia AY (2020) The influence of ultrasonic irradiation on catalytic performance of ZnO nanoparticles towards the synthesis of chiral 1-substituted-1H-tetrazole derivatives from \u03b1-amino acid ethyl esters. Appl Organomet Chem 34(9):57\u201358","journal-title":"Appl Organomet Chem"},{"issue":"11","key":"14089_CR48","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1080\/10715760903196925","volume":"43","author":"AS Mueller","year":"2009","unstructured":"Mueller AS, Mueller K, Wolf NM, Pallauf J (2009) Selenium and diabetes: an enigma? Free Radic Res 43(11):1029\u20131059","journal-title":"Free Radic Res"},{"key":"14089_CR49","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1056\/NEJM198402093100602","volume":"310","author":"DM Nathan","year":"1984","unstructured":"Nathan DM, Singer DE, Hurxthal K, Goodson JD (1984) The clinical information value of the glycosylated hemoglobin assay. N Engl J Med 310:341\u2013346","journal-title":"N Engl J Med"},{"issue":"4","key":"14089_CR50","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1208\/s12249-015-0405-y","volume":"17","author":"A Nazarizadeh","year":"2016","unstructured":"Nazarizadeh A, Asri-Rezaie S (2016) Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic Rats. AAPS PharmSciTech 17(4):834\u2013843","journal-title":"AAPS PharmSciTech"},{"key":"14089_CR51","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2265.1992.tb00945.x","volume":"36","author":"S O\u2019Rahilly","year":"1992","unstructured":"O\u2019Rahilly S, Moller DE (1992) Mutant insulin receptors in syndromes of insulin resistance. Clinical Endocrinology (Oxf) 36:121\u2013132","journal-title":"Clinical Endocrinology (Oxf)"},{"key":"14089_CR52","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"14089_CR53","first-page":"1","volume":"12","author":"SM Othman","year":"2019","unstructured":"Othman SM, Hafez MM, Abdel Moneim EA (2019) The Potential role of zinc oxide nanoparticles in micrornas dysregulation in STZ-induced type2 diabetes in rats. Biol Trace Elem Res 12:1\u201313","journal-title":"Biol Trace Elem Res"},{"key":"14089_CR54","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3109\/10520295.2015.1042050","volume":"90","author":"Z Ozt\u00fcrk","year":"2015","unstructured":"Ozt\u00fcrk Z, Gurpinar T, Vural K, Boyac\u0131oglu S, Korkmaz M, Var A (2015) Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet. Biotech Histochem 90:506\u2013515","journal-title":"Biotech Histochem"},{"issue":"1","key":"14089_CR55","first-page":"1","volume":"12","author":"C Park","year":"2017","unstructured":"Park C, Kim J, Lee E, Hur W, Kwon O, Park H, Yoon S (2017) Aronia melanocarpa extract ameliorates hepatic lipid metabolism through PPAR\u03b32 downregulation. PLoS One 12(1):1\u201322","journal-title":"PLoS One"},{"issue":"123","key":"14089_CR56","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"26","author":"PG Reeves","year":"1993","unstructured":"Reeves PG, Nielsen FH, Fahey JR (1993) AIN-93 Purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A Rodent Diet. J Nutr 26(123):1939\u20131951","journal-title":"J Nutr"},{"key":"14089_CR57","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) Colourimetric determination of serum GOT [glutomic oxaloacetic transsaminase] activity. Am J Clin Pathol 28:56\u201363","journal-title":"Am J Clin Pathol"},{"key":"14089_CR58","first-page":"155","volume":"21","author":"M Rezaei-Kelishadi","year":"2017","unstructured":"Rezaei-Kelishadi M, Ghasemi A, Abdolyosefi NN, Zamani-Doabi S, Ramezani M, Changizi-Ashtiyani S, Rahimi A (2017) Effects of selenium nanoparticles on kidney and liver functional disorders in streptozotocin-induced diabetic rats. J Physiol Pharmacol 21:155\u2013162","journal-title":"J Physiol Pharmacol"},{"key":"14089_CR59","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11302-008-9126-y","volume":"4","author":"C Richards-Williams","year":"2008","unstructured":"Richards-Williams C, Contreras LJ, Berecek HK, Schwiebert ME (2008) Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion. Purinergic Signal 4:393\u2013405","journal-title":"Purinergic Signal"},{"key":"14089_CR60","unstructured":"Ronald D (1997) Quantitative determination of low levels of C-Reactive Protein (CRP). Journal of Clinical Ligand Assay:313\u2013315"},{"key":"14089_CR61","first-page":"303","volume":"51","author":"V Rotter","year":"2002","unstructured":"Rotter V, Nagaev I, Smith U (2002) Interleukin-6 (IL-6) reduces gene and protein expression of IRS-1 and GLUT4 and is overexpressed in human fat cells from insulin-resistant subjects. Diabetes 51:303","journal-title":"Diabetes"},{"issue":"8","key":"14089_CR62","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s00125-010-1793-x","volume":"53","author":"J Rungby","year":"2010","unstructured":"Rungby J (2010) Zinc, zinc transporters and diabetes. Diabetologia 53(8):1549\u20131551","journal-title":"Diabetologia"},{"key":"14089_CR63","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1017\/S0007114512004850","volume":"110","author":"K Sahin","year":"2013","unstructured":"Sahin K, Tuzcu M, Orhan C, Sahin N, Kucuk O, Ozercan HI, Ibrahim HO, Juturu V, Komorowski RJ (2013) Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin. Br J Nutr 110:197\u2013205","journal-title":"Br J Nutr"},{"issue":"2","key":"14089_CR64","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S1383-5718(00)00157-1","volume":"490","author":"S Sardas","year":"2001","unstructured":"Sardas S, Yilmaz M, Oztok U, Caki N, Karakaya AE (2001) Assessment of DNA strands breakage by comet assay in diabetic patients and the role of antioxidant supplementation. Mutat Res 490(2):123\u2013129","journal-title":"Mutat Res"},{"key":"14089_CR65","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.smallrumres.2010.11.005","volume":"96","author":"L Shi","year":"2011","unstructured":"Shi L, Xun W, Yue W, Zhang C, Ren Y (2011) Effect of sodium selenite, Se-yeast and nano-elemental selenium on growth performance, Se concentration and antioxidant status in growing male goats. Small Rumin Res 96:49\u201352","journal-title":"Small Rumin Res"},{"key":"14089_CR66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mce.2015.07.012","volume":"414","author":"MS Shihabudeen","year":"2015","unstructured":"Shihabudeen MS, Roy D, James J, Thirumurugan K (2015) Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. Molecular and Cellular Endocrinology 414:19\u201328","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"3","key":"14089_CR67","doi-asserted-by":"publisher","first-page":"e5684","DOI":"10.1371\/journal.pone.0005684","volume":"4","author":"K Smidt","year":"2009","unstructured":"Smidt K, Jessen N, Petersen AB, Larsen A, Magnusson N, Jeppesen JB, Stoltenberg M, Culvenor JG, Tsatsanis A, Brock B, Schmitz O, Wogensen L, Bush AI, Rungby J (2009) SLC30A3 Responds to Glucose- and Zinc Variations in \u00dfCells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During \u00df-Cell Stress. PLoS ONE 4(3):e5684","journal-title":"PLoS ONE"},{"issue":"2","key":"14089_CR68","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/17518253.2016.1151083","volume":"9","author":"BT Sone","year":"2016","unstructured":"Sone BT, Manikandan E, Gurib-Fakim A, Maaza M (2016) Single-phase \u03b1-Cr2O3 nanoparticles\u2019 green synthesis using Callistemon viminalis\u2019 red flower extract. Green Chemistry Letters and Reviews 9(2):85\u201390","journal-title":"Green Chemistry Letters and Reviews"},{"key":"14089_CR69","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1002\/btpr.1992","volume":"30","author":"P Srivastava","year":"2014","unstructured":"Srivastava P, Braganca JM, Kowshik M (2014) In vivo synthesis of selenium nanoparticles by Halococcus salifodinae BK18 and their anti-proliferative properties against HeLa cell line. Biotechnol Prog 30:1480\u20131487","journal-title":"Biotechnol Prog"},{"issue":"11","key":"14089_CR70","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.bbagen.2009.02.014","volume":"1790","author":"H Steinbrenner","year":"2009","unstructured":"Steinbrenner H, Sies H (2009) Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta 1790(11):1478\u20131485","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"14089_CR71","doi-asserted-by":"publisher","first-page":"79","DOI":"10.21608\/ejnf.2019.75842","volume":"22","author":"N Tag-ElDin","year":"2019","unstructured":"Tag-ElDin N (2019) Effects of dietary nano-Zinc and nano-selenium addition on productive and physiological performance of growing rabbits at fattening period. Egyptian Journal of Nutrition and Feeds 22(1):79\u201389","journal-title":"Egyptian Journal of Nutrition and Feeds"},{"issue":"4","key":"14089_CR72","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.jinorgbio.2008.12.003","volume":"103","author":"KH Thompson","year":"2009","unstructured":"Thompson KH, Lichter J, LeBel C, Scaife MC, McNeill JH, Orvig C (2009) Vanadium treatment of Type 2 diabetes: a view to the future. J Inorg Biochem 103(4):554\u2013558","journal-title":"J Inorg Biochem"},{"key":"14089_CR73","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","volume":"35","author":"RR Tice","year":"2000","unstructured":"Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000) Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206\u2013221","journal-title":"Environ Mol Mutagen"},{"key":"14089_CR74","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ars.2007.1957","volume":"10","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Lu W, Weiqin L, Marcia AO, Del R, Huang P (2008) Redox regulation of cell survival. Antioxid Redox Signal 10:1343\u20131374","journal-title":"Antioxid Redox Signal"},{"key":"14089_CR75","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/000456326900600108","volume":"6","author":"L Trinder","year":"1969","unstructured":"Trinder L (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem 6:24\u201327","journal-title":"Ann Clin Biochem"},{"issue":"1","key":"14089_CR76","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3233\/s12349-009-0069-9","volume":"3","author":"JU Ukperoro","year":"2010","unstructured":"Ukperoro JU, Offiah N, Idris T, Awogoke D (2010) Antioxidant effect of zinc, selenium and their combination on the liver and kidney of alloxan-induced diabetes in rats. Mediterr J Nutr Metab 3(1):25\u201330","journal-title":"Mediterr J Nutr Metab"},{"issue":"1","key":"14089_CR77","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2217\/nnm.12.205","volume":"9","author":"DR Umrani","year":"2014","unstructured":"Umrani DR, Paknikar KM (2014) Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Types 1 and 2 diabetic rats. Nanomedicine 9(1):89\u2013104","journal-title":"Nanomedicine"},{"key":"14089_CR78","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0304-4165(85)90182-5","volume":"839","author":"F Ursini","year":"1985","unstructured":"Ursini F, Maiorion M, Gregolin CT (1985) the selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim Biophys Acta 839:62\u201370","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"14089_CR79","first-page":"1","volume":"2","author":"E Usrey","year":"2020","unstructured":"Usrey E, Fatah-Allah NG, Hany M, Mohsen AE, Maher AAA (2020) Biochemical and histopathological studies on the role of selenium nanoparticles and selenium oxide against chemically-induced diabetes in male rats. Research Article 2(2) e scientific:1\u201310","journal-title":"Research Article"},{"key":"14089_CR80","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ejphar.2010.09.066","volume":"650","author":"A Vikram","year":"2011","unstructured":"Vikram A, Jena G, Ramarao P (2011) Insulin-resistance reduces botulinum neurotoxin-type A induced prostatic atrophy and apoptosis in rats. Eur J Pharmacol 650:356\u2013363","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"14089_CR81","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s11892-010-0097-3","volume":"10","author":"ZQ Wang","year":"2010","unstructured":"Wang ZQ, Cefalu WT (2010) Current concepts about chromium supplementation in type 2 diabetes and insulin resistance. Current diabetes reports 10(2):145\u2013151","journal-title":"Current diabetes reports"},{"issue":"1","key":"14089_CR82","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12937-016-0169-6","volume":"15","author":"XL Wang","year":"2016","unstructured":"Wang XL, Yang TB, Wei J, Lei GH, Zeng C (2016) Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose-response meta-analysis of observational studies. Nutr J 15(1):48","journal-title":"Nutr J"},{"key":"14089_CR83","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"S Wild","year":"2004","unstructured":"Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047\u20131053","journal-title":"Diabetes Care"},{"key":"14089_CR84","unstructured":"World Health Organization. (2014) \"About diabetes. Retrieved 4 April."}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-14089-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-14089-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-14089-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:00:24Z","timestamp":1744185624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-14089-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":84,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["14089"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-14089-w","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"19 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors hereby declare that \"Principles of laboratory animal care\" (NIH publication No. 85-23, revised 1985) were followed, as well as specific national laws where applicable. All animal experiments were performed under protocol approved by the Local Institutional Animal Ethics Committee of Ain Shams University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Conflict of interest"}}]}}