{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:59:34Z","timestamp":1792810774281,"version":"4.5.0"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"25","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Department of Biotechnology, Government of India","award":["BT\/IN\/Indo-UK\/AMR\/04\/AK\/2018-19"],"award-info":[{"award-number":["BT\/IN\/Indo-UK\/AMR\/04\/AK\/2018-19"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s11356-021-14178-w","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T09:04:06Z","timestamp":1619773446000},"page":"32111-32124","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-5155","authenticated-orcid":false,"given":"Anita","family":"Kotwani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-7257","authenticated-orcid":false,"given":"Jyoti","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6193-5120","authenticated-orcid":false,"given":"Deeksha","family":"Kaloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"14178_CR1","unstructured":"Acess to medicine foundation (2017) 2017 Methodology for the 2018 Access to Medicine Index Available at:\u00a0https:\/\/accesstomedicineindex.org\/media\/atmi\/2017-Methodology-2018-Access-to-Medicine-Index.pdf.\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-65635-4","volume":"10","author":"J Alexander","year":"2020","unstructured":"Alexander J, Hembach N, Schwartz T (2020) Evaluation of antibiotic resistance dissemination by wastewater treatment plant effluents with different catchment areas in Germany. Sci Rep 10:1\u20139. https:\/\/doi.org\/10.1038\/s41598-020-65635-4","journal-title":"Sci Rep"},{"key":"14178_CR3","unstructured":"AMR Industry Alliance (2018) Progress Report. Geneva (C.H.): IFPMA. Available at: https:\/\/www.amrindustryalliance.org\/progress-report\/. Accessed Sept 26 2020"},{"issue":"3","key":"14178_CR4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.drup.2012.03.005","volume":"15","author":"DI Andersson","year":"2012","unstructured":"Andersson DI, Hughes D (2012) Evolution of antibiotic resistance at non-lethal drug concentrations. Drug Resist Updat 15(3):162\u2013172. https:\/\/doi.org\/10.1016\/j.drup.2012.03.005","journal-title":"Drug Resist Updat"},{"key":"14178_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrmicro3270","volume":"12","author":"DI Andersson","year":"2014","unstructured":"Andersson DI, Hughes D (2014) Microbiological effects of sublethal levels of antibiotics. Nat Rev Microbiol 12:465\u2013478. https:\/\/doi.org\/10.1038\/nrmicro3270","journal-title":"Nat Rev Microbiol"},{"key":"14178_CR6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.chemosphere.2014.06.062","volume":"119","author":"M Andrieu","year":"2015","unstructured":"Andrieu M, Rico A, Phu TM, Huong DTT, Phuong NT, Brink PJVD (2015) Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta, Vietnam. Chemosphere 119:407\u2013414. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.06.062","journal-title":"Chemosphere"},{"key":"14178_CR7","unstructured":"Antimicrobial Resistance Benchmark (2020) Available at: https:\/\/accesstomedicinefoundation.org\/media\/uploads\/downloads\/5e270aa36821a_Antimicrobial_Resistance_Benchmark_2020.pdf. Accessed on Sept 24 2020"},{"key":"14178_CR8","unstructured":"Arnum PV (2013) The Weaknesses and Strengths of the Global API Market. PTSM: Pharmaceutical Technology Sourcing and Management 9. Available at: https:\/\/www.pharmtech.com\/view\/weaknesses-and-strengths-global-api-market. Accessed 22 Apr 2021"},{"key":"14178_CR9","doi-asserted-by":"publisher","unstructured":"Aslan A, Cole Z, Bhattacharya A, and Oyibo O (2018) Presence of antibiotic-resistant Escherichia coli in wastewater treatment plant effluents utilized as water reuse for irrigation. Water 10. https:\/\/doi.org\/10.3390\/w10060805","DOI":"10.3390\/w10060805"},{"key":"14178_CR10","unstructured":"Babatunde AI, Bamgbola EP, Oyelola OT (2014) The effect of pharmaceutical effluents on the quality of groundwater: a case study of Ikeja industrial area of Lagos, Nigeria. Int J Med Res Health Sci 4.\u00a0http:\/\/ijsk.org\/uploads\/3\/1\/1\/7\/3117743\/1_environmental_pollution.pdf"},{"key":"14178_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1365\/s10337-006-0109-2","volume":"65","author":"S Babic","year":"2007","unstructured":"Babic S, Mutavdzic D, Asperger D, Horvat AJM, Kastelan-Macan M (2007) Determination of veterinary pharmaceuticals in production wastewater by HPTLC-videodensitometry. Chromatographia 65:105\u2013110. https:\/\/doi.org\/10.1365\/s10337-006-0109-2","journal-title":"Chromatographia"},{"key":"14178_CR12","first-page":"586","volume":"16","author":"Y Bai","year":"2014","unstructured":"Bai Y, Meng W, Xu J, Zhang Y, Guo C (2014) Occurrence, distribution and bioaccumulation of antibiotics in he river Liao River Basin in China. R Soc Chem 16:586\u2013593","journal-title":"R Soc Chem"},{"key":"14178_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3329\/bjvm.v11i2.19144","volume":"11","author":"MA Bakar","year":"2013","unstructured":"Bakar MA, Morshed AJM, Islam F, Karim R (2013) Screening of Chloramphenicol Residues in Chickens and Fish in Chittagong City of Bangladesh. Bangl J Vet Med 11:173\u2013175. https:\/\/doi.org\/10.3329\/bjvm.v11i2.19144","journal-title":"Bangl J Vet Med"},{"key":"14178_CR14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","volume":"169","author":"Y Ben","year":"2019","unstructured":"Ben Y, Fu C, Hu M, Liu L, Wong MH, Zheng C (2019) Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: a review. Environ Res 169:483\u2013493. https:\/\/doi.org\/10.1016\/j.envres.2018.11.040","journal-title":"Environ Res"},{"key":"14178_CR15","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","volume":"86","author":"J Bengtsson-Palme","year":"2016","unstructured":"Bengtsson-Palme J, Larsson DGJ (2016) Concentration of antibiotics predicted to select for resistant bacteria:Proposed limit for environmental regulation. Environ Int 86:140\u2013149. https:\/\/doi.org\/10.1016\/j.envint.2015.10.015","journal-title":"Environ Int"},{"key":"14178_CR16","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3389\/fmicb.2014.00648","volume":"5","author":"J Bengtsson-Palme","year":"2014","unstructured":"Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DGJ (2014) Shotgun metagenomics reveals a wide array ofantibiotic resistance genes and mobile elements in a polluted lake in India. Front Microbiol 5:648. https:\/\/doi.org\/10.3389\/fmicb.2014.00648","journal-title":"Front Microbiol"},{"key":"14178_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jclepro.2017.09.247","volume":"171","author":"J Bengtsson-Palme","year":"2018","unstructured":"Bengtsson-Palme J, Gunnarsson L, Larsson DGJ (2018) Can branding and price of pharmaceuticals guide informed choices towards improved pollution control during manufacturing? J Clean Prod 171:137\u2013146. https:\/\/doi.org\/10.1016\/j.jclepro.2017.09.247","journal-title":"J Clean Prod"},{"key":"14178_CR18","unstructured":"Best Practice Guidelines for Reducing Transmission of Antibiotic Resistant Organisms (AROs) In Acute &Long Term Care Settings, Home Care & Prehospital Care (2012) Infection Prevention and Control Nova Scotia (IPCNS), Department of Health and Wellness. Available at: https:\/\/ipc.gov.ns.ca\/sites\/default\/files\/BestPracticesGuidelineforAROsAcuteandLTCSettings.pdf. Accessed 22 Apr 2021"},{"key":"14178_CR19","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.mib.2012.07.007","volume":"15","author":"J Bl\u00e1zquez","year":"2012","unstructured":"Bl\u00e1zquez J, Couce A, Rodr\u00edguez-Beltr\u00e1n J, Rodr\u00edguez-Rojas A (2012) Antimicrobials as promoters of genetic variation. Curr Opin Microbiol 15:561\u2013569","journal-title":"Curr Opin Microbiol"},{"key":"14178_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ecoenv.2013.01.016","volume":"91","author":"C Bouki","year":"2013","unstructured":"Bouki C, Venieri D, Diamadopoulos E (2013) Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: a review. Ecotoxicol Environ Saf 91:1\u20139. https:\/\/doi.org\/10.1016\/j.ecoenv.2013.01.016","journal-title":"Ecotoxicol Environ Saf"},{"key":"14178_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.envint.2015.09.013","volume":"85","author":"KK Brandt","year":"2015","unstructured":"Brandt KK, Amezquito A, Backhaus T, Boxall A et al (2015) Ecotoxicological assessment of antibiotics: a call for improved consideration of microorganisms. Environ Int 85:189\u2013205. https:\/\/doi.org\/10.1016\/j.envint.2015.09.013","journal-title":"Environ Int"},{"key":"14178_CR22","doi-asserted-by":"publisher","unstructured":"Brolund A (2014) Overview of ESBL-producing Enterobacteriaceae from a Nordic perspective. Infect Ecol Epidemiol 4. https:\/\/doi.org\/10.3402\/iee.v4.24555","DOI":"10.3402\/iee.v4.24555"},{"key":"14178_CR23","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1007\/s11356-013-1521-4","volume":"20","author":"J Bruchmann","year":"2013","unstructured":"Bruchmann J, Kirchen S, Schwartz T (2013) Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Environ Sci Pollut Res Int 20:3539\u20133549","journal-title":"Environ Sci Pollut Res Int"},{"key":"14178_CR24","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1021\/es020158e","volume":"37","author":"D Calamari","year":"2003","unstructured":"Calamari D, Zuccato E, Castiglioni S, Bagnati R, Fanelli R (2003) Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environ Sci Technol 37:1241\u20131248","journal-title":"Environ Sci Technol"},{"key":"14178_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chemosphere.2014.02.004","volume":"115","author":"O Cardoso","year":"2014","unstructured":"Cardoso O, Porcher JM, Sanchez W (2014) Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge. Chemosphere 115:20\u201330. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.02.004","journal-title":"Chemosphere"},{"key":"14178_CR26","unstructured":"CDC (2019a) Information on Diseases and Organisms in Healthcare Settings, Healthcare Associated Infections ,National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP). Available at: https:\/\/www.cdc.gov\/ncezid\/dhqp\/index.html. Accessed 22 Apr 2021"},{"key":"14178_CR27","unstructured":"CDC (2019b) Antibiotic Resistance Threats in the United States. U.S. Department of Health and Human Services, CDC, Atlanta Available at: https:\/\/www.cdc.gov\/drugresistance\/pdf\/threats-report\/2019-ar-threats-report-508.pdf. Accessed 22 Apr 2021"},{"key":"14178_CR28","doi-asserted-by":"publisher","first-page":"13950","DOI":"10.1007\/s11356-015-4636-y","volume":"22","author":"B Chen","year":"2015","unstructured":"Chen B, Hao L, Guo X, Wang N, Ye B (2015) Prevalence of antibiotic resistance genes of wastewater and surface water in livestock farms of Jiangsu Province, China. Environ Sci Pollut Res 22:13950\u201313959. https:\/\/doi.org\/10.1007\/s11356-015-4636-y","journal-title":"Environ Sci Pollut Res"},{"key":"14178_CR29","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.3389\/fmicb.2017.01133","volume":"8","author":"Z Chen","year":"2017","unstructured":"Chen Z, Yu D, He S, Ye H, Zhang L, Wen Y, Chen S (2017) Prevalence of antibiotic-resistant Escherichia coli in drinking water sources in Hangzhou city. Front Microbiol 8:1133. https:\/\/doi.org\/10.3389\/fmicb.2017.01133","journal-title":"Front Microbiol"},{"key":"14178_CR30","doi-asserted-by":"publisher","unstructured":"Chen D, Liu S, Zhang M, Li S, Wang J (2018) Comparison of the occurrence of antibiotic residues in two rural ponds: implication for ecopharmacovigilance. Environ Monit Assess 190. https:\/\/doi.org\/10.1007\/s10661-018-6883-0","DOI":"10.1007\/s10661-018-6883-0"},{"key":"14178_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jes.2020.05.030","volume":"99","author":"LKM Chow","year":"2021","unstructured":"Chow LKM, Ghaly TM, Gillings MR (2021) A survey of sub-inhibitory concentrations of antibiotics in the environment. J Environ Sci 99:21\u201327","journal-title":"J Environ Sci"},{"key":"14178_CR32","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/10408440903373590","volume":"40","author":"J Corcoran","year":"2010","unstructured":"Corcoran J, Winter MJ, Tyler CR (2010) Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol 40:287\u2013304. https:\/\/doi.org\/10.3109\/10408440903373590","journal-title":"Crit Rev Toxicol"},{"key":"14178_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1574-6976.2009.00165.x","volume":"33","author":"A Couce","year":"2009","unstructured":"Couce A, Blazquez J (2009) Side effects of antibiotics on genetic variability. FEMS Microbiol Rev 33:531\u2013538","journal-title":"FEMS Microbiol Rev"},{"key":"14178_CR34","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fmicb.2019.00338","volume":"10","author":"M Cycon","year":"2019","unstructured":"Cycon M, Mrozik A, Piotrowska-Seget Z (2019) Antibiotics in the soil environment\u2014degradation and their impact on microbial activity and diversity. Front Microbiol 10:338. https:\/\/doi.org\/10.3389\/fmicb.2019.00338","journal-title":"Front Microbiol"},{"key":"14178_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.envint.2015.04.005","volume":"81","author":"N Czekalski","year":"2015","unstructured":"Czekalski N, Sigdel R, Birtel J, Matthews B, B\u00fcrgmann H (2015) Does human activity impact the natural antibiotic resistance background? Abundance of antibiotic resistance genes in 21 Swiss lakes. Environ Int 81:45\u201355. https:\/\/doi.org\/10.1016\/j.envint.2015.04.005","journal-title":"Environ Int"},{"key":"14178_CR36","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.mib.2006.08.006","volume":"9","author":"J Davies","year":"2006","unstructured":"Davies J, Spiegelman GB, Yim G (2006) The world of subinhibitory antibiotic concentrations. Curr Opin Microbiol 9:445\u2013453. https:\/\/doi.org\/10.1016\/j.mib.2006.08.006","journal-title":"Curr Opin Microbiol"},{"key":"14178_CR37","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1590\/s1984-82502012000400017","volume":"48","author":"E Deschamps","year":"2012","unstructured":"Deschamps E, Vasconcelos O, Lange L, Donnici C, Silva M, Sales J (2012) Management of Effluents and Waste from Pharmaceutical Industry in Minas Gerais, Brazil. Braz J Pharm Sci 48:727\u2013736. https:\/\/doi.org\/10.1590\/s1984-82502012000400017","journal-title":"Braz J Pharm Sci"},{"key":"14178_CR38","unstructured":"EMA (2018) Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use (Draft). Available at:\u00a0https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/draft-guideline-environmental-risk-assessment-medicinal-products-human-use-revision-1_en.pdf. Accessed 22 Apr 2021"},{"key":"14178_CR39","unstructured":"EUCAST (2013) [EUCAST] European Committee on Antimicrobial Susceptibility Testing. 2013. Available at: http:\/\/www.eucast.org\/. Accessed on Oct 15 2020"},{"key":"14178_CR40","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chemosphere.2005.02.016","volume":"61","author":"CM Flaherty","year":"2005","unstructured":"Flaherty CM, Dodson SI (2005) Effects of pharmaceuticals on Daphnia survival, growth, and reproduction. Chemosphere 61:200\u2013207. https:\/\/doi.org\/10.1016\/j.chemosphere.2005.02.016","journal-title":"Chemosphere"},{"key":"14178_CR41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12199-015-0468-0","volume":"20","author":"S Fletcher","year":"2015","unstructured":"Fletcher S (2015) Understanding the contribution of environmental factors in the spread of antimicrobial resistance. Environ Health Prev Med 20:243\u2013252. https:\/\/doi.org\/10.1007\/s12199-015-0468-0","journal-title":"Environ Health Prev Med"},{"issue":"6098","key":"14178_CR42","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1126\/science.1220761","volume":"337","author":"KJ Forsberg","year":"2012","unstructured":"Forsberg KJ, Reyes A, Wang B, Selleck EM, Sommer MOA, Dantas G (2012) The shared antibiotic resistome of soil bacteria and human pathogens. Science 337(6098):1107\u20131111. https:\/\/doi.org\/10.1126\/science.1220761","journal-title":"Science"},{"key":"14178_CR43","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1080\/10409230701648494","volume":"42","author":"PL Foster","year":"2007","unstructured":"Foster PL (2007) Stress-induced mutagenesis in bacteria. Crit Rev Biochem Mol Biol 42:373\u2013397. https:\/\/doi.org\/10.1080\/10409230701648494","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"14178_CR44","first-page":"1","volume":"2","author":"BE Franco","year":"2009","unstructured":"Franco BE, Mart\u00ednez MA, S\u00e1nchez Rodr\u00edguez MA, Wertheimer AI (2009) The determinants of the antibiotic resistance process. Infect Drug Resist 2:1\u201311","journal-title":"Infect Drug Resist"},{"key":"14178_CR45","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40545-019-0182-1","volume":"12","author":"S Gandra","year":"2019","unstructured":"Gandra S, Kotwani A (2019) Need to improve availability of \u201caccess\u201d group antibiotics and reduce the use of \u201cwatch\u201d group antibiotics in India for optimum use of antibiotics to contain antimicrobial resistance. J Pharm Pol Pract 12:20. https:\/\/doi.org\/10.1186\/s40545-019-0182-1","journal-title":"J Pharm Pol Pract"},{"key":"14178_CR46","unstructured":"Gandra S, Joshi J, Trett A, Lamkang AS, Laxminarayan R (2017) Scoping report on antimicrobial resistance in India. Center for Disease Dynamics, Economics & Policy, Washington, DC.\u00a0https:\/\/cddep.org\/wp-content\/uploads\/2017\/11\/AMR-INDIA-SCOPING-REPORT.pdf. Accessed 22 Apr 2021"},{"key":"14178_CR47","unstructured":"Global Pharmaceuticals Industry Analysis and Trends 2023 (2019) https:\/\/www.reportlinker.com\/p05750669\/?utm_source=GNW. Accessed on 01 Oct 2020"},{"key":"14178_CR48","doi-asserted-by":"publisher","first-page":"17025","DOI":"10.1073\/pnas.252607699","volume":"99","author":"EB Goh","year":"2002","unstructured":"Goh EB, Yim G, Tsui W, McClure J, Surette MG, Davies J (2002) Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci U S A 99:17025\u201317030. https:\/\/doi.org\/10.1073\/pnas.252607699","journal-title":"Proc Natl Acad Sci U S A"},{"key":"14178_CR49","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0165-2427(85)90075-3","volume":"9","author":"JL Grondel","year":"1985","unstructured":"Grondel JL, Gloudemans AG, Van Muiswinkle WB (1985) The influence of antibiotics on the immune system II. Modulation of fish leukocyte responses in culture. Vet Immunol Immunopathol 9:251\u2013260. https:\/\/doi.org\/10.1016\/0165-2427(85)90075-3","journal-title":"Vet Immunol Immunopathol"},{"key":"14178_CR50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.scitotenv.2013.12.008","volume":"473","author":"P Guerra","year":"2014","unstructured":"Guerra P, Kim M, Shah A, Alaee M, Smyth SA (2014) Occurrence and fate of antibiotic, analgesic\/anti-inflammatory, and anti-fungal compounds in five wastewater treatment processes. Sci Total Environ 473:235\u2013243. https:\/\/doi.org\/10.1016\/j.scitotenv.2013.12.008","journal-title":"Sci Total Environ"},{"key":"14178_CR51","doi-asserted-by":"publisher","first-page":"e1002158","DOI":"10.1371\/journal.ppat.1002158","volume":"7","author":"E Gullberg","year":"2011","unstructured":"Gullberg E, Cao S, Berg OG, Ilb\u00e4ck C, Sandegren L, Hughes D, Andersson DI (2011) Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog 7:e1002158","journal-title":"PLoS Pathog"},{"key":"14178_CR52","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1021\/ac015588m","volume":"74","author":"G Hamscher","year":"2002","unstructured":"Hamscher G, Sczesny S, H\u00f6per H, Nau H (2002) Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Anal Chem 74:1509\u20131518","journal-title":"Anal Chem"},{"key":"14178_CR53","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0048-9697(98)00337-4","volume":"225","author":"R Hirsch","year":"1999","unstructured":"Hirsch R, Ternes T, Haberer K, Kratz KL (1999) Occurrence of antibiotics in the aquatic environment. Sci Total Environ 225:109\u2013118. https:\/\/doi.org\/10.1016\/S0048-9697(98)00337-4","journal-title":"Sci Total Environ"},{"key":"14178_CR54","doi-asserted-by":"publisher","first-page":"11993","DOI":"10.1021\/acs.est.5b02566","volume":"49","author":"PMC Huijbers","year":"2015","unstructured":"Huijbers PMC, Blaak H, De Jong MCM, Graat EAM, Vandenbroucke-Grauls CMJE, Husman AMR (2015) Role of the environment in the transmission of antimicrobial resistance to humans:a review. Environ Sci Technol 49:11993\u201312004. https:\/\/doi.org\/10.1021\/acs.est.5b02566","journal-title":"Environ Sci Technol"},{"key":"14178_CR55","doi-asserted-by":"publisher","first-page":"104880","DOI":"10.1016\/j.envint.2019.05.074","volume":"130","author":"PMC Huijbers","year":"2019","unstructured":"Huijbers PMC, Flach C, Larsson DGJ (2019) A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance. Environ Int 130:104880. https:\/\/doi.org\/10.1016\/j.envint.2019.05.074","journal-title":"Environ Int"},{"key":"14178_CR56","unstructured":"IACG (2018) AMR Indicators and their relevance to the global indicator framework for SDGs and targets for the 2030 Agenda for sustainable development. Available at:\u00a0https:\/\/www.who.int\/antimicrobial-resistance\/interagency-coordination-group\/AMR_SDG_indicators_analysis_slides.pdf. Accessed 22 Apr 2021"},{"key":"14178_CR57","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0003-2670(02)01232-1","volume":"483","author":"S Impens","year":"2003","unstructured":"Impens S, Reybroeck W, Vercammen J (2003) Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS2 and LC-MS2. Anal Chim Acta 483:153\u2013163. https:\/\/doi.org\/10.1016\/S0003-2670(02)01232-1","journal-title":"Anal Chim Acta"},{"key":"14178_CR58","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.envres.2010.06.008","volume":"110","author":"K Ji","year":"2010","unstructured":"Ji K, Kho Y, Park C, Paek D, Ryu P, Paek D, Kim M, Kim P, Choi K (2010) Influence of water and food consumption on inadvertent antibiotics intake among general population. Environ Res 110:641\u2013649","journal-title":"Environ Res"},{"key":"14178_CR59","unstructured":"Jonas Olga B, Irwin Alec, Berthe Franck Cesar Jean, Le Gall Francois G, Marquez Patricio V (2017)Drug-resistant infections : a threat to our economic future (Vol. 2) : final report (English). HNP\/Agriculture Global Antimicrobial Resistance Initiative Washington, D.C.: World Bank Group. http:\/\/documents.worldbank.org\/curated\/en\/323311493396993758\/final-report. Accessed 22 Apr\u00a02021"},{"key":"14178_CR60","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.tim.2017.09.005","volume":"26","author":"A Karkman","year":"2017","unstructured":"Karkman A, Do TT, Walsh F, Virta MPJ (2017) Antibiotic-resistance genes in wastewater. Trends Microbiol 26:220\u2013228. https:\/\/doi.org\/10.1016\/j.tim.2017.09.005","journal-title":"Trends Microbiol"},{"key":"14178_CR61","doi-asserted-by":"publisher","first-page":"e62712","DOI":"10.1371\/journal.pone.0062712","volume":"8","author":"GA Khan","year":"2013","unstructured":"Khan GA, Berglund B, Khan KM, Lindgren PE, Fick J (2013) Occurrence and abundance of antibiotics and resistance genes in rivers, canal and near drug formulation facilities: a study in Pakistan. PLoS One 8:e62712. https:\/\/doi.org\/10.1371\/journal.pone.0062712","journal-title":"PLoS One"},{"key":"14178_CR62","unstructured":"Khurana A, Sinha R (2019) Tackling AMR Starts with the environment. Sanit Environ:78\u201380"},{"key":"14178_CR63","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1021\/es011055j","volume":"36","author":"DW Kolpin","year":"2002","unstructured":"Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999\u22122000: a national reconnaissance. Environ Sci Technol 36:1202\u20131211. https:\/\/doi.org\/10.1021\/es011055j","journal-title":"Environ Sci Technol"},{"key":"14178_CR64","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.envpol.2013.09.013","volume":"184","author":"MS Kostich","year":"2014","unstructured":"Kostich MS, Batt AL, Lazorchak JM (2014) Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the U.S. and implications for risk estimation. Environ Pollut 184:354\u2013359. https:\/\/doi.org\/10.1016\/j.envpol.2013.09.013","journal-title":"Environ Pollut"},{"key":"14178_CR65","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3390\/microorganisms7060180","volume":"7","author":"SA Kraemer","year":"2019","unstructured":"Kraemer SA, Ramachandran A, Perron GG (2019) Antibiotic pollution in the environment: from microbial ecology to public policy. Microorganisms 7:180. https:\/\/doi.org\/10.3390\/microorganisms7060180","journal-title":"Microorganisms"},{"key":"14178_CR66","first-page":"65","volume":"59","author":"R Kumar","year":"2017","unstructured":"Kumar R, Kotwani A (2017) Rising threat of antimicrobial resistance: judicious use of antibiotics is the way forward. Indian J Chest Dis Allied Sci 59:65\u2013166","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"14178_CR67","doi-asserted-by":"publisher","first-page":"20130571","DOI":"10.1098\/rstb.2013.0571","volume":"369","author":"DGJ Larsson","year":"2014","unstructured":"Larsson DGJ (2014) Pollution from drug manufacturing: review and perspectives. Philos Trans R Soc Lond Ser B Biol Sci 369:20130571. https:\/\/doi.org\/10.1098\/rstb.2013.0571","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"14178_CR68","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jhazmat.2007.07.008","volume":"148","author":"DGJ Larsson","year":"2007","unstructured":"Larsson DGJ, Pedro CD, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751\u2013755. https:\/\/doi.org\/10.1016\/j.jhazmat.2007.07.008","journal-title":"J Hazard Mater"},{"key":"14178_CR69","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.envint.2018.04.041","volume":"117","author":"DGJ Larsson","year":"2018","unstructured":"Larsson DGJ, Antoine A, Johan B, Kristian K, Maria A, Husman DR, Fagerstedt P et al (2018) Critical knowledge gaps and research needs related to the environmental imensions of antibiotic resistance. Environ Int 117:132\u2013138. https:\/\/doi.org\/10.1016\/j.envint.2018.04.041","journal-title":"Environ Int"},{"key":"14178_CR70","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.scitotenv.2019.03.372","volume":"671","author":"D Lee","year":"2019","unstructured":"Lee D, Choi K (2019) Comparison of regulatory frameworks of environmental risk assessments for human pharmaceuticals in E.U., USA, and Canada. Sci Total Environ 671:1026\u20131035. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.03.372","journal-title":"Sci Total Environ"},{"key":"14178_CR71","unstructured":"Leo L (2020) Check effluents for antibiotic residue: government to pharma firms [Internet]. Livemint., 2020. Available at:\u00a0https:\/\/www.livemint.com\/news\/india\/govt-urges-pharma-cos-to-be-vigilant-about-pollution-at-manufacturing-pl.\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR72","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1897\/07-080.1","volume":"27","author":"D Li","year":"2008","unstructured":"Li D, Yang M, Hu J et al (2008) Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and receiving river. Environ Toxicol Chem 27:80\u201386. https:\/\/doi.org\/10.1897\/07-080.1","journal-title":"Environ Toxicol Chem"},{"key":"14178_CR73","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.2134\/jeq2015.03.0139","volume":"44","author":"X Li","year":"2015","unstructured":"Li X, Atwill ER, Antaki E, Applegate O, Bergamaschi B, Bond RF, Chase J, Ransom KM, Samuels W, Watanabe N, Harter T (2015) Fecal indicator and pathogenic bacteria and their antibiotic resistance in alluvial groundwater of an irrigated agricultural region with dairies. J Environ Qual 44:1435\u20131447. https:\/\/doi.org\/10.2134\/jeq2015.03.0139","journal-title":"J Environ Qual"},{"key":"14178_CR74","doi-asserted-by":"publisher","first-page":"105007","DOI":"10.1016\/j.envint.2019.105007","volume":"131","author":"B Li","year":"2019","unstructured":"Li B, Qiu Y, Song Y, Lin H, Yin H (2019) Dissecting horizontal and vertical gene transfer of antibiotic resistance plasmid in bacterial community using microfluidics. Environ Int 131:105007. https:\/\/doi.org\/10.1016\/j.envint.2019.105007","journal-title":"Environ Int"},{"key":"14178_CR75","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1016\/j.scitotenv.2009.03.009","volume":"407","author":"AY Lin","year":"2009","unstructured":"Lin AY, Tsai YT (2009) Occurrence of pharmaceuticals in Taiwan\u2019s surface waters: impact of waste streams from hospitals and pharmaceutical production facilities. Sci Total Environ 407:3793\u20133802. https:\/\/doi.org\/10.1016\/j.scitotenv.2009.03.009","journal-title":"Sci Total Environ"},{"key":"14178_CR76","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.chemosphere.2008.08.027","volume":"74","author":"AY Lin","year":"2008","unstructured":"Lin AY, Yu TH, Lin CF (2008) Pharmaceutical contamination in residential, industrial, and agricultural waste streams: risk to aqueous environments in Taiwan. Chemosphere 74:131\u2013141. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.08.027","journal-title":"Chemosphere"},{"key":"14178_CR77","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.chnaes.2018.01.006","volume":"38","author":"L Liu","year":"2018","unstructured":"Liu L, Wu W, Zhang J, Lv P, Xu L, Yan Y (2018) Progress of research on the toxicology of antibiotic pollution in aquatic organisms. Acta Ecol Sin 38:36\u201341","journal-title":"Acta Ecol Sin"},{"key":"14178_CR78","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/s0021-9673(03)00059-1","volume":"1000","author":"D Loffler","year":"2003","unstructured":"Loffler D, Ternes TA (2003) Analytical method for the determination of the aminoglycoside gentamicin in hospital wastewater via liquid chromatography electrospraytandem mass spectrometry. J Chromatogr A 1000:583\u2013588. https:\/\/doi.org\/10.1016\/s0021-9673(03)00059-1","journal-title":"J Chromatogr A"},{"key":"14178_CR79","doi-asserted-by":"publisher","first-page":"e71001","DOI":"10.1371\/journal.pone.0071001","volume":"8","author":"C L\u00f3pez-Causap\u00e9","year":"2013","unstructured":"L\u00f3pez-Causap\u00e9 C, Rojo-Molinero E, Mulet X, Cabot G, Moy\u00e0 B, Figuerola J, Togores B, P\u00e9rez JL, Oliver A (2013) Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in pseudomonas aeruginosa cystic fibrosis chronic lung infection. PLoS One 8:e71001. https:\/\/doi.org\/10.1371\/journal.pone.0071001","journal-title":"PLoS One"},{"key":"14178_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7851354","volume":"2019","author":"AR Mahmood","year":"2019","unstructured":"Mahmood AR, Al-haideri HH, Hassan FM (2019) Detection of antibiotics in drinking water treatment plants in Baghdad City, Iraq. Adv Public Health 2019:1\u201310. https:\/\/doi.org\/10.1155\/2019\/7851354","journal-title":"Adv Public Health"},{"issue":"3","key":"14178_CR81","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.tim.2016.11.014","volume":"25","author":"CM Manaia","year":"2017","unstructured":"Manaia CM (2017) Assessing the risk of antibiotic resistance transmission from the environment to humans: non-direct proportionality between abundance and risk. Trends Microbiol 25(3):173\u2013181","journal-title":"Trends Microbiol"},{"key":"14178_CR82","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s00253-015-7202-0","volume":"100","author":"CM Manaia","year":"2016","unstructured":"Manaia CM, Macedo G, Fatta-Kassinos D, Nunes OC (2016) Antibiotic resistance in urban aquatic environments: can it be controlled? Appl Microbiol Biotechnol 100:1543\u20131557. https:\/\/doi.org\/10.1007\/s00253-015-7202-0","journal-title":"Appl Microbiol Biotechnol"},{"key":"14178_CR83","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1098\/rspb.2009.0320","volume":"276","author":"JL Martinez","year":"2009","unstructured":"Martinez JL (2009) The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc Biol Sci 276:2521\u20132530. https:\/\/doi.org\/10.1098\/rspb.2009.0320","journal-title":"Proc Biol Sci"},{"key":"14178_CR84","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez JL (2017) Effect of antibiotics on bacterial populations: a multi-hierarchical selection process. F1000Research 6. https:\/\/doi.org\/10.12688\/f1000research.9685.1","DOI":"10.12688\/f1000research.9685.1"},{"key":"14178_CR85","doi-asserted-by":"publisher","unstructured":"Meersche TVD, Rasschaert G, Nest TV, Haesebrouck F, Herman L et al (2020) Longitudinal screening of antibiotic residues, antibiotic resistance genes and zoonotic bacteria in soils fertilized with pig manure. Environ Sci Pollut Res:28016\u201328029. https:\/\/doi.org\/10.1007\/s11356-020-09119-y","DOI":"10.1007\/s11356-020-09119-y"},{"key":"14178_CR86","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/S0043-1354(96)00412-5","volume":"31","author":"L Migliore","year":"1997","unstructured":"Migliore L, Civitareale C, Brambilla G, Dojmi Di Delupis G (1997) Toxicity of several important agriculturalantibiotics to Artemia. Water Res 31:1801\u20131806. https:\/\/doi.org\/10.1016\/S0043-1354(96)00412-5","journal-title":"Water Res"},{"key":"14178_CR87","unstructured":"Ministry of Environment, Forest & Climate Change (2020) Available at: http:\/\/moef.gov.in\/wp-content\/uploads\/2020\/01\/finalization.pdfAvailable at: http:\/\/moef.gov.in\/wp-content\/uploads\/2020\/01\/finalization.pdf. Accessed on 26 Mar 2020"},{"key":"14178_CR88","unstructured":"Nahar S (2020) Understanding How The Indian Pharmaceutical Industry Works \u2013 Part 2. https:\/\/www.alphainvesco.com\/blog\/understanding-how-the-indian-pharmaceutical-industry-works-part-2\/. Accessed on 05 Oct 2020"},{"key":"14178_CR89","unstructured":"Norwegian Environment Agency (2005) http:\/\/www.miljodirektoratet.no\/no\/Nyheter\/Nyheter\/Old-klif\/2005\/September\/Nye_antibiotikautslipp_fra_Alpharma_i_Oslo\/. Accessed on 27 Sept 2020"},{"key":"14178_CR90","unstructured":"O'Neill J (2016) The Review on Antimicrobial Resistance-Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Available at: https:\/\/amr-review.org\/sites\/default\/files\/160518_Finalpaper_withcover.pdf.\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR91","first-page":"278","volume":"4","author":"S Pareek","year":"2015","unstructured":"Pareek S, Mathur N, Singh A, Nepalia A (2015) Antibiotics in the environment: a review. Int J Curr Microbiol App Sci 4:278\u2013285","journal-title":"Int J Curr Microbiol App Sci"},{"key":"14178_CR92","unstructured":"Patel JB (2017) Performance standards for antimicrobial susceptibility testing. Clinical and laboratory standards institute"},{"key":"14178_CR93","doi-asserted-by":"crossref","unstructured":"Peake BM, Braund R, Tong AYC, Tremblay LA (2016) Impact of pharmaceuticals on the environment. In: The life-cycle of pharmaceuticals in the environment. Woodhead Publisher, pp 109\u2013152","DOI":"10.1016\/B978-1-907568-25-1.00005-0"},{"key":"14178_CR94","unstructured":"Pharma Compass (2016) An Inconvenient Truth about Chinese Drug Manufacturing Available at : http:\/\/www.pharmacompass.com\/radio-compass-blog\/an-inconve-nient-truth-about-chinese-drug-manufacturing. Accessed on 20 Sept 2020"},{"key":"14178_CR95","doi-asserted-by":"publisher","first-page":"4910","DOI":"10.1021\/es100356f","volume":"44","author":"PJ Phillips","year":"2010","unstructured":"Phillips PJ, Smith SG, Kolpin DW, Zaugg SD, Buxton HT, Furlong ET, Esposito K, Stinson B (2010) Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environ Sci Technol 44:4910\u20134916. https:\/\/doi.org\/10.1021\/es100356f","journal-title":"Environ Sci Technol"},{"key":"14178_CR96","unstructured":"Rader RA, Langer ES (2018) Worldwide Biopharmaceutical Manufacturing Capacity Analysis: Growth Continues Across the Board, Bioprocess International. Available at:\u00a0https:\/\/bioprocessintl.com\/business\/economics\/worldwide-biopharmaceutical-manufacturing-capacity-analysis-growth-continues-across-the-board\/.\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR97","unstructured":"Rees V (2020) Limiting antibiotic manufacturing discharge in Indian wastewater (2020) Available at: https:\/\/www.europeanpharmaceuticalreview.com\/article\/115074\/limiting-antibiotic-manufacturing-discharge-in-indian-wastewater\/. Accessed on 29 Sept 2020"},{"key":"14178_CR98","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","volume":"447","author":"L Rizzo","year":"2013","unstructured":"Rizzo L, Manaia C, Merlin C, Schwartz T, Dagot C, Ploy MC, Michael I, Fatta-Kassinos D (2013) Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. Sci Total Environ 447:345\u2013360","journal-title":"Sci Total Environ"},{"key":"14178_CR99","doi-asserted-by":"publisher","first-page":"105733","DOI":"10.1016\/j.envint.2020.105733","volume":"140","author":"S Rodriguez-Mozaz","year":"2020","unstructured":"Rodriguez-Mozaz S, Vaz-Moreira I, Varela Della Giustina S, Llorca M, Barcel\u00f3 D, Schubert S, Berendonk TU, Michael-Kordatou I, Fatta-Kassinos D, Martinez JL, Elpers C, Henriques I, Jaeger T, Schwartz T, Paulshus E, O'Sullivan K, P\u00e4rn\u00e4nen KMM, Virta M, Do TT, Walsh F, Manaia CM (2020) Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment. Environ Int 140:105733. https:\/\/doi.org\/10.1016\/j.envint.2020.105733","journal-title":"Environ Int"},{"key":"14178_CR100","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1073\/pnas.1316084111","volume":"111","author":"MA Sanchez-Romero","year":"2013","unstructured":"Sanchez-Romero MA, Casadesus J (2013) Contribution of phenotypic heterogeneity to adaptive antibiotic resistance. Proc Natl Acad Sci U S A 111:355\u2013360. https:\/\/doi.org\/10.1073\/pnas.1316084111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"14178_CR101","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3109\/03009734.2014.904457","volume":"119","author":"L Sandegren","year":"2014","unstructured":"Sandegren L (2014) Selection of antibiotic resistance at very low antibiotic concentrations. Ups J Med Sci 119:103\u2013107","journal-title":"Ups J Med Sci"},{"key":"14178_CR102","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.3390\/w12123313","volume":"12","author":"L Serwecinska","year":"2020","unstructured":"Serwecinska L (2020) Antimicrobials and antibiotic-resistant bacteria: a risk to the environment and to public health: a review. Water 12:3313. https:\/\/doi.org\/10.3390\/w12123313www.mdpi.com\/journal\/water","journal-title":"Water"},{"key":"14178_CR103","unstructured":"Shanghai Daily (2012) H.K. Drug maker accused of destroying lake. Available at: https:\/\/archive.shine.cn\/nation\/HK-drug-maker-accused-of-destroying-lake\/shdaily.shtml. Accessed on 25 Sept 2020"},{"key":"14178_CR104","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.chemosphere.2010.10.026","volume":"82","author":"W-J Sim","year":"2011","unstructured":"Sim W-J, Lee J-W, Lee E-S, Shin S-K, Hwang S-R, Oh J-E (2011) Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. Chemospere 82:179\u2013186. https:\/\/doi.org\/10.1016\/j.chemosphere.2010.10.026","journal-title":"Chemospere"},{"key":"14178_CR105","doi-asserted-by":"publisher","unstructured":"Singer AC, Shaw H, Rhodes V, Hart A (2016) Review of antimicrobial resistance in the environment and its relevance to environmental regulators. Front Microbiol 7. https:\/\/doi.org\/10.3389\/fmicb.2016.01728","DOI":"10.3389\/fmicb.2016.01728"},{"key":"14178_CR106","unstructured":"SIWI (2020) New initiative to tackle antimicrobial resistance in manufacturing. Available at: New initiative to tackle antimicrobial resistance in manufacturing - Stockholm International Water Institute (siwi.org).\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR107","unstructured":"SPHS (2020) UN informal interagency task team on sustainable procurement in the global health sector. Available at: UN informal Interagency Task Team on Sustainable Procurement in the Health Sector (savinglivesustainably.org).\u00a0Accessed 22 Apr 2021"},{"key":"14178_CR108","first-page":"344","volume":"41","author":"KM Swapna","year":"2012","unstructured":"Swapna KM, Rajesh R, Lakshmanan PT (2012) incidence of antibiotic residues in farmed shrimps from the southern states of India. Indian J GeoMar Sci 41:344\u2013347","journal-title":"Indian J GeoMar Sci"},{"key":"14178_CR109","doi-asserted-by":"publisher","unstructured":"Tamhankar AJ, Lundborg CS (2019) Antimicrobials and antimicrobial resistance in the environment and its remediation: a global one health perspective. Int J Environ Res Public Health 16. https:\/\/doi.org\/10.3390\/ijerph16234614","DOI":"10.3390\/ijerph16234614"},{"key":"14178_CR110","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.scitotenv.2018.07.126","volume":"645","author":"P Thai","year":"2018","unstructured":"Thai P, Ky L, Binh V, Nhung P, Nhan P, Hieu N et al (2018) Occurrence of antibiotic residues and antibiotic-resistant bacteria in effluents of pharmaceutical manufacturers and other sources around Hanoi, Vietnam. Sci Total Environ 645:393\u2013400. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.07.126","journal-title":"Sci Total Environ"},{"key":"14178_CR111","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.chemosphere.2008.10.051","volume":"74","author":"L Tong","year":"2009","unstructured":"Tong L, Li P, Zhu K (2009) Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPE-LC\/MS\/MS. Chemosphere 74:1090\u20131097. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.10.051","journal-title":"Chemosphere"},{"key":"14178_CR112","doi-asserted-by":"publisher","first-page":"31995","DOI":"10.1007\/s11356-020-09487-5","volume":"27","author":"L Tong","year":"2020","unstructured":"Tong L, Qin L, Guan C, Wilson ME, Li X, Cheng D, Ma J, Liu H (2020) Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China. Environ Sci Pollut Res Int 27:31995\u201332005. https:\/\/doi.org\/10.1007\/s11356-020-09487-5","journal-title":"Environ Sci Pollut Res Int"},{"key":"14178_CR113","doi-asserted-by":"publisher","unstructured":"Topp E, Larsson J, Miller D, Van den Eede C, Virta M (2018) Antimicrobial resistance and the environment: assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing. FEMS. Microb Ecol 94. https:\/\/doi.org\/10.1093\/femsec\/fix185","DOI":"10.1093\/femsec\/fix185"},{"key":"14178_CR114","unstructured":"Tripartite Plus Recent Update and Memorandum of Understanding on Antimicrobial Resistance (2018) https:\/\/www.who.int\/antimicrobial-resistance\/interagency-coordinationgroup\/Tripartite_Plus_update_info_session_011018.pdf?ua=1. Accessed on 01 Oct 2020"},{"key":"14178_CR115","unstructured":"Turner S (2020) Antimicrobial resistance: is pharmaceutical pollution creating superbugs? Available at: https:\/\/www.pharmaceutical-technology.com\/features\/antimicrobial-resistance-superbugs\/. Accessed on 26 Sept 2020"},{"key":"14178_CR116","unstructured":"UNEP (2017) Emerging Issues of Environmental Concern. United Nations Environment Programme, Nairobi. Frontiers. Available at: https:\/\/wedocs.unep.org\/bitstream\/%0Ahandle\/20.500.11822\/22255\/Frontiers_2017_EN.pdf. Accessed on 01 Oct 2020"},{"key":"14178_CR117","unstructured":"United Nations (U.N.) Interagency Task Team on Sustainable Procurement in the Health Sector (SPHS). Available at https:\/\/savinglivesustainably.org\/who-we-are. Accessed on 18 Dec 2020"},{"issue":"4","key":"14178_CR118","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1111\/1574-6976.12062","volume":"38","author":"I Vaz-Moreira","year":"2014","unstructured":"Vaz-Moreira I, Nunes OC, Manaia CM (2014) Bacterial diversity and antibiotic resistance in water habitats: searching the links with the human microbiome.FEMS. Microbiol Rev 38(4):761\u2013778. https:\/\/doi.org\/10.1111\/1574-6976.12062","journal-title":"Microbiol Rev"},{"key":"14178_CR119","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","volume":"429","author":"P Verlicchi","year":"2012","unstructured":"Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment\u2014a review. Sci Total Environ 429:123\u2013155","journal-title":"Sci Total Environ"},{"issue":"4","key":"14178_CR120","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1021\/acs.accounts.8b00643","volume":"52","author":"P Vikesland","year":"2019","unstructured":"Vikesland P, Garner E, Gupta S, Kang S, Maile-Moskowitz A, Zhu N (2019) Differential drivers of antimicrobial resistance across the world. Acc Chem Res 52(4):916\u2013924. https:\/\/doi.org\/10.1021\/acs.accounts.8b00643","journal-title":"Acc Chem Res"},{"key":"14178_CR121","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.envpol.2010.03.019","volume":"158","author":"Q-JY Wang","year":"2010","unstructured":"Wang Q-JY, Mo C-H, Li Y-W, Gao P, Tai Y-P, Zhang Y, Ruan Z-L, Xu J-W (2010) Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao. Environ Pollut 158:2350\u20132358","journal-title":"Environ Pollut"},{"key":"14178_CR122","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/tox.21843","volume":"29","author":"H Wang","year":"2014","unstructured":"Wang H, Che B, Duan A, Mao J, Dahlgren RA, Zhang M, Zhang H, Zeng A, Wang X (2014) Toxicity evaluation of \u03b2-diketone antibiotics on the development of embryo-larval zebrafish (Danio rerio). Environ Toxicol 29:1134\u20131146. https:\/\/doi.org\/10.1002\/tox.21843","journal-title":"Environ Toxicol"},{"key":"14178_CR123","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/j.chemosphere.2010.11.067","volume":"82","author":"R Wei","year":"2011","unstructured":"Wei R, Ge F, Huang S, Chen M, Wang R (2011) Ocurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China. Chemosphere 82:1408\u20131414. https:\/\/doi.org\/10.1016\/j.chemosphere.2010.11.067","journal-title":"Chemosphere"},{"key":"14178_CR124","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1016\/S0038-0717(01)00134-1","volume":"33","author":"K Westergaard","year":"2001","unstructured":"Westergaard K, M\u00fcller AK, Christensen S, Bloem J, S\u00f8rensen SJ (2001) Effects of tylosin as a disturbance onthe soil microbial community. Soil Biol Biochem 33:2061\u20132071. https:\/\/doi.org\/10.1016\/S0038-0717(01)00134-1","journal-title":"Soil Biol Biochem"},{"key":"14178_CR125","unstructured":"WHO (2011) Local Production and Access to Medicines in Low- and Middle-Income Countries. Available at: https:\/\/www.who.int\/phi\/publications\/Local_Production_Literature_Review.pdf. Accessed on 29 Sept 2020"},{"key":"14178_CR126","unstructured":"WHO (2019) Environmental Aspects of Good Manufacturing Practices: Points to Consider for Manufacturers and Inspectors in the Prevention of Antimicrobial Resistance. Available at: https:\/\/www.who.int\/medicines\/areas\/quality_safety\/quality_assurance\/qas19_802_environmental_aspects_of_GMP.pdf?ua=1. Accessed on 01 Oct 2020"},{"key":"14178_CR127","unstructured":"WHO (2020) Antimicrobial Resistance. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance. Accessed on 28 Sept 2020"},{"key":"14178_CR128","doi-asserted-by":"publisher","first-page":"4526","DOI":"10.1016\/j.watres.2007.06.023","volume":"41","author":"W Xu","year":"2007","unstructured":"Xu W, Zhang G, Li XD (2007) Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China. Water Res 41:4526\u20134534. https:\/\/doi.org\/10.1016\/j.watres.2007.06.023","journal-title":"Water Res"},{"key":"14178_CR129","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.chemosphere.2014.02.040","volume":"119","author":"J Xu","year":"2015","unstructured":"Xu J, Xu Y, Wang H, Guo C, Qiu H, He Y, Zhang Y, Li X, Meng W (2015) Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river. Chemosphere 119:1379\u20131385","journal-title":"Chemosphere"},{"key":"14178_CR130","doi-asserted-by":"publisher","first-page":"18222","DOI":"10.1007\/s11356-016-7018-1","volume":"23","author":"Z Yan","year":"2016","unstructured":"Yan Z, Lu G, Ye Q, Liu J (2016) Long-term effects of antibiotics, norfloxacin, and sulfamethoxazole, in a partial life-cycle study with zebrafish (Danio rerio): effects on growth, development, and reproduction. Environ Sci Pollut Res 23:18222\u201318228. https:\/\/doi.org\/10.1007\/s11356-016-7018-1","journal-title":"Environ Sci Pollut Res"},{"key":"14178_CR131","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/tox.22087","volume":"31","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Wang X, Yin X, Shi M, Dahlgren RA, Wang H (2016) Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish (Danio rerio). Environ Toxicol 31:736\u2013750. https:\/\/doi.org\/10.1002\/tox.22087","journal-title":"Environ Toxicol"},{"key":"14178_CR132","doi-asserted-by":"publisher","first-page":"105914","DOI":"10.1016\/j.envint.2020.105914","volume":"143","author":"W Zielinski","year":"2020","unstructured":"Zielinski W, Korzeniewska E, Harnisz M, Hubeny J, Buta M, Rolbiecki D (2020) The prevalence of drug-resistant and virulent Staphylococcus spp. in a municipal wastewater treatment plant and their spread in the environment. Environ Int 143:105914. https:\/\/doi.org\/10.1016\/j.envint.2020.105914","journal-title":"Environ Int"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-14178-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-14178-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-14178-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:00:54Z","timestamp":1744174854000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-14178-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":132,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["14178"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-14178-w","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]},"assertion":[{"value":"21 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}