{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:02:39Z","timestamp":1783353759791,"version":"3.54.6"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"48","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31873031"],"award-info":[{"award-number":["31873031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2017YFD0502200"],"award-info":[{"award-number":["2017YFD0502200"]}]},{"name":"Tibet Agricultural and Animal Husbandry University flexible introduction of talent project funding"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11356-021-15286-3","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T01:02:31Z","timestamp":1626397351000},"page":"68288-68299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chlorogenic acid inhibits apoptosis in thiram-induced tibial dyschondroplasia via intrinsic pathway"],"prefix":"10.1007","volume":"28","author":[{"given":"Jialu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Waqas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fakhar-e-Alam","family":"Kulyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangkang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-6648","authenticated-orcid":false,"given":"Jiakui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"15286_CR1","doi-asserted-by":"crossref","unstructured":"Ahmed M, Mohanad M, Ahmed A, Aboulhoda B, El-Awdan S (2021): Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: modulation of the cross talk between autophagy and apoptosis signaling. Life Sci., 119370","DOI":"10.1016\/j.lfs.2021.119370"},{"key":"15286_CR2","doi-asserted-by":"crossref","unstructured":"Arnold A, Dennison E, Kovacs C, Mannstadt M, Rizzoli R, Brandi M, Clarke B, Thakker R (2021): Hormonal regulation of biomineralization. Nature Reviews Endocrinology. 17(5):261\u2013275","DOI":"10.1038\/s41574-021-00477-2"},{"key":"15286_CR3","first-page":"117","volume":"5","author":"A Caplan","year":"1987","unstructured":"Caplan A (1987) The cellular and molecular embryology of bone formation. Bone Miner. Res. 5:117\u2013183","journal-title":"Bone Miner. Res."},{"key":"15286_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.intimp.2010.09.021","volume":"11","author":"W-P Chen","year":"2011","unstructured":"Chen W-P, Tang J-L, Bao J-P, Hu P-F, Shi Z-L, Wu L-D (2011) Anti-arthritic effects of chlorogenic acid in interleukin-1\u03b2-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int. Immunopharmacol. 11:23\u201328","journal-title":"Int. Immunopharmacol."},{"key":"15286_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4161\/cc.9.1.10420","volume":"9","author":"C da Costa","year":"2010","unstructured":"da Costa C, Checler F (2010) A novel parkin-mediated transcriptional function links p53 to familial Parkinson ' s disease. Cell cycle 9:16\u201317","journal-title":"Cell cycle"},{"key":"15286_CR6","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1158\/1078-0432.CCR-16-2172","volume":"23","author":"A Derakhshan","year":"2017","unstructured":"Derakhshan A, Chen Z, Van Waes C (2017) Therapeutic small molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways. Clinical Cancer Research 23:1379\u20131387","journal-title":"Clinical Cancer Research"},{"key":"15286_CR7","doi-asserted-by":"crossref","unstructured":"Dies H, Siampani M, Escobedo C, Docoslis A (2018): Direct detection of toxic contaminants in minimally processed food products using dendritic surface-enhanced raman scattering substrates. Sensors (Basel, Switzerland) 18","DOI":"10.3390\/s18082726"},{"key":"15286_CR8","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.neuro.2007.04.008","volume":"28","author":"LM Domico","year":"2007","unstructured":"Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28:1079\u20131091","journal-title":"Neurotoxicology"},{"key":"15286_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","volume":"102","author":"C Du","year":"2000","unstructured":"Du C, Fang M, Li Y, Li L, Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33\u201342","journal-title":"Cell"},{"key":"15286_CR10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/cdd.2009.33","volume":"16","author":"A Eisenberg-Lerner","year":"2009","unstructured":"Eisenberg-Lerner A, Bialik S, Simon H, Kimchi A (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 16:966\u2013975","journal-title":"Cell Death Differ."},{"key":"15286_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/aja.1001860404","volume":"186","author":"C Farnum","year":"1989","unstructured":"Farnum C, Wilsman N (1989) Condensation of hypertrophic chondrocytes at the chondro-osseous junction of growth plate cartilage in Yucatan swine: relationship to long bone growth. The American Journal of Anatomy 186:346\u2013358","journal-title":"The American Journal of Anatomy"},{"key":"15286_CR12","doi-asserted-by":"publisher","first-page":"330","DOI":"10.18632\/aging.100459","volume":"4","author":"B Favaloro","year":"2012","unstructured":"Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V (2012) Role of apoptosis in disease. Aging 4:330\u2013349","journal-title":"Aging"},{"key":"15286_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jhazmat.2014.06.051","volume":"279","author":"OM Filipe","year":"2014","unstructured":"Filipe OM, Santos SA, Domingues MRM, Vidal MM, Silvestre AJ, Santos EB (2014) Effect of copper ions on the degradation of thiram in aqueous solution: identification of degradation products by HPLC\u2013MS\/MS. J. Hazard. Mater. 279:125\u2013132","journal-title":"J. Hazard. Mater."},{"key":"15286_CR14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cdd.2011.96","volume":"19","author":"L Galluzzi","year":"2012","unstructured":"Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, el-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nu\u00f1ez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell death differentiation 19:107\u2013120","journal-title":"Cell death differentiation"},{"key":"15286_CR15","doi-asserted-by":"publisher","first-page":"119324","DOI":"10.1016\/j.lfs.2021.119324","volume":"274","author":"Q Ge","year":"2021","unstructured":"Ge Q, Ying J, Shi Z, Mao Q, Jin H, Wang P, Chen J, Yuan W, Tong P, Li J (2021) Chlorogenic acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-\u03baB signaling. Life Sci. 274:119324","journal-title":"Life Sci."},{"key":"15286_CR16","first-page":"878","volume":"22","author":"M Halimah","year":"2010","unstructured":"Halimah M, Zulkifli H, Vijaya S, Tan Y, Wei P, Let C, May C (2010) Life cycle assessment of oil palm seedling production (Part 1). Journal of Oil Palm Research 22:878\u2013886","journal-title":"Journal of Oil Palm Research"},{"key":"15286_CR17","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1136\/ard.59.12.959","volume":"59","author":"F H\u00e9raud","year":"2000","unstructured":"H\u00e9raud F, H\u00e9raud A, Harmand M (2000) Apoptosis in normal and osteoarthritic human articular cartilage. Ann. Rheum. Dis. 59:959\u2013965","journal-title":"Ann. Rheum. Dis."},{"key":"15286_CR18","doi-asserted-by":"publisher","first-page":"103831","DOI":"10.1016\/j.dci.2020.103831","volume":"114","author":"A Jahejo","year":"2021","unstructured":"Jahejo A, Jia F, Raza S, Shah M, Yin J, Ahsan A, Waqas M, Niu S, Ning G, Zhang D, Khan A, Tian W (2021) Screening of toll-like receptor signaling pathway-related genes and the response of recombinant glutathione S-transferase A3 protein to thiram induced apoptosis in chicken erythrocytes. Developmental and Comparative Immunology 114:103831","journal-title":"Developmental and Comparative Immunology"},{"key":"15286_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/cdd.2011.121","volume":"19","author":"T Kaufmann","year":"2012","unstructured":"Kaufmann T, Strasser A, Jost P (2012) Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differentiation 19:42\u201350","journal-title":"Cell Death Differentiation"},{"key":"15286_CR20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.fct.2016.10.027","volume":"98","author":"S Kaur","year":"2016","unstructured":"Kaur S, Kumar M, Kaur P, Kaur V, Kaur S (2016) Modulatory effects of Cassia fistula fruits against free radicals and genotoxicity of mutagens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 98:220\u2013231","journal-title":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"},{"key":"15286_CR21","doi-asserted-by":"crossref","unstructured":"Kaur S, Kumar A, Thakur S, Kumar K, Sharma R, Sharma A, Singh P, Sharma U, Kumar S, Landi M, Bresti\u010d M, Kaur S (2020a): Cassia fistula antioxidant, antiproliferative and apoptosis-inducing efficacy of fractions from L. leaves. Antioxidants (Basel, Switzerland) 9(2):173","DOI":"10.3390\/antiox9020173"},{"key":"15286_CR22","doi-asserted-by":"publisher","first-page":"32017","DOI":"10.1007\/s11356-020-08916-9","volume":"27","author":"S Kaur","year":"2020","unstructured":"Kaur S, Pandit K, Chandel M, Kaur S (2020b) Antiproliferative and apoptogenic effects of Cassia fistula L. n-hexane fraction against human cervical cancer (HeLa) cells. Environ. Sci. Pollut. Res. Int. 27:32017\u201332033","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"15286_CR23","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/cdd.2011.17","volume":"18","author":"P Kelly","year":"2011","unstructured":"Kelly P, Strasser A (2011) The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell death differentiation 18:1414\u20131424","journal-title":"Cell death differentiation"},{"key":"15286_CR24","doi-asserted-by":"crossref","unstructured":"Kopeina G, Zhivotovsky B (2021): Caspase-2 as a master regulator of genomic stability. Trends Cell Biol.","DOI":"10.1016\/j.tcb.2021.03.002"},{"key":"15286_CR25","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1136\/ard.2004.034090","volume":"64","author":"M L\u00f3pez-Armada","year":"2005","unstructured":"L\u00f3pez-Armada M, Caram\u00e9s B, Cillero-Pastor B, Lires-De\u00e1n M, Maneiro E, Fuentes I, Ru\u00edz C, Galdo F, Blanco F (2005) Phosphatase-1 and -2A inhibition modulates apoptosis in human osteoarthritis chondrocytes independently of nitric oxide production. Ann. Rheum. Dis. 64:1079\u20131082","journal-title":"Ann. Rheum. Dis."},{"key":"15286_CR26","doi-asserted-by":"crossref","unstructured":"Pimentel A, Ure\u00f1a-Torres P, Bover J, Luis Fernandez-Mart\u00edn J, Cohen-Solal M (2020): Bone fragility fractures in CKD patients. Calcif. Tissue Int.","DOI":"10.1007\/s00223-020-00779-z"},{"key":"15286_CR27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.2307\/1592578","volume":"42","author":"N Rath","year":"1998","unstructured":"Rath N, Huff W, Bayyari G, Balog J (1998) Cell death in avian tibial dyschondroplasia. Avian Dis. 42:72\u201379","journal-title":"Avian Dis."},{"key":"15286_CR28","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/ps\/83.2.266","volume":"83","author":"N Rath","year":"2004","unstructured":"Rath N, Huff W, Balog J, Huff G (2004) Comparative efficacy of different dithiocarbamates to induce tibial dyschondroplasia in poultry. Poultr. Sci. 83:266\u2013274","journal-title":"Poultr. Sci."},{"key":"15286_CR29","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/jaoac\/83.1.196","volume":"83","author":"BD Ripley","year":"2000","unstructured":"Ripley BD, Lissemore LI, Leishman PD, Denomm\u00e9 MA, Ritter L (2000) Pesticide residues on fruits and vegetables from Ontario, Canada, 1991\u20131995. J. AOAC Int. 83:196\u2013213","journal-title":"J. AOAC Int."},{"key":"15286_CR30","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3382\/ps.0720798","volume":"72","author":"K Roberson","year":"1993","unstructured":"Roberson K, Hill C, Ferket P (1993) Additive amelioration of tibial dyschondroplasia in broilers by supplemental calcium or feed deprivation. Poultr. Sci. 72:798\u2013805","journal-title":"Poultr. Sci."},{"key":"15286_CR31","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/ps.4844","volume":"74","author":"T Thind","year":"2018","unstructured":"Thind T, Hollomon D (2018) Thiocarbamate fungicides: reliable tools in resistance management and future outlook. Pest Manage. Sci. 74:1547\u20131551","journal-title":"Pest Manage. Sci."},{"key":"15286_CR32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/1471-2164-14-276","volume":"14","author":"W Tian","year":"2013","unstructured":"Tian W, Li J, Qin P, Wang R, Ning G, Qiao J, Li H, Bi D, Pan S, Guo D (2013) Screening of differentially expressed genes in the growth plate of broiler chickens with tibial dyschondroplasia by microarray analysis. BMC Genomics 14:276","journal-title":"BMC Genomics"},{"key":"15286_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/sj.cr.7310028","volume":"16","author":"MF Van Delft","year":"2006","unstructured":"Van Delft MF, Huang DC (2006) How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res. 16:203\u2013213","journal-title":"Cell Res."},{"key":"15286_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.aca.2020.09.032","volume":"1139","author":"Z Wang","year":"2020","unstructured":"Wang Z, Yang L, Ye X, Huang C, Yang W, Zhang L, Wu Z, Fu F (2020) Multicolor visual screening of total dithiocarbamate pesticides in foods based on sulfydryl-mediated growth of gold nanobipyramids. Anal. Chim. Acta 1139:59\u201367","journal-title":"Anal. Chim. Acta"},{"key":"15286_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","volume":"72","author":"R Whelan","year":"2010","unstructured":"Whelan R, Kaplinskiy V, Kitsis R (2010) Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu. Rev. Physiol. 72:19\u201344","journal-title":"Annu. Rev. Physiol."},{"key":"15286_CR36","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/iub.51","volume":"60","author":"W Wong","year":"2008","unstructured":"Wong W, Puthalakath H (2008) Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. IUBMB life 60:390\u2013397","journal-title":"IUBMB life"},{"key":"15286_CR37","doi-asserted-by":"publisher","first-page":"7489","DOI":"10.1039\/C9FO00502A","volume":"10","author":"M Xu","year":"2019","unstructured":"Xu M, Yang L, Zhu Y, Liao M, Chu L, Li X, Lin L, Zheng G (2019) Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPK\u03b1-LXR\u03b1\/SREBP-1c pathway in high-fat diet-induced obese mice. Food function 10:7489\u20137497","journal-title":"Food function"},{"key":"15286_CR38","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jchromb.2018.05.045","volume":"1092","author":"X Yao","year":"2018","unstructured":"Yao X, Xu J, Hao J, Wan Y, Chen T, Zhang D, Li L (2018) Microwave assisted extraction for the determination of chlorogenic acid in Flos Lonicerae by direct analysis in real time mass spectrometry (DART-MS). Journal of Chromatography B, Analytical technologies in the biomedical and life sciences 1092:82\u201387","journal-title":"Journal of Chromatography B, Analytical technologies in the biomedical and life sciences"},{"key":"15286_CR39","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1007\/s00204-021-03030-2","volume":"95","author":"L You","year":"2021","unstructured":"You L, Zhao Y, Kuca K, Wang X, Oleksak P, Chrienova Z, Nepovimova E, Ja\u0107evi\u0107 V, Wu Q, Wu W (2021) Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON). Arch. Toxicol. 95:1899\u20131915","journal-title":"Arch. Toxicol."},{"key":"15286_CR40","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jnutbio.2011.06.018","volume":"23","author":"N Yun","year":"2012","unstructured":"Yun N, Kang J-W, Lee S-M (2012) Protective effects of chlorogenic acid against ischemia\/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. The Journal of Nutritional Biochemistry 23:1249\u20131255","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"15286_CR41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<430::AID-PATH691>3.0.CO;2-H","volume":"180","author":"M Zenmyo","year":"1996","unstructured":"Zenmyo M, Komiya S, Kawabata R, Sasaguri Y, Inoue A, Morimatsu M (1996) Morphological and biochemical evidence for apoptosis in the terminal hypertrophic chondrocytes of the growth plate. The Journal of Pathology 180:430\u2013433","journal-title":"The Journal of Pathology"},{"key":"15286_CR42","doi-asserted-by":"crossref","unstructured":"Zhang J, Huang S, Tong X, Zhang L, Jiang X, Zhang H, Mehmood K, Li J (2019): Chlorogenic acid alleviates thiram-induced tibial dyschondroplasia by modulating caspases, BECN1 expression and ECM degradation. Int. J. Mol. Sci. 20(13):3160","DOI":"10.3390\/ijms20133160"},{"key":"15286_CR43","doi-asserted-by":"publisher","first-page":"6422","DOI":"10.1016\/j.psj.2020.08.055","volume":"99","author":"H Zhang","year":"2020","unstructured":"Zhang H, Wang Y, Mehmood K, Chang Y, Tang Z, Li Y (2020) Treatment of tibial dyschondroplasia with traditional Chinese medicines: \"lesson and future directions\". Poultr. Sci. 99:6422\u20136433","journal-title":"Poultr. Sci."}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-15286-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-15286-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-15286-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T18:07:19Z","timestamp":1640887639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-15286-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":43,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["15286"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-15286-3","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"22 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethical Committee of the Huazhong Agricultural University (Permit No. 4200695757).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors have given consent to their contribution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have agreed with the content and all have given explicit consent to publish.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}