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The potential of waste sludge protein hydrolysates obtained by chemical sludge conditioning was reported. The discussed areas include acidic and alkaline hydrolysis, lime conditioning, polyelectrolyte dewatering and other supporting techniques such as ultrasounds, microwave or thermal methods. The legislative aspects related to the indication of the development method and admission to various applications based on specified criteria were discussed. Particular attention was devoted to the legally regulated content of toxic elements: cadmium, lead, nickel, mercury, chromium and microelements that may be toxic: copper and zinc. Various methods of extracting valuable proteins from sewage sludge have been proposed: chemical, physical and enzymatic. While developing the process concept, you need to consider extraction efficiency (time, temperature, humidity, pH), drainage efficiency of post-extraction residues and directions of their management. The final process optimization is crucial. Despite the development of assumptions for various technologies, excess sewage sludge remains a big problem for sewage treatment plants. The high costs of enzymatic hydrolysis, thermal hydrolysis and ultrasonic methods and the need for a neutralizing agent in acid solubilization limit the rapid implementation of these processes in industrial practice.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s11356-021-15293-4","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T02:02:44Z","timestamp":1626660164000},"page":"47725-47740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Agricultural and non-agricultural directions of bio-based sewage sludge valorization by chemical conditioning"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-8857","authenticated-orcid":false,"given":"Grzegorz","family":"Izydorczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Mikula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Skrzypczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzystof","family":"Trzaska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Witek-Krowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Chojnacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"15293_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jclepro.2016.02.073","volume":"124","author":"T Ahmad","year":"2016","unstructured":"Ahmad T, Ahmad K, Alam M (2016) Sustainable management of water treatment sludge through 3\u2019R\u2019 concept. 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