{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:59:32Z","timestamp":1776365972480,"version":"3.51.2"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s11356-021-16070-z","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T18:02:36Z","timestamp":1630087356000},"page":"6317-6333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats"],"prefix":"10.1007","volume":"29","author":[{"given":"Kritika","family":"Pandit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subheet Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satwinderjeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"16070_CR1","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3109\/1547691X.2013.832444","volume":"11","author":"DM Abd El Motteleb","year":"2014","unstructured":"Abd El Motteleb DM, Selim SA, Mohamed AM (2014) Differential effects of eugenol against hepatic inflammation and overall damage induced by ischemia\/re-perfusion injury. J Immunotoxicol 11:238\u2013245","journal-title":"J Immunotoxicol"},{"key":"16070_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) [13] Catalase in vitro. Meth Enzymol 105:121\u2013126","journal-title":"Meth Enzymol"},{"key":"16070_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/6661937","volume":"2021","author":"MA Alsahli","year":"2021","unstructured":"Alsahli MA, Almatroodi SA, Almatroudi A, Khan AA, Anwar S, Almutary AG, Alrumaihi F, Rahmani AH (2021) 6-Gingerol, a major ingredient of ginger attenuates diethylnitrosamine-induced liver injury in rats through the modulation of oxidative stress and anti-inflammatory activity. Mediat Inflamm 2021:1\u201317","journal-title":"Mediat Inflamm"},{"key":"16070_CR4","doi-asserted-by":"crossref","unstructured":"Al-Sayed E, Martiskainen O, Seif el-Din SH, ANA S, Hammam OA, El-Lakkany NM, Abdel-Daim MM (2014, 2014) Hepatoprotective and antioxidant effect of Bauhinia hookeri extract against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive compounds by HPLC-PDA-ESI-MS\/MS. Biomed Res Int","DOI":"10.1155\/2014\/245171"},{"issue":"7","key":"16070_CR5","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.3109\/0886022X.2015.1061886","volume":"37","author":"E Al-Sayed","year":"2015","unstructured":"Al-Sayed E, Abdel-daim MM, Kilany OE, Karonen M, Sinkkonen J (2015) Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato-and nephrotoxicity in mice. Ren Fail 37(7):1198\u20131207","journal-title":"Ren Fail"},{"issue":"2","key":"16070_CR6","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/ptr.6242","volume":"33","author":"E Al-Sayed","year":"2019","unstructured":"Al-Sayed E, Abdel-Daim MM, Khattab MA (2019) Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride-induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis. Phytother Res 33(2):461\u2013470","journal-title":"Phytother Res"},{"key":"16070_CR7","doi-asserted-by":"crossref","unstructured":"Anderson ME (1985) Determination of glutathione and glutathione disulphide in biological samples. In: Meister A (ed) Meth. Enzymol, vol 113. Academic Press, New York, 548\u2013551","DOI":"10.1016\/S0076-6879(85)13073-9"},{"key":"16070_CR8","doi-asserted-by":"publisher","first-page":"12286","DOI":"10.1111\/jfbc.12286","volume":"41","author":"R Aysun Kepek\u00e7i","year":"2017","unstructured":"Aysun Kepek\u00e7i R, Polat S, \u00c7o\u015fkun G, \u00c7elik A, Bozkurt AS, Yumruta\u015f \u00d6, Pehlivan M (2017) Preliminary characterization of phenolic acid composition and hepatoprotective effect of Stachys pumila. J Food Biochem 41:12286","journal-title":"J Food Biochem"},{"issue":"9","key":"16070_CR9","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1007\/s00044-012-0420-4","volume":"22","author":"SS Azab","year":"2013","unstructured":"Azab SS, Abdel-Daim MM, Eldahshan OA (2013) Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract. Med Chem Res 22(9):4269\u20134277","journal-title":"Med Chem Res"},{"issue":"5","key":"16070_CR10","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.jcmgh.2021.01.006","volume":"11","author":"LE Buitrago-Molina","year":"2021","unstructured":"Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD (2021) p53-independent induction of p21 fails to control regeneration and hepatocarcinogenesis in a murine liver injury model. Cell Mol Gastroenterol Hepato 11(5):1387\u20131404","journal-title":"Cell Mol Gastroenterol Hepato"},{"key":"16070_CR11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","volume":"113","author":"I Carlberg","year":"1975","unstructured":"Carlberg I, Mannervik B (1975) [59] Glutathione reductase. Meth Enzymol 113:484\u2013490","journal-title":"Meth Enzymol"},{"issue":"38","key":"16070_CR12","doi-asserted-by":"publisher","first-page":"21596","DOI":"10.1039\/C8RA03321H","volume":"8","author":"WC Chang","year":"2018","unstructured":"Chang WC, Huang DW, Chen JA, Chang YF, Wu JSB, Shen SC (2018) Protective effect of Ruellia tuberosa L. extracts against abnormal expression of hepatic detoxification enzymes in diabetic rats. RSC Adv 8(38):21596\u201321605","journal-title":"RSC Adv"},{"issue":"8-9","key":"16070_CR13","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.phymed.2012.02.017","volume":"19","author":"CH Chen","year":"2012","unstructured":"Chen CH, DeGraffenried LA (2012) Anethole suppressed cell survival and induced apoptosis in human breast cancer cells independent of estrogen receptor status. Phytomedicine 19(8-9):763\u2013767","journal-title":"Phytomedicine"},{"issue":"21","key":"16070_CR14","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.3748\/wjg.v10.i21.3201","volume":"10","author":"NL Chen","year":"2004","unstructured":"Chen NL, Bai L, Li L, Chen PL, Zhang C, Liu CY, Deng T, Chen H, Jia KM, Zhou ZQ (2004) Apoptosis pathway of liver cells in chronic hepatitis. World J Gastroenterol: WJG 10(21):3201\u20133204","journal-title":"World J Gastroenterol: WJG"},{"issue":"3","key":"16070_CR15","doi-asserted-by":"publisher","first-page":"332","DOI":"10.5483\/BMBRep.2003.36.3.332","volume":"36","author":"SJ Choi","year":"2003","unstructured":"Choi SJ, Kim MR, Kim SI, Jeon JK (2003) Microplate assay measurement of cytochrome P450-carbon monoxide complexes. BMB Rep 36(3):332\u2013335","journal-title":"BMB Rep"},{"key":"16070_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1248\/bpb.34.41","volume":"34","author":"EJ Choo","year":"2011","unstructured":"Choo EJ, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ (2011) Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2\/9 and AKT\/mitogen-activated kinase\/nuclear factor kappa B signaling pathways. Biol Pharm Bull 34:41\u201346","journal-title":"Biol Pharm Bull"},{"key":"16070_CR17","unstructured":"Das RN, Lee Y, Mukherjee S, Kim J (2019) Relationship of Alanine Aminotransferase (SGPT) with other Liver Biomarkers. J. gastroenterol. pancreatol. liver disord 7:1\u20135"},{"key":"16070_CR18","first-page":"5389","volume":"61","author":"NG Deane","year":"2001","unstructured":"Deane NG, Parker MA, Aramandla R, Diehl L, Lee WJ, Washington MK, Nanney LB, Shyr Y, Beauchamp RD (2001) Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res 61:5389\u20135395","journal-title":"Cancer Res"},{"issue":"5","key":"16070_CR19","first-page":"300","volume":"40","author":"TPA Devasagayam","year":"2003","unstructured":"Devasagayam TPA, Boloor KK, Ramasarma T (2003) Methods for estimating lipid peroxidation: an analysis of merits and demerits. Indian J Biochem Biophys 40(5):300\u2013308","journal-title":"Indian J Biochem Biophys"},{"key":"16070_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/biomedicines5020018","volume":"5","author":"F Ekinci Akdemir","year":"2017","unstructured":"Ekinci Akdemir F, Albayrak M, \u00c7alik M, Bayir Y, G\u00fcl\u00e7in I (2017) The protective effects of p-coumaric acid on acute liver and kidney damages induced by cisplatin. Biomedicines 5:18","journal-title":"Biomedicines"},{"issue":"8","key":"16070_CR21","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.3109\/13880209.2015.1078381","volume":"54","author":"AE El-Hadary","year":"2016","unstructured":"El-Hadary AE, Ramadan Hassanien MF (2016) Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Pharm Biol 54(8):1364\u20131372","journal-title":"Pharm Biol"},{"key":"16070_CR22","doi-asserted-by":"publisher","first-page":"100151","DOI":"10.1016\/j.phanu.2019.100151","volume":"9","author":"AE El-Hadary","year":"2019","unstructured":"El-Hadary AE, Elsanhoty RM, Ramadan MF (2019) In vivo protective effect of Rosmarinus officinalis oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. PharmaNutrition 9:100151","journal-title":"PharmaNutrition"},{"issue":"2","key":"16070_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3109\/13880209.2015.1035794","volume":"54","author":"NM Fahmy","year":"2016","unstructured":"Fahmy NM, Al-Sayed E, Abdel-Daim MM, Karonen M, Singab AN (2016) Protective effect of Terminalia muelleri against carbon tetrachloride-induced hepato and nephro-toxicity in mice and characterization of its bioactive constituents. Pharm Biol 54(2):303\u2013313","journal-title":"Pharm Biol"},{"key":"16070_CR24","doi-asserted-by":"crossref","unstructured":"Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM (2021) In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit. Phytomedicine 153479","DOI":"10.1016\/j.phymed.2021.153479"},{"key":"16070_CR25","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s12906-016-1235-5","volume":"16","author":"D Gweshelo","year":"2016","unstructured":"Gweshelo D, Muswe R, Mukanganyama S (2016) In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae). BMC Complement Altern Med 16:238","journal-title":"BMC Complement Altern Med"},{"key":"16070_CR26","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139","journal-title":"J Biol Chem"},{"key":"16070_CR27","doi-asserted-by":"publisher","first-page":"109354","DOI":"10.1016\/j.biopha.2019.109354","volume":"122","author":"X Huo","year":"2020","unstructured":"Huo X, Meng X, Zhang J, Zhao Y (2020) Hepatoprotective effect of different combinations of 18\u03b1-and 18\u03b2-Glycyrrhizic acid against CCl4-induced liver injury in rats. Biomed. Pharmacother. 122:109354","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"16070_CR28","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.apjtm.2017.10.008","volume":"10","author":"F Hussain","year":"2017","unstructured":"Hussain F, Malik A, Ayyaz U, Shafique H, Rana Z, Hussain Z (2017) Efficient hepatoprotective activity of cranberry extract against CCl4-induced hepatotoxicity in Wistar albino rat model: down-regulation of liver enzymes and strong antioxidant activity. Asian Pac J Trop Med 10(11):1054\u20131058","journal-title":"Asian Pac J Trop Med"},{"issue":"6","key":"16070_CR29","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN, Phillips MJ (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22(6):696\u2013699","journal-title":"J Hepatol"},{"issue":"70","key":"16070_CR30","doi-asserted-by":"publisher","first-page":"56549","DOI":"10.1039\/C5RA07230A","volume":"5","author":"S Jana","year":"2015","unstructured":"Jana S, Patra K, Mukherjee G, Bhattacharjee S, Mandal DP (2015) Antitumor potential of anethole singly and in combination with cyclophosphamide in murine Sarcoma-180 transplantable tumor model. RSC Adv 5(70):56549\u201356559","journal-title":"RSC Adv"},{"issue":"2","key":"16070_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1034\/j.1600-0676.2001.021002089.x","volume":"21","author":"M Joo","year":"2001","unstructured":"Joo M, Kang YK, Kim MR, Lee HK, Jang JJ (2001) Cyclin D1 overexpression in hepatocellular carcinoma. Liver 21(2):89\u201395","journal-title":"Liver"},{"issue":"29","key":"16070_CR32","doi-asserted-by":"publisher","first-page":"29930","DOI":"10.1007\/s11356-019-06158-y","volume":"26","author":"S Kaur","year":"2019","unstructured":"Kaur S, Sharma D, Singh AP, Kaur S (2019) Amelioration of hepatic function, oxidative stress, and histopathologic damages by Cassia fistula L. fraction in thioacetamide-induced liver toxicity. Environ Sci Pollut Res 26(29):29930\u201329945","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"16070_CR33","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1515\/chem-2020-0062","volume":"18","author":"MZ Khan","year":"2020","unstructured":"Khan MZ, Shabbir MI, Saqib Z, Gilani SA, Jogezai NU, Kiyani MM, Malik MA (2020) Investigation of polyphenol profile, antioxidant activity and hepatoprotective potential of Aconogonon alpinum (All.) Schur roots. Open Chem J 18(1):516\u2013536","journal-title":"Open Chem J"},{"key":"16070_CR34","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.biopha.2017.05.032","volume":"91","author":"KY Kim","year":"2017","unstructured":"Kim KY, Lee HS, Seol GH (2017) Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease. Biomed Pharmacother 91:925\u2013930","journal-title":"Biomed Pharmacother"},{"key":"16070_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40816-018-0096-5","volume":"5","author":"R Krithika","year":"2019","unstructured":"Krithika R, Verma RJ (2019) Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism. Clin Phytoscience 5:1","journal-title":"Clin Phytoscience"},{"key":"16070_CR36","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/fsn3.893","volume":"7","author":"YS Lee","year":"2019","unstructured":"Lee YS, Cho IJ, Kim JW, Lee MK, Ku SK, Choi JS, Lee HJ (2019) Hepatoprotective effects of blue honeysuckle on CCl4-induced acute liver damaged mice. Food Sci Nutr 7:322\u2013338","journal-title":"Food Sci Nutr"},{"key":"16070_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.intimp.2016.02.003","volume":"34","author":"Y Lu","year":"2016","unstructured":"Lu Y, Hu D, Ma S, Zhao X, Wang S, Wei G, Wang X, Wen A, Wang J (2016) Protective effect of wedelolactone against CCl4-induced acute liver injury in mice. Int Immunopharmacol 34:44\u201352","journal-title":"Int Immunopharmacol"},{"issue":"40","key":"16070_CR38","doi-asserted-by":"publisher","first-page":"14787","DOI":"10.3748\/wjg.v20.i40.14787","volume":"20","author":"E Madrigal-Santill\u00e1n","year":"2014","unstructured":"Madrigal-Santill\u00e1n E, Madrigal-Bujaidar E, \u00c1lvarez-Gonz\u00e1lez I, Sumaya-Mart\u00ednez MT, Guti\u00e9rrez-Salinas J, Bautista M, Morales-Gonz\u00e1lez \u00c1, Gonz\u00e1lez-Rubio MGL, Aguilar-Faisal JL, Morales-Gonz\u00e1lez JA (2014) Review of natural products with hepatoprotective effects. World J Gastroenterol WJG 20(40):14787\u201314804","journal-title":"World J Gastroenterol WJG"},{"issue":"4","key":"16070_CR39","first-page":"725","volume":"71","author":"K Mihara","year":"1972","unstructured":"Mihara K, Sato R (1972) Partial purification of NADH-cytochrome b5 reductase from rabbit liver microsomes with detergents and its properties. J Biochem 71(4):725\u2013735","journal-title":"J Biochem"},{"issue":"1","key":"16070_CR40","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.sjbs.2020.10.063","volume":"28","author":"S Mukhtar","year":"2021","unstructured":"Mukhtar S, Xiaoxiong Z, Qamer S, Saad M, Mubarik MS, Mahmoud AH, Mohammed OB (2021) Hepatoprotective activity of silymarin encapsulation against hepatic damage in albino rats. Saudi J Biol Sci 28(1):717\u2013723","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"16070_CR41","first-page":"56","volume":"17","author":"KG N\u00fa\u00f1ez","year":"2017","unstructured":"N\u00fa\u00f1ez KG, Gonzalez-Rosario J, Thevenot PT, Cohen AJ (2017) Cyclin D1 in the liver: role of noncanonical signaling in liver steatosis and hormone regulation. Ochsner J 17(1):56\u201365","journal-title":"Ochsner J"},{"key":"16070_CR42","doi-asserted-by":"crossref","unstructured":"Ojeaburu SI, Oriakhi K (2021) Hepatoprotective, antioxidant and, anti- inflammatory potentials of gallic acid in carbon tetrachloride-induced hepatic damage in Wistar rats. Toxicol Rep 8:177\u2013185","DOI":"10.1016\/j.toxrep.2021.01.001"},{"issue":"7","key":"16070_CR43","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","volume":"239","author":"T Omura","year":"1964","unstructured":"Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature. J Biol Chem 239(7):2370\u20132378","journal-title":"J Biol Chem"},{"key":"16070_CR44","doi-asserted-by":"crossref","unstructured":"Omura T, Takesue S (1970) A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. J Biochem 67(2):249-257","DOI":"10.1093\/oxfordjournals.jbchem.a129248"},{"key":"16070_CR45","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3390\/cancers3010994","volume":"3","author":"T Ozaki","year":"2011","unstructured":"Ozaki T, Nakagawara (2011) A role of p53 in cell death and human cancers. Cancers 3:994\u20131013","journal-title":"Cancers"},{"issue":"7","key":"16070_CR46","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/modpathol.3800146","volume":"17","author":"R Persad","year":"2004","unstructured":"Persad R, Liu C, Wu TT, Houlihan PS, Hamilton SR, Diehl AM, Rashid A (2004) Overexpressioof caspase-3 in hepatocellular carcinomas. Mod Pathol 17(7):861\u2013867","journal-title":"Mod Pathol"},{"key":"16070_CR47","doi-asserted-by":"crossref","unstructured":"Rakib A, Ahmed S, Islam MA, Haye A, Uddin SN, Uddin MMN, Hossain MK, Pau A, Emran TB (2020) Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches. Food Sci Nutr 8:547\u2013556","DOI":"10.1002\/fsn3.1339"},{"key":"16070_CR48","doi-asserted-by":"publisher","first-page":"110942","DOI":"10.1016\/j.biopha.2020.110942","volume":"132","author":"MS Reza","year":"2020","unstructured":"Reza MS, Shuvo MSR, Hassan MM, Basher MA, Islam MA, Naznin NE, Jafrin S, Ahmed KS, Hossain H, Daula ASU (2020) Antidiabetic and hepatoprotective potential of whole plant extract and isolated compounds of Aeginetia indica. Biomed Pharmacother 132:110942","journal-title":"Biomed Pharmacother"},{"key":"16070_CR49","doi-asserted-by":"crossref","unstructured":"Sahin E, Bagci R, Bektur Aykanat NE, Kacar S, Sahinturk V (2020) Silymarin attenuated nonalcoholic fatty liver disease through the regulation of endoplasmic reticulum stress proteins GRP78 and XBP-1 in mice. J Food Biochem:13194","DOI":"10.1111\/jfbc.13194"},{"key":"16070_CR50","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5958\/2229-4473.2018.00063.0","volume":"31","author":"UK Sharma","year":"2018","unstructured":"Sharma UK, Kumar R, Ganguly R, Gupta A, Sharma AK, Pandey AK (2018) Cinnamaldehyde, an active component of cinnamon provides protection against food colour induced oxidative stress and hepatotoxicity in albino Wistar rats. Vegetos. 31:123\u2013129","journal-title":"Vegetos."},{"key":"16070_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.fct.2019.01.032","volume":"126","author":"UK Sharma","year":"2019","unstructured":"Sharma UK, Kumar R, Gupta A, Ganguly R, Singh AK, Ojha AK, Pandey AK (2019) Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats. Food Chem Toxicol 126:34\u201340","journal-title":"Food Chem Toxicol"},{"key":"16070_CR52","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.biopha.2018.12.074","volume":"111","author":"Y Shen","year":"2019","unstructured":"Shen Y, Song X, Li L, Sun J, Jaiswal Y, Huang J, Liu C, Yang W, Williams L, Zhang H, Guan Y (2019) Protective effects of p-coumaric acid against oxidant and hyperlipidemia\u2014an in vitro and in vivo evaluation. Biomed Pharmacother 111:579\u2013587","journal-title":"Biomed Pharmacother"},{"issue":"9-10","key":"16070_CR53","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S0891-5849(99)00177-X","volume":"27","author":"H Sies","year":"1999","unstructured":"Sies H (1999) Glutathione and its role in cellular functions. Free Radic Biol Med 27(9-10):916\u2013921","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"16070_CR54","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"PE Smith","year":"1985","unstructured":"Smith PE, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano M, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150(1):76\u201385","journal-title":"Anal Biochem"},{"key":"16070_CR55","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jff.2017.12.055","volume":"41","author":"M Sobeh","year":"2018","unstructured":"Sobeh M, Esmat A, Petruk G, Abdelfattah MA, Dmirieh M, Monti DM, Abdel-Naim AB, Wink M (2018) Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo. J Funct Foods 41:223\u2013231","journal-title":"J Funct Foods"},{"key":"16070_CR56","volume-title":"Biometry: the principles and practice of statistics in biological research","author":"RR Sokal","year":"1981","unstructured":"Sokal RR, Rohlf FJ (1981) Biometry: the principles and practice of statistics in biological research. W.H. Freeman and Company, San Francisco"},{"issue":"6","key":"16070_CR57","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3390\/foods9060804","volume":"9","author":"A Taamalli","year":"2020","unstructured":"Taamalli A, Feriani A, Lozano-Sanchez J, Ghazouani L, El Mufti A, Allagui MS, Segura-Carretero A, Mhamdi R, Arr\u00e1ez-Roman D (2020) Potential hepatoprotective activity of super critical carbon dioxide olive leaf extracts against CCl4-induced liver damage. Foods 9(6):804","journal-title":"Foods"},{"issue":"6","key":"16070_CR58","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1039\/D0FO02894K","volume":"12","author":"Y Wang","year":"2021","unstructured":"Wang Y, Tian L, Wang Y, Zhao T, Khan A, Wang Y, Cao J, Cheng G (2021) Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress, inflammation, and apoptosis. Food Funct. 12(6):2468\u20132480","journal-title":"Food Funct."},{"issue":"8","key":"16070_CR59","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1093\/carcin\/bgi122","volume":"26","author":"KS Yee","year":"2005","unstructured":"Yee KS, Vousden KH (2005) Complicating the complexity of p53. Carcinogenesis 26(8):1317\u20131322","journal-title":"Carcinogenesis"},{"key":"16070_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43141-020-00027-9","volume":"18","author":"RF Zahran","year":"2020","unstructured":"Zahran RF, Geba ZM, Tabll AA, Mashaly MM (2020) Therapeutic potential of a novel combination of Curcumin with Sulfamethoxazole against carbon tetrachloride-induced acute liver injury in Swiss albino mice. J Genet Eng Biotechnol 18:1\u201316","journal-title":"J Genet Eng Biotechnol"},{"issue":"11","key":"16070_CR61","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1016\/j.fct.2008.08.013","volume":"46","author":"H Zeashan","year":"2008","unstructured":"Zeashan H, Amresh G, Singh S, Rao CV (2008) Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol 46(11):3417\u20133421","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"16070_CR62","first-page":"1369","volume":"18","author":"S Zhang","year":"2018","unstructured":"Zhang S, Chen X, Devshilt I, Yun Q, Huang C, An L, Dorjbat S, He X (2018) Fennel main constituent, trans-anethole treatment against LPS-induced acute lung injury by regulation of Th17\/Treg function. Mol Med Rep 18(2):1369\u20131376","journal-title":"Mol Med Rep"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16070-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-16070-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16070-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T04:19:06Z","timestamp":1676521146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-16070-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["16070"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-16070-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-316185\/v1","asserted-by":"object"}]},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"6 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol for all animal experimentation conducted in the present study was approved by Institutional Animal Ethics Committee (IAEC), Guru Nanak Dev University, Amritsar, according to the regulation of CPCSEA (protocol approval no. 226\/CPCSEA\/2017\/05). All animal experiments were performed as per CPCSEA (Committee for the Purpose of Control and Supervision of Experiments on Animals), Government of India, New Delhi, guidelines for animal experimentation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This research did not involve human subjects, so clinical trial registration is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Plant reproducibility"}},{"value":"All authors agree with the content and give consent to publish.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}