{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:18:28Z","timestamp":1789661908136,"version":"4.0.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11356-021-16527-1","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:04:28Z","timestamp":1633561468000},"page":"14767-14779","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of high-molecular-weight polyvinyl chloride on Xenopus laevis adults and embryos: the mRNA expression profiles of Myf5, Esr1, Bmp4, Pax6, and Hsp70 genes during early embryonic development"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-605X","authenticated-orcid":false,"given":"Ayper Boga","family":"Pekmezekmek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Emre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"Erdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Sertdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131lmaz","family":"Emre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"16527_CR1","unstructured":"Ackerman S (1992) Discovering the brain (1992). Washington (DC): National Academies Press (US)"},{"key":"16527_CR2","doi-asserted-by":"publisher","first-page":"110795","DOI":"10.1016\/j.marpolbul.2019.110795","volume":"151","author":"C Ahrendt","year":"2020","unstructured":"Ahrendt C, Perez-Venegas DJ, Urbina M, Gonzalez C, Echeveste P, Aldana M, Pulgar J, Galb\u00e1n-Malag\u00f3n CC (2020) Microplastic ingestion cause intestinal lesions in the intertidal fish Girella laevifrons. Mar Pollut Bull 2020 151:110795. https:\/\/doi.org\/10.1016\/j.marpolbul.2019.110795","journal-title":"Mar Pollut Bull 2020"},{"issue":"15","key":"16527_CR3","doi-asserted-by":"publisher","first-page":"14373","DOI":"10.1007\/s11356-018-1999-x","volume":"25","author":"S Anbumani","year":"2018","unstructured":"Anbumani S, Kakkar P (2018) Ecotoxicological effects of microplastics on biota: a review. Environ Sci Pollut Res Int 25(15):14373\u201314396. https:\/\/doi.org\/10.1007\/s11356-018-1999-x","journal-title":"Environ Sci Pollut Res Int"},{"key":"16527_CR4","doi-asserted-by":"publisher","first-page":"111446","DOI":"10.1016\/j.marpolbul.2020.111446","volume":"158","author":"M Assas","year":"2020","unstructured":"Assas M, Qiu X, Chen K, Ogawa H, Xu H, Shimasaki Y, Oshima Y (2020) Bioaccumulation and reproductive effects of fluorescent microplastics in medaka fish. Mar Pollut Bull 158:111446. https:\/\/doi.org\/10.1016\/j.marpolbul.2020.111446","journal-title":"Mar Pollut Bull"},{"key":"16527_CR5","unstructured":"ASTM (American Society forTesting Materials) (2004) Standart guide for conducting the frog embryo-teratogenesis assay\u2014Xenopus, FETAX, E1439-98. In: ASTM Standards on 381 Biological Effects and Environmental Fate. vol.11.05.Philadelphia, pp. 447\u2013457."},{"key":"16527_CR6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/jat.3811","volume":"39","author":"JO Babalola","year":"2019","unstructured":"Babalola JO, Truter C, van Wyk HJ (2019) Mortality, teratogenicity and growth inhibition of threeglyphosate formulations using Frog Embryo TeratogenesisAssay-Xenopus. J Appl Toxicol 39:1257\u20131266","journal-title":"J Appl Toxicol"},{"issue":"1-2","key":"16527_CR7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0925-4773(02)00199-5","volume":"117","author":"I Bachy","year":"2002","unstructured":"Bachy I, Berthon J, R\u00e9taux S (2002) Defining pallial and subpallial divisions in the developing Xenopus forebrain. Mech Dev 117(1-2):163\u2013172","journal-title":"Mech Dev"},{"issue":"Pt2","key":"16527_CR8","doi-asserted-by":"publisher","first-page":"128502","DOI":"10.1016\/j.chemosphere.2020.12850","volume":"264","author":"MK Bharath","year":"2021","unstructured":"Bharath MK, Srinivasalu S, Natesan U, Ayyamperumal R, Kalam SN, Anbalagan S, Sujatha K, Alagarasan C (2021) Microplastics as an emerging threat to the freshwater ecosystems of Veeranam lake in south India: a multidimensional approach. Chemosphere 264(Pt2):128502. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.12850","journal-title":"Chemosphere"},{"key":"16527_CR9","doi-asserted-by":"publisher","first-page":"124335","DOI":"10.1016\/j.chemosphere.2019.07.066","volume":"236","author":"M Banaee","year":"2019","unstructured":"Banaee M, Soltanian S, Sureda A, Gholamhosseini A, Haghi BN, Akhlaghi M, Derikvandy A (2019) Evaluation of single and combined effects of cadmium and micro-plastic particles on biochemical and immunological parameters of common carp (Cyprinus carpio). Chemosphere 236:124335. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.07.066","journal-title":"Chemosphere"},{"key":"16527_CR10","doi-asserted-by":"publisher","first-page":"9221","DOI":"10.1007\/s11356-020-11419-2","volume":"28","author":"M Banaee","year":"2020","unstructured":"Banaee M, Gholamhosseini A, Sureda A, Soltanian S, Fereidouni MS, Ibrahim ATA (2020) Effects of microplastic exposure on the blood biochemical parameters in the pond turtle (Emys orbicularis). Environ Sci Pollut Res 28:9221\u20139234. https:\/\/doi.org\/10.1007\/s11356-020-11419-2","journal-title":"Environ Sci Pollut Res"},{"issue":"1526","key":"16527_CR11","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1098\/rstb.2008.0205","volume":"364","author":"DKA Barnes","year":"2009","unstructured":"Barnes DKA, Galgani F, Thompson RC, Morton B (2009) Accumulation and Fragmentation of plastic debris in global environments. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):1985\u20131998","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"16527_CR12","doi-asserted-by":"crossref","unstructured":"Baumann L, Schmidt-Posthaus H, Segner H, Wolf JC (2016) Comment on \u201cUptake and Accumulation of Polystyrene Microplastics in zebrafish (Danio rerio) and Toxic Effects in Liver. Environ Sci Technol 50(22): 12521-12522.","DOI":"10.1021\/acs.est.6b04193"},{"key":"16527_CR13","doi-asserted-by":"publisher","first-page":"138707","DOI":"10.1016\/j.scitotenv.2020.138707","volume":"728","author":"J Bhagat","year":"2020","unstructured":"Bhagat J, Zang L, Nishimura N, Shimada Y (2020) Zebrafish: an emerging model to study microplastic and nanoplastic toxicity. Sci Total Environ 728:138707. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138707","journal-title":"Sci Total Environ"},{"key":"16527_CR14","doi-asserted-by":"publisher","first-page":"123590","DOI":"10.1016\/j.jhazmat.2020.123590","volume":"403","author":"I Brandts","year":"2021","unstructured":"Brandts I, Barr\u00eda C, Martins MA, Franco-Mart\u00ednez L, Barreto A, Tvarijonaviciute A, Tort L, Oliveira M, Teles M (2021) Waterborne exposure of gilthead seabream (Sparus aurata) to polymethylmethacrylate nanoplastics causes effects at cellular and molecular levels. J Hazard Mater 403:123590. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123590","journal-title":"J Hazard Mater"},{"key":"16527_CR15","first-page":"265","volume":"37","author":"A Boga Pekmezekmek","year":"2013","unstructured":"Boga Pekmezekmek A, Binokay US, Ak\u0131ll\u0131oglu K, Sertdemir Y (2013) Evaluation of E330-induced developmental toxicity using FETAX. Turk J Biol 37:265\u2013272","journal-title":"Turk J Biol"},{"key":"16527_CR16","doi-asserted-by":"crossref","unstructured":"Bonfanti P, Saibene M, Bacchetta R, Mantecca P, Colombo AA (2018) A glyphosate micro-emulsion formulation displays teratogenicity in Xenopus laevis. Aquat Toxicol 195:103-113. doi: 10.1016\/j.aquatox.2017.12.007.","DOI":"10.1016\/j.aquatox.2017.12.007"},{"issue":"4","key":"16527_CR17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ieam.5630030412","volume":"3","author":"MA Browne","year":"2007","unstructured":"Browne MA, Galloway T, Thompson R (2007) Microplastic-an emerging contaminant of potential concern? Integr Environ Assess Manag 3(4):559\u2013566","journal-title":"Integr Environ Assess Manag"},{"issue":"21","key":"16527_CR18","doi-asserted-by":"crossref","first-page":"9175e9179","DOI":"10.1021\/es201811s","volume":"45","author":"MA Browne","year":"2011","unstructured":"Browne MA, Crump P, Nivens SJ, Teuten E, Tonkin A, Galloway T, Thompson R (2011) Accumulation of microplastics on shorelines worldwide: sources and sinks. Environ Sci Technol 45(21):9175e9179","journal-title":"Environ Sci Technol"},{"key":"16527_CR19","doi-asserted-by":"crossref","unstructured":"Campanella C, Bavisotto CC, Gammazza AM, Nikolic D, Rappa F, David S, Cappello F, Bucchieri F, Fais S (2014). Exosomal heat shock proteins as new players in tumour cell-to-cell communication. JCB [Internet]. [cited 15Jun.2021];3(1).","DOI":"10.33393\/jcb.2014.2046"},{"issue":"1","key":"16527_CR20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ydbio.2008.10.023","volume":"325","author":"L Chen","year":"2009","unstructured":"Chen L, Melendez J, Campbell K, Kuan CY, Zheng Y (2009) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev Biol 325(1):162\u2013170","journal-title":"Dev Biol"},{"issue":"10","key":"16527_CR21","doi-asserted-by":"crossref","first-page":"2199e2204","DOI":"10.1016\/j.marpolbul.2011.06.030","volume":"62","author":"M Claessens","year":"2011","unstructured":"Claessens M, De Meester S, Van Landuyt L, De Clerck K, Janssen CR (2011) Occurrence and distribution of microplastics in marine sediments along the Belgian coast. Mar Pollut Bull 62(10):2199e2204\u20132199e2204","journal-title":"Mar Pollut Bull"},{"issue":"4","key":"16527_CR22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jat.2550070403","volume":"7","author":"DA Dawson","year":"1987","unstructured":"Dawson DA, Bantle JA (1987) Development of a reconstituted water medium and preliminary validation of the frog embryo teratogenesis assay-xenopus (FETAX). J Appl Toxicol 7(4):237\u2013244","journal-title":"J Appl Toxicol"},{"key":"16527_CR23","doi-asserted-by":"crossref","first-page":"34644","DOI":"10.1007\/s11356-018-3408-x","volume":"25","author":"B De Felice","year":"2018","unstructured":"De Felice B, Bacchetta R, Santo N, Tremolada P, Parolini M (2018) Polystyrene microplastics did not affect body growth and swimming activity in Xenopus laevis tadpoles. Environ Sci Pollut Res 25:34644\u201334651","journal-title":"Environ Sci Pollut Res"},{"key":"16527_CR24","doi-asserted-by":"publisher","first-page":"122693","DOI":"10.1016\/j.jhazmat.2020.122693","volume":"396","author":"J Ding","year":"2020","unstructured":"Ding J, Huang Y, Liu S, Zhang S, Zou H, Wang Z, Zhu W, Geng J (2020) Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: are larger plastic particles more harmless? J Hazard Mater 396:122693. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.122693","journal-title":"J Hazard Mater"},{"key":"16527_CR25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.watres.2015.02.012","volume":"75","author":"D Eerkes-Medrano","year":"2015","unstructured":"Eerkes-Medrano D, Thompson RC, Aldridge DC (2015) Microplastics in freshwater systems: a review of the emerging threats, identification of knowledge gaps and prioritisation of research needs. Water Res 75:63\u201382","journal-title":"Water Res"},{"issue":"9","key":"16527_CR26","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/dvg.22409","volume":"51","author":"C Elso","year":"2013","unstructured":"Elso C, Lu X, Weisner PA, Thompson HL, Skinner A, Carver E, Stubbs L (2013) A reciprocal translocation dissects roles of Pax6 alternative promoters and upstream regulatory elements in the development of pancreas, brain, and eye. Genesis 51(9):630\u2013646. https:\/\/doi.org\/10.1002\/dvg.22409 Epub 2013 Jul 23","journal-title":"Genesis"},{"issue":"21","key":"16527_CR27","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1002\/j.1460-2075.1994.tb06830.x","volume":"13","author":"A Fainsod","year":"1994","unstructured":"Fainsod A, Steinbeisser H, De Robertis EM (1994) On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J 13(21):5015\u20135025","journal-title":"EMBO J"},{"issue":"27","key":"16527_CR28","doi-asserted-by":"crossref","first-page":"11310","DOI":"10.1073\/pnas.0611299104","volume":"104","author":"J Giordani","year":"2007","unstructured":"Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M, Maire P (2007) Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. PNAS 104(27):11310\u201311315","journal-title":"PNAS"},{"issue":"5","key":"16527_CR29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1098\/rsbl.2012.0298","volume":"8","author":"MC Goldstein","year":"2012","unstructured":"Goldstein MC, Rosenberg M, Cheng L (2012) Increased oceanic microplastic debris enhances oviposition in an endemic pelagic insect. Biol Lett 8(5):817\u2013820","journal-title":"Biol Lett"},{"issue":"12","key":"16527_CR30","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.4161\/cc.3.12.1287","volume":"3","author":"M Gyrd-Hansen","year":"2004","unstructured":"Gyrd-Hansen M, Nylandsted J, J\u00e4\u00e4ttel\u00e4 M (2004) Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity. Cell Cycle 3(12):1484\u20131485","journal-title":"Cell Cycle"},{"issue":"1526","key":"16527_CR31","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1098\/rstb.2008.0311","volume":"364","author":"J Hopewell","year":"2009","unstructured":"Hopewell J, Dvorak R, Kosior E (2009) Plastics recycling: challenges and opportunities. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):2115\u20132126","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"16527_CR32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.chemosphere.2016.09.002","volume":"164","author":"L Hu","year":"2016","unstructured":"Hu L, Su L, Xue Y, Mu J, Zhu J, Xu J, Shi H (2016) Uptake, accumulation and elimination of polystyrene microspheres in tadpoles of Xenopus tropicalis. Chemosphere 164:611\u2013617","journal-title":"Chemosphere"},{"key":"16527_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.mod.2014.12.007","volume":"136","author":"CA Hurney","year":"2015","unstructured":"Hurney CA, Babcock SK, Shook DR, Pelletier TM, Turner SD, Maturo J, Cogbill S, Snow MC, Kinch K (2015) Normal table of embryonic development in the four-toed salamander, Hemidactylium scutatum. Mech Dev 136:99\u2013110. https:\/\/doi.org\/10.1016\/j.mod.2014.12.007","journal-title":"Mech Dev"},{"key":"16527_CR34","unstructured":"IBM Corp Released (2011) IBM SPSS statistics for windows, Version 20.0. Armonk NY:IBM Corp."},{"issue":"3","key":"16527_CR35","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ieam.1913","volume":"13","author":"B Jovanovi\u0107","year":"2017","unstructured":"Jovanovi\u0107 B (2017) Ingestion of microplastics by fish and its potential consequences from a physical perspective. Integr Environ Assess Manag 13(3):510\u2013515. https:\/\/doi.org\/10.1002\/ieam.1913","journal-title":"Integr Environ Assess Manag"},{"key":"16527_CR36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.marpolbul.2018.03.016","volume":"130","author":"B Jovanovi\u0107","year":"2018","unstructured":"Jovanovi\u0107 B, G\u00f6kda\u011f K, G\u00fcven O, Emre Y, Whitley EM, Kideys AE (2018) Virgin microplastics are not causing imminent harm to fish after dietary exposure. Mar Pollut Bull 130:123\u2013131","journal-title":"Mar Pollut Bull"},{"issue":"1","key":"16527_CR37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(88)90189-3","volume":"127","author":"KR Kao","year":"1988","unstructured":"Kao KR, Elinson R (1988) The entire mesodermal mantle behaves as Spemann\u2019s organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev Biol 127(1):64\u201377","journal-title":"Dev Biol"},{"issue":"3","key":"16527_CR38","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1021\/es404295e","volume":"48","author":"KL Kaposi","year":"2014","unstructured":"Kaposi KL, Mos B, Kelaher BP, Dworjanyn SA (2014) Ingestion of microplastic has limited impact on a marine larva. Environ Sci Technol 48(3):1638\u20131645","journal-title":"Environ Sci Technol"},{"key":"16527_CR39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ydbio.2005.09.020","volume":"228","author":"A Keren","year":"2005","unstructured":"Keren A, Bengal E, Frank D (2005) p38 MAP kinase regulates the expression of XMyf5 and affects distinct myogenic programs during Xenopus development. Dev Biol 228:73\u201386","journal-title":"Dev Biol"},{"key":"16527_CR40","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/dev.01937","volume":"132","author":"E Lamar","year":"2005","unstructured":"Lamar E, Kintner C (2005) The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors. Development 132:3619\u20133630","journal-title":"Development"},{"key":"16527_CR41","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neulet.2016.09.054","volume":"652","author":"D Lee-Liu","year":"2017","unstructured":"Lee-Liu D, M\u00e9ndez-Olivos EE, Mu\u00f1oz R, Juan Larra\u00edn J (2017) The African clawed frog Xenopus laevis: a model organism to study regeneration of the central nervous system. Review Neurosci Lett 652:82\u201393. https:\/\/doi.org\/10.1016\/j.neulet.2016.09.054","journal-title":"Review Neurosci Lett"},{"key":"16527_CR42","first-page":"388","volume":"36","author":"C Lindi","year":"2001","unstructured":"Lindi C, Montorfano G, Rossi F, Gornati R, Rizzo AM (2001) Effect of ethanol exposure on Xenopus embryo lipid composition. AlcoholAlcohol 36:388\u2013392","journal-title":"AlcoholAlcohol"},{"key":"16527_CR43","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.envpol.2017.10.095","volume":"233","author":"HKA Lo","year":"2018","unstructured":"Lo HKA, Chan KYK (2018) Negative effects of microplastic exposure on growth and development of Crepidula onyx. Environ Pollut 233:588\u2013595","journal-title":"Environ Pollut"},{"issue":"7","key":"16527_CR44","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","volume":"50","author":"Y Lu","year":"2016","unstructured":"Lu Y, Zhang Y, Deng Y, Jiang W, Zhao Y, Geng J, Ding L, Ren H (2016) Uptake and accumulation of polystyrene microplastics in zebrafish (Danio Rerio) and toxic effects in liver. Environ Sci Technol 50(7):4054\u20134060","journal-title":"Environ Sci Technol"},{"key":"16527_CR45","unstructured":"Lusher AL, Hollman PCH, Mendoza-Hill JJ (2017) Microplastics in fisheries and aquaculture: status of knowledge on their occurrence and implications for aquatic organisms and food safety. FAO Fisheries and Aquaculture Technical Paper No. 615. Rome Italy."},{"key":"16527_CR46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ydbio.2012.08.027","volume":"371","author":"RJ Maguire","year":"2012","unstructured":"Maguire RJ, Isaacs HV, Pownall ME (2012) Early transcriptional targets of MyoDlink myogenesis and somitogenesis. Dev Biol 371:256\u2013268","journal-title":"Dev Biol"},{"issue":"11","key":"16527_CR47","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1002\/etc.4257","volume":"37","author":"TD Malinich","year":"2018","unstructured":"Malinich TD, Chou N, Sepulveda MS, H\u00f6\u00f6k TO (2018) No Evidence of microplastic impacts on consumption or growth of larval Pimephales promelas. Environ Toxicol Chem 37(11):2912\u20132918","journal-title":"Environ Toxicol Chem"},{"key":"16527_CR48","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1098\/rstb.2008.0268","volume":"364","author":"JD Meeker","year":"2009","unstructured":"Meeker JD, Sathyanarayana S, Swan SH (2009) Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc B 364:2097\u20132113","journal-title":"Philos Trans R Soc B"},{"issue":"1239","key":"16527_CR49","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainres.2008.08.052","volume":"6","author":"N Moreno","year":"2008","unstructured":"Moreno N, R\u00e9taux S, Gonz\u00e1lez A (2008) Spatio-temporal expression of Pax6 in Xenopus forebrain. Brain Res 6(1239):92\u201399. https:\/\/doi.org\/10.1016\/j.brainres.2008.08.052","journal-title":"Brain Res"},{"key":"16527_CR50","unstructured":"Nieuwkoop PD, Faber J (1994) Normal table of Xenopus laevis (Daudin). Newyork&London: Garland Publishing INC"},{"issue":"1526","key":"16527_CR51","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1098\/rstb.2008.0242","volume":"364","author":"J Oehlmann","year":"2009","unstructured":"Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, Van Look KJW, Tyler CR (2009) A critical analysis of the biological impacts of plasticizers on wildlife. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):2047\u20132062","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"issue":"4","key":"16527_CR52","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1073\/pnas.022626999","volume":"99","author":"Y Onuma","year":"2002","unstructured":"Onuma Y, Takahashi S, Asashima M, Kurata S, Gehring WJ (2002) Conservation of Pax6 function and upstream activation by Notch signaling in eye development of frogs and flies. Proc Natl Acad Sci U S A 99(4):2020\u20132025","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"16527_CR53","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.nbd.2004.03.004","volume":"16","author":"Y Peng","year":"2004","unstructured":"Peng Y, Yang PH, Ng SS, Wong OG, Liu J, He ML, Kung HF, Lin MC (2004) A critical role of Pax6 in alcohol-induced fetal microcephaly. Neurobiol Dis 16(2):370\u2013376","journal-title":"Neurobiol Dis"},{"key":"16527_CR54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0092-8674(00)80132-4","volume":"86(4","author":"S Piccolo","year":"1996","unstructured":"Piccolo S, Sasa Y, Lu B, Robertis EMD (1996) Dorsoventral patterning in xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86(4:589\u2013598","journal-title":"Cell"},{"key":"16527_CR55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.preteyeres.2016.03.001","volume":"52","author":"N Piri","year":"2016","unstructured":"Piri N, Kwong JM, Gu L, Caprioli J (2016) Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival. Prog Retin Eye Res 52:22\u201346","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"16527_CR56","first-page":"71","volume":"3","author":"X Rao","year":"2013","unstructured":"Rao X, Huang X, Zhou Z, Lin X (2013) An improvement of the 2\u02c6(\u2013delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath 3(3):71\u201385","journal-title":"Biostat Bioinforma Biomath"},{"issue":"1526","key":"16527_CR57","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1098\/rstb.2008.0207","volume":"364","author":"PG Ryan","year":"2009","unstructured":"Ryan PG, Moore CJ, van Franeker JA, Moloney CL (2009) Monitoring the abundance of plastic debris in the marine environment. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):1999\u20132012","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"issue":"4","key":"16527_CR58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1634\/stemcells.22-4-457","volume":"22","author":"TJ Sadlon","year":"2004","unstructured":"Sadlon TJ, Lewis ID, D'Andrea RJ (2004) BMP4: its role in development of the hematopoietic system and potential as a hematopoietic growth factor. Stem Cells 22(4):457\u2013474","journal-title":"Stem Cells"},{"issue":"717","key":"16527_CR59","doi-asserted-by":"crossref","first-page":"137064","DOI":"10.1016\/j.scitotenv.2020.137064","volume":"15","author":"S Shabbir","year":"2020","unstructured":"Shabbir S, Faheem M, Ali N, Kerr PG, Wang LF, Kuppusamy S, Li Y (2020) Periphytic biofilm: an innovative approach for biodegradation of microplastics. Sci Total Environ 15(717):137064","journal-title":"Sci Total Environ"},{"issue":"9","key":"16527_CR60","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/etc.2267","volume":"32","author":"LS Segundo","year":"2013","unstructured":"Segundo LS, Martini F, Pablos MV (2013) Gene expression responses for detecting sublethal effects of xenobiotics and whole effluents on a Xenopus laevis embryo assay. Environ Toxicol Chem 32(9):2018\u20132025","journal-title":"Environ Toxicol Chem"},{"issue":"1526","key":"16527_CR61","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1098\/rstb.2008.0283","volume":"364","author":"L Shaxson","year":"2009","unstructured":"Shaxson L (2009) Structuring policy problems for plastics, the environment and human health: reflections from the UK. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):2141\u20132151","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"16527_CR62","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40572-018-0206-z","volume":"5","author":"M Smith","year":"2018","unstructured":"Smith M, Love DC, Rochman CM, Neff RA (2018) Microplastics in seafood and the implications for human health. Curr Environ Health Rep 5:375\u2013386","journal-title":"Curr Environ Health Rep"},{"issue":"1526","key":"16527_CR63","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1098\/rstb.2008.0289","volume":"364","author":"JH Song","year":"2009","unstructured":"Song JH, Murphy RJ, Narayan R, Davies GBH (2009) Biodegradable and compostable alternatives to conventional plastics. Philos Trans R Soc Lond Ser B Biol Sci 364(1526):2127\u20132139","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"16527_CR64","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1134\/S1022795418090156","volume":"54","author":"TA Vasilyeva","year":"2018","unstructured":"Vasilyeva TA, Voskresenskaya AA, Pozdeyeva NA, Marakhonov AV, Zinchenko RA (2018) Pax6 gene characteristic and causative role of Pax6 mutations in inherited eye pathologies. Russ J Genet 54:995\u20131002","journal-title":"Russ J Genet"},{"issue":"743","key":"16527_CR65","doi-asserted-by":"publisher","first-page":"140708","DOI":"10.1016\/j.scitotenv.2020.140708","volume":"15","author":"C Wang","year":"2020","unstructured":"Wang C, Xing R, Sun M, Ling W, Shi W, Cui S, An L (2020) Microplastics profile in a typical urban river in Beijing. Sci Total Environ 15(743):140708. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.140708","journal-title":"Sci Total Environ"},{"key":"16527_CR66","unstructured":"Weis J, Andrews CJ, Dyksen JE, et al. (2015) Human health impact of microplastics and nanoplastics. NJDEP - Science Advisory Board."},{"key":"16527_CR67","doi-asserted-by":"crossref","unstructured":"Wibowo YG, Maryani AT, Rosanti D, Rosarina D (2019) Microplastic in marine environment and its impact.Sainmatika 16:1.","DOI":"10.31851\/sainmatika.v16i1.2884"},{"key":"16527_CR68","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envpol.2013.02.031","volume":"178","author":"A Wright","year":"2013","unstructured":"Wright A, Thompson RC, Galloway TS (2013) The physical impacts of microplastics on marine organisms. A review Stephanie L Environ Pollut 178:483\u2013492","journal-title":"A review Stephanie L Environ Pollut"},{"issue":"6","key":"16527_CR69","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1440-169X.1989.00531.x","volume":"31","author":"Y Yamaguchi","year":"1983","unstructured":"Yamaguchi Y, Shinagawa A (1983) Marked alteration at midblastula transition in the effect of lithium on formation of the larval body pattern of Xenopus laevis. Develop Growth Differ 31(6):531\u2013541","journal-title":"Develop Growth Differ"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16527-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-16527-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16527-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T07:41:53Z","timestamp":1643787713000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-16527-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["16527"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-16527-1","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,7]]},"assertion":[{"value":"31 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study entitled \u201cEffects of high-molecular-weight polyvinyl chloride on <i>X. laevis<\/i> adultes and embryos: the mRNA expression profiles of Myf5, Esr1, Bmp4, Pax6, and Hsp70 genes during early embryonic development\u201d was approved by Cukurova University Health Sciences Assay Application and Research Center. Decision No: 4(5) on July 8, 2019.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}