{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:09:53Z","timestamp":1771945793189,"version":"3.50.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007684","name":"ministry of education and science of ukraine","doi-asserted-by":"publisher","award":["132 B"],"award-info":[{"award-number":["132 B"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007684","name":"ministry of education and science of ukraine","doi-asserted-by":"publisher","award":["M19\/2020"],"award-info":[{"award-number":["M19\/2020"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]},{"name":"research council of lithuania","award":["S-LU-20-10"],"award-info":[{"award-number":["S-LU-20-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11356-021-16775-1","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T19:32:37Z","timestamp":1633375957000},"page":"14131-14142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Environmental concentrations of Roundup in combination with chlorpromazine or heating causes biochemical disturbances in the bivalve mollusc Unio tumidus"],"prefix":"10.1007","volume":"29","author":[{"given":"Vira","family":"Khoma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Martinyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana","family":"Matskiv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesya","family":"Gnatyshyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliy","family":"Baranovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mykola","family":"Gladiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigita","family":"Gylyt\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levonas","family":"Manusad\u017eianas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-2881","authenticated-orcid":false,"given":"Oksana","family":"Stoliar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"key":"16775_CR1","doi-asserted-by":"publisher","first-page":"109123","DOI":"10.1016\/j.cbi.2020.109123","volume":"325","author":"GD Alkimin","year":"2020","unstructured":"Alkimin GD, Nunes B, Soares AMVM, Bellot M, G\u00f3mez-Canela C, Barata C (2020)Daphnia magna responses to fish kairomone and chlorpromazine exposures. Chem Biol Interact 325:109123. https:\/\/doi.org\/10.1016\/j.cbi.2020.109123","journal-title":"Chem Biol Interact"},{"key":"16775_CR2","doi-asserted-by":"publisher","first-page":"13360","DOI":"10.1007\/s11356-016-8320-7","volume":"25","author":"C Amid","year":"2018","unstructured":"Amid C, Olstedt M, Gunnarsson JS, Le Lan H, Tran Thi Minh H, Van den Brink PJ, Hellstr\u00f6m M, Tedengren M (2018) Additive effects of the herbicide glyphosate and elevated temperature on the branched coral Acropora formosa in Nha Trang, Vietnam. Environ Sci Pollut Res 25:13360\u201313372. https:\/\/doi.org\/10.1007\/s11356-016-8320-7","journal-title":"Environ Sci Pollut Res"},{"key":"16775_CR3","unstructured":"Baresel C, Palm Cousins A, H\u00f6rsing M, Ek M, Ejhed H, Allard AS, Magn\u00e9r J, Westling K, Wahlberg C, Fortkamp U, S\u00f6hr S (2015) Pharmaceutical residues and other emerging substances in the effluent of sewage treatment plants. IVL Swedish Environmental Research Institute, Report B, 2226."},{"key":"16775_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/toxics6010003","volume":"6","author":"RI Bonansea","year":"2018","unstructured":"Bonansea RI, Filippi I, Wunderlin DA, Marino DJ, Am\u00e9 MV (2018) The fate of glyphosate and AMPA in a freshwater endorheic basin: an ecotoxicological risk assessment. Toxics 6:3. https:\/\/doi.org\/10.3390\/toxics6010003","journal-title":"Toxics"},{"key":"16775_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00424-013-1295-z","volume":"466","author":"A Bouron","year":"2013","unstructured":"Bouron A, Oberwinkler J (2013) Contribution of calcium-conducting channels to the transport of zinc ions. Pflugers Arch 466:381\u2013387. https:\/\/doi.org\/10.1007\/s00424-013-1295-z","journal-title":"Pflugers Arch"},{"key":"16775_CR6","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.envint.2018.12.064","volume":"124","author":"L Carles","year":"2019","unstructured":"Carles L, Gardon H, Joseph L, Sanch\u00eds J, Farre M, Artigas J (2019)Meta-analysis of glyphosate contamination in surface waters and dissipation by biofilms. Environment International 124:284\u2013293. https:\/\/doi.org\/10.1016\/j.envint.2018.12.064","journal-title":"Environment International"},{"key":"16775_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.06.043","volume":"65","author":"VL De Liz Oliveira Cavalli","year":"2013","unstructured":"De Liz Oliveira Cavalli VL, Cattani D, Heinz Rieg CE, Pierozan P, Zanatta L, Benedetti Parisotto E, Wilhelm Filho D, Mena Barreto Silva FR, Pessoa-Pureur R, Zamoner A (2013) Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells. Free Radic Biol Med 65:335\u2013346. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.06.043","journal-title":"Free Radic Biol Med"},{"key":"16775_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/etc.23","volume":"29","author":"I Domingues","year":"2010","unstructured":"Domingues I, Agra AR, Monaghan K, Soares AM, Nogueira AJ (2010) Cholinesterase and glutathione-S-transferase activities in freshwater invertebrates as biomarkers to assess pesticide contamination. Environ Toxicol Chem 29:5\u201318. https:\/\/doi.org\/10.1002\/etc.23","journal-title":"Environ Toxicol Chem"},{"key":"16775_CR9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev-publhealth-012420-105026","volume":"42","author":"KL Ebi","year":"2021","unstructured":"Ebi KL, Vanos J, Baldwin JW, Bell JE, Hondula DM, Errett NA, Hayes K, Reid CE, Saha S, Spector J, Berry P (2021) Extreme weather and climate change: population health and health system implications. Annu Rev Public Health 42:293\u2013315. https:\/\/doi.org\/10.1146\/annurev-publhealth-012420-105026","journal-title":"Annu Rev Public Health"},{"key":"16775_CR10","doi-asserted-by":"publisher","first-page":"31198","DOI":"10.1007\/s11356-019-06256-x","volume":"26","author":"Y El Haj","year":"2019","unstructured":"El Haj Y, Bohn S, Souza MM (2019) Tolerance of native and invasive bivalves under herbicide and metal contamination: an ex vivo approach. Environ Sci Pollut Res Int 26:31198\u201331206. https:\/\/doi.org\/10.1007\/s11356-019-06256-x","journal-title":"Environ Sci Pollut Res Int"},{"key":"16775_CR11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres VJ, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88\u201390. https:\/\/doi.org\/10.1016\/0006-2952(61)90145-9","journal-title":"Biochem Pharmacol"},{"key":"16775_CR12","doi-asserted-by":"publisher","first-page":"cov033","DOI":"10.1093\/conphys\/cov033","volume":"3","author":"EE Flynn","year":"2015","unstructured":"Flynn EE, Bjelde BE, Miller NA, Todgham AE (2015) Ocean acidification exerts negative effects during warming conditions in a developing Antarctic fish. Conserv Physiol 3:cov033. https:\/\/doi.org\/10.1093\/conphys\/cov033","journal-title":"Conserv Physiol"},{"key":"16775_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.chemosphere.2014.01.016","volume":"115","author":"O Fr\u00e9d\u00e9ric","year":"2014","unstructured":"Fr\u00e9d\u00e9ric O, Yves P (2014) Pharmaceuticals in hospital wastewater: their ecotoxicity and contribution to the environmental hazard of the effluent. Chemosphere 115:31\u201339. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.01.016","journal-title":"Chemosphere"},{"issue":"4","key":"16775_CR14","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.bbrc.2019.04.074","volume":"513","author":"H Gaur","year":"2019","unstructured":"Gaur H, Bhargava A (2019) Glyphosate induces toxicity and modulates calcium and NO signaling in zebrafish embryos. Biochem Biophys Res Commun 513(4):1070\u20131075. https:\/\/doi.org\/10.1016\/j.bbrc.2019.04.074","journal-title":"Biochem Biophys Res Commun"},{"key":"16775_CR15","doi-asserted-by":"publisher","first-page":"21858","DOI":"10.1007\/s11356-019-04653-w","volume":"26","author":"V Gim\u00e9nez","year":"2019","unstructured":"Gim\u00e9nez V, Nunes B (2019) Effects of commonly used therapeutic drugs, paracetamol, and acetylsalicylic acid, on key physiological traits of the sea snail Gibbula umbilicalis. Environ Sci Pollut Res 26:21858\u201321870. https:\/\/doi.org\/10.1007\/s11356-019-04653-w","journal-title":"Environ Sci Pollut Res"},{"key":"16775_CR16","doi-asserted-by":"publisher","first-page":"11038","DOI":"10.1007\/s11356-020-07698-4","volume":"27","author":"L Gnatyshyna","year":"2020","unstructured":"Gnatyshyna L, Khoma V, Mishchuk O, Martinyuk V, Spri\u0146\u0123e G, Stoliar O (2020)Multi-marker study of the responses of the Unio tumidus from the areas of small and micro hydropower plants at the Dniester River Basin, Ukraine. Environ Sci Pollut Res 27:11038\u201311049. https:\/\/doi.org\/10.1007\/s11356-020-07698-4","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"16775_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","volume":"106","author":"OW Griffith","year":"1980","unstructured":"Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106(1):207\u2013212. https:\/\/doi.org\/10.1016\/0003-2697(80)90139-6","journal-title":"Anal Biochem"},{"key":"16775_CR18","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139","journal-title":"J Biol Chem"},{"key":"16775_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10565-014-9269-2","volume":"30","author":"R Hamaguchi","year":"2014","unstructured":"Hamaguchi R, Haginaka J, Tanimoto T, Kuroda Y (2014) Maintenance of luminal pH and protease activity in lysosomes\/late endosomes by vacuolar ATPase in chlorpromazine-treated RAW264 cells accumulating phospholipids. Cell Biol Toxicol 30:67\u201377. https:\/\/doi.org\/10.1007\/s10565-014-9269-2","journal-title":"Cell Biol Toxicol"},{"key":"16775_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.aquatox.2016.08.010","volume":"179","author":"LR Hansen","year":"2016","unstructured":"Hansen LR, Roslev P (2016) Behavioral responses of juvenile Daphnia magna after exposure to glyphosate and glyphosate-copper complexes. Aquat Toxicol 179:36\u201343. https:\/\/doi.org\/10.1016\/j.aquatox.2016.08.010","journal-title":"Aquat Toxicol"},{"key":"16775_CR21","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1159\/000485089","volume":"44","author":"L He","year":"2017","unstructured":"He L, HeT FS, Ji L, Liu T, Ma X (2017) Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 44:532\u2013553. https:\/\/doi.org\/10.1159\/000485089","journal-title":"Cell Physiol Biochem"},{"key":"16775_CR22","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1080\/10643389.2017.1393264","volume":"47","author":"E-M Hong","year":"2017","unstructured":"Hong E-M, Pachepsky YA, Whelan G, Nicholson T (2017) Simpler models in environmental studies and predictions. Critical Reviews in Environmental Science and Technology 47:1669\u20131712. https:\/\/doi.org\/10.1080\/10643389.2017.1393264","journal-title":"Critical Reviews in Environmental Science and Technology"},{"key":"16775_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jneuroim.2009.04.002","volume":"211","author":"T Hu","year":"2009","unstructured":"Hu T, Fu Q, Liu X, Zhang H, Dong M (2009) Increased acetylcholinesterase and caspase-3 expression in the brain and peripheral immune system of focal cerebral ischemic rats. J Neuroimmunol 211:84\u201391. https:\/\/doi.org\/10.1016\/j.jneuroim.2009.04.002","journal-title":"J Neuroimmunol"},{"key":"16775_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.aquatox.2014.01.013","volume":"149","author":"U Izagirre","year":"2014","unstructured":"Izagirre U, Errasti A, Bilbao E, M\u00fagica M, Marig\u00f3mez I (2014) Combined effects of thermal stress and Cd on lysosomal biomarkers and transcription of genes encoding lysosomal enzymes and HSP70 in mussels, Mytilus galloprovincialis. Aquat Toxicol 149:145\u2013156. https:\/\/doi.org\/10.1016\/j.aquatox.2014.01.013","journal-title":"Aquat Toxicol"},{"key":"16775_CR25","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.chemosphere.2016.07.107","volume":"162","author":"JJ Jim\u00e9nez","year":"2016","unstructured":"Jim\u00e9nez JJ, Mu\u00f1oz BE, S\u00e1nchez MI, Pardo R, Vega MS (2016) Fate of the drug chlorpromazine in river water according to laboratory assays. Identification and evolution over time of degradation products. Sorption to sediment. Chemosphere 162:285\u2013292. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.07.107","journal-title":"Chemosphere"},{"key":"16775_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.15407\/ubj92.05.087","volume":"92","author":"VV Khoma","year":"2020","unstructured":"Khoma VV, Gnatyshyna LL, Martinyuk VV, Mackiv TR, Mishchuk NY, Stoliar O (2020) Metallothioneins contribution to the response of bivalve mollusk to xenobiotics. Ukr Biochem J 92:87\u201396. https:\/\/doi.org\/10.15407\/ubj92.05.087","journal-title":"Ukr Biochem J"},{"key":"16775_CR27","doi-asserted-by":"publisher","first-page":"111695","DOI":"10.1016\/j.ecoenv.2020.111695","volume":"208","author":"V Khoma","year":"2021","unstructured":"Khoma V, Gnatyshyna L, Martinyuk V, Mackiv T, Mishchenko L, Manusad\u017eianas L, Stoliar O (2021) Common and particular biochemical responses of Unio tumidus to herbicide, pharmaceuticals and their combined exposure with heating. Ecotoxicol Environ Saf 208:111695. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111695","journal-title":"Ecotoxicol Environ Saf"},{"key":"16775_CR28","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0003-2697(84)90144-1","volume":"140","author":"AV Klotz","year":"1984","unstructured":"Klotz AV, Stegeman JJ, Walsh C (1984) An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity. Anal Biochem 140:138\u2013145. https:\/\/doi.org\/10.1016\/0003-2697(84)90144-1","journal-title":"Anal Biochem"},{"key":"16775_CR29","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s10495-020-01630-4","volume":"25","author":"DY Knorr","year":"2020","unstructured":"Knorr DY, Georges NS, Pauls S, Heinrich R (2020) Acetylcholinesterase promotes apoptosis in insect neurons. Apoptosis 25:730\u2013746. https:\/\/doi.org\/10.1007\/s10495-020-01630-4","journal-title":"Apoptosis"},{"issue":"3","key":"16775_CR30","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2983\/035.037.0301","volume":"37","author":"W Koagouw","year":"2018","unstructured":"Koagouw W, Ciocan C (2018) Impact of metformin and increased temperature on blue mussels Mytilus edulis\u2013 evidence for synergism. J Shellfish Res 37(3):467\u2013474. https:\/\/doi.org\/10.2983\/035.037.0301","journal-title":"J Shellfish Res"},{"key":"16775_CR31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.abb.2016.04.010","volume":"611","author":"A Kr\u0119\u017cel","year":"2016","unstructured":"Kr\u0119\u017cel A, Maret W (2016) The biological inorganic chemistry of zinc ions. Arch Biochem Biophys 611:3\u201319. https:\/\/doi.org\/10.1016\/j.abb.2016.04.010","journal-title":"Arch Biochem Biophys"},{"key":"16775_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1177\/1091581814540481","volume":"33","author":"K Larsen","year":"2014","unstructured":"Larsen K, Najle R, Lifschitz A, Mat\u00e9 ML, Lanusse C, Virkel GL (2014) Effects of sublethal exposure to a glyphosate-based herbicide formulation on metabolic activities of different xenobiotic-metabolizing enzymes in rats. Int J Toxicol 33:307\u2013318. https:\/\/doi.org\/10.1177\/1091581814540481","journal-title":"Int J Toxicol"},{"issue":"1","key":"16775_CR33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10393-008-0158-0","volume":"5","author":"H Lefcort","year":"2008","unstructured":"Lefcort H, Freedman Z, House S et al (2008) Hormetic effects of heavy metals in aquatic snails: is a little bit of pollution good? EcoHealth 5(1):10\u201317. https:\/\/doi.org\/10.1007\/s10393-008-0158-0","journal-title":"EcoHealth"},{"key":"16775_CR34","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.2174\/1568026616666160608084834","volume":"16","author":"P Li","year":"2016","unstructured":"Li P, Snyder GL, Vanover KE (2016) Dopamine targeting drugs for the treatment of schizophrenia: past, present and future. Curr Top Med Chem 16:3385\u20133403. https:\/\/doi.org\/10.2174\/1568026616666160608084834","journal-title":"Curr Top Med Chem"},{"key":"16775_CR35","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.scitotenv.2018.11.213","volume":"655","author":"N Liu","year":"2019","unstructured":"Liu N, Zhong G, Zhou J, Liu Y, Pang Y, Cai H, Wu Z (2019) Separate and combined effects of glyphosate and copper on growth and antioxidative enzymes in Salvinia natans (L.) All. Sci Total Environ. 655:1448\u20131456. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.11.213","journal-title":"Sci Total Environ."},{"key":"16775_CR36","doi-asserted-by":"publisher","first-page":"138450","DOI":"10.1016\/j.scitotenv.2020.138450","volume":"725","author":"F Louis","year":"2020","unstructured":"Louis F, Rocher B, Barjhoux I, Bultelle F, Dedourge-Geffard O, Gaillet V, Bonnard I, Delahaut L, Pain-Devin S, Geffard A, Paris-Palacios S, David E (2020) Seasonal monitoring of cellular energy metabolism in a sentinel species, Dreissena polymorpha (bivalve): effect of global change? Sci Total Environ 725:138450. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138450","journal-title":"Sci Total Environ"},{"key":"16775_CR37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebroungh HJ, Farr AL, Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193:265\u2013275. https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","journal-title":"J Biol Chem"},{"key":"16775_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.envint.2019.04.053","volume":"128","author":"OV Martin","year":"2019","unstructured":"Martin OV, Adams J, Beasley A, Belanger S, Breton RL, Brock TCM, Buonsante VA, Galay Burgos M, Green J, Guiney PD, Hall T, Hanson M, Harris MJ, Henry TR, Huggett D, Junghans M, Laskowski R, Maack G, Moermond CTA et al (2019) Improving environmental risk assessments of chemicals: steps towards evidence-based ecotoxicology. Environ Int 128:210\u2013217. https:\/\/doi.org\/10.1016\/j.envint.2019.04.053","journal-title":"Environ Int"},{"key":"16775_CR39","doi-asserted-by":"publisher","first-page":"14302","DOI":"10.1038\/s41598-019-50607-0","volume":"9","author":"V Matozzo","year":"2019","unstructured":"Matozzo V, Munari M, Masiero L, Finos L, Marin MG (2019) Ecotoxicological hazard of a mixture of glyphosate and aminomethylphosphonic acid to the mussel Mytilus galloprovincialis (Lamarck 1819). Sci Rep 9:14302. https:\/\/doi.org\/10.1038\/s41598-019-50607-0","journal-title":"Sci Rep"},{"key":"16775_CR40","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3390\/jmse8060399","volume":"8","author":"V Matozzo","year":"2020","unstructured":"Matozzo V, Fabrello J, Marin MG (2020) The effects of glyphosate and its commercial formulations to marine invertebrates: a review. J Mar Sci Eng 8:399. https:\/\/doi.org\/10.3390\/jmse8060399","journal-title":"J Mar Sci Eng"},{"key":"16775_CR41","unstructured":"Maycock D, Crane M, Atkinson C, Johnson J (2012) Proposed EQS for water framework directive annex VIII substances: glyphosate (for consultation). Water Framework Directive \u2013 United Kingdom Technical Advisory Group (WFD-UKTAG). Sniffer, Edinburgh, 121 pp. https:\/\/www.wfduk.org\/sites\/default\/files\/Media\/Glyphosate%20-%20UKTAG.pdf. Accessed February 2021."},{"key":"16775_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ecoenv.2016.10.014","volume":"135","author":"F Melo Tarouco","year":"2017","unstructured":"Melo Tarouco F, De Godoi FGA, Velasques RR, Da Silveira GA, Geihs MA, Da Rosa CE (2017) Effects of the herbicide Roundup on the polychaeta Laeonereis acuta: cholinesterases and oxidative stress. Ecotoxicol Environ Saf 135:259\u2013266. https:\/\/doi.org\/10.1016\/j.ecoenv.2016.10.014","journal-title":"Ecotoxicol Environ Saf"},{"key":"16775_CR43","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1007\/s11356-017-1080-1","volume":"25","author":"M Mertens","year":"2018","unstructured":"Mertens M, H\u00f6ss S, Neumann G, Afzal J, Reichenbecher W (2018) Glyphosate, a chelating agent \u2013 relevant for ecological risk assessment? Environ Sci Pollut Res 25:5298\u20135317. https:\/\/doi.org\/10.1007\/s11356-017-1080-1","journal-title":"Environ Sci Pollut Res"},{"key":"16775_CR44","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fpubh.2017.00316","volume":"5","author":"R Mesnage","year":"2017","unstructured":"Mesnage R, Antoniou MN (2017) Facts and fallacies in the debate on glyphosate toxicity. Front Public Health 5:316. https:\/\/doi.org\/10.3389\/fpubh.2017.00316","journal-title":"Front Public Health"},{"key":"16775_CR45","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.envint.2019.04.038","volume":"129","author":"TH Miller","year":"2019","unstructured":"Miller TH, Ng KT, Bury ST, Bury SE, Bury NR, Barron LP (2019) Biomonitoring of pesticides, pharmaceuticals and illicit drugs in a freshwater invertebrate to estimate toxic or effect pressure. Environ Int 129:595\u2013606. https:\/\/doi.org\/10.1016\/j.envint.2019.04.038","journal-title":"Environ Int"},{"key":"16775_CR46","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1242\/jeb.01052","volume":"207","author":"ST Mukai","year":"2004","unstructured":"Mukai ST, Kiehn L, Saleuddin ASM (2004) Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor. J Exp Biol 207:2507\u20132518. https:\/\/doi.org\/10.1242\/jeb.01052","journal-title":"J Exp Biol"},{"key":"16775_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066802","volume":"8","author":"A Negri","year":"2013","unstructured":"Negri A, Oliveri C, Sforzini S, Mignione F, Viarengo A, Banni M (2013) Transcriptional response of the mussel Mytilus galloprovincialis (Lam.) following exposure to heat stress and copper. PLoS One 8:e66802. https:\/\/doi.org\/10.1371\/journal.pone.0066802","journal-title":"PLoS One"},{"key":"16775_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbpc.2018.07.002","volume":"213","author":"M Nelson","year":"2018","unstructured":"Nelson M, Adams T, Ojo C, Carroll MA, Catapane EJ (2018) Manganese toxicity is targeting an early step in the dopamine signal transduction pathway that controls lateral cilia activity in the bivalve mollusc Crassostrea virginica. Comp Biochem Physiol C Toxicol Pharmacol 213:1\u20136. https:\/\/doi.org\/10.1016\/j.cbpc.2018.07.002","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"16775_CR49","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ecoenv.2015.04.028","volume":"119","author":"LLD Oliveira","year":"2015","unstructured":"Oliveira LLD, Antunes SC, Gon\u00e7alves F, Rocha O, Nunes B (2015) Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers. Ecotoxicol Environ Saf 119:123\u2013131. https:\/\/doi.org\/10.1016\/j.ecoenv.2015.04.028","journal-title":"Ecotoxicol Environ Saf"},{"key":"16775_CR50","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/etc.2990","volume":"34","author":"RW Patra","year":"2015","unstructured":"Patra RW, Chapman JC, Lim RP, Gehrke PC, Sunderam RM (2015) Interactions between water temperature and contaminant toxicity to freshwater fish. Environ Toxicol Chem. 34:1809\u20131817. https:\/\/doi.org\/10.1002\/etc.2990","journal-title":"Environ Toxicol Chem."},{"issue":"Pt 22","key":"16775_CR51","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1242\/jeb.140129","volume":"219","author":"SL Payton","year":"2016","unstructured":"Payton SL, Johnson PD, Jenny MJ (2016) Comparative physiological, biochemical and molecular thermal stress response profiles for two unionid freshwater mussel species. J Exp Biol 219(Pt 22):3562\u20133574. https:\/\/doi.org\/10.1242\/jeb.140129","journal-title":"J Exp Biol"},{"key":"16775_CR52","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.encep.2020.05.006","volume":"46","author":"M Plaze","year":"2020","unstructured":"Plaze M, Attali D, Petit AC, Blatzer M, Simon-Loriere E, Vinckier F, Cachia A, Chr\u00e9tien F, Gaillard R (2020) Repurposing chlorpromazine to treat COVID-19: the reCoVery study. L'Enc\u00e9phale 46:169\u2013172. https:\/\/doi.org\/10.1016\/j.encep.2020.05.006","journal-title":"L'Enc\u00e9phale"},{"key":"16775_CR53","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231\u20131237. https:\/\/doi.org\/10.1016\/S0891-5849(98)00315-3","journal-title":"Free Radic Biol Med"},{"key":"16775_CR54","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1201\/b10519-9","volume-title":"Tolerance to Environmental Contaminants","author":"F Regoli","year":"2011","unstructured":"Regoli F, Benedetti M, Giuliani ME (2011) Antioxidant defenses and acquisition of tolerance to chemical stress. In: Amiard-Triquet \u0421, Rainbow PS, Romeo M (eds) Tolerance to Environmental Contaminants, 1st edn. CRC Press, Boca Raton, pp 153\u2013173. https:\/\/doi.org\/10.1201\/b10519-9","edition":"1"},{"key":"16775_CR55","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/s0076-6879(94)33041-7","volume":"233","author":"AZ Reznick","year":"1994","unstructured":"Reznick AZ, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Meth Enzymol 233:357\u2013363. https:\/\/doi.org\/10.1016\/s0076-6879(94)33041-7","journal-title":"Meth Enzymol"},{"key":"16775_CR56","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0076-6879(91)05106-6","volume":"205B","author":"G Roesijadi","year":"1991","unstructured":"Roesijadi G, Fowler B (1991) Purification of invertebrate metallothioneins. Meth Enzymol 205B:263\u2013273. https:\/\/doi.org\/10.1016\/0076-6879(91)05106-6","journal-title":"Meth Enzymol"},{"key":"16775_CR57","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/03067319808032607","volume":"70","author":"C Skark","year":"1998","unstructured":"Skark C, Zullei-Seibert N, Schottler U, Schlett C (1998) The occurrence of glyphosate in surface water. Int J Environ Anal Chem 70:93\u2013104. https:\/\/doi.org\/10.1080\/03067319808032607","journal-title":"Int J Environ Anal Chem"},{"key":"16775_CR58","doi-asserted-by":"publisher","first-page":"577678","DOI":"10.3389\/fphar.2020.577678","volume":"11","author":"E Stip","year":"2020","unstructured":"Stip E, Rizvi TA, Mustafa F, Javaid S, Aburuz S, Ahmed NN, Abdel Aziz K, Arnone D, Subbarayan A, Al Mugaddam F, Khan G (2020) The large action of chlorpromazine: translational and transdisciplinary considerations in the face of COVID-19. Front Pharmacol 11:577678. https:\/\/doi.org\/10.3389\/fphar.2020.577678","journal-title":"Front Pharmacol"},{"key":"16775_CR59","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jchromb.2012.01.022","volume":"889\u2013890","author":"C Trautwein","year":"2012","unstructured":"Trautwein C, K\u00fcmmerer K (2012) Degradation of the tricyclic antipsychotic drug chlorpromazine under environmental conditions, identification of its main aquatic biotic and abiotic transformation products by LC-MSn and their effects on environmental bacteria. J Chromatogr B 889\u2013890:24\u201338. https:\/\/doi.org\/10.1016\/j.jchromb.2012.01.022","journal-title":"J Chromatogr B"},{"key":"16775_CR60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.envpol.2005.02.018","volume":"138","author":"MTK Tsui","year":"2005","unstructured":"Tsui MTK, Wang WX, Chu LM (2005) Influence of glyphosate and its formulation (Roundup\u00ae) on the toxicity and bioavailability of metals to Ceriodaphnia dubia. Environ Pollut 138:59\u201368. https:\/\/doi.org\/10.1016\/j.envpol.2005.02.018","journal-title":"Environ Pollut"},{"issue":"9","key":"16775_CR61","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1080\/07391102.2020.1763200","volume":"39","author":"F T\u00fcrkan","year":"2020","unstructured":"T\u00fcrkan F, Calimli MH, Kanbero\u011flu GS, Karaman M (2020) Inhibition effects of isoproterenol, chlorpromazine, carbamazepine, tamoxifen drugs on glutathione S-transferase, cholinesterases enzymes and molecular docking studies. J Biomol Struct Dyn 39(9):3277\u20133284. https:\/\/doi.org\/10.1080\/07391102.2020.1763200","journal-title":"J Biomol Struct Dyn"},{"key":"16775_CR62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0141-1136(96)00103-1","volume":"44","author":"A Viarengo","year":"1997","unstructured":"Viarengo A, Ponzano E, Dondero F, Fabbri R (1997) A simple spectrophotometric method for metallothionein evaluation in marine organisms: an application to Mediterranean and Antarctic molluscs. Mar Environ Res 44:69\u201384. https:\/\/doi.org\/10.1016\/S0141-1136(96)00103-1","journal-title":"Mar Environ Res"},{"key":"16775_CR63","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.foodchem.2017.10.054","volume":"245","author":"J Wang","year":"2018","unstructured":"Wang J, Niu Y, Zhang C, Chen Y (2018) A micro-plate colorimetric assay for rapid determination of trace zinc in animal feed, pet food and drinking water by ion masking nd statistical partitioning correction. Food Chem 245:337\u2013345. https:\/\/doi.org\/10.1016\/j.foodchem.2017.10.054","journal-title":"Food Chem"},{"key":"16775_CR64","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.etp.2008.12.009","volume":"62","author":"B Xu","year":"2010","unstructured":"Xu B, Xu ZF, Deng Y, Yang JH (2010) Protective effects of chlorpromazine and verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol 62:27\u201334. https:\/\/doi.org\/10.1016\/j.etp.2008.12.009","journal-title":"Exp Toxicol Pathol"},{"key":"16775_CR65","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/08927014.2011.553717","volume":"27","author":"JL Yang","year":"2011","unstructured":"Yang JL, Li YF, Bao WY, Satuito CG, Kitamura H (2011) Larval metamorphosis of the mussel Mytilus galloprovincialis Lamarck, 1819 in response to neurotransmitter blockers and tetraethylammonium. Biofouling 27:193\u2013199. https:\/\/doi.org\/10.1080\/08927014.2011.553717","journal-title":"Biofouling"},{"key":"16775_CR66","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fnmol.2012.00040","volume":"5","author":"X-J Zhang","year":"2012","unstructured":"Zhang X-J, Greenberg DS (2012) Acetylcholinesterase involvement in apoptosis. Front Mol Neurosci 5:40. https:\/\/doi.org\/10.3389\/fnmol.2012.00040https:\/\/ukr.seatemperature.net\/seas-and-rivers\/reka-dnestr","journal-title":"Front Mol Neurosci"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11356-021-16775-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-021-16775-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T10:27:50Z","timestamp":1744194470000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11356-021-16775-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["16775"],"URL":"https:\/\/doi.org\/10.1007\/s11356-021-16775-1","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]},"assertion":[{"value":"25 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have approved this version of the work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}